ISMARA results: NRF1

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NRF1

Z-value: 8.17

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Transcription factors associated with NRF1

Gene Symbol	Gene ID	Gene Info
NRF1 Ensembl NCBI GeneCards UniProt	ENSG00000106459.10	nuclear respiratory factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NRF1	hg19_v2_chr7_+_129251531_129251601	0.93	2.9e-09	Click!

Activity profile of NRF1 motif

Sorted Z-values of NRF1 motif

No targets for NRF1

Network of associatons between targets according to the STRING database.

First level regulatory network of NRF1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	22.2	GO:0045876	positive regulation of sister chromatid cohesion(GO:0045876)
0.5	19.2	GO:0034080	CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.2	18.7	GO:0007062	sister chromatid cohesion(GO:0007062)
1.3	15.9	GO:0010032	meiotic chromosome condensation(GO:0010032)
3.1	15.4	GO:1903615	regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615)
0.1	13.5	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
1.0	12.7	GO:0098870	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
1.3	12.6	GO:2001300	lipoxin metabolic process(GO:2001300)
0.8	12.5	GO:0034501	protein localization to kinetochore(GO:0034501)
0.3	12.5	GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)

Showing 1 to 10 of 616 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	34.4	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.3	32.3	GO:0000777	condensed chromosome kinetochore(GO:0000777)
0.0	22.7	GO:0005635	nuclear envelope(GO:0005635)
2.1	21.1	GO:0000798	nuclear cohesin complex(GO:0000798)
1.6	20.7	GO:0000796	condensin complex(GO:0000796)
2.9	20.4	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.1	18.0	GO:0005819	spindle(GO:0005819)
0.2	16.9	GO:0016235	aggresome(GO:0016235)
0.4	14.3	GO:0043218	compact myelin(GO:0043218)
0.0	13.9	GO:0016324	apical plasma membrane(GO:0016324)

Showing 1 to 10 of 302 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	33.4	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
2.6	18.2	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.4	16.3	GO:0005540	hyaluronic acid binding(GO:0005540)
0.0	13.9	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.3	12.7	GO:0044183	protein binding involved in protein folding(GO:0044183)
3.2	12.6	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404)
0.3	12.3	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.4	12.1	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.3	11.0	GO:0051537	2 iron, 2 sulfur cluster binding(GO:0051537)
0.2	10.8	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)

Showing 1 to 10 of 404 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	59.7	PID PLK1 PATHWAY	PLK1 signaling events
0.3	25.7	PID AURORA B PATHWAY	Aurora B signaling
0.2	13.6	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.3	13.4	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.1	13.3	PID P73PATHWAY	p73 transcription factor network
0.1	10.2	PID FANCONI PATHWAY	Fanconi anemia pathway
0.9	8.9	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.1	7.6	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
0.2	7.3	PID CMYB PATHWAY	C-MYB transcription factor network
0.1	5.8	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling

Showing 1 to 10 of 70 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	92.3	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
1.4	27.3	REACTOME POL SWITCHING	Genes involved in Polymerase switching
0.4	17.6	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.3	16.5	REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT	Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.9	15.8	REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION	Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.2	15.8	REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21	Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.4	14.4	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.6	11.9	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.2	11.7	REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.7	11.5	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network

Showing 1 to 10 of 135 entries

Results for NRF1

Z-value: 8.17

Motif logo

Transcription factors associated with NRF1

Activity-expression correlation:

Activity profile of NRF1 motif

Sorted Z-values of NRF1 motif

No targets for NRF1

Network of associatons between targets according to the STRING database.

First level regulatory network of NRF1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: