ISMARA results: POU2F2

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for POU2F2_POU3F1

Z-value: 1.99

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Transcription factors associated with POU2F2_POU3F1

Gene Symbol	Gene ID	Gene Info
POU2F2 Ensembl NCBI GeneCards UniProt	ENSG00000028277.16	POU class 2 homeobox 2
POU3F1 Ensembl NCBI GeneCards UniProt	ENSG00000185668.5	POU class 3 homeobox 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
POU2F2	hg19_v2_chr19_-_42636543_42636607	-0.31	1.8e-01	Click!
POU3F1	hg19_v2_chr1_-_38512450_38512474	-0.27	2.5e-01	Click!

Activity profile of POU2F2_POU3F1 motif

Sorted Z-values of POU2F2_POU3F1 motif

No targets for POU2F2_POU3F1

Network of associatons between targets according to the STRING database.

First level regulatory network of POU2F2_POU3F1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	8.1	GO:0006081	cellular aldehyde metabolic process(GO:0006081)
1.4	7.1	GO:0036343	psychomotor behavior(GO:0036343)
0.4	5.7	GO:0030223	neutrophil differentiation(GO:0030223)
0.4	4.2	GO:0090324	negative regulation of oxidative phosphorylation(GO:0090324)
0.7	4.1	GO:0061624	fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.0	4.0	GO:0006342	chromatin silencing(GO:0006342)
0.2	3.6	GO:0060050	positive regulation of protein glycosylation(GO:0060050)
0.2	3.4	GO:0060056	mammary gland involution(GO:0060056)
0.4	3.3	GO:1903026	negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.3	2.9	GO:0051013	microtubule severing(GO:0051013)

Showing 1 to 10 of 148 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.8	GO:0000786	nucleosome(GO:0000786)
0.0	3.8	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.0	3.6	GO:0072562	blood microparticle(GO:0072562)
0.0	2.8	GO:0005771	multivesicular body(GO:0005771)
0.0	2.8	GO:0036064	ciliary basal body(GO:0036064)
0.3	2.6	GO:0035976	AP1 complex(GO:0035976)
0.0	2.1	GO:0000145	exocyst(GO:0000145)
0.0	2.0	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
0.1	1.7	GO:0000788	nuclear nucleosome(GO:0000788)
0.1	1.5	GO:0033270	paranode region of axon(GO:0033270)

Showing 1 to 10 of 43 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	11.8	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0	7.8	GO:0046982	protein heterodimerization activity(GO:0046982)
0.0	6.1	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0	5.8	GO:0008083	growth factor activity(GO:0008083)
0.3	2.9	GO:0070740	tubulin-glutamic acid ligase activity(GO:0070740)
0.2	2.9	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0	2.9	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.2	2.8	GO:0019103	pyrimidine nucleotide binding(GO:0019103)
0.1	2.7	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.0	2.3	GO:0003785	actin monomer binding(GO:0003785)

Showing 1 to 10 of 87 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
7.0	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
2.6	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
2.1	PID CMYB PATHWAY	C-MYB transcription factor network
2.0	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
2.0	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
1.1	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
1.0	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.9	PID RAS PATHWAY	Regulation of Ras family activation
0.7	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.7	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Showing 1 to 10 of 14 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.3	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.2	4.1	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.0	3.6	REACTOME INTEGRATION OF ENERGY METABOLISM	Genes involved in Integration of energy metabolism
0.0	2.9	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.2	2.8	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.1	2.4	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.0	2.2	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.1	1.9	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.0	1.7	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	1.5	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters

Showing 1 to 10 of 32 entries

Results for POU2F2_POU3F1

Z-value: 1.99

Motif logo

Transcription factors associated with POU2F2_POU3F1

Activity-expression correlation:

Activity profile of POU2F2_POU3F1 motif

Sorted Z-values of POU2F2_POU3F1 motif

No targets for POU2F2_POU3F1

Network of associatons between targets according to the STRING database.

First level regulatory network of POU2F2_POU3F1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: