ISMARA results: PITX2

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PITX2

Z-value: 0.75

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Transcription factors associated with PITX2

Gene Symbol	Gene ID	Gene Info
PITX2 Ensembl NCBI GeneCards UniProt	ENSG00000164093.11	paired like homeodomain 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PITX2	hg19_v2_chr4_-_111563076_111563172	-0.60	4.8e-03	Click!

Activity profile of PITX2 motif

Sorted Z-values of PITX2 motif

No targets for PITX2

Network of associatons between targets according to the STRING database.

First level regulatory network of PITX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.5	GO:0043415	positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.0	1.5	GO:0043647	inositol phosphate metabolic process(GO:0043647)
0.0	1.2	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.1	0.8	GO:0097475	motor neuron migration(GO:0097475)
0.0	0.8	GO:0072540	T-helper 17 cell lineage commitment(GO:0072540)
0.2	0.6	GO:2000342	negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.1	0.6	GO:0009236	cobalamin biosynthetic process(GO:0009236)
0.0	0.6	GO:0010818	T cell chemotaxis(GO:0010818)
0.0	0.6	GO:0015813	L-glutamate transport(GO:0015813)
0.0	0.5	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)

Showing 1 to 10 of 28 entries

Gene overrepresentation in cellular_component category:

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Total log-likelihood	Term	Description
0.6	GO:0005719	nuclear euchromatin(GO:0005719)
0.4	GO:0036157	outer dynein arm(GO:0036157)
0.4	GO:0045277	respiratory chain complex IV(GO:0045277)
0.2	GO:0033391	chromatoid body(GO:0033391)
0.1	GO:0001534	radial spoke(GO:0001534)

Showing 1 to 5 of 5 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.5	GO:0036041	long-chain fatty acid binding(GO:0036041)
0.0	1.5	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.1	0.6	GO:0001010	transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.0	0.6	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)
0.1	0.5	GO:0004641	phosphoribosylamine-glycine ligase activity(GO:0004637) phosphoribosylformylglycinamidine cyclo-ligase activity(GO:0004641) phosphoribosylglycinamide formyltransferase activity(GO:0004644)
0.0	0.4	GO:0045504	dynein heavy chain binding(GO:0045504)
0.0	0.4	GO:0015002	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0	0.3	GO:0015319	sodium:inorganic phosphate symporter activity(GO:0015319)
0.0	0.2	GO:0009922	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0	0.2	GO:0019869	chloride channel inhibitor activity(GO:0019869)

Showing 1 to 10 of 12 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.6	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor

Showing 1 to 1 of 1 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
0.6	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.5	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.3	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.1	REACTOME HORMONE LIGAND BINDING RECEPTORS	Genes involved in Hormone ligand-binding receptors

Showing 1 to 4 of 4 entries

Results for PITX2

Z-value: 0.75

Motif logo

Transcription factors associated with PITX2

Activity-expression correlation:

Activity profile of PITX2 motif

Sorted Z-values of PITX2 motif

No targets for PITX2

Network of associatons between targets according to the STRING database.

First level regulatory network of PITX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: