ISMARA results: NR2C1

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NR2C1

Z-value: 0.79

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Transcription factors associated with NR2C1

Gene Symbol	Gene ID	Gene Info
NR2C1 Ensembl NCBI GeneCards UniProt	ENSG00000120798.12	nuclear receptor subfamily 2 group C member 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NR2C1	hg19_v2_chr12_-_95467356_95467479	-0.70	6.5e-04	Click!

Activity profile of NR2C1 motif

Sorted Z-values of NR2C1 motif

No targets for NR2C1

Network of associatons between targets according to the STRING database.

First level regulatory network of NR2C1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	3.6	GO:0045110	intermediate filament bundle assembly(GO:0045110)
0.5	3.2	GO:0042335	cuticle development(GO:0042335)
0.1	2.3	GO:0048672	positive regulation of collateral sprouting(GO:0048672)
0.2	1.8	GO:2000609	regulation of thyroid hormone generation(GO:2000609)
0.5	1.5	GO:1902362	melanocyte apoptotic process(GO:1902362)
0.2	1.2	GO:0003070	age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571)
0.0	1.2	GO:0008038	neuron recognition(GO:0008038)
0.0	1.0	GO:0016540	protein autoprocessing(GO:0016540)
0.0	1.0	GO:0048025	negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.0	0.9	GO:0016577	histone demethylation(GO:0016577)

Showing 1 to 10 of 49 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.5	GO:0045095	keratin filament(GO:0045095)
0.1	1.5	GO:0071438	invadopodium membrane(GO:0071438)
0.2	0.7	GO:0035525	NF-kappaB p50/p65 complex(GO:0035525)
0.1	0.7	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1	0.6	GO:0097129	cyclin D2-CDK4 complex(GO:0097129)
0.1	0.6	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.1	0.6	GO:0061574	ASAP complex(GO:0061574)
0.0	0.5	GO:0044295	axonal growth cone(GO:0044295)
0.0	0.4	GO:0031304	intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.1	0.3	GO:0072534	perineuronal net(GO:0072534)

Showing 1 to 10 of 15 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	3.6	GO:1990254	keratin filament binding(GO:1990254)
0.2	3.2	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.1	2.3	GO:0019841	retinal binding(GO:0016918) retinol binding(GO:0019841)
0.1	1.5	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.1	1.2	GO:0004784	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.9	GO:0032452	histone demethylase activity(GO:0032452)
0.1	0.7	GO:0043183	vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1	0.7	GO:0071532	ankyrin repeat binding(GO:0071532)
0.0	0.7	GO:0000150	recombinase activity(GO:0000150)
0.2	0.6	GO:0017095	heparan sulfate 6-O-sulfotransferase activity(GO:0017095)

Showing 1 to 10 of 31 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
3.6	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
1.2	PID FOXO PATHWAY	FoxO family signaling
1.1	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
1.0	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.9	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.7	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.7	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.5	PID ARF 3PATHWAY	Arf1 pathway
0.5	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.4	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes

Showing 1 to 10 of 10 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
0.9	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.9	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.7	REACTOME REGULATED PROTEOLYSIS OF P75NTR	Genes involved in Regulated proteolysis of p75NTR
0.7	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.7	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.6	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.6	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.6	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.5	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.3	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

Showing 1 to 10 of 11 entries

Results for NR2C1

Z-value: 0.79

Motif logo

Transcription factors associated with NR2C1

Activity-expression correlation:

Activity profile of NR2C1 motif

Sorted Z-values of NR2C1 motif

No targets for NR2C1

Network of associatons between targets according to the STRING database.

First level regulatory network of NR2C1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: