ISMARA results: PKNOX2

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PKNOX2

Z-value: 0.97

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Transcription factors associated with PKNOX2

Gene Symbol	Gene ID	Gene Info
PKNOX2 Ensembl NCBI GeneCards UniProt	ENSG00000165495.11	PBX/knotted 1 homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PKNOX2	hg19_v2_chr11_+_125034586_125034604	0.44	5.0e-02	Click!

Activity profile of PKNOX2 motif

Sorted Z-values of PKNOX2 motif

No targets for PKNOX2

Network of associatons between targets according to the STRING database.

First level regulatory network of PKNOX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.9	GO:0001895	retina homeostasis(GO:0001895)
0.1	2.4	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.1	2.0	GO:0006307	DNA dealkylation involved in DNA repair(GO:0006307)
0.4	1.7	GO:0035616	histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.1	1.4	GO:0060052	neurofilament cytoskeleton organization(GO:0060052)
0.3	1.3	GO:0071894	histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
0.1	1.3	GO:0000056	ribosomal small subunit export from nucleus(GO:0000056)
0.0	1.3	GO:0003334	keratinocyte development(GO:0003334)
0.0	1.3	GO:0001502	cartilage condensation(GO:0001502)
0.1	1.1	GO:0045541	negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)

Showing 1 to 10 of 56 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.4	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.1	1.3	GO:0005642	annulate lamellae(GO:0005642)
0.0	1.3	GO:0002102	podosome(GO:0002102)
0.0	1.1	GO:0097542	ciliary tip(GO:0097542)
0.2	0.9	GO:0016939	kinesin II complex(GO:0016939)
0.0	0.8	GO:0032839	dendrite cytoplasm(GO:0032839)
0.0	0.7	GO:0031931	TORC1 complex(GO:0031931)
0.2	0.6	GO:0036194	muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0	0.6	GO:0044754	autolysosome(GO:0044754)
0.0	0.6	GO:0090544	BAF-type complex(GO:0090544)

Showing 1 to 10 of 18 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.2	GO:0005161	platelet-derived growth factor receptor binding(GO:0005161)
0.2	1.8	GO:0043140	ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.2	1.7	GO:0061649	ubiquitinated histone binding(GO:0061649)
0.4	1.4	GO:0070012	oligopeptidase activity(GO:0070012)
0.1	1.3	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	1.3	GO:0000993	RNA polymerase II core binding(GO:0000993)
0.2	1.1	GO:0052829	inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829)
0.0	1.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	1.1	GO:0015485	cholesterol binding(GO:0015485)
0.1	1.0	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)

Showing 1 to 10 of 43 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.2	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.0	1.5	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.0	1.4	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	0.7	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	0.5	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.5	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway

Showing 1 to 6 of 6 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.2	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	1.8	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.0	1.3	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.0	0.9	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.9	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	0.8	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.8	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.7	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.0	0.7	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0	0.6	REACTOME RNA POL I TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase I Transcription Termination

Showing 1 to 10 of 18 entries

Results for PKNOX2

Z-value: 0.97

Motif logo

Transcription factors associated with PKNOX2

Activity-expression correlation:

Activity profile of PKNOX2 motif

Sorted Z-values of PKNOX2 motif

No targets for PKNOX2

Network of associatons between targets according to the STRING database.

First level regulatory network of PKNOX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: