ISMARA results: OTP_PHOX2B_LHX1_LMX1A_LHX5

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Z-value: 0.75

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Transcription factors associated with OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Gene Symbol	Gene ID	Gene Info
OTP Ensembl NCBI GeneCards UniProt	ENSG00000171540.6	orthopedia homeobox
PHOX2B Ensembl NCBI GeneCards UniProt	ENSG00000109132.5	paired like homeobox 2B
LHX1 Ensembl NCBI GeneCards UniProt	ENSG00000132130.7	LIM homeobox 1
LMX1A Ensembl NCBI GeneCards UniProt	ENSG00000162761.10	LIM homeobox transcription factor 1 alpha
LHX5 Ensembl NCBI GeneCards UniProt	ENSG00000089116.3	LIM homeobox 5
HOXC4 Ensembl NCBI GeneCards UniProt	ENSG00000198353.6	homeobox C4
HOXC4 Ensembl NCBI GeneCards UniProt	ENSG00000273266.1	homeobox C4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
LHX1	hg19_v2_chr17_+_35294075_35294102	-0.53	1.6e-02	Click!
HOXC4	hg19_v2_chr12_+_54447637_54447661	-0.41	7.0e-02	Click!
LHX5	hg19_v2_chr12_-_113909877_113909877	0.32	1.7e-01	Click!
OTP	hg19_v2_chr5_-_76935513_76935513	-0.11	6.4e-01	Click!

Activity profile of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Sorted Z-values of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

No targets for OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Network of associatons between targets according to the STRING database.

First level regulatory network of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.5	GO:0046597	negative regulation of viral entry into host cell(GO:0046597)
0.1	1.9	GO:0042420	dopamine catabolic process(GO:0042420)
0.2	1.2	GO:0071279	cellular response to cobalt ion(GO:0071279)
0.3	1.1	GO:0060166	olfactory pit development(GO:0060166)
0.1	1.1	GO:0042354	fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0	1.1	GO:0071481	cellular response to X-ray(GO:0071481)
0.1	1.0	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.0	1.0	GO:0031581	hemidesmosome assembly(GO:0031581)
0.3	0.9	GO:0002416	IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.1	0.9	GO:0010133	proline catabolic process to glutamate(GO:0010133)

Showing 1 to 10 of 59 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.7	GO:0031902	late endosome membrane(GO:0031902)
0.1	1.3	GO:0043203	axon hillock(GO:0043203)
0.1	1.1	GO:0097129	cyclin D2-CDK4 complex(GO:0097129)
0.1	1.0	GO:0005577	fibrinogen complex(GO:0005577)
0.0	1.0	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.9	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.0	0.9	GO:0043209	myelin sheath(GO:0043209)
0.0	0.9	GO:0015030	Cajal body(GO:0015030)
0.1	0.6	GO:0060187	cell pole(GO:0060187)
0.1	0.6	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)

Showing 1 to 10 of 23 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.9	GO:0008131	primary amine oxidase activity(GO:0008131)
0.0	1.7	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.1	1.1	GO:0070324	thyroid hormone binding(GO:0070324)
0.1	1.1	GO:0008417	fucosyltransferase activity(GO:0008417)
0.2	0.9	GO:0004657	proline dehydrogenase activity(GO:0004657)
0.2	0.9	GO:0019770	IgG receptor activity(GO:0019770)
0.1	0.6	GO:0047894	flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.0	0.6	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.6	GO:0015266	protein channel activity(GO:0015266)
0.0	0.6	GO:0005540	hyaluronic acid binding(GO:0005540)

Showing 1 to 10 of 39 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
1.2	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
1.1	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
1.0	NABA COLLAGENS	Genes encoding collagen proteins
0.5	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Showing 1 to 4 of 4 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.7	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	1.9	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0	1.0	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	1.0	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	1.0	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.6	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.0	0.5	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	0.4	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.0	0.4	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine

Showing 1 to 9 of 9 entries

Results for OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Z-value: 0.75

Motif logo

Transcription factors associated with OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Activity-expression correlation:

Activity profile of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Sorted Z-values of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

No targets for OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Network of associatons between targets according to the STRING database.

First level regulatory network of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: