ISMARA results: POU3F3

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for POU3F3_POU3F4

Z-value: 0.66

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Transcription factors associated with POU3F3_POU3F4

Gene Symbol	Gene ID	Gene Info
POU3F3 Ensembl NCBI GeneCards UniProt	ENSG00000198914.2	POU class 3 homeobox 3
POU3F4 Ensembl NCBI GeneCards UniProt	ENSG00000196767.4	POU class 3 homeobox 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
POU3F3	hg19_v2_chr2_+_105471969_105471969	0.02	9.4e-01	Click!

Activity profile of POU3F3_POU3F4 motif

Sorted Z-values of POU3F3_POU3F4 motif

No targets for POU3F3_POU3F4

Network of associatons between targets according to the STRING database.

First level regulatory network of POU3F3_POU3F4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	3.2	GO:0070563	negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.5	2.0	GO:0007499	ectoderm and mesoderm interaction(GO:0007499)
0.2	0.8	GO:0010983	positive regulation of high-density lipoprotein particle clearance(GO:0010983)
0.1	0.7	GO:0014809	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.2	0.6	GO:0032289	central nervous system myelin formation(GO:0032289)
0.0	0.6	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0	0.6	GO:0061014	positive regulation of mRNA catabolic process(GO:0061014)
0.1	0.5	GO:0042796	snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.0	0.5	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0	0.5	GO:0070050	neuron cellular homeostasis(GO:0070050)

Showing 1 to 10 of 65 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.5	GO:0005791	rough endoplasmic reticulum(GO:0005791)
0.1	0.7	GO:0097442	CA3 pyramidal cell dendrite(GO:0097442)
0.1	0.7	GO:0016013	syntrophin complex(GO:0016013)
0.1	0.6	GO:0035354	Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.0	0.6	GO:0000177	cytoplasmic exosome (RNase complex)(GO:0000177)
0.1	0.5	GO:0097169	AIM2 inflammasome complex(GO:0097169)
0.0	0.4	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.0	0.4	GO:0000974	Prp19 complex(GO:0000974)
0.0	0.3	GO:0044300	cerebellar mossy fiber(GO:0044300)
0.0	0.3	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)

Showing 1 to 10 of 21 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.0	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1	2.0	GO:0097371	MDM2/MDM4 family protein binding(GO:0097371)
0.1	0.9	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.1	0.7	GO:0004522	ribonuclease A activity(GO:0004522)
0.0	0.7	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.7	GO:0003785	actin monomer binding(GO:0003785)
0.1	0.6	GO:0071723	lipopolysaccharide receptor activity(GO:0001875) lipopeptide binding(GO:0071723)
0.0	0.6	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.6	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.6	GO:0050700	CARD domain binding(GO:0050700)

Showing 1 to 10 of 49 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
5.1	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.8	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.4	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.2	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway

Showing 1 to 4 of 4 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.0	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.0	1.0	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	0.8	REACTOME ELONGATION ARREST AND RECOVERY	Genes involved in Elongation arrest and recovery
0.0	0.6	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	0.5	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.0	0.5	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.4	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	0.4	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.0	0.3	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.0	0.3	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination

Showing 1 to 10 of 13 entries

Results for POU3F3_POU3F4

Z-value: 0.66

Motif logo

Transcription factors associated with POU3F3_POU3F4

Activity-expression correlation:

Activity profile of POU3F3_POU3F4 motif

Sorted Z-values of POU3F3_POU3F4 motif

No targets for POU3F3_POU3F4

Network of associatons between targets according to the STRING database.

First level regulatory network of POU3F3_POU3F4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: