ISMARA results: PGR

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PGR

Z-value: 0.75

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Transcription factors associated with PGR

Gene Symbol	Gene ID	Gene Info
PGR Ensembl NCBI GeneCards UniProt	ENSG00000082175.10	progesterone receptor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PGR	hg19_v2_chr11_-_100999775_100999801	-0.33	1.6e-01	Click!

Activity profile of PGR motif

Sorted Z-values of PGR motif

No targets for PGR

Network of associatons between targets according to the STRING database.

First level regulatory network of PGR

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.5	GO:2001190	positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.0	1.1	GO:0097119	postsynaptic density protein 95 clustering(GO:0097119)
0.0	0.9	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.9	GO:0042776	mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0	0.7	GO:0006704	glucocorticoid biosynthetic process(GO:0006704)
0.0	0.7	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1	0.5	GO:0035482	gastric motility(GO:0035482) gastric emptying(GO:0035483)
0.1	0.5	GO:0002384	hepatic immune response(GO:0002384) response to prolactin(GO:1990637)
0.1	0.5	GO:0090362	positive regulation of platelet-derived growth factor production(GO:0090362)
0.0	0.5	GO:0072520	seminiferous tubule development(GO:0072520)

Showing 1 to 10 of 94 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.1	GO:0042613	MHC class II protein complex(GO:0042613)
0.2	1.0	GO:0071062	rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0	0.9	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1	0.6	GO:0071953	elastic fiber(GO:0071953)
0.0	0.6	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.1	0.5	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.1	0.5	GO:0034991	nuclear meiotic cohesin complex(GO:0034991)
0.1	0.5	GO:0043196	varicosity(GO:0043196)
0.0	0.5	GO:0033269	internode region of axon(GO:0033269)
0.1	0.4	GO:0005595	collagen type XII trimer(GO:0005595)

Showing 1 to 10 of 28 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.1	GO:0023026	MHC class II protein complex binding(GO:0023026)
0.0	1.0	GO:0030247	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.9	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2	0.7	GO:0003845	11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.0	0.7	GO:0038132	neuregulin binding(GO:0038132)
0.2	0.5	GO:0035033	histone deacetylase regulator activity(GO:0035033)
0.0	0.5	GO:0005138	interleukin-6 receptor binding(GO:0005138)
0.1	0.4	GO:0048030	disaccharide binding(GO:0048030)
0.1	0.4	GO:0004504	peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.1	0.4	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)

Showing 1 to 10 of 47 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
1.2	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.7	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.5	ST STAT3 PATHWAY	STAT3 Pathway

Showing 1 to 3 of 3 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
0.9	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.7	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.7	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.5	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.5	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.4	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.3	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.2	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.2	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation

Showing 1 to 9 of 9 entries

Results for PGR

Z-value: 0.75

Motif logo

Transcription factors associated with PGR

Activity-expression correlation:

Activity profile of PGR motif

Sorted Z-values of PGR motif

No targets for PGR

Network of associatons between targets according to the STRING database.

First level regulatory network of PGR

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: