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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for PPARD
Z-value: 1.25
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Transcription factors associated with PPARD
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
PPARD
|
ENSG00000112033.9 | peroxisome proliferator activated receptor delta |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PPARD | hg19_v2_chr6_+_35310391_35310410 | -0.91 | 2.3e-08 | Click! |
Activity profile of PPARD motif
Sorted Z-values of PPARD motif
Network of associatons between targets according to the STRING database.
First level regulatory network of PPARD
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.5 | GO:0032581 | ER-dependent peroxisome organization(GO:0032581) |
| 0.3 | 1.6 | GO:1902109 | negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109) |
| 0.3 | 4.1 | GO:0046322 | negative regulation of fatty acid oxidation(GO:0046322) |
| 0.2 | 0.9 | GO:1905225 | response to thyrotropin-releasing hormone(GO:1905225) |
| 0.2 | 4.5 | GO:0006853 | carnitine shuttle(GO:0006853) |
| 0.2 | 0.9 | GO:0016267 | O-glycan processing, core 1(GO:0016267) |
| 0.2 | 1.0 | GO:0019303 | D-ribose catabolic process(GO:0019303) |
| 0.2 | 1.3 | GO:1902896 | terminal web assembly(GO:1902896) |
| 0.2 | 1.7 | GO:0015793 | glycerol transport(GO:0015793) |
| 0.2 | 4.0 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
| 0.2 | 0.6 | GO:0035544 | negative regulation of SNARE complex assembly(GO:0035544) |
| 0.2 | 0.6 | GO:0009224 | CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035) |
| 0.1 | 1.8 | GO:0032286 | central nervous system myelin maintenance(GO:0032286) |
| 0.1 | 1.6 | GO:0018406 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.1 | 0.4 | GO:0071661 | granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663) |
| 0.1 | 0.5 | GO:0019285 | glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456) |
| 0.1 | 2.7 | GO:0006703 | estrogen biosynthetic process(GO:0006703) |
| 0.1 | 1.0 | GO:0032483 | regulation of Rab protein signal transduction(GO:0032483) |
| 0.1 | 0.4 | GO:0033076 | alkaloid catabolic process(GO:0009822) isoquinoline alkaloid metabolic process(GO:0033076) cellular organohalogen metabolic process(GO:0090345) cellular organofluorine metabolic process(GO:0090346) |
| 0.1 | 1.9 | GO:0051599 | response to hydrostatic pressure(GO:0051599) |
| 0.1 | 0.7 | GO:0035624 | receptor transactivation(GO:0035624) |
| 0.1 | 1.8 | GO:0021978 | telencephalon regionalization(GO:0021978) |
| 0.1 | 0.2 | GO:1900073 | regulation of neuromuscular synaptic transmission(GO:1900073) positive regulation of neuromuscular synaptic transmission(GO:1900075) |
| 0.1 | 1.0 | GO:0097491 | sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491) |
| 0.1 | 1.0 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440) |
| 0.1 | 0.7 | GO:0006013 | mannose metabolic process(GO:0006013) |
| 0.1 | 0.9 | GO:2000821 | regulation of grooming behavior(GO:2000821) |
| 0.1 | 0.4 | GO:1900063 | regulation of peroxisome organization(GO:1900063) |
| 0.1 | 2.8 | GO:0005980 | glycogen catabolic process(GO:0005980) |
| 0.1 | 1.2 | GO:0033617 | mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034) |
| 0.1 | 0.4 | GO:1901529 | positive regulation of anion channel activity(GO:1901529) |
| 0.0 | 0.4 | GO:0048625 | myoblast fate commitment(GO:0048625) |
| 0.0 | 0.4 | GO:0034551 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033) |
| 0.0 | 2.5 | GO:0061718 | NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
| 0.0 | 0.2 | GO:0008611 | ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503) |
| 0.0 | 2.7 | GO:0071377 | cellular response to glucagon stimulus(GO:0071377) |
| 0.0 | 0.7 | GO:0045023 | G0 to G1 transition(GO:0045023) |
| 0.0 | 0.3 | GO:0000160 | phosphorelay signal transduction system(GO:0000160) |
| 0.0 | 0.1 | GO:1900365 | positive regulation of mRNA polyadenylation(GO:1900365) |
| 0.0 | 0.1 | GO:2000910 | negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910) |
| 0.0 | 0.2 | GO:0000270 | peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253) |
| 0.0 | 0.5 | GO:0000730 | DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003) |
| 0.0 | 3.3 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.0 | 1.4 | GO:0006298 | mismatch repair(GO:0006298) |
| 0.0 | 0.5 | GO:0098828 | positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828) |
| 0.0 | 0.1 | GO:0006267 | pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299) |
| 0.0 | 0.7 | GO:1901685 | glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687) |
| 0.0 | 0.5 | GO:0051085 | chaperone mediated protein folding requiring cofactor(GO:0051085) |
| 0.0 | 1.2 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
| 0.0 | 0.4 | GO:0010561 | negative regulation of glycoprotein biosynthetic process(GO:0010561) |
| 0.0 | 0.6 | GO:0030207 | chondroitin sulfate catabolic process(GO:0030207) |
| 0.0 | 2.1 | GO:0032411 | positive regulation of transporter activity(GO:0032411) |
| 0.0 | 0.7 | GO:0032008 | positive regulation of TOR signaling(GO:0032008) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 3.4 | GO:0001405 | presequence translocase-associated import motor(GO:0001405) |
| 0.3 | 1.2 | GO:0031251 | PAN complex(GO:0031251) |
| 0.3 | 2.5 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.1 | 0.5 | GO:0032798 | Swi5-Sfr1 complex(GO:0032798) |
| 0.1 | 3.3 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.1 | 1.0 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.1 | 1.2 | GO:0099634 | postsynaptic specialization membrane(GO:0099634) |
| 0.1 | 4.1 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.1 | 1.3 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.0 | 1.9 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 0.7 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.0 | 1.5 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.0 | 0.4 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.0 | 0.1 | GO:0036387 | nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387) |
| 0.0 | 3.4 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 0.2 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.0 | 1.6 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 0.7 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 0.5 | GO:0016592 | mediator complex(GO:0016592) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.7 | GO:0004967 | glucagon receptor activity(GO:0004967) |
| 0.6 | 2.8 | GO:0008466 | glycogenin glucosyltransferase activity(GO:0008466) |
| 0.5 | 4.3 | GO:0004095 | carnitine O-palmitoyltransferase activity(GO:0004095) |
| 0.5 | 4.1 | GO:0004466 | long-chain-acyl-CoA dehydrogenase activity(GO:0004466) |
| 0.4 | 1.1 | GO:0047025 | 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025) |
| 0.3 | 1.7 | GO:0015254 | glycerol channel activity(GO:0015254) |
| 0.3 | 2.5 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.2 | 0.7 | GO:0004464 | leukotriene-C4 synthase activity(GO:0004464) |
| 0.2 | 1.4 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
| 0.2 | 0.9 | GO:0031811 | G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812) |
| 0.2 | 1.6 | GO:0047045 | testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045) |
| 0.2 | 0.9 | GO:0016263 | glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263) |
| 0.2 | 0.6 | GO:0004423 | iduronate-2-sulfatase activity(GO:0004423) |
| 0.2 | 3.1 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
| 0.2 | 1.6 | GO:0003988 | acetyl-CoA C-acyltransferase activity(GO:0003988) |
| 0.1 | 0.7 | GO:0004572 | mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity(GO:0004572) |
| 0.1 | 1.3 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
| 0.1 | 0.4 | GO:0003986 | acetyl-CoA hydrolase activity(GO:0003986) |
| 0.1 | 0.4 | GO:0090554 | phosphatidylcholine-translocating ATPase activity(GO:0090554) |
| 0.1 | 0.3 | GO:0015227 | acyl carnitine transmembrane transporter activity(GO:0015227) |
| 0.1 | 2.1 | GO:0017081 | chloride channel regulator activity(GO:0017081) |
| 0.1 | 1.0 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
| 0.1 | 0.6 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.0 | 0.4 | GO:0016681 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.0 | 1.6 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 0.0 | 1.2 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.0 | 0.1 | GO:0004421 | hydroxymethylglutaryl-CoA synthase activity(GO:0004421) |
| 0.0 | 0.3 | GO:0000155 | phosphorelay sensor kinase activity(GO:0000155) |
| 0.0 | 0.3 | GO:0035251 | UDP-glucosyltransferase activity(GO:0035251) |
| 0.0 | 1.0 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.0 | 0.1 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 0.0 | 1.0 | GO:0019200 | carbohydrate kinase activity(GO:0019200) |
| 0.0 | 0.2 | GO:0003796 | lysozyme activity(GO:0003796) |
| 0.0 | 0.1 | GO:0004449 | isocitrate dehydrogenase (NAD+) activity(GO:0004449) |
| 0.0 | 0.7 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.0 | 1.9 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.0 | 0.4 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.0 | 0.7 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.0 | 0.6 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.0 | 0.4 | GO:0042288 | MHC class I protein binding(GO:0042288) |
| 0.0 | 0.8 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 0.7 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 0.2 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 1.0 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 0.7 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 1.9 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 0.9 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.2 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.1 | 1.7 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.1 | 4.5 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.1 | 2.8 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.1 | 0.9 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.0 | 2.7 | REACTOME GLUCAGON TYPE LIGAND RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 0.0 | 1.0 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 2.4 | REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 0.0 | 2.5 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 2.9 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 0.7 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 0.4 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 0.4 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.0 | 0.5 | REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.0 | 0.6 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 0.6 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 0.7 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.4 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.0 | 0.7 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 0.6 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |