avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

• Motif significance table
• Sample table
• Mean activities
• All promoters sorted by FOV

• Activity table
• Activity delta table
• Regulatory interactions
• Motifs sorted by significance
• Expression table
• Download the whole report

Gene Symbol	Gene ID	Gene Info
PBX3 Links Ensembl NCBI GeneCards UniProt	ENSG00000167081.12	PBX homeobox 3

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PBX3	hg19_v2_chr9_+_128510454_128510478	0.33	1.6e-01	Click!

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Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
4.0	16.1	GO:0070893	transposon integration(GO:0070893) regulation of transposon integration(GO:0070894) negative regulation of transposon integration(GO:0070895)
2.6	10.5	GO:0072086	specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268)
2.4	12.2	GO:0072137	condensed mesenchymal cell proliferation(GO:0072137)
1.5	2.9	GO:0035065	regulation of histone acetylation(GO:0035065)
1.4	4.1	GO:0021776	smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
1.3	4.0	GO:1903676	regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
1.3	3.8	GO:1903526	negative regulation of membrane tubulation(GO:1903526)
1.2	2.4	GO:2000974	auditory receptor cell fate determination(GO:0042668) negative regulation of pro-B cell differentiation(GO:2000974)
1.2	3.5	GO:0008052	sensory organ boundary specification(GO:0008052) formation of organ boundary(GO:0010160) taste bud development(GO:0061193)
1.1	8.0	GO:0060671	epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
1.1	2.1	GO:1903204	negative regulation of oxidative stress-induced neuron death(GO:1903204)
1.0	3.1	GO:0002661	B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
1.0	2.9	GO:0048210	Golgi vesicle fusion to target membrane(GO:0048210)
0.9	4.6	GO:0036414	protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.9	3.7	GO:0021849	neuroblast division in subventricular zone(GO:0021849)
0.9	3.6	GO:0043456	regulation of pentose-phosphate shunt(GO:0043456)
0.9	2.7	GO:1903570	coronary vein morphogenesis(GO:0003169) regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.9	2.7	GO:0060734	regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734)
0.9	5.3	GO:0002378	immunoglobulin biosynthetic process(GO:0002378)
0.8	5.8	GO:0071630	nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.7	5.2	GO:0002767	immune response-inhibiting cell surface receptor signaling pathway(GO:0002767)
0.7	5.8	GO:0010908	regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) myoblast fate commitment(GO:0048625) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.7	5.0	GO:0097501	stress response to metal ion(GO:0097501)
0.6	1.9	GO:0002276	basophil activation involved in immune response(GO:0002276)
0.6	4.3	GO:1904381	Golgi apparatus mannose trimming(GO:1904381)
0.6	13.3	GO:0097264	self proteolysis(GO:0097264)
0.6	4.2	GO:0006740	NADPH regeneration(GO:0006740)
0.5	1.6	GO:0031587	positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
0.5	6.4	GO:2000270	negative regulation of fibroblast apoptotic process(GO:2000270)
0.5	5.2	GO:1904327	protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.5	1.5	GO:1904717	excitatory chemical synaptic transmission(GO:0098976) regulation of AMPA glutamate receptor clustering(GO:1904717) positive regulation of AMPA glutamate receptor clustering(GO:1904719)
0.5	7.6	GO:0018026	peptidyl-lysine monomethylation(GO:0018026)
0.5	1.0	GO:0032289	central nervous system myelin formation(GO:0032289)
0.5	2.9	GO:0070417	regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) cellular response to cold(GO:0070417)
0.5	1.4	GO:1904247	positive regulation of polynucleotide adenylyltransferase activity(GO:1904247)
0.5	2.3	GO:0006051	mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051)
0.4	2.2	GO:0032796	uropod organization(GO:0032796)
0.4	16.2	GO:0031581	hemidesmosome assembly(GO:0031581)
0.4	1.7	GO:0032764	negative regulation of mast cell cytokine production(GO:0032764)
0.4	7.3	GO:0015871	choline transport(GO:0015871)
0.4	1.6	GO:0032915	positive regulation of transforming growth factor beta2 production(GO:0032915)
0.4	1.6	GO:0048205	COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.4	1.6	GO:0060940	epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940)
0.4	1.5	GO:2000820	negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.4	8.6	GO:0060044	negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.4	1.5	GO:0035408	histone H3-T6 phosphorylation(GO:0035408)
0.3	6.2	GO:0090168	Golgi reassembly(GO:0090168)
0.3	5.8	GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.3	1.3	GO:1902683	regulation of receptor localization to synapse(GO:1902683)
0.3	12.3	GO:0006783	heme biosynthetic process(GO:0006783)
0.3	2.2	GO:0048852	diencephalon morphogenesis(GO:0048852)
0.3	4.1	GO:0015889	cobalt ion transport(GO:0006824) cobalamin transport(GO:0015889)
0.3	1.9	GO:1901727	positive regulation of histone deacetylase activity(GO:1901727)
0.3	1.9	GO:1900147	Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.3	4.2	GO:0060252	positive regulation of glial cell proliferation(GO:0060252)
0.3	1.5	GO:0046546	male gonad development(GO:0008584) development of primary male sexual characteristics(GO:0046546)
0.3	1.4	GO:0070980	biphenyl catabolic process(GO:0070980)
0.3	1.4	GO:2000691	regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691)
0.3	3.5	GO:0070544	histone H3-K36 demethylation(GO:0070544)
0.3	3.4	GO:2000042	negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.3	1.3	GO:0035513	oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.2	4.7	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
0.2	3.0	GO:1900029	positive regulation of ruffle assembly(GO:1900029)
0.2	1.8	GO:0051592	response to calcium ion(GO:0051592)
0.2	2.5	GO:2000467	positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.2	0.6	GO:0044313	protein K6-linked deubiquitination(GO:0044313)
0.2	6.3	GO:0001502	cartilage condensation(GO:0001502)
0.2	1.6	GO:0021592	fourth ventricle development(GO:0021592)
0.2	1.2	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.2	1.3	GO:0006982	response to lipid hydroperoxide(GO:0006982)
0.2	4.4	GO:0030150	protein import into mitochondrial matrix(GO:0030150)
0.2	4.6	GO:0097201	negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.2	1.5	GO:0030578	PML body organization(GO:0030578)
0.2	2.4	GO:0006265	DNA topological change(GO:0006265)
0.2	0.7	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.2	2.5	GO:0007258	JUN phosphorylation(GO:0007258)
0.2	2.9	GO:0090557	establishment of endothelial intestinal barrier(GO:0090557)
0.2	1.1	GO:0070458	establishment of blood-nerve barrier(GO:0008065) cellular detoxification of nitrogen compound(GO:0070458)
0.2	2.4	GO:0002098	tRNA wobble uridine modification(GO:0002098)
0.2	4.1	GO:0016024	CDP-diacylglycerol biosynthetic process(GO:0016024)
0.2	2.1	GO:0030091	protein repair(GO:0030091)
0.2	1.0	GO:1901909	diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.2	0.8	GO:0044501	modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.2	5.9	GO:0009083	branched-chain amino acid catabolic process(GO:0009083)
0.1	2.9	GO:0048243	norepinephrine secretion(GO:0048243)
0.1	1.5	GO:0032534	regulation of microvillus assembly(GO:0032534)
0.1	1.1	GO:0007008	outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.1	2.9	GO:0036148	phosphatidylglycerol acyl-chain remodeling(GO:0036148)
0.1	1.9	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.1	0.8	GO:0002729	positive regulation of natural killer cell cytokine production(GO:0002729) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.1	1.2	GO:2000660	negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.1	1.0	GO:0070358	actin polymerization-dependent cell motility(GO:0070358)
0.1	1.9	GO:0038166	angiotensin-activated signaling pathway(GO:0038166)
0.1	1.1	GO:0060120	auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.1	0.7	GO:0097498	endothelial tube lumen extension(GO:0097498)
0.1	3.7	GO:0030033	microvillus assembly(GO:0030033)
0.1	4.1	GO:0022038	corpus callosum development(GO:0022038)
0.1	1.3	GO:0061458	reproductive system development(GO:0061458)
0.1	1.3	GO:0002191	cap-dependent translational initiation(GO:0002191)
0.1	0.8	GO:1904491	protein localization to ciliary transition zone(GO:1904491)
0.1	1.2	GO:1903147	negative regulation of macromitophagy(GO:1901525) negative regulation of mitophagy(GO:1903147)
0.1	0.5	GO:0043686	co-translational protein modification(GO:0043686)
0.1	5.3	GO:0019433	triglyceride catabolic process(GO:0019433)
0.1	5.8	GO:0045022	early endosome to late endosome transport(GO:0045022)
0.1	2.7	GO:0036010	protein localization to endosome(GO:0036010)
0.1	2.2	GO:0034656	nucleobase-containing small molecule catabolic process(GO:0034656)
0.1	1.8	GO:1902018	negative regulation of cilium assembly(GO:1902018)
0.1	0.9	GO:0010587	miRNA catabolic process(GO:0010587)
0.1	1.8	GO:0000338	protein deneddylation(GO:0000338)
0.1	0.5	GO:0090156	cellular sphingolipid homeostasis(GO:0090156)
0.1	1.2	GO:0030497	fatty acid elongation(GO:0030497)
0.1	3.3	GO:0048025	negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.1	5.4	GO:0010107	potassium ion import(GO:0010107)
0.1	1.5	GO:0030210	heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.1	2.1	GO:0006895	Golgi to endosome transport(GO:0006895)
0.1	1.1	GO:0033314	mitotic DNA replication checkpoint(GO:0033314)
0.1	0.9	GO:0035524	proline transmembrane transport(GO:0035524)
0.1	0.2	GO:1902725	negative regulation of satellite cell differentiation(GO:1902725)
0.1	0.7	GO:0071910	determination of pancreatic left/right asymmetry(GO:0035469) determination of liver left/right asymmetry(GO:0071910)
0.1	1.6	GO:0030308	negative regulation of cell growth(GO:0030308)
0.1	0.6	GO:1903593	regulation of histamine secretion by mast cell(GO:1903593)
0.1	1.0	GO:0061669	spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.1	0.8	GO:0048227	plasma membrane to endosome transport(GO:0048227)
0.1	2.2	GO:0045332	phospholipid translocation(GO:0045332)
0.1	2.6	GO:0071157	negative regulation of cell cycle arrest(GO:0071157)
0.1	3.7	GO:0030262	apoptotic nuclear changes(GO:0030262)
0.1	0.5	GO:0006620	posttranslational protein targeting to membrane(GO:0006620)
0.1	2.5	GO:0045839	negative regulation of mitotic nuclear division(GO:0045839)
0.1	8.0	GO:0010923	negative regulation of phosphatase activity(GO:0010923)
0.1	0.7	GO:0032237	activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1	0.4	GO:0090206	negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.1	1.7	GO:0006939	smooth muscle contraction(GO:0006939)
0.1	0.5	GO:0002326	B cell lineage commitment(GO:0002326) immunoglobulin V(D)J recombination(GO:0033152)
0.1	1.7	GO:0042749	regulation of circadian sleep/wake cycle(GO:0042749) regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.1	1.0	GO:0046784	viral mRNA export from host cell nucleus(GO:0046784)
0.1	0.1	GO:1901896	positive regulation of calcium-transporting ATPase activity(GO:1901896)
0.1	0.2	GO:0046338	phosphatidylethanolamine catabolic process(GO:0046338)
0.1	2.3	GO:0018345	protein palmitoylation(GO:0018345)
0.1	2.0	GO:0032479	regulation of type I interferon production(GO:0032479)
0.1	0.5	GO:1904936	cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1	1.6	GO:0044342	type B pancreatic cell proliferation(GO:0044342)
0.1	2.4	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol(GO:0051281)
0.1	1.5	GO:0002230	positive regulation of defense response to virus by host(GO:0002230)
0.1	2.4	GO:0046676	negative regulation of insulin secretion(GO:0046676)
0.1	0.9	GO:1904896	ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.1	0.4	GO:0032486	Rap protein signal transduction(GO:0032486)
0.1	0.7	GO:0098734	macromolecule depalmitoylation(GO:0098734)
0.1	0.5	GO:1900004	negative regulation of serine-type endopeptidase activity(GO:1900004) negative regulation of serine-type peptidase activity(GO:1902572)
0.0	0.4	GO:0007288	sperm axoneme assembly(GO:0007288)
0.0	5.4	GO:0006306	DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0	4.9	GO:0060828	regulation of canonical Wnt signaling pathway(GO:0060828)
0.0	0.5	GO:2000628	regulation of miRNA metabolic process(GO:2000628)
0.0	2.3	GO:0060325	face morphogenesis(GO:0060325)
0.0	0.9	GO:0034394	protein localization to cell surface(GO:0034394)
0.0	0.7	GO:0007512	adult heart development(GO:0007512)
0.0	0.4	GO:0031022	nuclear migration along microfilament(GO:0031022)
0.0	0.6	GO:0045651	positive regulation of macrophage differentiation(GO:0045651)
0.0	2.6	GO:0006699	bile acid biosynthetic process(GO:0006699)
0.0	0.5	GO:0035826	rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
0.0	1.0	GO:0045948	positive regulation of translational initiation(GO:0045948)
0.0	0.2	GO:0038110	interleukin-2-mediated signaling pathway(GO:0038110)
0.0	0.1	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	1.9	GO:0060338	regulation of type I interferon-mediated signaling pathway(GO:0060338)
0.0	2.1	GO:0060218	hematopoietic stem cell differentiation(GO:0060218)
0.0	0.3	GO:0070345	negative regulation of fat cell proliferation(GO:0070345)
0.0	1.3	GO:0042776	mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0	1.7	GO:1900739	regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.0	1.6	GO:0051180	vitamin transport(GO:0051180)
0.0	1.0	GO:0046339	diacylglycerol metabolic process(GO:0046339)
0.0	3.9	GO:1902017	regulation of cilium assembly(GO:1902017)
0.0	2.8	GO:0043966	histone H3 acetylation(GO:0043966)
0.0	6.5	GO:0051781	positive regulation of cell division(GO:0051781)
0.0	1.3	GO:0032728	positive regulation of interferon-beta production(GO:0032728)
0.0	0.3	GO:0070933	histone H4 deacetylation(GO:0070933)
0.0	1.4	GO:0097502	mannosylation(GO:0097502)
0.0	0.3	GO:0017062	respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) positive regulation of mitochondrial translation(GO:0070131) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0	1.4	GO:0048741	skeletal muscle fiber development(GO:0048741)
0.0	3.4	GO:0006027	glycosaminoglycan catabolic process(GO:0006027)
0.0	2.6	GO:0016239	positive regulation of macroautophagy(GO:0016239)
0.0	1.0	GO:0006359	regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0	2.0	GO:0006891	intra-Golgi vesicle-mediated transport(GO:0006891)
0.0	0.3	GO:0038092	nodal signaling pathway(GO:0038092)
0.0	4.7	GO:0002433	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.0	0.3	GO:0016191	synaptic vesicle uncoating(GO:0016191)
0.0	2.3	GO:0008156	negative regulation of DNA replication(GO:0008156)
0.0	1.3	GO:0060765	regulation of androgen receptor signaling pathway(GO:0060765)
0.0	1.0	GO:0070584	mitochondrion morphogenesis(GO:0070584)
0.0	2.4	GO:0009250	glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0	1.5	GO:1904837	beta-catenin-TCF complex assembly(GO:1904837)
0.0	0.8	GO:0016525	negative regulation of angiogenesis(GO:0016525)
0.0	1.2	GO:0071526	semaphorin-plexin signaling pathway(GO:0071526)
0.0	0.6	GO:0070262	peptidyl-serine dephosphorylation(GO:0070262)
0.0	1.2	GO:0030970	retrograde protein transport, ER to cytosol(GO:0030970)
0.0	0.3	GO:0051044	positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0	1.1	GO:0061014	positive regulation of mRNA catabolic process(GO:0061014)
0.0	0.2	GO:0048105	establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105)
0.0	0.9	GO:0021522	spinal cord motor neuron differentiation(GO:0021522)
0.0	2.2	GO:0030574	collagen catabolic process(GO:0030574)
0.0	0.2	GO:1904783	regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) positive regulation of NMDA glutamate receptor activity(GO:1904783) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.0	1.9	GO:0030279	negative regulation of ossification(GO:0030279)
0.0	0.1	GO:1901421	positive regulation of response to alcohol(GO:1901421)
0.0	0.1	GO:0046836	glycolipid transport(GO:0046836)
0.0	2.9	GO:0019079	viral genome replication(GO:0019079)
0.0	3.1	GO:0006661	phosphatidylinositol biosynthetic process(GO:0006661)
0.0	4.5	GO:0016579	protein deubiquitination(GO:0016579)
0.0	0.7	GO:0007257	activation of JUN kinase activity(GO:0007257)
0.0	0.4	GO:0048240	sperm capacitation(GO:0048240)
0.0	5.9	GO:0090305	nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.0	7.8	GO:0000209	protein polyubiquitination(GO:0000209)
0.0	0.7	GO:0007274	neuromuscular synaptic transmission(GO:0007274)
0.0	0.3	GO:0031639	plasminogen activation(GO:0031639)
0.0	0.3	GO:0030225	macrophage differentiation(GO:0030225)
0.0	0.7	GO:0000413	protein peptidyl-prolyl isomerization(GO:0000413)
0.0	2.8	GO:0060348	bone development(GO:0060348)
0.0	4.2	GO:0010951	negative regulation of endopeptidase activity(GO:0010951)
0.0	0.2	GO:0099601	regulation of neurotransmitter receptor activity(GO:0099601)
0.0	0.2	GO:0001829	trophectodermal cell differentiation(GO:0001829)
0.0	0.9	GO:0006369	termination of RNA polymerase II transcription(GO:0006369)
0.0	2.8	GO:0008360	regulation of cell shape(GO:0008360)
0.0	0.7	GO:0042982	amyloid precursor protein metabolic process(GO:0042982)
0.0	0.1	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.0	0.8	GO:0031110	regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0	0.7	GO:0045454	cell redox homeostasis(GO:0045454)
0.0	0.2	GO:0036158	outer dynein arm assembly(GO:0036158)
0.0	0.2	GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.5	16.2	GO:0005610	laminin-5 complex(GO:0005610)
0.8	4.9	GO:0000308	cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.8	4.8	GO:0097513	myosin II filament(GO:0097513)
0.8	4.0	GO:0019031	viral envelope(GO:0019031) viral membrane(GO:0036338)
0.7	5.8	GO:0070369	beta-catenin-TCF7L2 complex(GO:0070369)
0.7	4.1	GO:0044308	axonal spine(GO:0044308)
0.6	1.9	GO:0002139	stereocilia coupling link(GO:0002139)
0.6	9.6	GO:0098799	outer mitochondrial membrane protein complex(GO:0098799)
0.6	0.6	GO:1990246	uniplex complex(GO:1990246)
0.5	5.2	GO:0042612	MHC class I protein complex(GO:0042612)
0.5	4.1	GO:0005587	collagen type IV trimer(GO:0005587)
0.4	5.2	GO:0072379	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.4	1.9	GO:0035838	growing cell tip(GO:0035838)
0.3	3.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.3	5.7	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.2	1.2	GO:0000839	Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.2	0.7	GO:0097637	intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.2	2.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.2	1.4	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.2	2.8	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.2	1.7	GO:0070695	FHF complex(GO:0070695)
0.2	5.8	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.2	6.2	GO:0097546	ciliary base(GO:0097546)
0.1	1.8	GO:0036057	filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1	3.3	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.1	1.8	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1	5.1	GO:0016581	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1	5.4	GO:0035861	site of double-strand break(GO:0035861)
0.1	4.2	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.1	1.4	GO:0042405	nuclear inclusion body(GO:0042405)
0.1	3.3	GO:0001891	phagocytic cup(GO:0001891)
0.1	1.0	GO:0000439	core TFIIH complex(GO:0000439)
0.1	0.5	GO:1990425	ryanodine receptor complex(GO:1990425)
0.1	10.4	GO:0035577	azurophil granule membrane(GO:0035577)
0.1	2.0	GO:0010369	chromocenter(GO:0010369)
0.1	1.0	GO:0033588	Elongator holoenzyme complex(GO:0033588)
0.1	0.9	GO:0035686	sperm fibrous sheath(GO:0035686)
0.1	1.0	GO:0000445	THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1	15.6	GO:0016605	PML body(GO:0016605)
0.1	0.5	GO:0035339	SPOTS complex(GO:0035339)
0.1	1.4	GO:0000124	SAGA complex(GO:0000124) STAGA complex(GO:0030914)
0.1	2.6	GO:0000178	exosome (RNase complex)(GO:0000178)
0.1	5.3	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.1	0.9	GO:0000788	nuclear nucleosome(GO:0000788)
0.1	5.9	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.1	4.4	GO:0030286	dynein complex(GO:0030286)
0.1	3.5	GO:0008180	COP9 signalosome(GO:0008180)
0.1	0.4	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.1	2.6	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.1	1.3	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1	4.0	GO:0005801	cis-Golgi network(GO:0005801)
0.0	0.2	GO:0060187	cell pole(GO:0060187)
0.0	1.4	GO:0035145	exon-exon junction complex(GO:0035145)
0.0	1.9	GO:0044295	axonal growth cone(GO:0044295)
0.0	0.4	GO:0036128	CatSper complex(GO:0036128)
0.0	4.3	GO:0031526	brush border membrane(GO:0031526)
0.0	9.1	GO:0044309	neuron spine(GO:0044309)
0.0	0.6	GO:0005687	U4 snRNP(GO:0005687)
0.0	13.2	GO:0043209	myelin sheath(GO:0043209)
0.0	1.8	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.0	1.3	GO:0005753	mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.0	1.2	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	3.5	GO:0035580	specific granule lumen(GO:0035580)
0.0	7.6	GO:0042470	melanosome(GO:0042470) pigment granule(GO:0048770)
0.0	3.7	GO:0000151	ubiquitin ligase complex(GO:0000151)
0.0	1.2	GO:0071782	endoplasmic reticulum tubular network(GO:0071782)
0.0	1.3	GO:0001772	immunological synapse(GO:0001772)
0.0	4.0	GO:0005604	basement membrane(GO:0005604)
0.0	2.9	GO:0005902	microvillus(GO:0005902)
0.0	4.9	GO:0101002	ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0	0.8	GO:0035869	ciliary transition zone(GO:0035869)
0.0	2.6	GO:0005811	lipid particle(GO:0005811)
0.0	3.5	GO:0035579	specific granule membrane(GO:0035579)
0.0	2.4	GO:0016234	inclusion body(GO:0016234)
0.0	2.4	GO:0005758	mitochondrial intermembrane space(GO:0005758)
0.0	1.7	GO:0005657	replication fork(GO:0005657)
0.0	2.1	GO:0017053	transcriptional repressor complex(GO:0017053)
0.0	2.2	GO:0032587	ruffle membrane(GO:0032587)
0.0	5.1	GO:0030425	dendrite(GO:0030425)
0.0	10.3	GO:0005667	transcription factor complex(GO:0005667)
0.0	1.7	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0	1.7	GO:0005746	mitochondrial respiratory chain(GO:0005746)
0.0	5.0	GO:0014069	postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0	1.0	GO:0048786	presynaptic active zone(GO:0048786)
0.0	2.1	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0	5.5	GO:0030027	lamellipodium(GO:0030027)
0.0	0.4	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	2.9	GO:0031225	anchored component of membrane(GO:0031225)
0.0	0.3	GO:1902711	GABA-A receptor complex(GO:1902711)
0.0	0.8	GO:0055038	recycling endosome membrane(GO:0055038)
0.0	5.6	GO:0016607	nuclear speck(GO:0016607)
0.0	1.2	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0	0.9	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.0	0.1	GO:0017059	serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	1.6	GO:0072562	blood microparticle(GO:0072562)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.4	4.2	GO:0008746	NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
1.1	6.5	GO:0047179	platelet-activating factor acetyltransferase activity(GO:0047179)
1.1	5.3	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.9	4.6	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.9	3.6	GO:0004619	bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.8	2.4	GO:0061505	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.8	7.3	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.8	4.0	GO:0071074	eukaryotic initiation factor eIF2 binding(GO:0071074)
0.8	3.1	GO:0005026	transforming growth factor beta receptor activity, type II(GO:0005026)
0.6	3.6	GO:0031749	D2 dopamine receptor binding(GO:0031749)
0.5	2.0	GO:0005483	soluble NSF attachment protein activity(GO:0005483)
0.5	1.5	GO:0030158	protein xylosyltransferase activity(GO:0030158)
0.5	3.5	GO:0005166	neurotrophin p75 receptor binding(GO:0005166)
0.5	3.4	GO:0061649	ubiquitinated histone binding(GO:0061649)
0.5	1.9	GO:0035651	AP-3 adaptor complex binding(GO:0035651)
0.5	12.0	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.5	2.7	GO:0043183	vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.4	9.7	GO:0001161	intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.4	1.6	GO:0008431	vitamin E binding(GO:0008431)
0.4	1.2	GO:0005128	erythropoietin receptor binding(GO:0005128)
0.4	1.5	GO:0035939	microsatellite binding(GO:0035939)
0.4	1.5	GO:0035403	histone kinase activity (H3-T6 specific)(GO:0035403)
0.4	8.2	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.3	1.4	GO:0000026	alpha-1,2-mannosyltransferase activity(GO:0000026)
0.3	1.0	GO:0015361	low-affinity sodium:dicarboxylate symporter activity(GO:0015361)
0.3	4.1	GO:0031419	cobalamin binding(GO:0031419)
0.3	3.4	GO:0047498	calcium-dependent phospholipase A2 activity(GO:0047498)
0.3	2.1	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.3	4.2	GO:1990247	N6-methyladenosine-containing RNA binding(GO:1990247)
0.3	4.3	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.3	3.4	GO:0035251	UDP-glucosyltransferase activity(GO:0035251)
0.3	2.5	GO:1904929	coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.3	1.3	GO:0035515	oxidative RNA demethylase activity(GO:0035515)
0.3	5.8	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.2	1.0	GO:0004711	ribosomal protein S6 kinase activity(GO:0004711)
0.2	1.2	GO:0017099	very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.2	4.4	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.2	5.2	GO:0015643	toxic substance binding(GO:0015643)
0.2	3.2	GO:0046870	cadmium ion binding(GO:0046870)
0.2	2.5	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.2	2.7	GO:0015288	porin activity(GO:0015288)
0.2	4.8	GO:0030898	actin-dependent ATPase activity(GO:0030898)
0.2	2.4	GO:0005168	neurotrophin TRKA receptor binding(GO:0005168)
0.2	4.4	GO:0045504	dynein heavy chain binding(GO:0045504)
0.2	3.0	GO:0042608	T cell receptor binding(GO:0042608)
0.2	3.5	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.2	2.8	GO:1990825	sequence-specific mRNA binding(GO:1990825)
0.2	1.7	GO:0072542	protein phosphatase activator activity(GO:0072542)
0.2	9.7	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624)
0.2	1.0	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.2	1.0	GO:0052840	endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.1	3.7	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
0.1	2.3	GO:0000182	rDNA binding(GO:0000182)
0.1	1.8	GO:0019784	NEDD8-specific protease activity(GO:0019784)
0.1	3.7	GO:0045294	alpha-catenin binding(GO:0045294)
0.1	9.8	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1	5.3	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1	0.5	GO:0048763	calcium-induced calcium release activity(GO:0048763)
0.1	5.2	GO:0042605	peptide antigen binding(GO:0042605)
0.1	4.1	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1	1.9	GO:0051787	misfolded protein binding(GO:0051787)
0.1	4.2	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.1	4.0	GO:0001671	ATPase activator activity(GO:0001671)
0.1	2.9	GO:0031489	myosin V binding(GO:0031489)
0.1	2.3	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.1	1.3	GO:0019869	chloride channel inhibitor activity(GO:0019869)
0.1	4.7	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.1	11.9	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1	2.7	GO:0005003	ephrin receptor activity(GO:0005003)
0.1	1.6	GO:0034452	dynactin binding(GO:0034452)
0.1	2.9	GO:0001223	transcription coactivator binding(GO:0001223)
0.1	1.7	GO:0048156	tau protein binding(GO:0048156)
0.1	0.3	GO:0005298	proline:sodium symporter activity(GO:0005298)
0.1	4.2	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750)
0.1	1.9	GO:0009931	calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1	1.0	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.1	0.7	GO:0045134	uridine-diphosphatase activity(GO:0045134)
0.1	0.5	GO:0070644	vitamin D response element binding(GO:0070644)
0.1	4.2	GO:0031492	nucleosomal DNA binding(GO:0031492)
0.1	0.6	GO:0060698	endoribonuclease inhibitor activity(GO:0060698)
0.1	0.2	GO:0004618	phosphoglycerate kinase activity(GO:0004618)
0.1	0.6	GO:0015193	L-proline transmembrane transporter activity(GO:0015193)
0.1	0.6	GO:0005157	macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1	2.2	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.1	8.0	GO:0002039	p53 binding(GO:0002039)
0.1	9.0	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1	1.0	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.1	0.6	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1	0.7	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.1	1.3	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1	2.5	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.1	0.3	GO:0052812	phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.1	1.3	GO:0008430	selenium binding(GO:0008430)
0.1	1.3	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.1	2.3	GO:0019707	protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1	2.6	GO:0015248	sterol transporter activity(GO:0015248)
0.1	5.9	GO:0004004	ATP-dependent RNA helicase activity(GO:0004004)
0.1	39.0	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1	0.2	GO:0042806	fucose binding(GO:0042806)
0.1	2.3	GO:0051959	dynein light intermediate chain binding(GO:0051959)
0.1	0.7	GO:0008474	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.4	GO:0070740	tubulin-glutamic acid ligase activity(GO:0070740)
0.0	1.4	GO:0001102	RNA polymerase II activating transcription factor binding(GO:0001102)
0.0	1.9	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	1.0	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0	1.3	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0	2.9	GO:0003707	steroid hormone receptor activity(GO:0003707)
0.0	6.3	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	0.2	GO:0005497	androgen binding(GO:0005497)
0.0	1.4	GO:0001972	retinoic acid binding(GO:0001972)
0.0	4.4	GO:0042826	histone deacetylase binding(GO:0042826)
0.0	0.3	GO:0005237	inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0	0.9	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.2	GO:0004911	interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
0.0	0.5	GO:0004576	oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.5	GO:0004565	beta-galactosidase activity(GO:0004565)
0.0	9.5	GO:0017137	Rab GTPase binding(GO:0017137)
0.0	0.7	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	3.3	GO:0030276	clathrin binding(GO:0030276)
0.0	1.8	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	4.1	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.5	GO:0008494	translation activator activity(GO:0008494)
0.0	1.4	GO:0070063	RNA polymerase binding(GO:0070063)
0.0	1.2	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	4.5	GO:0019888	protein phosphatase regulator activity(GO:0019888)
0.0	0.4	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0	10.0	GO:0046982	protein heterodimerization activity(GO:0046982)
0.0	8.7	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	85.5	GO:0003677	DNA binding(GO:0003677)
0.0	1.2	GO:0038191	neuropilin binding(GO:0038191)
0.0	0.9	GO:0035064	methylated histone binding(GO:0035064)
0.0	3.0	GO:0001618	virus receptor activity(GO:0001618)
0.0	0.7	GO:0003756	protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0	1.7	GO:0050136	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0	1.1	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0005242	inward rectifier potassium channel activity(GO:0005242)
0.0	0.3	GO:0019855	calcium channel inhibitor activity(GO:0019855)
0.0	1.1	GO:0008083	growth factor activity(GO:0008083)
0.0	1.1	GO:0004364	glutathione transferase activity(GO:0004364)
0.0	0.7	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.0	0.1	GO:0004447	iodide peroxidase activity(GO:0004447)
0.0	0.2	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.6	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	1.1	GO:0004521	endoribonuclease activity(GO:0004521)
0.0	2.0	GO:0005125	cytokine activity(GO:0005125)
0.0	0.4	GO:0043495	protein anchor(GO:0043495)
0.0	0.2	GO:0030548	acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0	1.0	GO:0043022	ribosome binding(GO:0043022)
0.0	0.2	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.0	0.1	GO:0031386	protein tag(GO:0031386)
0.0	6.6	GO:0045296	cadherin binding(GO:0045296)
0.0	0.4	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	1.5	GO:0050660	flavin adenine dinucleotide binding(GO:0050660)
0.0	0.6	GO:0032934	cholesterol binding(GO:0015485) sterol binding(GO:0032934)
0.0	0.1	GO:0005132	type I interferon receptor binding(GO:0005132)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.6	16.2	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.3	16.4	PID VEGFR1 PATHWAY	VEGFR1 specific signals
0.2	8.9	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.1	8.3	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.1	2.0	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.1	6.5	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.1	7.8	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.1	6.0	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.1	8.4	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1	2.3	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1	4.4	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.1	4.4	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.1	3.8	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.1	1.2	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.1	4.1	PID EPHB FWD PATHWAY	EPHB forward signaling
0.1	1.9	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.1	4.1	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.1	1.6	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.1	1.4	PID MYC PATHWAY	C-MYC pathway
0.1	4.1	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1	3.7	PID SHP2 PATHWAY	SHP2 signaling
0.1	1.6	PID ARF 3PATHWAY	Arf1 pathway
0.0	3.2	PID P53 REGULATION PATHWAY	p53 pathway
0.0	2.3	PID ARF6 PATHWAY	Arf6 signaling events
0.0	2.8	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.0	1.7	PID FGF PATHWAY	FGF signaling pathway
0.0	3.4	PID AP1 PATHWAY	AP-1 transcription factor network
0.0	3.8	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.0	2.8	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.0	1.4	PID ATM PATHWAY	ATM pathway
0.0	1.3	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	0.8	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.0	0.3	PID NECTIN PATHWAY	Nectin adhesion pathway
0.0	0.8	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.0	0.2	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.0	1.4	PID LKB1 PATHWAY	LKB1 signaling events
0.0	1.6	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	4.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	0.6	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.0	3.1	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	0.7	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0	0.6	PID BCR 5PATHWAY	BCR signaling pathway
0.0	0.2	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	5.2	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.2	7.3	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.2	12.0	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.2	5.9	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2	2.9	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
0.2	5.8	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.2	8.2	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.2	3.8	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.2	8.4	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.1	4.2	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.1	4.0	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.1	1.2	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.1	4.2	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.1	4.1	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.1	2.7	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.1	1.8	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1	1.6	REACTOME RNA POL III CHAIN ELONGATION	Genes involved in RNA Polymerase III Chain Elongation
0.1	1.6	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.1	5.1	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1	5.4	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.1	2.5	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	2.0	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.1	1.9	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1	4.2	REACTOME MRNA 3 END PROCESSING	Genes involved in mRNA 3'-end processing
0.1	1.0	REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.1	11.1	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.1	1.9	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.1	1.8	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.1	5.3	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.1	34.2	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.1	1.3	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.1	1.7	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.1	1.3	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.1	1.3	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.1	4.2	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification
0.1	1.4	REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING	Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1	1.5	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1	2.4	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	1.0	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	3.1	REACTOME SIGNALING BY NOTCH1	Genes involved in Signaling by NOTCH1
0.0	1.3	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0	1.4	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.0	2.8	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.0	1.6	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	1.6	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0	4.5	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.0	1.2	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	1.5	REACTOME PERK REGULATED GENE EXPRESSION	Genes involved in PERK regulated gene expression
0.0	1.5	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0	1.0	REACTOME FORMATION OF INCISION COMPLEX IN GG NER	Genes involved in Formation of incision complex in GG-NER
0.0	0.4	REACTOME ARMS MEDIATED ACTIVATION	Genes involved in ARMS-mediated activation
0.0	0.9	REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0	1.0	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0	1.5	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	2.7	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	1.6	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	2.1	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	1.2	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	1.9	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	0.6	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	1.1	REACTOME GLUCOSE METABOLISM	Genes involved in Glucose metabolism
0.0	0.3	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
0.0	1.7	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.0	6.2	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0	0.3	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0	0.2	REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	Genes involved in Sema3A PAK dependent Axon repulsion
0.0	0.2	REACTOME ACYL CHAIN REMODELLING OF PE	Genes involved in Acyl chain remodelling of PE
0.0	0.7	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane