ISMARA results: POU5F1

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for POU5F1_POU2F3

Z-value: 1.28

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Transcription factors associated with POU5F1_POU2F3

Gene Symbol	Gene ID	Gene Info
POU5F1 Ensembl NCBI GeneCards UniProt	ENSG00000204531.11	POU class 5 homeobox 1
POU2F3 Ensembl NCBI GeneCards UniProt	ENSG00000137709.5	POU class 2 homeobox 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
POU2F3	hg19_v2_chr11_+_120107344_120107351	0.58	7.6e-03	Click!
POU5F1	hg19_v2_chr6_-_31138439_31138475	0.22	3.5e-01	Click!

Activity profile of POU5F1_POU2F3 motif

Sorted Z-values of POU5F1_POU2F3 motif

No targets for POU5F1_POU2F3

Network of associatons between targets according to the STRING database.

First level regulatory network of POU5F1_POU2F3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.4	GO:0030449	regulation of complement activation(GO:0030449)
0.0	4.2	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.7	3.7	GO:0036343	psychomotor behavior(GO:0036343)
0.4	2.6	GO:0061624	fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.2	2.5	GO:0030223	neutrophil differentiation(GO:0030223)
0.1	2.5	GO:0046135	pyrimidine nucleoside catabolic process(GO:0046135)
0.3	2.4	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.5	2.2	GO:0048691	modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.1	2.0	GO:0007625	grooming behavior(GO:0007625)
0.0	1.8	GO:0043252	sodium-independent organic anion transport(GO:0043252)

Showing 1 to 10 of 284 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.5	GO:0031225	anchored component of membrane(GO:0031225)
0.0	2.2	GO:0036064	ciliary basal body(GO:0036064)
0.0	2.2	GO:0072562	blood microparticle(GO:0072562)
0.0	1.5	GO:0070821	tertiary granule membrane(GO:0070821)
0.1	1.3	GO:0035976	AP1 complex(GO:0035976)
0.1	1.3	GO:0071953	elastic fiber(GO:0071953)
0.0	1.3	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	1.3	GO:0000786	nucleosome(GO:0000786)
0.1	1.1	GO:0042567	insulin-like growth factor ternary complex(GO:0042567)
0.1	1.1	GO:0005577	fibrinogen complex(GO:0005577)

Showing 1 to 10 of 90 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.9	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.3	3.9	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0	3.7	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	3.4	GO:0008083	growth factor activity(GO:0008083)
0.4	3.3	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0	2.5	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1	2.2	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.1	1.9	GO:0019103	pyrimidine nucleotide binding(GO:0019103)
0.1	1.8	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)
0.0	1.6	GO:0004708	MAP kinase kinase activity(GO:0004708)

Showing 1 to 10 of 183 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.1	PID SHP2 PATHWAY	SHP2 signaling
0.0	1.9	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.1	1.6	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	1.4	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	1.3	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0	1.0	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.1	0.9	PID AURORA A PATHWAY	Aurora A signaling
0.0	0.8	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	0.8	NABA COLLAGENS	Genes encoding collagen proteins
0.0	0.7	PID CIRCADIAN PATHWAY	Circadian rhythm pathway

Showing 1 to 10 of 21 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.8	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	3.4	REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE	Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.1	2.8	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.1	1.9	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.0	1.6	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.1	1.5	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.1	1.5	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.1	1.3	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.0	1.3	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	1.3	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis

Showing 1 to 10 of 43 entries

Results for POU5F1_POU2F3

Z-value: 1.28

Motif logo

Transcription factors associated with POU5F1_POU2F3

Activity-expression correlation:

Activity profile of POU5F1_POU2F3 motif

Sorted Z-values of POU5F1_POU2F3 motif

No targets for POU5F1_POU2F3

Network of associatons between targets according to the STRING database.

First level regulatory network of POU5F1_POU2F3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: