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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PBX2

Z-value: 0.41

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Transcription factors associated with PBX2

Gene Symbol Gene ID Gene Info
ENSG00000204304.7 PBX homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PBX2hg19_v2_chr6_-_32157947_321579920.912.3e-08Click!

Activity profile of PBX2 motif

Sorted Z-values of PBX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PBX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0045081 negative regulation of interleukin-10 biosynthetic process(GO:0045081)
0.2 0.8 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.1 3.5 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.1 0.2 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.1 0.2 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.1 0.7 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.0 0.2 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.0 0.2 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.6 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.2 GO:2000467 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.0 0.1 GO:0035026 leading edge cell differentiation(GO:0035026)
0.0 0.5 GO:0015695 organic cation transport(GO:0015695)
0.0 0.0 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:1990075 periciliary membrane compartment(GO:1990075)
0.0 0.6 GO:0097512 cardiac myofibril(GO:0097512)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1 3.5 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 1.2 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.1 GO:0019115 benzaldehyde dehydrogenase activity(GO:0019115)
0.0 0.5 GO:0019534 toxin transporter activity(GO:0019534)
0.0 0.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.2 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.7 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.7 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.1 GO:0047522 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.5 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.8 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.5 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.7 REACTOME GLUCURONIDATION Genes involved in Glucuronidation