ISMARA results: OTX2

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for OTX2_CRX

Z-value: 0.91

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Transcription factors associated with OTX2_CRX

Gene Symbol	Gene ID	Gene Info
OTX2 Ensembl NCBI GeneCards UniProt	ENSG00000165588.12	orthodenticle homeobox 2
CRX Ensembl NCBI GeneCards UniProt	ENSG00000105392.11	cone-rod homeobox

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
CRX	hg19_v2_chr19_+_48325097_48325211	0.54	1.3e-02	Click!

Activity profile of OTX2_CRX motif

Sorted Z-values of OTX2_CRX motif

No targets for OTX2_CRX

Network of associatons between targets according to the STRING database.

First level regulatory network of OTX2_CRX

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.6	GO:0021516	dorsal spinal cord development(GO:0021516)
0.5	2.8	GO:0061143	alveolar primary septum development(GO:0061143)
0.2	2.4	GO:0032286	central nervous system myelin maintenance(GO:0032286)
0.1	2.4	GO:0071420	cellular response to histamine(GO:0071420)
0.1	2.4	GO:0035641	locomotory exploration behavior(GO:0035641)
0.0	2.3	GO:0032981	NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1	1.7	GO:0001502	cartilage condensation(GO:0001502)
0.1	1.4	GO:0030450	regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959)
0.1	1.4	GO:0014029	neural crest formation(GO:0014029)
0.0	1.4	GO:0010107	potassium ion import(GO:0010107)

Showing 1 to 10 of 92 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.4	GO:1902711	GABA-A receptor complex(GO:1902711)
0.1	1.7	GO:0097381	photoreceptor disc membrane(GO:0097381)
0.0	1.4	GO:0045171	intercellular bridge(GO:0045171)
0.1	1.1	GO:0098554	cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0	1.1	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.2	0.9	GO:0016035	zeta DNA polymerase complex(GO:0016035)
0.0	0.9	GO:0032059	bleb(GO:0032059)
0.1	0.7	GO:0030915	Smc5-Smc6 complex(GO:0030915)
0.0	0.7	GO:0005719	nuclear euchromatin(GO:0005719)
0.0	0.7	GO:0005834	heterotrimeric G-protein complex(GO:0005834)

Showing 1 to 10 of 37 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.9	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1	2.8	GO:0051183	vitamin transporter activity(GO:0051183)
0.2	2.2	GO:0022851	GABA-gated chloride ion channel activity(GO:0022851)
0.1	1.5	GO:0005112	Notch binding(GO:0005112)
0.0	1.4	GO:0001103	RNA polymerase II repressing transcription factor binding(GO:0001103)
0.3	1.3	GO:0008665	2'-phosphotransferase activity(GO:0008665)
0.1	1.3	GO:0008020	G-protein coupled photoreceptor activity(GO:0008020)
0.1	1.3	GO:0005522	profilin binding(GO:0005522)
0.1	1.3	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0	1.2	GO:0030145	manganese ion binding(GO:0030145)

Showing 1 to 10 of 61 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
1.8	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
1.5	PID NOTCH PATHWAY	Notch signaling pathway
1.4	PID CD40 PATHWAY	CD40/CD40L signaling
1.3	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
1.2	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
1.1	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.8	PID RHODOPSIN PATHWAY	Visual signal transduction: Rods
0.6	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.5	ST GA12 PATHWAY	G alpha 12 Pathway
0.5	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Showing 1 to 10 of 13 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.4	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.0	1.4	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	1.4	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.1	1.3	REACTOME OPSINS	Genes involved in Opsins
0.0	1.3	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.2	1.1	REACTOME HORMONE LIGAND BINDING RECEPTORS	Genes involved in Hormone ligand-binding receptors
0.0	0.8	REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D	Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0	0.7	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.6	REACTOME KINESINS	Genes involved in Kinesins
0.0	0.6	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Showing 1 to 10 of 17 entries

Results for OTX2_CRX

Z-value: 0.91

Motif logo

Transcription factors associated with OTX2_CRX

Activity-expression correlation:

Activity profile of OTX2_CRX motif

Sorted Z-values of OTX2_CRX motif

No targets for OTX2_CRX

Network of associatons between targets according to the STRING database.

First level regulatory network of OTX2_CRX

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: