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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for OLIG2_NEUROD1_ATOH1
Z-value: 1.14
Motif logo
Transcription factors associated with OLIG2_NEUROD1_ATOH1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
OLIG2
|
ENSG00000205927.4 | oligodendrocyte transcription factor 2 |
|
NEUROD1
|
ENSG00000162992.3 | neuronal differentiation 1 |
|
ATOH1
|
ENSG00000172238.3 | atonal bHLH transcription factor 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| OLIG2 | hg19_v2_chr21_+_34398153_34398250 | -0.16 | 5.0e-01 | Click! |
| ATOH1 | hg19_v2_chr4_+_94750014_94750042 | -0.15 | 5.2e-01 | Click! |
| NEUROD1 | hg19_v2_chr2_-_182545603_182545603 | 0.12 | 6.0e-01 | Click! |
Activity profile of OLIG2_NEUROD1_ATOH1 motif
Sorted Z-values of OLIG2_NEUROD1_ATOH1 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of OLIG2_NEUROD1_ATOH1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 4.6 | GO:0070563 | negative regulation of vitamin D receptor signaling pathway(GO:0070563) |
| 0.5 | 3.2 | GO:0018032 | protein amidation(GO:0018032) |
| 0.4 | 1.6 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 0.3 | 1.0 | GO:1902362 | melanocyte apoptotic process(GO:1902362) |
| 0.3 | 1.6 | GO:0030807 | positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123) |
| 0.3 | 3.2 | GO:0018377 | protein myristoylation(GO:0018377) |
| 0.3 | 0.8 | GO:0060279 | regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279) |
| 0.3 | 0.8 | GO:0008057 | eye pigment granule organization(GO:0008057) |
| 0.3 | 1.3 | GO:0018125 | peptidyl-cysteine methylation(GO:0018125) |
| 0.2 | 0.7 | GO:0046521 | sphingoid catabolic process(GO:0046521) |
| 0.2 | 2.8 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.2 | 0.6 | GO:1904404 | cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404) |
| 0.2 | 0.8 | GO:0044752 | response to human chorionic gonadotropin(GO:0044752) |
| 0.2 | 0.5 | GO:0034970 | histone H3-R2 methylation(GO:0034970) |
| 0.1 | 0.4 | GO:0021569 | rhombomere 3 development(GO:0021569) |
| 0.1 | 1.5 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.1 | 0.7 | GO:0038018 | Wnt receptor catabolic process(GO:0038018) |
| 0.1 | 0.4 | GO:0035697 | CD8-positive, alpha-beta T cell extravasation(GO:0035697) CD8-positive, alpha-beta cytotoxic T cell extravasation(GO:0035698) positive regulation of necroptotic process(GO:0060545) regulation of T cell extravasation(GO:2000407) regulation of CD8-positive, alpha-beta T cell extravasation(GO:2000449) regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation(GO:2000452) |
| 0.1 | 1.4 | GO:0015760 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 0.1 | 0.7 | GO:0070295 | renal water absorption(GO:0070295) |
| 0.1 | 0.5 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.1 | 1.1 | GO:0002329 | pre-B cell differentiation(GO:0002329) |
| 0.1 | 2.2 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.1 | 1.3 | GO:0009414 | response to water deprivation(GO:0009414) |
| 0.1 | 0.7 | GO:0072675 | multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675) |
| 0.1 | 0.5 | GO:0014043 | negative regulation of neuron maturation(GO:0014043) |
| 0.1 | 0.3 | GO:0046707 | IDP metabolic process(GO:0046707) IDP catabolic process(GO:0046709) |
| 0.1 | 0.4 | GO:0072086 | specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268) |
| 0.1 | 0.6 | GO:0036089 | cleavage furrow formation(GO:0036089) |
| 0.1 | 0.3 | GO:0002894 | positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894) |
| 0.1 | 0.3 | GO:0007499 | ectoderm and mesoderm interaction(GO:0007499) |
| 0.1 | 0.4 | GO:0038098 | sequestering of BMP from receptor via BMP binding(GO:0038098) |
| 0.1 | 0.3 | GO:0010983 | positive regulation of high-density lipoprotein particle clearance(GO:0010983) |
| 0.1 | 1.7 | GO:0071481 | cellular response to X-ray(GO:0071481) |
| 0.1 | 0.4 | GO:0090285 | negative regulation of protein glycosylation in Golgi(GO:0090285) |
| 0.1 | 0.4 | GO:0042441 | eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474) |
| 0.1 | 0.2 | GO:0042137 | sequestering of neurotransmitter(GO:0042137) |
| 0.1 | 0.4 | GO:0044240 | multicellular organism lipid catabolic process(GO:0044240) |
| 0.1 | 0.2 | GO:0021589 | hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589) |
| 0.1 | 1.0 | GO:0030046 | parallel actin filament bundle assembly(GO:0030046) |
| 0.1 | 0.3 | GO:0050902 | leukocyte adhesive activation(GO:0050902) |
| 0.1 | 0.5 | GO:1990592 | protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592) |
| 0.1 | 0.2 | GO:1900108 | inner medullary collecting duct development(GO:0072061) negative regulation of nodal signaling pathway(GO:1900108) |
| 0.1 | 0.3 | GO:0015917 | aminophospholipid transport(GO:0015917) |
| 0.1 | 0.2 | GO:0043388 | positive regulation of DNA binding(GO:0043388) |
| 0.1 | 0.3 | GO:0009138 | pyrimidine nucleoside diphosphate metabolic process(GO:0009138) |
| 0.1 | 0.1 | GO:0055073 | cadmium ion homeostasis(GO:0055073) |
| 0.1 | 0.2 | GO:0097498 | endothelial tube lumen extension(GO:0097498) |
| 0.1 | 0.2 | GO:0008052 | sensory organ boundary specification(GO:0008052) formation of organ boundary(GO:0010160) taste bud development(GO:0061193) |
| 0.1 | 0.2 | GO:0007206 | phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206) |
| 0.1 | 0.3 | GO:0072660 | maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.1 | 0.3 | GO:0039534 | negative regulation of MDA-5 signaling pathway(GO:0039534) |
| 0.0 | 0.7 | GO:0032119 | sequestering of zinc ion(GO:0032119) |
| 0.0 | 0.2 | GO:0030311 | poly-N-acetyllactosamine biosynthetic process(GO:0030311) |
| 0.0 | 0.7 | GO:1902951 | negative regulation of dendritic spine maintenance(GO:1902951) |
| 0.0 | 0.2 | GO:0036269 | swimming behavior(GO:0036269) |
| 0.0 | 0.4 | GO:0048050 | post-embryonic eye morphogenesis(GO:0048050) |
| 0.0 | 0.2 | GO:0043456 | regulation of pentose-phosphate shunt(GO:0043456) |
| 0.0 | 0.2 | GO:0014734 | skeletal muscle hypertrophy(GO:0014734) |
| 0.0 | 0.4 | GO:0070278 | extracellular matrix constituent secretion(GO:0070278) |
| 0.0 | 0.2 | GO:0007525 | somatic muscle development(GO:0007525) |
| 0.0 | 0.1 | GO:0015670 | carbon dioxide transport(GO:0015670) |
| 0.0 | 0.2 | GO:0018101 | protein citrullination(GO:0018101) histone citrullination(GO:0036414) |
| 0.0 | 1.2 | GO:0035988 | chondrocyte proliferation(GO:0035988) |
| 0.0 | 0.2 | GO:0099640 | axo-dendritic protein transport(GO:0099640) |
| 0.0 | 0.3 | GO:0061739 | protein lipidation involved in autophagosome assembly(GO:0061739) |
| 0.0 | 0.4 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis(GO:0051045) |
| 0.0 | 0.5 | GO:0006824 | cobalt ion transport(GO:0006824) |
| 0.0 | 0.2 | GO:0034165 | positive regulation of toll-like receptor 9 signaling pathway(GO:0034165) |
| 0.0 | 0.2 | GO:0016240 | autophagosome docking(GO:0016240) |
| 0.0 | 0.2 | GO:2000639 | regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639) |
| 0.0 | 0.2 | GO:0045607 | regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980) |
| 0.0 | 0.1 | GO:0001808 | negative regulation of type IV hypersensitivity(GO:0001808) |
| 0.0 | 0.4 | GO:1905247 | positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) positive regulation of aspartic-type peptidase activity(GO:1905247) |
| 0.0 | 0.1 | GO:0035822 | meiotic gene conversion(GO:0006311) gene conversion(GO:0035822) |
| 0.0 | 0.2 | GO:1903237 | negative regulation of leukocyte tethering or rolling(GO:1903237) |
| 0.0 | 0.4 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) positive regulation of glycogen (starch) synthase activity(GO:2000467) |
| 0.0 | 0.6 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
| 0.0 | 0.2 | GO:0060437 | lung growth(GO:0060437) |
| 0.0 | 0.2 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.0 | 0.1 | GO:0002949 | tRNA threonylcarbamoyladenosine modification(GO:0002949) |
| 0.0 | 0.2 | GO:1902045 | negative regulation of Fas signaling pathway(GO:1902045) |
| 0.0 | 0.6 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.0 | 0.0 | GO:2000672 | negative regulation of motor neuron apoptotic process(GO:2000672) |
| 0.0 | 0.1 | GO:0043449 | cellular alkene metabolic process(GO:0043449) |
| 0.0 | 0.1 | GO:1903966 | monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966) |
| 0.0 | 0.3 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.0 | 0.3 | GO:2000580 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 0.0 | 0.4 | GO:1902414 | protein localization to cell junction(GO:1902414) |
| 0.0 | 0.1 | GO:0061056 | sclerotome development(GO:0061056) |
| 0.0 | 0.3 | GO:0034351 | regulation of glial cell apoptotic process(GO:0034350) negative regulation of glial cell apoptotic process(GO:0034351) |
| 0.0 | 0.6 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 0.0 | 0.1 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
| 0.0 | 0.1 | GO:0009386 | translational attenuation(GO:0009386) |
| 0.0 | 0.9 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 0.6 | GO:0008340 | determination of adult lifespan(GO:0008340) |
| 0.0 | 0.1 | GO:0002337 | B-1a B cell differentiation(GO:0002337) |
| 0.0 | 0.5 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.0 | 0.2 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.0 | 0.1 | GO:0055129 | L-proline biosynthetic process(GO:0055129) |
| 0.0 | 0.4 | GO:0050930 | induction of positive chemotaxis(GO:0050930) |
| 0.0 | 0.1 | GO:0071421 | manganese ion transmembrane transport(GO:0071421) |
| 0.0 | 0.3 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.0 | 0.1 | GO:0043553 | vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.0 | 0.2 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
| 0.0 | 0.7 | GO:0007398 | ectoderm development(GO:0007398) |
| 0.0 | 0.3 | GO:1904424 | regulation of GTP binding(GO:1904424) |
| 0.0 | 0.0 | GO:0007509 | mesoderm migration involved in gastrulation(GO:0007509) |
| 0.0 | 0.1 | GO:0035509 | negative regulation of myosin-light-chain-phosphatase activity(GO:0035509) negative regulation of bicellular tight junction assembly(GO:1903347) |
| 0.0 | 0.1 | GO:0052331 | hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331) |
| 0.0 | 0.3 | GO:0072520 | seminiferous tubule development(GO:0072520) |
| 0.0 | 0.0 | GO:0033364 | mast cell secretory granule organization(GO:0033364) |
| 0.0 | 0.2 | GO:0007406 | negative regulation of neuroblast proliferation(GO:0007406) |
| 0.0 | 0.1 | GO:0046086 | adenosine biosynthetic process(GO:0046086) |
| 0.0 | 0.2 | GO:0060056 | mammary gland involution(GO:0060056) |
| 0.0 | 0.6 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.0 | 0.4 | GO:0007176 | regulation of epidermal growth factor-activated receptor activity(GO:0007176) |
| 0.0 | 0.1 | GO:0098912 | membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912) positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879) |
| 0.0 | 0.4 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
| 0.0 | 0.1 | GO:1903045 | neural crest cell migration involved in sympathetic nervous system development(GO:1903045) |
| 0.0 | 0.4 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.0 | 0.1 | GO:0016080 | synaptic vesicle targeting(GO:0016080) |
| 0.0 | 0.4 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.0 | 0.2 | GO:0032510 | endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510) |
| 0.0 | 0.3 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
| 0.0 | 1.2 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
| 0.0 | 0.0 | GO:0035408 | histone H3-T6 phosphorylation(GO:0035408) |
| 0.0 | 0.1 | GO:0060844 | arterial endothelial cell fate commitment(GO:0060844) positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068) |
| 0.0 | 0.0 | GO:0097374 | sensory neuron axon guidance(GO:0097374) |
| 0.0 | 0.5 | GO:0060384 | innervation(GO:0060384) |
| 0.0 | 0.2 | GO:0045198 | establishment of epithelial cell apical/basal polarity(GO:0045198) |
| 0.0 | 1.0 | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531) |
| 0.0 | 0.1 | GO:0015870 | acetylcholine transport(GO:0015870) |
| 0.0 | 0.1 | GO:0070777 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.0 | 0.1 | GO:0097211 | response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211) |
| 0.0 | 0.0 | GO:0002522 | leukocyte migration involved in immune response(GO:0002522) |
| 0.0 | 0.4 | GO:0050962 | detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962) |
| 0.0 | 0.1 | GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037) |
| 0.0 | 0.1 | GO:0048194 | Golgi vesicle budding(GO:0048194) |
| 0.0 | 0.2 | GO:0061577 | calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577) |
| 0.0 | 0.1 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
| 0.0 | 0.1 | GO:0010886 | positive regulation of cholesterol storage(GO:0010886) |
| 0.0 | 0.1 | GO:0048539 | bone marrow development(GO:0048539) |
| 0.0 | 0.1 | GO:0035878 | nail development(GO:0035878) |
| 0.0 | 0.4 | GO:0010719 | negative regulation of epithelial to mesenchymal transition(GO:0010719) |
| 0.0 | 0.3 | GO:0060712 | spongiotrophoblast layer development(GO:0060712) |
| 0.0 | 0.4 | GO:0045947 | negative regulation of translational initiation(GO:0045947) |
| 0.0 | 0.1 | GO:0021983 | pituitary gland development(GO:0021983) |
| 0.0 | 0.2 | GO:0010818 | T cell chemotaxis(GO:0010818) |
| 0.0 | 0.2 | GO:2000774 | positive regulation of cellular senescence(GO:2000774) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.8 | GO:0043512 | inhibin complex(GO:0043511) inhibin A complex(GO:0043512) |
| 0.1 | 1.0 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.1 | 1.0 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.1 | 1.1 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.1 | 0.2 | GO:0033268 | node of Ranvier(GO:0033268) |
| 0.1 | 1.0 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.1 | 0.3 | GO:0031673 | H zone(GO:0031673) |
| 0.1 | 1.3 | GO:0042588 | zymogen granule(GO:0042588) |
| 0.1 | 0.9 | GO:0097449 | astrocyte projection(GO:0097449) |
| 0.1 | 0.4 | GO:0070435 | Shc-EGFR complex(GO:0070435) |
| 0.0 | 0.3 | GO:0034991 | nuclear meiotic cohesin complex(GO:0034991) |
| 0.0 | 0.3 | GO:0016013 | syntrophin complex(GO:0016013) |
| 0.0 | 0.6 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.0 | 0.6 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 0.2 | GO:0020016 | ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018) |
| 0.0 | 0.1 | GO:1990032 | parallel fiber(GO:1990032) |
| 0.0 | 1.3 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 0.1 | GO:1990604 | IRE1-TRAF2-ASK1 complex(GO:1990604) |
| 0.0 | 1.8 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.0 | 0.2 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.0 | 0.2 | GO:0005899 | insulin receptor complex(GO:0005899) |
| 0.0 | 0.4 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 0.3 | GO:0000322 | storage vacuole(GO:0000322) |
| 0.0 | 0.4 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.0 | 0.3 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.0 | 0.1 | GO:1990745 | EARP complex(GO:1990745) |
| 0.0 | 2.3 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 0.4 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 0.4 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.0 | 0.4 | GO:0097342 | ripoptosome(GO:0097342) |
| 0.0 | 0.3 | GO:0030914 | STAGA complex(GO:0030914) |
| 0.0 | 0.4 | GO:0033162 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.0 | 0.1 | GO:0000801 | central element(GO:0000801) |
| 0.0 | 0.3 | GO:0010369 | chromocenter(GO:0010369) |
| 0.0 | 0.1 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 2.5 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 0.3 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.0 | 0.2 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.0 | 0.3 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.0 | 1.6 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 2.2 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 0.2 | GO:0044453 | nuclear membrane part(GO:0044453) |
| 0.0 | 0.2 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.0 | 0.1 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.0 | 0.7 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 0.2 | GO:0061700 | GATOR2 complex(GO:0061700) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.2 | GO:0004504 | peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598) |
| 0.3 | 3.2 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.2 | 2.8 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.2 | 0.6 | GO:0061663 | NEDD8 ligase activity(GO:0061663) |
| 0.2 | 0.5 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.2 | 1.4 | GO:0015119 | hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513) |
| 0.1 | 0.8 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.1 | 0.7 | GO:0015254 | glycerol channel activity(GO:0015254) |
| 0.1 | 0.5 | GO:0035241 | protein-arginine omega-N monomethyltransferase activity(GO:0035241) |
| 0.1 | 0.8 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 0.1 | 0.4 | GO:0071633 | dihydroceramidase activity(GO:0071633) |
| 0.1 | 0.7 | GO:0017050 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 0.1 | 1.0 | GO:0008440 | inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) |
| 0.1 | 1.1 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.1 | 1.6 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.1 | 0.6 | GO:0030172 | troponin C binding(GO:0030172) |
| 0.1 | 0.2 | GO:0035643 | L-DOPA receptor activity(GO:0035643) L-DOPA binding(GO:0072544) |
| 0.1 | 0.1 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.1 | 0.3 | GO:0009041 | uridylate kinase activity(GO:0009041) |
| 0.1 | 0.6 | GO:0004704 | NF-kappaB-inducing kinase activity(GO:0004704) |
| 0.1 | 1.2 | GO:0005225 | volume-sensitive anion channel activity(GO:0005225) |
| 0.1 | 0.3 | GO:0019144 | ADP-sugar diphosphatase activity(GO:0019144) |
| 0.0 | 0.1 | GO:0043849 | Ras palmitoyltransferase activity(GO:0043849) |
| 0.0 | 0.2 | GO:0046538 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
| 0.0 | 0.2 | GO:0016971 | flavin-linked sulfhydryl oxidase activity(GO:0016971) |
| 0.0 | 0.4 | GO:0042610 | CD8 receptor binding(GO:0042610) |
| 0.0 | 0.4 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
| 0.0 | 0.2 | GO:0031728 | CCR3 chemokine receptor binding(GO:0031728) |
| 0.0 | 0.8 | GO:0015280 | ligand-gated sodium channel activity(GO:0015280) |
| 0.0 | 0.4 | GO:0004771 | sterol esterase activity(GO:0004771) |
| 0.0 | 0.5 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.0 | 0.2 | GO:0004668 | protein-arginine deiminase activity(GO:0004668) |
| 0.0 | 0.2 | GO:0008426 | protein kinase C inhibitor activity(GO:0008426) |
| 0.0 | 0.2 | GO:0016262 | protein N-acetylglucosaminyltransferase activity(GO:0016262) |
| 0.0 | 0.5 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.0 | 0.7 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.0 | 0.8 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.0 | 0.4 | GO:0016015 | morphogen activity(GO:0016015) |
| 0.0 | 0.3 | GO:0004699 | calcium-independent protein kinase C activity(GO:0004699) |
| 0.0 | 1.2 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 0.5 | GO:0031419 | cobalamin binding(GO:0031419) |
| 0.0 | 0.1 | GO:0015173 | aromatic amino acid transmembrane transporter activity(GO:0015173) |
| 0.0 | 0.2 | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity(GO:0008113) |
| 0.0 | 1.0 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.0 | 1.0 | GO:0000400 | four-way junction DNA binding(GO:0000400) |
| 0.0 | 1.2 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 0.4 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 0.6 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.0 | 0.2 | GO:0005166 | neurotrophin p75 receptor binding(GO:0005166) |
| 0.0 | 0.1 | GO:0004514 | nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514) |
| 0.0 | 0.4 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.0 | 0.1 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
| 0.0 | 0.1 | GO:0070815 | peptidyl-lysine 5-dioxygenase activity(GO:0070815) |
| 0.0 | 0.1 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
| 0.0 | 0.2 | GO:0015319 | sodium:inorganic phosphate symporter activity(GO:0015319) |
| 0.0 | 0.5 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.0 | 0.2 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.0 | 0.1 | GO:0003986 | acetyl-CoA hydrolase activity(GO:0003986) |
| 0.0 | 0.2 | GO:0099583 | neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) |
| 0.0 | 0.3 | GO:0004465 | lipoprotein lipase activity(GO:0004465) |
| 0.0 | 0.2 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.0 | 0.3 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.0 | 0.2 | GO:0004609 | phosphatidylserine decarboxylase activity(GO:0004609) |
| 0.0 | 0.1 | GO:0004968 | gonadotropin-releasing hormone receptor activity(GO:0004968) |
| 0.0 | 0.1 | GO:0098770 | FBXO family protein binding(GO:0098770) |
| 0.0 | 0.3 | GO:0097371 | MDM2/MDM4 family protein binding(GO:0097371) |
| 0.0 | 0.5 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.0 | 0.5 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.0 | 1.0 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 0.4 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.0 | 0.6 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 4.4 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 0.3 | GO:0089720 | caspase binding(GO:0089720) |
| 0.0 | 0.1 | GO:0098960 | postsynaptic neurotransmitter receptor activity(GO:0098960) |
| 0.0 | 0.3 | GO:0039706 | co-receptor binding(GO:0039706) |
| 0.0 | 0.9 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 1.1 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.0 | 0.1 | GO:0032038 | myosin II heavy chain binding(GO:0032038) |
| 0.0 | 1.4 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.0 | 0.0 | GO:0047275 | glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275) |
| 0.0 | 0.1 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.0 | 0.2 | GO:0035256 | G-protein coupled glutamate receptor binding(GO:0035256) |
| 0.0 | 0.3 | GO:0050998 | nitric-oxide synthase binding(GO:0050998) |
| 0.0 | 0.1 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.0 | 0.1 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.0 | 0.1 | GO:0005277 | acetylcholine transmembrane transporter activity(GO:0005277) acetate ester transmembrane transporter activity(GO:1901375) |
| 0.0 | 0.4 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 0.0 | 0.0 | GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935) |
| 0.0 | 0.3 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.0 | 0.1 | GO:0046870 | cadmium ion binding(GO:0046870) |
| 0.0 | 0.1 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.0 | 0.0 | GO:0035403 | histone kinase activity (H3-T6 specific)(GO:0035403) |
| 0.0 | 1.8 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 0.4 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.9 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 1.1 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 4.6 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 1.3 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 0.6 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 1.0 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.8 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 0.5 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 1.8 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 2.0 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 0.6 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 0.6 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 0.2 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.3 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 0.1 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.0 | 0.8 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.0 | 0.1 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.0 | 0.1 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 1.0 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.1 | 1.5 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.1 | 0.6 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.1 | 0.8 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 3.8 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 0.8 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 1.7 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 0.4 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.0 | 0.2 | REACTOME ACTIVATED POINT MUTANTS OF FGFR2 | Genes involved in Activated point mutants of FGFR2 |
| 0.0 | 0.6 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.0 | 0.6 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.0 | 2.1 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 1.0 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.6 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.0 | 0.4 | REACTOME SHC MEDIATED CASCADE | Genes involved in SHC-mediated cascade |
| 0.0 | 0.2 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.0 | 0.2 | REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 0.0 | 0.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 0.2 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.0 | 0.3 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 0.4 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 0.5 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.0 | 0.1 | REACTOME HORMONE LIGAND BINDING RECEPTORS | Genes involved in Hormone ligand-binding receptors |
| 0.0 | 0.7 | REACTOME G1 PHASE | Genes involved in G1 Phase |