ISMARA results: PPARD

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PPARD

Z-value: 1.25

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Transcription factors associated with PPARD

Gene Symbol	Gene ID	Gene Info
PPARD Ensembl NCBI GeneCards UniProt	ENSG00000112033.9	peroxisome proliferator activated receptor delta

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PPARD	hg19_v2_chr6_+_35310391_35310410	-0.91	2.3e-08	Click!

Activity profile of PPARD motif

Sorted Z-values of PPARD motif

No targets for PPARD

Network of associatons between targets according to the STRING database.

First level regulatory network of PPARD

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	4.5	GO:0006853	carnitine shuttle(GO:0006853)
0.3	4.1	GO:0046322	negative regulation of fatty acid oxidation(GO:0046322)
0.2	4.0	GO:0032780	negative regulation of ATPase activity(GO:0032780)
0.0	3.3	GO:0070125	mitochondrial translational elongation(GO:0070125)
0.1	2.8	GO:0005980	glycogen catabolic process(GO:0005980)
0.1	2.7	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.0	2.7	GO:0071377	cellular response to glucagon stimulus(GO:0071377)
0.0	2.5	GO:0061718	NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0	2.1	GO:0032411	positive regulation of transporter activity(GO:0032411)
0.1	1.9	GO:0051599	response to hydrostatic pressure(GO:0051599)

Showing 1 to 10 of 53 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.1	GO:0009295	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.7	3.4	GO:0001405	presequence translocase-associated import motor(GO:0001405)
0.0	3.4	GO:0043202	lysosomal lumen(GO:0043202)
0.1	3.3	GO:0005763	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.3	2.5	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.0	1.9	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	1.6	GO:0005637	nuclear inner membrane(GO:0005637)
0.0	1.5	GO:0005779	integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1	1.3	GO:0032433	filopodium tip(GO:0032433)
0.3	1.2	GO:0031251	PAN complex(GO:0031251)

Showing 1 to 10 of 19 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	4.3	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095)
0.5	4.1	GO:0004466	long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.2	3.1	GO:0003995	acyl-CoA dehydrogenase activity(GO:0003995)
0.6	2.8	GO:0008466	glycogenin glucosyltransferase activity(GO:0008466)
0.7	2.7	GO:0004967	glucagon receptor activity(GO:0004967)
0.3	2.5	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.1	2.1	GO:0017081	chloride channel regulator activity(GO:0017081)
0.0	1.9	GO:0097110	scaffold protein binding(GO:0097110)
0.3	1.7	GO:0015254	glycerol channel activity(GO:0015254)
0.2	1.6	GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)

Showing 1 to 10 of 43 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	8.4	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	1.9	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.1	1.0	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	0.9	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0	0.7	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network

Showing 1 to 5 of 5 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	7.2	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1	4.5	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0	2.9	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.1	2.8	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.0	2.7	REACTOME GLUCAGON TYPE LIGAND RECEPTORS	Genes involved in Glucagon-type ligand receptors
0.0	2.5	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	2.4	REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D	Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1	1.7	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.0	1.0	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.1	0.9	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins

Showing 1 to 10 of 20 entries

Results for PPARD

Z-value: 1.25

Motif logo

Transcription factors associated with PPARD

Activity-expression correlation:

Activity profile of PPARD motif

Sorted Z-values of PPARD motif

No targets for PPARD

Network of associatons between targets according to the STRING database.

First level regulatory network of PPARD

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: