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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PBX3

Z-value: 4.13

Motif logo

Transcription factors associated with PBX3

Gene Symbol Gene ID Gene Info
ENSG00000167081.12 PBX homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PBX3hg19_v2_chr9_+_128510454_1285104780.331.6e-01Click!

Activity profile of PBX3 motif

Sorted Z-values of PBX3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PBX3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 16.1 GO:0070893 transposon integration(GO:0070893) regulation of transposon integration(GO:0070894) negative regulation of transposon integration(GO:0070895)
2.6 10.5 GO:0072086 specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268)
2.4 12.2 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
1.5 2.9 GO:0035065 regulation of histone acetylation(GO:0035065)
1.4 4.1 GO:0021776 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
1.3 4.0 GO:1903676 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
1.3 3.8 GO:1903526 negative regulation of membrane tubulation(GO:1903526)
1.2 2.4 GO:2000974 auditory receptor cell fate determination(GO:0042668) negative regulation of pro-B cell differentiation(GO:2000974)
1.2 3.5 GO:0008052 sensory organ boundary specification(GO:0008052) formation of organ boundary(GO:0010160) taste bud development(GO:0061193)
1.1 8.0 GO:0060671 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
1.1 2.1 GO:1903204 negative regulation of oxidative stress-induced neuron death(GO:1903204)
1.0 3.1 GO:0002661 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
1.0 2.9 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
0.9 4.6 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.9 3.7 GO:0021849 neuroblast division in subventricular zone(GO:0021849)
0.9 3.6 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.9 2.7 GO:1903570 coronary vein morphogenesis(GO:0003169) regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.9 2.7 GO:0060734 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734)
0.9 5.3 GO:0002378 immunoglobulin biosynthetic process(GO:0002378)
0.8 5.8 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.7 5.2 GO:0002767 immune response-inhibiting cell surface receptor signaling pathway(GO:0002767)
0.7 5.8 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) myoblast fate commitment(GO:0048625) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.7 5.0 GO:0097501 stress response to metal ion(GO:0097501)
0.6 1.9 GO:0002276 basophil activation involved in immune response(GO:0002276)
0.6 4.3 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.6 13.3 GO:0097264 self proteolysis(GO:0097264)
0.6 4.2 GO:0006740 NADPH regeneration(GO:0006740)
0.5 1.6 GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
0.5 6.4 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.5 5.2 GO:1904327 protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.5 1.5 GO:1904717 excitatory chemical synaptic transmission(GO:0098976) regulation of AMPA glutamate receptor clustering(GO:1904717) positive regulation of AMPA glutamate receptor clustering(GO:1904719)
0.5 7.6 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.5 1.0 GO:0032289 central nervous system myelin formation(GO:0032289)
0.5 2.9 GO:0070417 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) cellular response to cold(GO:0070417)
0.5 1.4 GO:1904247 positive regulation of polynucleotide adenylyltransferase activity(GO:1904247)
0.5 2.3 GO:0006051 mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051)
0.4 2.2 GO:0032796 uropod organization(GO:0032796)
0.4 16.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.4 1.7 GO:0032764 negative regulation of mast cell cytokine production(GO:0032764)
0.4 7.3 GO:0015871 choline transport(GO:0015871)
0.4 1.6 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.4 1.6 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.4 1.6 GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940)
0.4 1.5 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.4 8.6 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.4 1.5 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
0.3 6.2 GO:0090168 Golgi reassembly(GO:0090168)
0.3 5.8 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.3 1.3 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.3 12.3 GO:0006783 heme biosynthetic process(GO:0006783)
0.3 2.2 GO:0048852 diencephalon morphogenesis(GO:0048852)
0.3 4.1 GO:0015889 cobalt ion transport(GO:0006824) cobalamin transport(GO:0015889)
0.3 1.9 GO:1901727 positive regulation of histone deacetylase activity(GO:1901727)
0.3 1.9 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.3 4.2 GO:0060252 positive regulation of glial cell proliferation(GO:0060252)
0.3 1.5 GO:0046546 male gonad development(GO:0008584) development of primary male sexual characteristics(GO:0046546)
0.3 1.4 GO:0070980 biphenyl catabolic process(GO:0070980)
0.3 1.4 GO:2000691 regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691)
0.3 3.5 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.3 3.4 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.3 1.3 GO:0035513 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.2 4.7 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.2 3.0 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.2 1.8 GO:0051592 response to calcium ion(GO:0051592)
0.2 2.5 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.2 0.6 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
0.2 6.3 GO:0001502 cartilage condensation(GO:0001502)
0.2 1.6 GO:0021592 fourth ventricle development(GO:0021592)
0.2 1.2 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.2 1.3 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.2 4.4 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.2 4.6 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.2 1.5 GO:0030578 PML body organization(GO:0030578)
0.2 2.4 GO:0006265 DNA topological change(GO:0006265)
0.2 0.7 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.2 2.5 GO:0007258 JUN phosphorylation(GO:0007258)
0.2 2.9 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.2 1.1 GO:0070458 establishment of blood-nerve barrier(GO:0008065) cellular detoxification of nitrogen compound(GO:0070458)
0.2 2.4 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.2 4.1 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.2 2.1 GO:0030091 protein repair(GO:0030091)
0.2 1.0 GO:1901909 diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.2 0.8 GO:0044501 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.2 5.9 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.1 2.9 GO:0048243 norepinephrine secretion(GO:0048243)
0.1 1.5 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.1 1.1 GO:0007008 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.1 2.9 GO:0036148 phosphatidylglycerol acyl-chain remodeling(GO:0036148)
0.1 1.9 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.1 0.8 GO:0002729 positive regulation of natural killer cell cytokine production(GO:0002729) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.1 1.2 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.1 1.0 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.1 1.9 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.1 1.1 GO:0060120 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.1 0.7 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.1 3.7 GO:0030033 microvillus assembly(GO:0030033)
0.1 4.1 GO:0022038 corpus callosum development(GO:0022038)
0.1 1.3 GO:0061458 reproductive system development(GO:0061458)
0.1 1.3 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.1 0.8 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.1 1.2 GO:1903147 negative regulation of macromitophagy(GO:1901525) negative regulation of mitophagy(GO:1903147)
0.1 0.5 GO:0043686 co-translational protein modification(GO:0043686)
0.1 5.3 GO:0019433 triglyceride catabolic process(GO:0019433)
0.1 5.8 GO:0045022 early endosome to late endosome transport(GO:0045022)
0.1 2.7 GO:0036010 protein localization to endosome(GO:0036010)
0.1 2.2 GO:0034656 nucleobase-containing small molecule catabolic process(GO:0034656)
0.1 1.8 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.1 0.9 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 1.8 GO:0000338 protein deneddylation(GO:0000338)
0.1 0.5 GO:0090156 cellular sphingolipid homeostasis(GO:0090156)
0.1 1.2 GO:0030497 fatty acid elongation(GO:0030497)
0.1 3.3 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.1 5.4 GO:0010107 potassium ion import(GO:0010107)
0.1 1.5 GO:0030210 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.1 2.1 GO:0006895 Golgi to endosome transport(GO:0006895)
0.1 1.1 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.1 0.9 GO:0035524 proline transmembrane transport(GO:0035524)
0.1 0.2 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
0.1 0.7 GO:0071910 determination of pancreatic left/right asymmetry(GO:0035469) determination of liver left/right asymmetry(GO:0071910)
0.1 1.6 GO:0030308 negative regulation of cell growth(GO:0030308)
0.1 0.6 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
0.1 1.0 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.1 0.8 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.1 2.2 GO:0045332 phospholipid translocation(GO:0045332)
0.1 2.6 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.1 3.7 GO:0030262 apoptotic nuclear changes(GO:0030262)
0.1 0.5 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.1 2.5 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
0.1 8.0 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 0.7 GO:0032237 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1 0.4 GO:0090206 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.1 1.7 GO:0006939 smooth muscle contraction(GO:0006939)
0.1 0.5 GO:0002326 B cell lineage commitment(GO:0002326) immunoglobulin V(D)J recombination(GO:0033152)
0.1 1.7 GO:0042749 regulation of circadian sleep/wake cycle(GO:0042749) regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.1 1.0 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.1 0.1 GO:1901896 positive regulation of calcium-transporting ATPase activity(GO:1901896)
0.1 0.2 GO:0046338 phosphatidylethanolamine catabolic process(GO:0046338)
0.1 2.3 GO:0018345 protein palmitoylation(GO:0018345)
0.1 2.0 GO:0032479 regulation of type I interferon production(GO:0032479)
0.1 0.5 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 1.6 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.1 2.4 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol(GO:0051281)
0.1 1.5 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.1 2.4 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.1 0.9 GO:1904896 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.1 0.4 GO:0032486 Rap protein signal transduction(GO:0032486)
0.1 0.7 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.1 0.5 GO:1900004 negative regulation of serine-type endopeptidase activity(GO:1900004) negative regulation of serine-type peptidase activity(GO:1902572)
0.0 0.4 GO:0007288 sperm axoneme assembly(GO:0007288)
0.0 5.4 GO:0006306 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 4.9 GO:0060828 regulation of canonical Wnt signaling pathway(GO:0060828)
0.0 0.5 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.0 2.3 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.9 GO:0034394 protein localization to cell surface(GO:0034394)
0.0 0.7 GO:0007512 adult heart development(GO:0007512)
0.0 0.4 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 0.6 GO:0045651 positive regulation of macrophage differentiation(GO:0045651)
0.0 2.6 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.0 0.5 GO:0035826 rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
0.0 1.0 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.0 0.2 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
0.0 0.1 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 1.9 GO:0060338 regulation of type I interferon-mediated signaling pathway(GO:0060338)
0.0 2.1 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.3 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.0 1.3 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 1.7 GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.0 1.6 GO:0051180 vitamin transport(GO:0051180)
0.0 1.0 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.0 3.9 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 2.8 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 6.5 GO:0051781 positive regulation of cell division(GO:0051781)
0.0 1.3 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.3 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 1.4 GO:0097502 mannosylation(GO:0097502)
0.0 0.3 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) positive regulation of mitochondrial translation(GO:0070131) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 1.4 GO:0048741 skeletal muscle fiber development(GO:0048741)
0.0 3.4 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.0 2.6 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.0 1.0 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 2.0 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.3 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 4.7 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.0 0.3 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 2.3 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 1.3 GO:0060765 regulation of androgen receptor signaling pathway(GO:0060765)
0.0 1.0 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 2.4 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 1.5 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 0.8 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.0 1.2 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.0 0.6 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.0 1.2 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.0 0.3 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 1.1 GO:0061014 positive regulation of mRNA catabolic process(GO:0061014)
0.0 0.2 GO:0048105 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105)
0.0 0.9 GO:0021522 spinal cord motor neuron differentiation(GO:0021522)
0.0 2.2 GO:0030574 collagen catabolic process(GO:0030574)
0.0 0.2 GO:1904783 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) positive regulation of NMDA glutamate receptor activity(GO:1904783) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.0 1.9 GO:0030279 negative regulation of ossification(GO:0030279)
0.0 0.1 GO:1901421 positive regulation of response to alcohol(GO:1901421)
0.0 0.1 GO:0046836 glycolipid transport(GO:0046836)
0.0 2.9 GO:0019079 viral genome replication(GO:0019079)
0.0 3.1 GO:0006661 phosphatidylinositol biosynthetic process(GO:0006661)
0.0 4.5 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.7 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.0 0.4 GO:0048240 sperm capacitation(GO:0048240)
0.0 5.9 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.0 7.8 GO:0000209 protein polyubiquitination(GO:0000209)
0.0 0.7 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.3 GO:0031639 plasminogen activation(GO:0031639)
0.0 0.3 GO:0030225 macrophage differentiation(GO:0030225)
0.0 0.7 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 2.8 GO:0060348 bone development(GO:0060348)
0.0 4.2 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.2 GO:0099601 regulation of neurotransmitter receptor activity(GO:0099601)
0.0 0.2 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.9 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 2.8 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.7 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.0 0.1 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.8 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0 0.7 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.2 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.2 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 16.2 GO:0005610 laminin-5 complex(GO:0005610)
0.8 4.9 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.8 4.8 GO:0097513 myosin II filament(GO:0097513)
0.8 4.0 GO:0019031 viral envelope(GO:0019031) viral membrane(GO:0036338)
0.7 5.8 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.7 4.1 GO:0044308 axonal spine(GO:0044308)
0.6 1.9 GO:0002139 stereocilia coupling link(GO:0002139)
0.6 9.6 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
0.6 0.6 GO:1990246 uniplex complex(GO:1990246)
0.5 5.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.5 4.1 GO:0005587 collagen type IV trimer(GO:0005587)
0.4 5.2 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.4 1.9 GO:0035838 growing cell tip(GO:0035838)
0.3 3.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.3 5.7 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 1.2 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.2 0.7 GO:0097637 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.2 2.1 GO:0000138 Golgi trans cisterna(GO:0000138)
0.2 1.4 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.2 2.8 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.2 1.7 GO:0070695 FHF complex(GO:0070695)
0.2 5.8 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 6.2 GO:0097546 ciliary base(GO:0097546)
0.1 1.8 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 3.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 1.8 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 5.1 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 5.4 GO:0035861 site of double-strand break(GO:0035861)
0.1 4.2 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 1.4 GO:0042405 nuclear inclusion body(GO:0042405)
0.1 3.3 GO:0001891 phagocytic cup(GO:0001891)
0.1 1.0 GO:0000439 core TFIIH complex(GO:0000439)
0.1 0.5 GO:1990425 ryanodine receptor complex(GO:1990425)
0.1 10.4 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 2.0 GO:0010369 chromocenter(GO:0010369)
0.1 1.0 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 0.9 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 1.0 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 15.6 GO:0016605 PML body(GO:0016605)
0.1 0.5 GO:0035339 SPOTS complex(GO:0035339)
0.1 1.4 GO:0000124 SAGA complex(GO:0000124) STAGA complex(GO:0030914)
0.1 2.6 GO:0000178 exosome (RNase complex)(GO:0000178)
0.1 5.3 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 0.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 5.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 4.4 GO:0030286 dynein complex(GO:0030286)
0.1 3.5 GO:0008180 COP9 signalosome(GO:0008180)
0.1 0.4 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 2.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 1.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 4.0 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.2 GO:0060187 cell pole(GO:0060187)
0.0 1.4 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 1.9 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.4 GO:0036128 CatSper complex(GO:0036128)
0.0 4.3 GO:0031526 brush border membrane(GO:0031526)
0.0 9.1 GO:0044309 neuron spine(GO:0044309)
0.0 0.6 GO:0005687 U4 snRNP(GO:0005687)
0.0 13.2 GO:0043209 myelin sheath(GO:0043209)
0.0 1.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.3 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.0 1.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 3.5 GO:0035580 specific granule lumen(GO:0035580)
0.0 7.6 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 3.7 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 1.2 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 1.3 GO:0001772 immunological synapse(GO:0001772)
0.0 4.0 GO:0005604 basement membrane(GO:0005604)
0.0 2.9 GO:0005902 microvillus(GO:0005902)
0.0 4.9 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 0.8 GO:0035869 ciliary transition zone(GO:0035869)
0.0 2.6 GO:0005811 lipid particle(GO:0005811)
0.0 3.5 GO:0035579 specific granule membrane(GO:0035579)
0.0 2.4 GO:0016234 inclusion body(GO:0016234)
0.0 2.4 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.7 GO:0005657 replication fork(GO:0005657)
0.0 2.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 2.2 GO:0032587 ruffle membrane(GO:0032587)
0.0 5.1 GO:0030425 dendrite(GO:0030425)
0.0 10.3 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.7 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.0 5.0 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 1.0 GO:0048786 presynaptic active zone(GO:0048786)
0.0 2.1 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 5.5 GO:0030027 lamellipodium(GO:0030027)
0.0 0.4 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 2.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.3 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.8 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 5.6 GO:0016607 nuclear speck(GO:0016607)
0.0 1.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.9 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.1 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 1.6 GO:0072562 blood microparticle(GO:0072562)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
1.1 6.5 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
1.1 5.3 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.9 4.6 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.9 3.6 GO:0004619 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.8 2.4 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.8 7.3 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.8 4.0 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.8 3.1 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.6 3.6 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.5 2.0 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.5 1.5 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.5 3.5 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.5 3.4 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.5 1.9 GO:0035651 AP-3 adaptor complex binding(GO:0035651)
0.5 12.0 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.5 2.7 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.4 9.7 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.4 1.6 GO:0008431 vitamin E binding(GO:0008431)
0.4 1.2 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.4 1.5 GO:0035939 microsatellite binding(GO:0035939)
0.4 1.5 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
0.4 8.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.3 1.4 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.3 1.0 GO:0015361 low-affinity sodium:dicarboxylate symporter activity(GO:0015361)
0.3 4.1 GO:0031419 cobalamin binding(GO:0031419)
0.3 3.4 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.3 2.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.3 4.2 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.3 4.3 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.3 3.4 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.3 2.5 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.3 1.3 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.3 5.8 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.2 1.0 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.2 1.2 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.2 4.4 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.2 5.2 GO:0015643 toxic substance binding(GO:0015643)
0.2 3.2 GO:0046870 cadmium ion binding(GO:0046870)
0.2 2.5 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.2 2.7 GO:0015288 porin activity(GO:0015288)
0.2 4.8 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.2 2.4 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.2 4.4 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 3.0 GO:0042608 T cell receptor binding(GO:0042608)
0.2 3.5 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.2 2.8 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.2 1.7 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.2 9.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.2 1.0 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.2 1.0 GO:0052840 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.1 3.7 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 2.3 GO:0000182 rDNA binding(GO:0000182)
0.1 1.8 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.1 3.7 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 9.8 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 5.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 0.5 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.1 5.2 GO:0042605 peptide antigen binding(GO:0042605)
0.1 4.1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 1.9 GO:0051787 misfolded protein binding(GO:0051787)
0.1 4.2 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 4.0 GO:0001671 ATPase activator activity(GO:0001671)
0.1 2.9 GO:0031489 myosin V binding(GO:0031489)
0.1 2.3 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.1 1.3 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.1 4.7 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.1 11.9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 2.7 GO:0005003 ephrin receptor activity(GO:0005003)
0.1 1.6 GO:0034452 dynactin binding(GO:0034452)
0.1 2.9 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 1.7 GO:0048156 tau protein binding(GO:0048156)
0.1 0.3 GO:0005298 proline:sodium symporter activity(GO:0005298)
0.1 4.2 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 1.9 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 1.0 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.1 0.7 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.1 0.5 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 4.2 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 0.6 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.1 0.2 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
0.1 0.6 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.1 0.6 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1 2.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 8.0 GO:0002039 p53 binding(GO:0002039)
0.1 9.0 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 1.0 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 0.6 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 0.7 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 1.3 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 2.5 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.1 0.3 GO:0052812 phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.1 1.3 GO:0008430 selenium binding(GO:0008430)
0.1 1.3 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 2.3 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 2.6 GO:0015248 sterol transporter activity(GO:0015248)
0.1 5.9 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 39.0 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 0.2 GO:0042806 fucose binding(GO:0042806)
0.1 2.3 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.1 0.7 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.4 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.0 1.4 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 1.9 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 1.0 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 1.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 2.9 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 6.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.2 GO:0005497 androgen binding(GO:0005497)
0.0 1.4 GO:0001972 retinoic acid binding(GO:0001972)
0.0 4.4 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.3 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 0.9 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.2 GO:0004911 interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
0.0 0.5 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.5 GO:0004565 beta-galactosidase activity(GO:0004565)
0.0 9.5 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.7 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 3.3 GO:0030276 clathrin binding(GO:0030276)
0.0 1.8 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 4.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.5 GO:0008494 translation activator activity(GO:0008494)
0.0 1.4 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 1.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 4.5 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.4 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 10.0 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 8.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 85.5 GO:0003677 DNA binding(GO:0003677)
0.0 1.2 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.9 GO:0035064 methylated histone binding(GO:0035064)
0.0 3.0 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.7 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 1.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.1 GO:0030332 cyclin binding(GO:0030332)
0.0 0.1 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.3 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 1.1 GO:0008083 growth factor activity(GO:0008083)
0.0 1.1 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.7 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.1 GO:0004447 iodide peroxidase activity(GO:0004447)
0.0 0.2 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 1.1 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 2.0 GO:0005125 cytokine activity(GO:0005125)
0.0 0.4 GO:0043495 protein anchor(GO:0043495)
0.0 0.2 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 1.0 GO:0043022 ribosome binding(GO:0043022)
0.0 0.2 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.1 GO:0031386 protein tag(GO:0031386)
0.0 6.6 GO:0045296 cadherin binding(GO:0045296)
0.0 0.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 1.5 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.0 0.6 GO:0032934 cholesterol binding(GO:0015485) sterol binding(GO:0032934)
0.0 0.1 GO:0005132 type I interferon receptor binding(GO:0005132)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 16.2 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.3 16.4 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.2 8.9 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 8.3 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 2.0 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 6.5 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 7.8 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.1 6.0 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.1 8.4 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 2.3 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 4.4 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 4.4 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.1 3.8 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.1 1.2 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.1 4.1 PID EPHB FWD PATHWAY EPHB forward signaling
0.1 1.9 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.1 4.1 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 1.6 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.1 1.4 PID MYC PATHWAY C-MYC pathway
0.1 4.1 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1 3.7 PID SHP2 PATHWAY SHP2 signaling
0.1 1.6 PID ARF 3PATHWAY Arf1 pathway
0.0 3.2 PID P53 REGULATION PATHWAY p53 pathway
0.0 2.3 PID ARF6 PATHWAY Arf6 signaling events
0.0 2.8 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 1.7 PID FGF PATHWAY FGF signaling pathway
0.0 3.4 PID AP1 PATHWAY AP-1 transcription factor network
0.0 3.8 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 2.8 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 1.4 PID ATM PATHWAY ATM pathway
0.0 1.3 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.8 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 0.3 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 0.8 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.0 0.2 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 1.4 PID LKB1 PATHWAY LKB1 signaling events
0.0 1.6 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 4.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.6 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 3.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.7 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 0.6 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.2 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.2 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.2 7.3 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.2 12.0 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.2 5.9 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2 2.9 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.2 5.8 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.2 8.2 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.2 3.8 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.2 8.4 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 4.2 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 4.0 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 1.2 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 4.2 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 4.1 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.1 2.7 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 1.8 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 1.6 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 1.6 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.1 5.1 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 5.4 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 2.5 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 2.0 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.1 1.9 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 4.2 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.1 1.0 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.1 11.1 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.1 1.9 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 1.8 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 5.3 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.1 34.2 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.1 1.3 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.1 1.7 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 1.3 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 1.3 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 4.2 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.1 1.4 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 1.5 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 2.4 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.0 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 3.1 REACTOME SIGNALING BY NOTCH1 Genes involved in Signaling by NOTCH1
0.0 1.3 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 1.4 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 2.8 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.6 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 1.6 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 4.5 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 1.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.5 REACTOME PERK REGULATED GENE EXPRESSION Genes involved in PERK regulated gene expression
0.0 1.5 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.0 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 0.4 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.0 0.9 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 1.0 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.5 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 2.7 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 1.6 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 2.1 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.2 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.9 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.6 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.1 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.0 0.3 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 1.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 6.2 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.3 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.2 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.0 0.7 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane