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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for POU1F1
Z-value: 0.71
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Transcription factors associated with POU1F1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
POU1F1
|
ENSG00000064835.6 | POU class 1 homeobox 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU1F1 | hg19_v2_chr3_-_87325728_87325739 | -0.46 | 4.4e-02 | Click! |
Activity profile of POU1F1 motif
Sorted Z-values of POU1F1 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of POU1F1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.4 | GO:0006428 | isoleucyl-tRNA aminoacylation(GO:0006428) |
| 0.3 | 0.9 | GO:0002590 | regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440) response to iron ion starvation(GO:1990641) |
| 0.2 | 0.9 | GO:0010636 | positive regulation of mitochondrial fusion(GO:0010636) |
| 0.2 | 0.7 | GO:0060166 | olfactory pit development(GO:0060166) |
| 0.2 | 0.5 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.1 | 0.7 | GO:1901675 | negative regulation of histone H3-K27 acetylation(GO:1901675) |
| 0.1 | 1.1 | GO:0071233 | cellular response to leucine(GO:0071233) |
| 0.1 | 0.5 | GO:1904685 | positive regulation of metalloendopeptidase activity(GO:1904685) |
| 0.1 | 0.7 | GO:0036353 | histone H2A-K119 monoubiquitination(GO:0036353) |
| 0.1 | 0.5 | GO:0010730 | negative regulation of hydrogen peroxide biosynthetic process(GO:0010730) |
| 0.1 | 0.5 | GO:0071874 | cellular response to norepinephrine stimulus(GO:0071874) |
| 0.1 | 1.0 | GO:0000055 | ribosomal large subunit export from nucleus(GO:0000055) |
| 0.1 | 0.4 | GO:1904020 | regulation of G-protein coupled receptor internalization(GO:1904020) |
| 0.1 | 0.3 | GO:1900369 | negative regulation of RNA interference(GO:1900369) |
| 0.1 | 0.6 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.1 | 0.2 | GO:0061534 | gamma-aminobutyric acid secretion, neurotransmission(GO:0061534) |
| 0.1 | 0.3 | GO:0031291 | Ran protein signal transduction(GO:0031291) |
| 0.1 | 0.3 | GO:0043456 | regulation of pentose-phosphate shunt(GO:0043456) |
| 0.1 | 0.5 | GO:0061767 | negative regulation of lung blood pressure(GO:0061767) |
| 0.1 | 0.2 | GO:1903988 | spleen trabecula formation(GO:0060345) iron cation export(GO:1903414) ferrous iron export(GO:1903988) |
| 0.1 | 0.7 | GO:0035507 | regulation of myosin-light-chain-phosphatase activity(GO:0035507) |
| 0.1 | 0.4 | GO:1904381 | Golgi apparatus mannose trimming(GO:1904381) |
| 0.1 | 0.3 | GO:1901979 | regulation of inward rectifier potassium channel activity(GO:1901979) |
| 0.1 | 0.3 | GO:0034334 | adherens junction maintenance(GO:0034334) |
| 0.1 | 0.3 | GO:0021502 | neural fold elevation formation(GO:0021502) elastin metabolic process(GO:0051541) epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) positive regulation of chemokine-mediated signaling pathway(GO:0070101) |
| 0.1 | 0.2 | GO:0045208 | MAPK phosphatase export from nucleus(GO:0045208) MAPK phosphatase export from nucleus, leptomycin B sensitive(GO:0045209) |
| 0.1 | 0.5 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
| 0.1 | 0.3 | GO:0046092 | deoxycytidine metabolic process(GO:0046092) |
| 0.1 | 0.2 | GO:0001560 | regulation of cell growth by extracellular stimulus(GO:0001560) |
| 0.0 | 0.6 | GO:0035973 | aggrephagy(GO:0035973) |
| 0.0 | 0.4 | GO:0000160 | phosphorelay signal transduction system(GO:0000160) |
| 0.0 | 0.2 | GO:1902045 | negative regulation of Fas signaling pathway(GO:1902045) |
| 0.0 | 0.4 | GO:0018211 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.0 | 0.3 | GO:1990481 | mRNA pseudouridine synthesis(GO:1990481) |
| 0.0 | 0.3 | GO:1904694 | negative regulation of vascular smooth muscle contraction(GO:1904694) |
| 0.0 | 0.4 | GO:0036444 | calcium ion transmembrane import into mitochondrion(GO:0036444) |
| 0.0 | 0.1 | GO:0006667 | sphinganine metabolic process(GO:0006667) |
| 0.0 | 0.2 | GO:0014038 | regulation of Schwann cell differentiation(GO:0014038) |
| 0.0 | 0.2 | GO:0001550 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) |
| 0.0 | 0.2 | GO:0051012 | microtubule sliding(GO:0051012) |
| 0.0 | 0.7 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.0 | 0.2 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.0 | 0.4 | GO:0090292 | nuclear matrix anchoring at nuclear membrane(GO:0090292) |
| 0.0 | 0.1 | GO:0070175 | positive regulation of enamel mineralization(GO:0070175) |
| 0.0 | 0.1 | GO:1903371 | regulation of endoplasmic reticulum tubular network organization(GO:1903371) |
| 0.0 | 0.1 | GO:0010430 | fatty acid omega-oxidation(GO:0010430) |
| 0.0 | 0.1 | GO:2000224 | sesquiterpenoid metabolic process(GO:0006714) sesquiterpenoid catabolic process(GO:0016107) farnesol metabolic process(GO:0016487) farnesol catabolic process(GO:0016488) regulation of testosterone biosynthetic process(GO:2000224) |
| 0.0 | 0.2 | GO:0034350 | regulation of glial cell apoptotic process(GO:0034350) negative regulation of glial cell apoptotic process(GO:0034351) |
| 0.0 | 0.1 | GO:0043126 | regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043126) positive regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043128) |
| 0.0 | 0.7 | GO:0045730 | respiratory burst(GO:0045730) |
| 0.0 | 0.1 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
| 0.0 | 0.3 | GO:1901078 | negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.0 | 0.3 | GO:0000722 | telomere maintenance via recombination(GO:0000722) |
| 0.0 | 0.1 | GO:1904550 | chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550) |
| 0.0 | 0.4 | GO:0016973 | poly(A)+ mRNA export from nucleus(GO:0016973) |
| 0.0 | 0.6 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 0.2 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 0.0 | 0.3 | GO:0043031 | negative regulation of macrophage activation(GO:0043031) |
| 0.0 | 0.4 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.0 | 0.3 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 0.0 | 0.3 | GO:0017121 | phospholipid scrambling(GO:0017121) |
| 0.0 | 0.3 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.0 | 0.2 | GO:0006451 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
| 0.0 | 0.0 | GO:0007206 | phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206) |
| 0.0 | 0.0 | GO:1903045 | neural crest cell migration involved in sympathetic nervous system development(GO:1903045) |
| 0.0 | 0.1 | GO:0032468 | Golgi calcium ion homeostasis(GO:0032468) |
| 0.0 | 0.1 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
| 0.0 | 0.1 | GO:0060020 | Bergmann glial cell differentiation(GO:0060020) |
| 0.0 | 0.2 | GO:0071670 | smooth muscle cell chemotaxis(GO:0071670) |
| 0.0 | 0.0 | GO:0061300 | cerebellum vasculature development(GO:0061300) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.5 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.1 | 0.5 | GO:1902912 | pyruvate kinase complex(GO:1902912) |
| 0.1 | 0.5 | GO:0097233 | lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233) |
| 0.1 | 0.9 | GO:1990357 | terminal web(GO:1990357) |
| 0.1 | 0.9 | GO:0031314 | extrinsic component of mitochondrial inner membrane(GO:0031314) |
| 0.1 | 1.1 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.1 | 0.7 | GO:0032010 | phagolysosome(GO:0032010) |
| 0.1 | 1.4 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.1 | 0.4 | GO:1990246 | uniplex complex(GO:1990246) |
| 0.1 | 0.6 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.1 | 0.2 | GO:0097635 | extrinsic component of autophagosome membrane(GO:0097635) |
| 0.0 | 0.5 | GO:1990812 | growth cone filopodium(GO:1990812) |
| 0.0 | 0.2 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 0.0 | 0.3 | GO:0035061 | interchromatin granule(GO:0035061) |
| 0.0 | 0.3 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.0 | 0.5 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.0 | 0.5 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.0 | 0.7 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
| 0.0 | 0.2 | GO:0000444 | MIS12/MIND type complex(GO:0000444) |
| 0.0 | 0.5 | GO:0030478 | actin cap(GO:0030478) |
| 0.0 | 0.2 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.0 | 1.3 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.0 | 0.1 | GO:0070931 | Golgi-associated vesicle lumen(GO:0070931) |
| 0.0 | 0.3 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.0 | 0.1 | GO:0042585 | germinal vesicle(GO:0042585) |
| 0.0 | 0.4 | GO:0000346 | transcription export complex(GO:0000346) |
| 0.0 | 0.2 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.0 | 0.7 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 0.6 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.0 | 0.1 | GO:1990589 | ATF4-CREB1 transcription factor complex(GO:1990589) |
| 0.0 | 0.2 | GO:0000836 | Hrd1p ubiquitin ligase complex(GO:0000836) |
| 0.0 | 0.1 | GO:0005968 | Rab-protein geranylgeranyltransferase complex(GO:0005968) |
| 0.0 | 0.1 | GO:0035032 | phosphatidylinositol 3-kinase complex, class III(GO:0035032) |
| 0.0 | 0.0 | GO:0042720 | mitochondrial inner membrane peptidase complex(GO:0042720) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.1 | GO:0001156 | TFIIIC-class transcription factor binding(GO:0001156) |
| 0.3 | 1.4 | GO:0004822 | isoleucine-tRNA ligase activity(GO:0004822) |
| 0.1 | 0.6 | GO:0004583 | dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583) |
| 0.1 | 0.5 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.1 | 0.6 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.1 | 0.2 | GO:0004366 | glycerol-3-phosphate O-acyltransferase activity(GO:0004366) |
| 0.1 | 0.9 | GO:1901612 | cardiolipin binding(GO:1901612) |
| 0.1 | 0.3 | GO:0046538 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
| 0.1 | 0.5 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
| 0.1 | 0.7 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.1 | 0.2 | GO:0097689 | iron channel activity(GO:0097689) |
| 0.1 | 0.9 | GO:1990459 | transferrin receptor binding(GO:1990459) |
| 0.1 | 0.3 | GO:0003726 | double-stranded RNA adenosine deaminase activity(GO:0003726) |
| 0.0 | 0.4 | GO:0000155 | phosphorelay sensor kinase activity(GO:0000155) |
| 0.0 | 0.3 | GO:0004797 | deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797) |
| 0.0 | 0.7 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.0 | 0.4 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.0 | 0.3 | GO:0004430 | 1-phosphatidylinositol 4-kinase activity(GO:0004430) |
| 0.0 | 0.5 | GO:0051425 | PTB domain binding(GO:0051425) |
| 0.0 | 0.5 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.0 | 0.2 | GO:0004699 | calcium-independent protein kinase C activity(GO:0004699) |
| 0.0 | 0.4 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.0 | 0.4 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.0 | 0.2 | GO:0004800 | thyroxine 5'-deiodinase activity(GO:0004800) |
| 0.0 | 0.1 | GO:0008431 | vitamin E binding(GO:0008431) |
| 0.0 | 0.1 | GO:1990254 | keratin filament binding(GO:1990254) |
| 0.0 | 0.7 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.0 | 0.1 | GO:0008798 | beta-aspartyl-peptidase activity(GO:0008798) |
| 0.0 | 0.1 | GO:0004031 | aldehyde oxidase activity(GO:0004031) |
| 0.0 | 0.1 | GO:0047017 | geranylgeranyl reductase activity(GO:0045550) prostaglandin-F synthase activity(GO:0047017) |
| 0.0 | 0.2 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
| 0.0 | 0.6 | GO:0034185 | apolipoprotein binding(GO:0034185) |
| 0.0 | 0.2 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
| 0.0 | 0.4 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.0 | 0.1 | GO:0004176 | ATP-dependent peptidase activity(GO:0004176) |
| 0.0 | 0.2 | GO:0003831 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831) |
| 0.0 | 0.3 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.0 | 0.5 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.0 | 0.3 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.0 | 0.1 | GO:1990763 | arrestin family protein binding(GO:1990763) |
| 0.0 | 0.1 | GO:0004758 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
| 0.0 | 0.4 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 0.0 | 0.5 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.0 | 0.2 | GO:0008429 | phosphatidylethanolamine binding(GO:0008429) |
| 0.0 | 0.4 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 0.0 | 0.2 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 0.1 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 0.0 | 0.3 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.0 | 0.7 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 0.0 | 0.1 | GO:0004663 | Rab geranylgeranyltransferase activity(GO:0004663) |
| 0.0 | 0.2 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.0 | 0.5 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 0.4 | GO:0005521 | lamin binding(GO:0005521) |
| 0.0 | 0.2 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.0 | 0.5 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 1.4 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 0.6 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 1.6 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 0.4 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 1.4 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 0.7 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 0.5 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 0.4 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 0.4 | REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.0 | 0.6 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 0.6 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.0 | 0.4 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.0 | 0.5 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.0 | 0.4 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 0.7 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.0 | 0.5 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 0.6 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |