ISMARA results: ONECUT2

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ONECUT2_ONECUT3

Z-value: 0.99

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Transcription factors associated with ONECUT2_ONECUT3

Gene Symbol	Gene ID	Gene Info
ONECUT2 Ensembl NCBI GeneCards UniProt	ENSG00000119547.5	one cut homeobox 2
ONECUT3 Ensembl NCBI GeneCards UniProt	ENSG00000205922.4	one cut homeobox 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ONECUT3	hg19_v2_chr19_+_1752372_1752372	-0.64	2.3e-03	Click!
ONECUT2	hg19_v2_chr18_+_55102917_55102985	-0.59	6.3e-03	Click!

Activity profile of ONECUT2_ONECUT3 motif

Sorted Z-values of ONECUT2_ONECUT3 motif

No targets for ONECUT2_ONECUT3

Network of associatons between targets according to the STRING database.

First level regulatory network of ONECUT2_ONECUT3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.8	GO:0006611	protein export from nucleus(GO:0006611)
0.5	2.1	GO:1905205	positive regulation of connective tissue replacement(GO:1905205)
0.4	2.0	GO:0006127	glycerophosphate shuttle(GO:0006127)
0.6	1.7	GO:2000616	negative regulation of histone H3-K9 acetylation(GO:2000616)
0.1	1.3	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
0.1	1.3	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0	1.3	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	1.3	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)
0.0	1.1	GO:0071481	cellular response to X-ray(GO:0071481)
0.1	1.0	GO:0019227	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)

Showing 1 to 10 of 59 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.1	GO:0005955	calcineurin complex(GO:0005955)
0.3	2.0	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	1.3	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	1.2	GO:0043194	axon initial segment(GO:0043194)
0.1	1.1	GO:0097129	cyclin D2-CDK4 complex(GO:0097129)
0.1	1.0	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0	1.0	GO:0031941	filamentous actin(GO:0031941)
0.0	0.9	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.1	0.7	GO:0005968	Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1	0.7	GO:0032584	growth cone membrane(GO:0032584)

Showing 1 to 10 of 19 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.6	GO:0016805	dipeptidase activity(GO:0016805)
0.0	2.6	GO:0008536	Ran GTPase binding(GO:0008536)
0.2	2.1	GO:0033192	calmodulin-dependent protein phosphatase activity(GO:0033192)
0.5	2.0	GO:0052590	sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
0.2	1.7	GO:0061665	SUMO ligase activity(GO:0061665)
0.1	1.3	GO:0004111	creatine kinase activity(GO:0004111)
0.0	1.3	GO:0031683	G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0	1.3	GO:0070888	E-box binding(GO:0070888)
0.1	1.0	GO:0035374	chondroitin sulfate binding(GO:0035374)
0.0	1.0	GO:0086080	protein binding involved in heterotypic cell-cell adhesion(GO:0086080)

Showing 1 to 10 of 32 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.1	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	1.3	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	1.3	PID EPHB FWD PATHWAY	EPHB forward signaling
0.0	1.2	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	1.0	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	0.7	PID VEGFR1 PATHWAY	VEGFR1 specific signals
0.0	0.7	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.0	0.3	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0	0.3	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta

Showing 1 to 9 of 9 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.1	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	1.7	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1	1.3	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	1.1	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	1.1	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	1.0	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	0.9	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0	0.7	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	0.6	REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0	0.5	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK

Showing 1 to 10 of 12 entries

Results for ONECUT2_ONECUT3

Z-value: 0.99

Motif logo

Transcription factors associated with ONECUT2_ONECUT3

Activity-expression correlation:

Activity profile of ONECUT2_ONECUT3 motif

Sorted Z-values of ONECUT2_ONECUT3 motif

No targets for ONECUT2_ONECUT3

Network of associatons between targets according to the STRING database.

First level regulatory network of ONECUT2_ONECUT3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: