ISMARA results: PBX3

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PBX3

Z-value: 4.13

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Transcription factors associated with PBX3

Gene Symbol	Gene ID	Gene Info
PBX3 Ensembl NCBI GeneCards UniProt	ENSG00000167081.12	PBX homeobox 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PBX3	hg19_v2_chr9_+_128510454_128510478	0.33	1.6e-01	Click!

Activity profile of PBX3 motif

Sorted Z-values of PBX3 motif

No targets for PBX3

Network of associatons between targets according to the STRING database.

First level regulatory network of PBX3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	16.2	GO:0031581	hemidesmosome assembly(GO:0031581)
4.0	16.1	GO:0070893	transposon integration(GO:0070893) regulation of transposon integration(GO:0070894) negative regulation of transposon integration(GO:0070895)
0.6	13.3	GO:0097264	self proteolysis(GO:0097264)
0.3	12.3	GO:0006783	heme biosynthetic process(GO:0006783)
2.4	12.2	GO:0072137	condensed mesenchymal cell proliferation(GO:0072137)
2.6	10.5	GO:0072086	specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268)
0.4	8.6	GO:0060044	negative regulation of cardiac muscle cell proliferation(GO:0060044)
1.1	8.0	GO:0060671	epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.1	8.0	GO:0010923	negative regulation of phosphatase activity(GO:0010923)
0.0	7.8	GO:0000209	protein polyubiquitination(GO:0000209)

Showing 1 to 10 of 225 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	16.2	GO:0005610	laminin-5 complex(GO:0005610)
0.1	15.6	GO:0016605	PML body(GO:0016605)
0.0	13.2	GO:0043209	myelin sheath(GO:0043209)
0.1	10.4	GO:0035577	azurophil granule membrane(GO:0035577)
0.0	10.3	GO:0005667	transcription factor complex(GO:0005667)
0.6	9.6	GO:0098799	outer mitochondrial membrane protein complex(GO:0098799)
0.0	9.1	GO:0044309	neuron spine(GO:0044309)
0.0	7.6	GO:0042470	melanosome(GO:0042470) pigment granule(GO:0048770)
0.2	6.2	GO:0097546	ciliary base(GO:0097546)
0.1	5.9	GO:0010494	cytoplasmic stress granule(GO:0010494)

Showing 1 to 10 of 95 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	85.5	GO:0003677	DNA binding(GO:0003677)
0.1	39.0	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.5	12.0	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.1	11.9	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0	10.0	GO:0046982	protein heterodimerization activity(GO:0046982)
0.1	9.8	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.4	9.7	GO:0001161	intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.2	9.7	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624)
0.0	9.5	GO:0017137	Rab GTPase binding(GO:0017137)
0.1	9.0	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843)

Showing 1 to 10 of 155 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	16.4	PID VEGFR1 PATHWAY	VEGFR1 specific signals
0.6	16.2	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.2	8.9	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.1	8.4	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1	8.3	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.1	7.8	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.1	6.5	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.1	6.0	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	4.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	4.4	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling

Showing 1 to 10 of 43 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	34.2	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.2	12.0	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.1	11.1	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.2	8.4	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.2	8.2	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.2	7.3	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.0	6.2	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2	5.9	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2	5.8	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.1	5.4	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development

Showing 1 to 10 of 68 entries

Results for PBX3

Z-value: 4.13

Motif logo

Transcription factors associated with PBX3

Activity-expression correlation:

Activity profile of PBX3 motif

Sorted Z-values of PBX3 motif

No targets for PBX3

Network of associatons between targets according to the STRING database.

First level regulatory network of PBX3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: