ISMARA results: PAX3

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PAX3

Z-value: 0.86

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Transcription factors associated with PAX3

Gene Symbol	Gene ID	Gene Info
PAX3 Ensembl NCBI GeneCards UniProt	ENSG00000135903.14	paired box 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PAX3	hg19_v2_chr2_-_223163465_223163730	-0.45	4.6e-02	Click!

Activity profile of PAX3 motif

Sorted Z-values of PAX3 motif

No targets for PAX3

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	3.0	GO:2000110	negative regulation of macrophage apoptotic process(GO:2000110)
1.0	2.9	GO:2001190	positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.3	2.0	GO:0033277	abortive mitotic cell cycle(GO:0033277)
0.1	1.9	GO:0006999	nuclear pore organization(GO:0006999)
0.0	1.8	GO:0097421	liver regeneration(GO:0097421)
0.1	1.6	GO:0010032	meiotic chromosome condensation(GO:0010032)
0.2	1.2	GO:0016480	negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.0	1.2	GO:0043403	skeletal muscle tissue regeneration(GO:0043403)
0.0	1.1	GO:0030728	ovulation(GO:0030728)
0.0	1.1	GO:0030513	positive regulation of BMP signaling pathway(GO:0030513)

Showing 1 to 10 of 49 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.9	GO:0042613	MHC class II protein complex(GO:0042613)
0.2	2.0	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.1	1.9	GO:0044615	nuclear pore nuclear basket(GO:0044615)
0.0	1.8	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.1	1.6	GO:0000796	condensin complex(GO:0000796)
0.1	1.2	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.1	1.2	GO:0060077	inhibitory synapse(GO:0060077)
0.0	1.1	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.1	0.9	GO:0030678	mitochondrial ribonuclease P complex(GO:0030678)
0.1	0.9	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)

Showing 1 to 10 of 21 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.0	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1	2.9	GO:0023026	MHC class II protein complex binding(GO:0023026)
0.0	2.4	GO:0005487	nucleocytoplasmic transporter activity(GO:0005487)
0.0	2.0	GO:0042169	SH2 domain binding(GO:0042169)
0.4	1.8	GO:0070180	large ribosomal subunit rRNA binding(GO:0070180)
0.4	1.2	GO:0000994	RNA polymerase III core binding(GO:0000994)
0.1	1.2	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.0	1.1	GO:0005540	hyaluronic acid binding(GO:0005540)
0.0	1.0	GO:0070064	proline-rich region binding(GO:0070064)
0.0	1.0	GO:0050699	WW domain binding(GO:0050699)

Showing 1 to 10 of 41 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
3.1	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
2.0	PID EPO PATHWAY	EPO signaling pathway
1.6	PID AURORA B PATHWAY	Aurora B signaling
1.0	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.9	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks

Showing 1 to 5 of 5 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.3	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.2	3.0	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	2.4	REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.1	2.0	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	1.9	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.0	1.6	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	1.4	REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1	0.9	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0	0.9	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.0	0.8	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins

Showing 1 to 10 of 16 entries

Results for PAX3

Z-value: 0.86

Motif logo

Transcription factors associated with PAX3

Activity-expression correlation:

Activity profile of PAX3 motif

Sorted Z-values of PAX3 motif

No targets for PAX3

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: