ISMARA results: PRDM1

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PRDM1

Z-value: 1.24

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Transcription factors associated with PRDM1

Gene Symbol	Gene ID	Gene Info
PRDM1 Ensembl NCBI GeneCards UniProt	ENSG00000057657.10	PR/SET domain 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PRDM1	hg19_v2_chr6_+_106546808_106546833	-0.50	2.3e-02	Click!

Activity profile of PRDM1 motif

Sorted Z-values of PRDM1 motif

No targets for PRDM1

Network of associatons between targets according to the STRING database.

First level regulatory network of PRDM1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.2	GO:0006521	regulation of cellular amino acid metabolic process(GO:0006521)
0.4	3.6	GO:0097039	protein linear polyubiquitination(GO:0097039)
0.6	3.1	GO:1902228	mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141)
0.1	2.8	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.0	1.9	GO:0006953	acute-phase response(GO:0006953)
0.3	1.6	GO:0060708	spongiotrophoblast differentiation(GO:0060708)
0.1	1.5	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.4	1.3	GO:1903225	negative regulation of endodermal cell differentiation(GO:1903225)
0.4	1.3	GO:0045062	extrathymic T cell selection(GO:0045062)
0.0	1.2	GO:0045668	negative regulation of osteoblast differentiation(GO:0045668)

Showing 1 to 10 of 68 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	3.6	GO:0071797	LUBAC complex(GO:0071797)
0.4	3.5	GO:1990111	spermatoproteasome complex(GO:1990111)
0.4	3.1	GO:1990682	CSF1-CSF1R complex(GO:1990682)
0.2	1.5	GO:0008537	proteasome activator complex(GO:0008537)
0.4	1.3	GO:0005588	collagen type V trimer(GO:0005588)
0.3	1.1	GO:0071062	rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0	1.1	GO:0016235	aggresome(GO:0016235)
0.2	0.8	GO:0097125	cyclin B1-CDK1 complex(GO:0097125)
0.2	0.6	GO:0070557	PCNA-p21 complex(GO:0070557)
0.1	0.6	GO:0042825	TAP complex(GO:0042825)

Showing 1 to 10 of 23 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.8	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0	3.6	GO:0043130	ubiquitin binding(GO:0043130)
0.4	3.1	GO:0005157	macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1	1.9	GO:0008035	high-density lipoprotein particle binding(GO:0008035)
0.5	1.6	GO:0005146	leukemia inhibitory factor receptor binding(GO:0005146)
0.2	1.5	GO:0061133	endopeptidase activator activity(GO:0061133)
0.1	1.5	GO:0044323	retinoic acid-responsive element binding(GO:0044323)
0.0	1.5	GO:0005109	frizzled binding(GO:0005109)
0.1	1.3	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	1.2	GO:0001972	retinoic acid binding(GO:0001972)

Showing 1 to 10 of 36 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.1	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	1.6	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0	1.3	NABA COLLAGENS	Genes encoding collagen proteins
0.0	1.1	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	0.8	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	0.8	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	0.7	ST GAQ PATHWAY	G alpha q Pathway

Showing 1 to 7 of 7 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.2	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0	3.6	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0	2.4	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	1.3	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.0	1.1	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	0.9	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.1	0.8	REACTOME RAF MAP KINASE CASCADE	Genes involved in RAF/MAP kinase cascade
0.0	0.8	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.7	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0	0.6	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand

Showing 1 to 10 of 19 entries

Results for PRDM1

Z-value: 1.24

Motif logo

Transcription factors associated with PRDM1

Activity-expression correlation:

Activity profile of PRDM1 motif

Sorted Z-values of PRDM1 motif

No targets for PRDM1

Network of associatons between targets according to the STRING database.

First level regulatory network of PRDM1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: