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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for POU6F2
Z-value: 0.83
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Transcription factors associated with POU6F2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
POU6F2
|
ENSG00000106536.15 | POU class 6 homeobox 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU6F2 | hg19_v2_chr7_+_39017504_39017598 | 0.24 | 3.1e-01 | Click! |
Activity profile of POU6F2 motif
Sorted Z-values of POU6F2 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of POU6F2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.0 | GO:0060995 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
| 0.2 | 0.6 | GO:0001994 | norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994) |
| 0.2 | 0.9 | GO:0002032 | desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032) |
| 0.2 | 1.3 | GO:0015811 | L-cystine transport(GO:0015811) |
| 0.1 | 0.6 | GO:0072334 | UDP-galactose transport(GO:0015785) UDP-galactose transmembrane transport(GO:0072334) |
| 0.1 | 0.9 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.1 | 0.3 | GO:1904204 | regulation of skeletal muscle hypertrophy(GO:1904204) |
| 0.1 | 0.6 | GO:0061113 | pancreas morphogenesis(GO:0061113) |
| 0.1 | 0.8 | GO:0006627 | protein processing involved in protein targeting to mitochondrion(GO:0006627) |
| 0.1 | 0.8 | GO:0031120 | snRNA pseudouridine synthesis(GO:0031120) |
| 0.1 | 0.7 | GO:0032483 | regulation of Rab protein signal transduction(GO:0032483) |
| 0.1 | 1.8 | GO:0048853 | forebrain morphogenesis(GO:0048853) |
| 0.1 | 0.7 | GO:0097068 | response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386) |
| 0.1 | 0.6 | GO:0090234 | regulation of kinetochore assembly(GO:0090234) |
| 0.1 | 0.5 | GO:0031860 | telomeric 3' overhang formation(GO:0031860) |
| 0.1 | 0.5 | GO:2001271 | negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271) |
| 0.1 | 1.0 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 0.1 | 0.3 | GO:1901143 | insulin catabolic process(GO:1901143) |
| 0.1 | 0.9 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.1 | 1.0 | GO:0090091 | positive regulation of extracellular matrix disassembly(GO:0090091) negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.1 | 0.4 | GO:2000661 | positive regulation of interleukin-1-mediated signaling pathway(GO:2000661) |
| 0.1 | 0.2 | GO:0001560 | regulation of cell growth by extracellular stimulus(GO:0001560) |
| 0.1 | 0.5 | GO:1903826 | arginine transmembrane transport(GO:1903826) |
| 0.1 | 1.1 | GO:0070166 | enamel mineralization(GO:0070166) |
| 0.1 | 0.4 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 0.0 | 0.3 | GO:1903899 | lung goblet cell differentiation(GO:0060480) positive regulation of PERK-mediated unfolded protein response(GO:1903899) |
| 0.0 | 0.6 | GO:1904354 | negative regulation of telomere capping(GO:1904354) |
| 0.0 | 0.2 | GO:0060708 | spongiotrophoblast differentiation(GO:0060708) |
| 0.0 | 0.2 | GO:0010816 | substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959) |
| 0.0 | 0.9 | GO:0046602 | regulation of mitotic centrosome separation(GO:0046602) |
| 0.0 | 1.4 | GO:0072663 | protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663) |
| 0.0 | 0.6 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.0 | 0.4 | GO:0045075 | interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075) |
| 0.0 | 0.9 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.0 | 0.1 | GO:1904647 | response to rotenone(GO:1904647) |
| 0.0 | 0.4 | GO:0035878 | nail development(GO:0035878) |
| 0.0 | 0.2 | GO:0061767 | negative regulation of lung blood pressure(GO:0061767) |
| 0.0 | 0.4 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.0 | 0.6 | GO:0043517 | positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) |
| 0.0 | 0.4 | GO:0090160 | Golgi to lysosome transport(GO:0090160) |
| 0.0 | 0.2 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.0 | 0.1 | GO:0051970 | negative regulation of transmission of nerve impulse(GO:0051970) |
| 0.0 | 0.3 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.0 | 0.3 | GO:0072718 | response to cisplatin(GO:0072718) |
| 0.0 | 0.1 | GO:0032468 | Golgi calcium ion homeostasis(GO:0032468) |
| 0.0 | 0.3 | GO:0038007 | netrin-activated signaling pathway(GO:0038007) |
| 0.0 | 0.0 | GO:0090370 | negative regulation of cholesterol efflux(GO:0090370) |
| 0.0 | 1.2 | GO:0006383 | transcription from RNA polymerase III promoter(GO:0006383) |
| 0.0 | 0.5 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.0 | 0.7 | GO:0032878 | regulation of establishment or maintenance of cell polarity(GO:0032878) |
| 0.0 | 0.3 | GO:0019532 | oxalate transport(GO:0019532) |
| 0.0 | 0.5 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.0 | 0.4 | GO:0045109 | intermediate filament organization(GO:0045109) |
| 0.0 | 0.2 | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus(GO:0002862) |
| 0.0 | 0.2 | GO:0005981 | regulation of glycogen catabolic process(GO:0005981) |
| 0.0 | 0.4 | GO:0048490 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.0 | 2.3 | GO:0046718 | viral entry into host cell(GO:0046718) |
| 0.0 | 0.2 | GO:0007084 | mitotic nuclear envelope reassembly(GO:0007084) |
| 0.0 | 0.6 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.8 | GO:0042720 | mitochondrial inner membrane peptidase complex(GO:0042720) |
| 0.2 | 0.5 | GO:0002947 | tumor necrosis factor receptor superfamily complex(GO:0002947) |
| 0.1 | 0.6 | GO:0000333 | telomerase catalytic core complex(GO:0000333) |
| 0.1 | 2.1 | GO:0031597 | cytosolic proteasome complex(GO:0031597) |
| 0.1 | 0.5 | GO:0016035 | zeta DNA polymerase complex(GO:0016035) |
| 0.1 | 0.8 | GO:0072588 | box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) |
| 0.1 | 1.0 | GO:0005828 | kinetochore microtubule(GO:0005828) |
| 0.0 | 0.6 | GO:0097504 | Gemini of coiled bodies(GO:0097504) |
| 0.0 | 0.2 | GO:0031302 | intrinsic component of endosome membrane(GO:0031302) |
| 0.0 | 0.5 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.0 | 0.4 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 0.3 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.0 | 0.3 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 0.0 | 1.4 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 0.2 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.0 | 0.2 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.0 | 0.2 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.0 | 0.3 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.0 | 0.4 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 3.1 | GO:0031514 | motile cilium(GO:0031514) |
| 0.0 | 0.2 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.0 | 1.3 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 0.9 | GO:0005876 | spindle microtubule(GO:0005876) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.9 | GO:0031859 | platelet activating factor receptor binding(GO:0031859) |
| 0.2 | 0.7 | GO:0008808 | cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572) CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity(GO:0043337) |
| 0.2 | 0.6 | GO:0061629 | RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629) |
| 0.2 | 1.3 | GO:0015184 | L-cystine transmembrane transporter activity(GO:0015184) |
| 0.1 | 0.6 | GO:0005459 | UDP-galactose transmembrane transporter activity(GO:0005459) |
| 0.1 | 0.6 | GO:0004936 | alpha-adrenergic receptor activity(GO:0004936) |
| 0.1 | 1.2 | GO:0030620 | U2 snRNA binding(GO:0030620) |
| 0.1 | 0.3 | GO:0031626 | beta-endorphin binding(GO:0031626) |
| 0.1 | 0.8 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
| 0.1 | 0.2 | GO:0005146 | leukemia inhibitory factor receptor binding(GO:0005146) |
| 0.1 | 0.3 | GO:0050115 | myosin-light-chain-phosphatase activity(GO:0050115) |
| 0.1 | 0.5 | GO:0015181 | arginine transmembrane transporter activity(GO:0015181) |
| 0.1 | 1.8 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.1 | 0.4 | GO:0004909 | interleukin-1, Type I, activating receptor activity(GO:0004909) |
| 0.1 | 0.9 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.0 | 1.4 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.0 | 0.6 | GO:0016929 | SUMO-specific protease activity(GO:0016929) |
| 0.0 | 1.3 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.0 | 1.0 | GO:0017081 | chloride channel regulator activity(GO:0017081) |
| 0.0 | 0.2 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
| 0.0 | 0.5 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 0.6 | GO:0008432 | JUN kinase binding(GO:0008432) |
| 0.0 | 0.3 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.0 | 0.9 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.0 | 0.5 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.0 | 0.2 | GO:0008607 | phosphorylase kinase regulator activity(GO:0008607) |
| 0.0 | 0.6 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.0 | 2.3 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.0 | 1.4 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.0 | 0.2 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.0 | 0.6 | GO:0070034 | telomerase RNA binding(GO:0070034) |
| 0.0 | 1.1 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.0 | 0.7 | GO:0005123 | death receptor binding(GO:0005123) |
| 0.0 | 0.5 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 0.3 | GO:0019531 | oxalate transmembrane transporter activity(GO:0019531) |
| 0.0 | 0.2 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.0 | 0.1 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.0 | 0.1 | GO:0004013 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.0 | 0.3 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 0.9 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 1.1 | PID TNF PATHWAY | TNF receptor signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.0 | 0.7 | REACTOME ACYL CHAIN REMODELLING OF PG | Genes involved in Acyl chain remodelling of PG |
| 0.0 | 0.9 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.2 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 1.8 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 0.9 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 0.9 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 0.6 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.0 | 0.6 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 0.0 | 0.5 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.0 | 0.3 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 0.2 | REACTOME EICOSANOID LIGAND BINDING RECEPTORS | Genes involved in Eicosanoid ligand-binding receptors |