ISMARA results: PPARG

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PPARG

Z-value: 1.53

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Transcription factors associated with PPARG

Gene Symbol	Gene ID	Gene Info
PPARG Ensembl NCBI GeneCards UniProt	ENSG00000132170.15	peroxisome proliferator activated receptor gamma

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PPARG	hg19_v2_chr3_+_12330560_12330579	0.12	6.2e-01	Click!

Activity profile of PPARG motif

Sorted Z-values of PPARG motif

No targets for PPARG

Network of associatons between targets according to the STRING database.

First level regulatory network of PPARG

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	5.0	GO:1990736	positive regulation of regulation of vascular smooth muscle cell membrane depolarization(GO:1904199) regulation of vascular smooth muscle cell membrane depolarization(GO:1990736)
0.1	3.1	GO:0048368	lateral mesoderm development(GO:0048368)
0.3	2.9	GO:0046618	drug export(GO:0046618)
0.1	2.9	GO:0046597	negative regulation of viral entry into host cell(GO:0046597)
0.1	2.6	GO:0006346	methylation-dependent chromatin silencing(GO:0006346)
0.8	2.5	GO:0002416	IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.2	2.3	GO:0046485	ether lipid metabolic process(GO:0046485)
0.0	2.2	GO:0018279	protein N-linked glycosylation via asparagine(GO:0018279)
0.0	2.0	GO:1904380	endoplasmic reticulum mannose trimming(GO:1904380)
0.6	1.9	GO:0043105	regulation of GTP cyclohydrolase I activity(GO:0043095) negative regulation of GTP cyclohydrolase I activity(GO:0043105)

Showing 1 to 10 of 151 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	5.0	GO:0034706	sodium channel complex(GO:0034706)
0.0	3.4	GO:0035580	specific granule lumen(GO:0035580)
0.6	3.1	GO:0071149	TEAD-2-YAP complex(GO:0071149)
0.1	2.6	GO:0016581	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0	1.7	GO:0001533	cornified envelope(GO:0001533)
0.1	1.6	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.2	1.5	GO:0032311	angiogenin-PRI complex(GO:0032311)
0.0	1.5	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.2	1.2	GO:0000839	Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1	1.1	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)

Showing 1 to 10 of 53 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.1	GO:0005227	calcium activated cation channel activity(GO:0005227)
0.1	3.1	GO:0001134	transcription factor activity, transcription factor recruiting(GO:0001134)
0.5	2.9	GO:0015307	drug:proton antiporter activity(GO:0015307)
0.0	2.7	GO:0003735	structural constituent of ribosome(GO:0003735)
0.1	2.6	GO:0008327	methyl-CpG binding(GO:0008327)
0.5	2.5	GO:0019770	IgG receptor activity(GO:0019770)
0.2	2.3	GO:0016803	ether hydrolase activity(GO:0016803)
0.3	2.1	GO:0008853	exodeoxyribonuclease III activity(GO:0008853)
0.0	2.0	GO:0001972	retinoic acid binding(GO:0001972)
0.0	2.0	GO:0005262	calcium channel activity(GO:0005262)

Showing 1 to 10 of 119 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.9	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.0	1.9	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.0	1.6	ST GA13 PATHWAY	G alpha 13 Pathway
0.0	1.5	PID IL23 PATHWAY	IL23-mediated signaling events
0.0	1.0	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	1.0	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.0	0.9	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1	0.8	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.0	0.8	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.0	0.7	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin

Showing 1 to 10 of 19 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.9	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.0	2.3	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	2.1	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	2.1	REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0	2.0	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.1	1.9	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0	1.6	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	1.5	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.1	1.4	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.0	1.4	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL

Showing 1 to 10 of 31 entries

Results for PPARG

Z-value: 1.53

Motif logo

Transcription factors associated with PPARG

Activity-expression correlation:

Activity profile of PPARG motif

Sorted Z-values of PPARG motif

No targets for PPARG

Network of associatons between targets according to the STRING database.

First level regulatory network of PPARG

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: