ISMARA results: PDX1

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PDX1

Z-value: 0.81

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Transcription factors associated with PDX1

Gene Symbol	Gene ID	Gene Info
PDX1 Ensembl NCBI GeneCards UniProt	ENSG00000139515.5	pancreatic and duodenal homeobox 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PDX1	hg19_v2_chr13_+_28494130_28494168	0.00	9.9e-01	Click!

Activity profile of PDX1 motif

Sorted Z-values of PDX1 motif

No targets for PDX1

Network of associatons between targets according to the STRING database.

First level regulatory network of PDX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	3.9	GO:0021840	directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.1	1.9	GO:0001833	inner cell mass cell proliferation(GO:0001833)
0.2	1.7	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)
0.1	1.6	GO:0090324	negative regulation of oxidative phosphorylation(GO:0090324)
0.1	1.6	GO:0061087	positive regulation of histone H3-K27 methylation(GO:0061087)
0.1	1.6	GO:0090331	negative regulation of platelet aggregation(GO:0090331)
0.0	1.4	GO:0042795	snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0	1.4	GO:0042246	tissue regeneration(GO:0042246)
0.1	1.3	GO:0046085	adenosine metabolic process(GO:0046085)
0.4	1.1	GO:0046013	regulation of T cell homeostatic proliferation(GO:0046013)

Showing 1 to 10 of 77 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.9	GO:0030673	axolemma(GO:0030673)
0.0	1.9	GO:0000792	heterochromatin(GO:0000792)
0.1	1.6	GO:0005577	fibrinogen complex(GO:0005577)
0.1	1.4	GO:0033276	transcription factor TFTC complex(GO:0033276)
0.0	1.4	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.3	0.8	GO:0042720	mitochondrial inner membrane peptidase complex(GO:0042720)
0.1	0.8	GO:0033093	Weibel-Palade body(GO:0033093)
0.1	0.6	GO:0031302	intrinsic component of endosome membrane(GO:0031302)
0.0	0.6	GO:0000930	gamma-tubulin complex(GO:0000930)
0.1	0.5	GO:0033061	DNA recombinase mediator complex(GO:0033061)

Showing 1 to 10 of 22 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	3.9	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	1.9	GO:0005504	fatty acid binding(GO:0005504)
0.0	1.6	GO:0035064	methylated histone binding(GO:0035064)
0.1	1.4	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.3	1.3	GO:0008665	2'-phosphotransferase activity(GO:0008665)
0.0	1.2	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.3	0.9	GO:0047225	acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0047225)
0.2	0.9	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.1	0.9	GO:0070700	BMP receptor binding(GO:0070700)
0.0	0.9	GO:0031593	polyubiquitin binding(GO:0031593)

Showing 1 to 10 of 43 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.9	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	1.9	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	1.9	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.0	0.9	PID BMP PATHWAY	BMP receptor signaling
0.0	0.7	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.

Showing 1 to 5 of 5 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.9	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1	2.8	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.1	1.6	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	1.5	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	1.4	REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING	Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0	0.9	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.9	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.0	0.7	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	0.4	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.3	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1	Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)

Showing 1 to 10 of 10 entries

Results for PDX1

Z-value: 0.81

Motif logo

Transcription factors associated with PDX1

Activity-expression correlation:

Activity profile of PDX1 motif

Sorted Z-values of PDX1 motif

No targets for PDX1

Network of associatons between targets according to the STRING database.

First level regulatory network of PDX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: