ISMARA results: PKNOX1

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PKNOX1_TGIF2

Z-value: 1.25

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Transcription factors associated with PKNOX1_TGIF2

Gene Symbol	Gene ID	Gene Info
PKNOX1 Ensembl NCBI GeneCards UniProt	ENSG00000160199.10	PBX/knotted 1 homeobox 1
TGIF2 Ensembl NCBI GeneCards UniProt	ENSG00000118707.5	TGFB induced factor homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PKNOX1	hg19_v2_chr21_+_44394620_44394737	0.75	1.5e-04	Click!
TGIF2	hg19_v2_chr20_+_35201857_35201891	0.40	8.3e-02	Click!

Activity profile of PKNOX1_TGIF2 motif

Sorted Z-values of PKNOX1_TGIF2 motif

No targets for PKNOX1_TGIF2

Network of associatons between targets according to the STRING database.

First level regulatory network of PKNOX1_TGIF2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	2.7	GO:0071409	cellular response to cycloheximide(GO:0071409)
0.1	2.5	GO:0043587	tongue morphogenesis(GO:0043587)
0.3	2.4	GO:2000660	negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.0	2.4	GO:0043647	inositol phosphate metabolic process(GO:0043647)
0.1	2.3	GO:0034454	microtubule anchoring at centrosome(GO:0034454)
0.4	2.2	GO:1901896	positive regulation of calcium-transporting ATPase activity(GO:1901896)
0.4	2.2	GO:0045658	regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.2	2.1	GO:0060753	regulation of mast cell chemotaxis(GO:0060753)
0.1	1.9	GO:1990416	cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.2	1.8	GO:0060052	neurofilament cytoskeleton organization(GO:0060052)

Showing 1 to 10 of 114 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.9	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.0	2.9	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	2.6	GO:0045095	keratin filament(GO:0045095)
0.4	2.2	GO:0031510	SUMO activating enzyme complex(GO:0031510)
0.0	2.1	GO:0005905	clathrin-coated pit(GO:0005905)
0.4	1.8	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.4	1.4	GO:0016939	kinesin II complex(GO:0016939)
0.0	1.4	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.1	1.2	GO:0030870	Mre11 complex(GO:0030870)
0.1	1.0	GO:0031931	TORC1 complex(GO:0031931)

Showing 1 to 10 of 42 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	3.4	GO:0004441	inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829)
0.3	2.7	GO:0004534	5'-3' exoribonuclease activity(GO:0004534)
0.8	2.4	GO:0005150	interleukin-1, Type I receptor binding(GO:0005150)
0.3	2.2	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.2	2.2	GO:0044388	small protein activating enzyme binding(GO:0044388)
0.1	2.1	GO:0000993	RNA polymerase II core binding(GO:0000993)
0.6	1.9	GO:0004676	3-phosphoinositide-dependent protein kinase activity(GO:0004676)
0.5	1.8	GO:0070012	oligopeptidase activity(GO:0070012)
0.2	1.6	GO:0061649	ubiquitinated histone binding(GO:0061649)
0.1	1.4	GO:0019871	sodium channel inhibitor activity(GO:0019871)

Showing 1 to 10 of 78 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.3	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.2	4.2	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.0	2.8	PID IL1 PATHWAY	IL1-mediated signaling events
0.0	2.5	PID IFNG PATHWAY	IFN-gamma pathway
0.0	2.3	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.0	2.1	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.0	1.9	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
0.0	1.8	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	1.8	PID ATM PATHWAY	ATM pathway
0.0	1.7	PID AP1 PATHWAY	AP-1 transcription factor network

Showing 1 to 10 of 23 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.3	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS	Genes involved in CREB phosphorylation through the activation of Ras
0.0	3.2	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.1	2.8	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1	2.7	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1	2.7	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	2.4	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.0	2.1	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.0	1.4	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.0	1.2	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.0	1.0	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling

Showing 1 to 10 of 32 entries

Results for PKNOX1_TGIF2

Z-value: 1.25

Motif logo

Transcription factors associated with PKNOX1_TGIF2

Activity-expression correlation:

Activity profile of PKNOX1_TGIF2 motif

Sorted Z-values of PKNOX1_TGIF2 motif

No targets for PKNOX1_TGIF2

Network of associatons between targets according to the STRING database.

First level regulatory network of PKNOX1_TGIF2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: