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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NR2F1

Z-value: 2.31

Motif logo

Transcription factors associated with NR2F1

Gene Symbol Gene ID Gene Info
ENSG00000175745.7 nuclear receptor subfamily 2 group F member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR2F1hg19_v2_chr5_+_92919043_929190820.905.2e-08Click!

Activity profile of NR2F1 motif

Sorted Z-values of NR2F1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NR2F1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 13.8 GO:0035565 regulation of pronephros size(GO:0035565)
3.1 9.2 GO:0070902 mitochondrial tRNA pseudouridine synthesis(GO:0070902)
1.9 5.6 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
1.5 4.4 GO:0050787 antibiotic metabolic process(GO:0016999) detoxification of mercury ion(GO:0050787)
1.4 4.1 GO:0045720 negative regulation of integrin biosynthetic process(GO:0045720)
1.3 3.8 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
1.3 12.7 GO:0000821 regulation of arginine metabolic process(GO:0000821)
1.2 2.5 GO:0097187 dentinogenesis(GO:0097187)
1.0 3.0 GO:0032917 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
1.0 2.9 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
0.9 2.6 GO:0014876 response to injury involved in regulation of muscle adaptation(GO:0014876)
0.9 9.4 GO:0019344 cysteine biosynthetic process(GO:0019344)
0.8 3.3 GO:0042361 menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377)
0.8 3.1 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.7 6.9 GO:0014827 intestine smooth muscle contraction(GO:0014827)
0.6 2.5 GO:0009822 alkaloid catabolic process(GO:0009822)
0.6 2.4 GO:0071348 cellular response to interleukin-11(GO:0071348)
0.5 1.6 GO:0061727 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.5 2.3 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.4 3.1 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.4 3.5 GO:0046618 drug export(GO:0046618)
0.4 1.5 GO:0098968 neurotransmitter receptor transport postsynaptic membrane to endosome(GO:0098968)
0.4 1.4 GO:1904106 protein localization to microvillus(GO:1904106)
0.3 1.7 GO:0007525 somatic muscle development(GO:0007525)
0.3 4.0 GO:0071321 cellular response to cGMP(GO:0071321)
0.3 1.9 GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
0.3 1.2 GO:0060032 notochord regression(GO:0060032)
0.3 2.0 GO:0042262 DNA protection(GO:0042262)
0.3 6.2 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.3 1.3 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.3 1.3 GO:0019303 D-ribose catabolic process(GO:0019303)
0.2 1.0 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.2 0.2 GO:0009441 glycolate metabolic process(GO:0009441)
0.2 2.5 GO:0006013 mannose metabolic process(GO:0006013)
0.2 0.9 GO:0035262 gonad morphogenesis(GO:0035262)
0.2 0.7 GO:1904247 positive regulation of polynucleotide adenylyltransferase activity(GO:1904247)
0.2 2.7 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.2 6.8 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.2 4.1 GO:0019532 oxalate transport(GO:0019532)
0.2 0.6 GO:1904640 response to methionine(GO:1904640)
0.2 1.2 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.2 3.3 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.2 1.4 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.2 1.5 GO:0033632 regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.2 1.9 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.2 1.2 GO:0006642 triglyceride mobilization(GO:0006642)
0.2 1.7 GO:0046485 ether lipid metabolic process(GO:0046485)
0.2 0.5 GO:0038178 complement component C5a signaling pathway(GO:0038178)
0.2 0.8 GO:0032571 response to vitamin K(GO:0032571)
0.2 3.2 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.2 1.1 GO:1902896 terminal web assembly(GO:1902896)
0.2 1.7 GO:0032264 IMP salvage(GO:0032264)
0.1 0.7 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.1 5.5 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 0.7 GO:0036115 fatty-acyl-CoA catabolic process(GO:0036115)
0.1 0.6 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.1 1.5 GO:0018211 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.1 1.6 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.5 GO:0031456 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.1 0.7 GO:0022614 membrane to membrane docking(GO:0022614)
0.1 2.6 GO:0051601 exocyst localization(GO:0051601)
0.1 3.4 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.1 2.7 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.1 1.6 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.1 0.6 GO:1905040 vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.1 1.7 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.5 GO:0035922 pulmonary valve formation(GO:0003193) visceral motor neuron differentiation(GO:0021524) foramen ovale closure(GO:0035922)
0.1 0.3 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.1 1.0 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.1 0.3 GO:0035674 tricarboxylic acid transmembrane transport(GO:0035674)
0.1 0.2 GO:2000532 renal protein absorption(GO:0097017) renal albumin absorption(GO:0097018) regulation of renal albumin absorption(GO:2000532)
0.1 0.4 GO:0002933 lipid hydroxylation(GO:0002933)
0.1 1.3 GO:0009125 nucleoside monophosphate catabolic process(GO:0009125)
0.1 0.8 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.1 0.8 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.1 0.4 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.1 2.1 GO:0032354 response to follicle-stimulating hormone(GO:0032354)
0.1 3.3 GO:0030252 growth hormone secretion(GO:0030252)
0.1 0.5 GO:0090131 mesenchyme migration(GO:0090131)
0.1 0.2 GO:0031427 response to methotrexate(GO:0031427)
0.1 5.5 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 0.8 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.1 1.4 GO:0060033 anatomical structure regression(GO:0060033)
0.1 2.1 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.1 0.5 GO:0006680 glucosylceramide catabolic process(GO:0006680)
0.1 0.4 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.1 1.4 GO:1990845 adaptive thermogenesis(GO:1990845)
0.1 2.3 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.1 1.2 GO:0006089 lactate metabolic process(GO:0006089)
0.1 7.8 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 0.3 GO:0015785 UDP-galactose transport(GO:0015785) UDP-galactose transmembrane transport(GO:0072334)
0.1 0.9 GO:0035608 protein deglutamylation(GO:0035608)
0.1 0.5 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.1 0.4 GO:0030997 regulation of centriole-centriole cohesion(GO:0030997)
0.1 0.3 GO:0032962 positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.1 0.4 GO:0098912 membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912) positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.1 0.3 GO:0002036 regulation of L-glutamate transport(GO:0002036)
0.1 0.4 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.0 0.5 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.0 3.1 GO:0043403 skeletal muscle tissue regeneration(GO:0043403)
0.0 0.2 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.0 1.3 GO:0043586 tongue development(GO:0043586)
0.0 1.0 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.3 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.0 1.3 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 2.2 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 0.1 GO:1901253 negative regulation of intracellular transport of viral material(GO:1901253)
0.0 0.9 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 0.7 GO:0016559 peroxisome fission(GO:0016559)
0.0 0.2 GO:0090261 positive regulation of inclusion body assembly(GO:0090261)
0.0 0.3 GO:0023041 neuronal signal transduction(GO:0023041)
0.0 0.4 GO:1901748 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.0 0.2 GO:0044380 protein localization to cytoskeleton(GO:0044380)
0.0 0.2 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.0 3.5 GO:0030449 regulation of complement activation(GO:0030449)
0.0 0.2 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.0 1.2 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 4.4 GO:0036503 ERAD pathway(GO:0036503)
0.0 0.5 GO:0071044 histone mRNA catabolic process(GO:0071044)
0.0 0.3 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.5 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 0.1 GO:1902358 sulfate transmembrane transport(GO:1902358)
0.0 0.2 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
0.0 0.3 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.3 GO:0060770 positive thymic T cell selection(GO:0045059) negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 1.5 GO:1900078 positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0 1.3 GO:0014003 oligodendrocyte development(GO:0014003)
0.0 0.7 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 0.3 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 1.4 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.0 1.2 GO:0001755 neural crest cell migration(GO:0001755)
0.0 0.1 GO:0061366 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0 0.2 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 1.5 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.2 GO:0002863 positive regulation of inflammatory response to antigenic stimulus(GO:0002863)
0.0 0.0 GO:2000909 regulation of cholesterol import(GO:0060620) negative regulation of cholesterol import(GO:0060621) regulation of sterol import(GO:2000909) negative regulation of sterol import(GO:2000910)
0.0 0.1 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.0 0.4 GO:0006525 arginine metabolic process(GO:0006525)
0.0 0.1 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
0.0 0.4 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 0.2 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.2 GO:0002861 regulation of inflammatory response to antigenic stimulus(GO:0002861) negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0 0.4 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 0.2 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.8 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.2 GO:0006924 activation-induced cell death of T cells(GO:0006924)
0.0 0.6 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.3 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.3 GO:0033561 regulation of water loss via skin(GO:0033561) establishment of skin barrier(GO:0061436)
0.0 0.1 GO:0015747 urate transport(GO:0015747)
0.0 0.7 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.2 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.0 0.3 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.2 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.1 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.3 GO:0018027 peptidyl-lysine dimethylation(GO:0018027)
0.0 1.0 GO:0002228 natural killer cell mediated immunity(GO:0002228)
0.0 0.2 GO:0016180 snRNA processing(GO:0016180)
0.0 0.3 GO:0097150 neuronal stem cell population maintenance(GO:0097150)
0.0 0.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 4.0 GO:0098855 HCN channel complex(GO:0098855)
0.4 1.6 GO:0031251 PAN complex(GO:0031251)
0.4 3.2 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.3 3.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.3 2.7 GO:0097165 nuclear stress granule(GO:0097165)
0.3 4.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.3 3.8 GO:0046581 intercellular canaliculus(GO:0046581)
0.2 0.7 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
0.2 1.5 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.2 5.6 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 2.3 GO:0031931 TORC1 complex(GO:0031931)
0.1 1.3 GO:0005638 lamin filament(GO:0005638)
0.1 4.4 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 9.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 2.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 1.0 GO:0044326 dendritic spine neck(GO:0044326)
0.1 0.8 GO:0071203 WASH complex(GO:0071203)
0.1 1.0 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 5.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 3.3 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 0.8 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.1 0.9 GO:0043296 apical junction complex(GO:0043296)
0.1 2.6 GO:0000145 exocyst(GO:0000145)
0.1 0.6 GO:0097443 sorting endosome(GO:0097443)
0.1 0.2 GO:0045281 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.1 0.3 GO:0036398 TCR signalosome(GO:0036398)
0.0 1.1 GO:0032433 filopodium tip(GO:0032433)
0.0 5.4 GO:0016459 myosin complex(GO:0016459)
0.0 3.1 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 1.4 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.7 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.6 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.0 1.9 GO:0097546 ciliary base(GO:0097546)
0.0 0.1 GO:0001534 radial spoke(GO:0001534)
0.0 1.3 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.3 GO:0042382 paraspeckles(GO:0042382)
0.0 0.9 GO:0043198 dendritic shaft(GO:0043198)
0.0 1.2 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.2 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.0 0.5 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 6.1 GO:0005923 bicellular tight junction(GO:0005923)
0.0 4.0 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.3 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 1.5 GO:0002102 podosome(GO:0002102)
0.0 0.7 GO:0031305 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.3 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.8 GO:0042101 T cell receptor complex(GO:0042101)
0.0 7.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 4.7 GO:0072562 blood microparticle(GO:0072562)
0.0 1.2 GO:0045171 intercellular bridge(GO:0045171)
0.0 2.7 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.2 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.2 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.9 GO:0016592 mediator complex(GO:0016592)
0.0 9.6 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 1.0 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.1 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 1.4 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.2 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 1.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 1.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.7 GO:0030315 T-tubule(GO:0030315)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 9.2 GO:0004730 pseudouridylate synthase activity(GO:0004730)
1.3 3.8 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
1.0 3.0 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.9 2.7 GO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
0.8 4.0 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.8 3.1 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.7 7.1 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.7 4.1 GO:0004882 androgen receptor activity(GO:0004882)
0.6 3.5 GO:0015307 drug:proton antiporter activity(GO:0015307)
0.6 12.6 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.5 9.8 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.5 1.6 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.5 2.3 GO:0031708 endothelin B receptor binding(GO:0031708)
0.3 3.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.3 1.5 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.3 1.2 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.3 4.1 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.2 2.6 GO:0035877 death effector domain binding(GO:0035877)
0.2 4.4 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.2 4.1 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.2 1.0 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.2 0.6 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.2 1.0 GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity(GO:0004572)
0.2 1.4 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.2 1.7 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.2 0.8 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.2 0.7 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.2 1.7 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.2 1.6 GO:0030249 cyclase regulator activity(GO:0010851) guanylate cyclase regulator activity(GO:0030249)
0.2 0.5 GO:0004878 complement component C5a receptor activity(GO:0004878)
0.1 0.7 GO:0015234 thiamine transmembrane transporter activity(GO:0015234) azole transmembrane transporter activity(GO:1901474)
0.1 0.5 GO:0002134 pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) pyrimidine ribonucleoside binding(GO:0032551)
0.1 0.5 GO:0008422 beta-glucosidase activity(GO:0008422)
0.1 1.2 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 0.7 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.1 4.1 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 2.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 1.6 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 3.2 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.1 1.0 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.1 3.2 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 0.8 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 1.1 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.1 4.4 GO:0005504 fatty acid binding(GO:0005504)
0.1 0.7 GO:0016936 galactoside binding(GO:0016936)
0.1 0.3 GO:0004103 choline kinase activity(GO:0004103)
0.1 2.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 5.5 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 3.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.2 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.1 1.5 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.1 0.7 GO:0005497 androgen binding(GO:0005497)
0.1 0.8 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.1 1.0 GO:0015288 porin activity(GO:0015288)
0.1 0.2 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.1 2.7 GO:0008143 poly(A) binding(GO:0008143)
0.1 0.9 GO:0052658 inositol-polyphosphate 5-phosphatase activity(GO:0004445) inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.1 1.2 GO:0015245 fatty acid transporter activity(GO:0015245)
0.1 0.3 GO:0038025 reelin receptor activity(GO:0038025)
0.1 0.3 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.1 2.6 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 1.6 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 1.6 GO:0070330 aromatase activity(GO:0070330)
0.1 1.9 GO:0035497 cAMP response element binding(GO:0035497)
0.1 0.4 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.1 0.3 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.1 0.3 GO:0015137 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.1 0.5 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 2.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.2 GO:0015056 corticotrophin-releasing factor receptor activity(GO:0015056)
0.0 1.2 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.2 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.6 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.0 2.6 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 0.3 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.1 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 0.4 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 1.3 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
0.0 0.3 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 1.1 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.7 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 6.1 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.2 GO:1990254 keratin filament binding(GO:1990254)
0.0 0.3 GO:0004969 histamine receptor activity(GO:0004969)
0.0 1.5 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.2 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 1.7 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 2.5 GO:0030145 manganese ion binding(GO:0030145)
0.0 0.2 GO:0051870 methotrexate binding(GO:0051870)
0.0 0.8 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 1.3 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 0.3 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 1.3 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.8 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 2.6 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 2.2 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.1 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.0 3.8 GO:0003774 motor activity(GO:0003774)
0.0 0.5 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.1 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.0 0.2 GO:0033691 sialic acid binding(GO:0033691)
0.0 1.4 GO:0005507 copper ion binding(GO:0005507)
0.0 0.1 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0 0.0 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.0 0.4 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.0 0.2 GO:0031996 thioesterase binding(GO:0031996)
0.0 1.8 GO:0008013 beta-catenin binding(GO:0008013)
0.0 3.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.5 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.5 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 1.3 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 2.2 GO:0005178 integrin binding(GO:0005178)
0.0 4.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 14.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 4.8 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.1 3.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 4.2 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 0.6 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 2.4 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 1.6 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 2.0 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 1.8 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 0.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.1 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.0 0.7 PID CONE PATHWAY Visual signal transduction: Cones
0.0 1.0 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.9 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 1.5 PID ENDOTHELIN PATHWAY Endothelins
0.0 1.1 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 1.1 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.5 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 2.3 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.7 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 6.9 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.2 11.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.2 13.7 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.2 12.7 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.2 3.5 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.1 1.7 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 5.9 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 3.4 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.1 1.2 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 1.9 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 2.3 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 2.2 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 1.4 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 4.6 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1 2.0 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.6 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 4.2 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.1 3.9 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 2.1 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 4.0 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 1.7 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 0.6 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 5.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.1 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.8 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.2 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.0 3.4 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.6 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 1.3 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.7 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 3.2 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.0 1.2 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 2.2 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 2.3 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 4.8 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.0 1.1 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.5 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.7 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 1.0 REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.0 0.6 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.7 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.3 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 1.4 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.2 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.8 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 3.0 REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
0.0 2.4 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.3 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 1.0 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 1.1 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.3 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.4 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.2 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.3 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.4 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.2 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.3 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 1.1 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.8 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors