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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4
Z-value: 0.75
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Transcription factors associated with OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
OTP
|
ENSG00000171540.6 | orthopedia homeobox |
|
PHOX2B
|
ENSG00000109132.5 | paired like homeobox 2B |
|
LHX1
|
ENSG00000132130.7 | LIM homeobox 1 |
|
LMX1A
|
ENSG00000162761.10 | LIM homeobox transcription factor 1 alpha |
|
LHX5
|
ENSG00000089116.3 | LIM homeobox 5 |
|
HOXC4
|
ENSG00000198353.6 | homeobox C4 |
|
HOXC4
|
ENSG00000273266.1 | homeobox C4 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| LHX1 | hg19_v2_chr17_+_35294075_35294102 | -0.53 | 1.6e-02 | Click! |
| HOXC4 | hg19_v2_chr12_+_54447637_54447661 | -0.41 | 7.0e-02 | Click! |
| LHX5 | hg19_v2_chr12_-_113909877_113909877 | 0.32 | 1.7e-01 | Click! |
| OTP | hg19_v2_chr5_-_76935513_76935513 | -0.11 | 6.4e-01 | Click! |
Activity profile of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif
Sorted Z-values of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.9 | GO:0002416 | IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416) |
| 0.3 | 1.1 | GO:0060166 | olfactory pit development(GO:0060166) |
| 0.2 | 0.6 | GO:0060489 | orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) |
| 0.2 | 1.2 | GO:0071279 | cellular response to cobalt ion(GO:0071279) |
| 0.2 | 0.5 | GO:0070563 | negative regulation of vitamin D receptor signaling pathway(GO:0070563) |
| 0.1 | 0.4 | GO:1902173 | negative regulation of keratinocyte apoptotic process(GO:1902173) |
| 0.1 | 0.9 | GO:0010133 | proline catabolic process to glutamate(GO:0010133) |
| 0.1 | 1.9 | GO:0042420 | dopamine catabolic process(GO:0042420) |
| 0.1 | 0.3 | GO:0031247 | actin rod assembly(GO:0031247) |
| 0.1 | 0.7 | GO:1903575 | cornified envelope assembly(GO:1903575) |
| 0.1 | 0.6 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 0.1 | 2.5 | GO:0046597 | negative regulation of viral entry into host cell(GO:0046597) |
| 0.1 | 0.3 | GO:0010983 | positive regulation of high-density lipoprotein particle clearance(GO:0010983) |
| 0.1 | 0.2 | GO:0070105 | positive regulation of interleukin-6-mediated signaling pathway(GO:0070105) |
| 0.1 | 1.1 | GO:0042354 | fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355) |
| 0.1 | 1.0 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.1 | 0.5 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.1 | 0.3 | GO:0046092 | deoxycytidine metabolic process(GO:0046092) |
| 0.1 | 0.6 | GO:0045040 | protein import into mitochondrial outer membrane(GO:0045040) |
| 0.0 | 0.1 | GO:0000454 | snoRNA guided rRNA pseudouridine synthesis(GO:0000454) |
| 0.0 | 1.1 | GO:0071481 | cellular response to X-ray(GO:0071481) |
| 0.0 | 0.2 | GO:0002304 | gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305) |
| 0.0 | 0.1 | GO:0050712 | negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712) |
| 0.0 | 0.2 | GO:0038172 | interleukin-33-mediated signaling pathway(GO:0038172) |
| 0.0 | 0.6 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 0.0 | 0.2 | GO:0032571 | response to vitamin K(GO:0032571) regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) bone regeneration(GO:1990523) |
| 0.0 | 1.0 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 0.2 | GO:1905068 | positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068) |
| 0.0 | 0.3 | GO:0071896 | protein localization to adherens junction(GO:0071896) |
| 0.0 | 0.4 | GO:0043249 | erythrocyte maturation(GO:0043249) |
| 0.0 | 0.1 | GO:0071596 | ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596) |
| 0.0 | 0.1 | GO:0042357 | thiamine diphosphate metabolic process(GO:0042357) |
| 0.0 | 0.1 | GO:0030186 | melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187) |
| 0.0 | 0.1 | GO:0090076 | relaxation of skeletal muscle(GO:0090076) |
| 0.0 | 0.3 | GO:0046426 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
| 0.0 | 0.2 | GO:1990253 | cellular response to leucine starvation(GO:1990253) |
| 0.0 | 0.1 | GO:0031455 | glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456) |
| 0.0 | 0.1 | GO:0034344 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) positive regulation of interferon-alpha biosynthetic process(GO:0045356) |
| 0.0 | 0.1 | GO:0043553 | vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.0 | 0.2 | GO:0046952 | ketone body catabolic process(GO:0046952) |
| 0.0 | 0.2 | GO:1901529 | positive regulation of anion channel activity(GO:1901529) |
| 0.0 | 0.1 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 0.0 | 0.1 | GO:0051097 | negative regulation of helicase activity(GO:0051097) |
| 0.0 | 0.1 | GO:0003409 | optic cup structural organization(GO:0003409) oculomotor nerve morphogenesis(GO:0021622) oculomotor nerve formation(GO:0021623) |
| 0.0 | 0.1 | GO:0043456 | regulation of pentose-phosphate shunt(GO:0043456) |
| 0.0 | 0.0 | GO:0002476 | antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476) |
| 0.0 | 0.2 | GO:0097475 | motor neuron migration(GO:0097475) |
| 0.0 | 0.3 | GO:0097264 | self proteolysis(GO:0097264) |
| 0.0 | 0.3 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 0.0 | 0.9 | GO:0034314 | Arp2/3 complex-mediated actin nucleation(GO:0034314) |
| 0.0 | 0.1 | GO:0070777 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.0 | 0.2 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 0.0 | 0.1 | GO:0010643 | cell communication by chemical coupling(GO:0010643) |
| 0.0 | 0.1 | GO:0018406 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.0 | 0.1 | GO:1901475 | pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475) |
| 0.0 | 0.1 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 0.0 | 0.1 | GO:2000521 | negative regulation of immunological synapse formation(GO:2000521) |
| 0.0 | 0.2 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) |
| 0.0 | 0.5 | GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle(GO:1900087) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.6 | GO:0060187 | cell pole(GO:0060187) |
| 0.1 | 1.1 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.1 | 0.4 | GO:0042585 | germinal vesicle(GO:0042585) |
| 0.1 | 1.0 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 0.5 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.1 | 1.3 | GO:0043203 | axon hillock(GO:0043203) |
| 0.1 | 0.6 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.0 | 0.2 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.0 | 0.9 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.0 | 0.1 | GO:1990032 | parallel fiber(GO:1990032) |
| 0.0 | 1.0 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.0 | 0.3 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
| 0.0 | 0.3 | GO:0002177 | manchette(GO:0002177) |
| 0.0 | 0.9 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 0.2 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.0 | 0.1 | GO:0090661 | box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661) |
| 0.0 | 0.3 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.0 | 0.2 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.0 | 0.3 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 2.7 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.0 | 0.9 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 0.2 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.0 | 0.1 | GO:0005787 | signal peptidase complex(GO:0005787) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.9 | GO:0004657 | proline dehydrogenase activity(GO:0004657) |
| 0.2 | 1.9 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 0.2 | 0.9 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 0.1 | 0.6 | GO:0047894 | flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294) |
| 0.1 | 1.1 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.1 | 0.2 | GO:0002113 | interleukin-33 binding(GO:0002113) |
| 0.1 | 0.3 | GO:0008281 | sulfonylurea receptor activity(GO:0008281) |
| 0.1 | 1.1 | GO:0008417 | fucosyltransferase activity(GO:0008417) |
| 0.1 | 0.5 | GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812) |
| 0.1 | 0.2 | GO:0031783 | corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783) |
| 0.0 | 0.3 | GO:0004797 | thymidine kinase activity(GO:0004797) |
| 0.0 | 0.6 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.0 | 0.6 | GO:0015266 | protein channel activity(GO:0015266) |
| 0.0 | 0.2 | GO:0008260 | 3-oxoacid CoA-transferase activity(GO:0008260) |
| 0.0 | 0.5 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.0 | 0.2 | GO:0090554 | phosphatidylcholine-translocating ATPase activity(GO:0090554) |
| 0.0 | 0.1 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.0 | 0.2 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.0 | 0.2 | GO:0046790 | virion binding(GO:0046790) |
| 0.0 | 0.1 | GO:0005477 | pyruvate secondary active transmembrane transporter activity(GO:0005477) |
| 0.0 | 0.1 | GO:0004910 | interleukin-1, Type II, blocking receptor activity(GO:0004910) |
| 0.0 | 0.3 | GO:0004465 | lipoprotein lipase activity(GO:0004465) |
| 0.0 | 0.1 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
| 0.0 | 0.1 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.0 | 0.1 | GO:0070728 | leucine binding(GO:0070728) |
| 0.0 | 0.1 | GO:0004060 | arylamine N-acetyltransferase activity(GO:0004060) |
| 0.0 | 0.1 | GO:0003998 | acylphosphatase activity(GO:0003998) |
| 0.0 | 0.1 | GO:0046538 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
| 0.0 | 0.2 | GO:0003696 | satellite DNA binding(GO:0003696) |
| 0.0 | 0.1 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 0.0 | 0.1 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
| 0.0 | 0.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 0.3 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.0 | 1.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.1 | GO:0019863 | IgE binding(GO:0019863) |
| 0.0 | 0.2 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.0 | 0.2 | GO:0034485 | phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485) |
| 0.0 | 0.1 | GO:0016778 | diphosphotransferase activity(GO:0016778) |
| 0.0 | 0.1 | GO:0042610 | CD8 receptor binding(GO:0042610) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 1.2 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 0.5 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 1.0 | NABA COLLAGENS | Genes encoding collagen proteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.9 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 1.0 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 0.4 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.0 | 2.7 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 0.4 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.0 | 0.5 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.0 | 0.6 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 1.0 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 1.0 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |