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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PROX1

Z-value: 0.58

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Transcription factors associated with PROX1

Gene Symbol Gene ID Gene Info
ENSG00000117707.11 prospero homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PROX1hg19_v2_chr1_+_214163033_2141630730.399.3e-02Click!

Activity profile of PROX1 motif

Sorted Z-values of PROX1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PROX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.4 GO:0001808 negative regulation of type IV hypersensitivity(GO:0001808)
0.2 0.8 GO:0032796 uropod organization(GO:0032796)
0.2 0.6 GO:0051413 response to cortisone(GO:0051413)
0.2 0.6 GO:0006218 uridine catabolic process(GO:0006218)
0.2 0.5 GO:0035604 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) fibroblast growth factor receptor signaling pathway involved in mammary gland specification(GO:0060595) mammary gland bud formation(GO:0060615) branch elongation involved in salivary gland morphogenesis(GO:0060667) mesenchymal cell differentiation involved in lung development(GO:0060915)
0.1 1.4 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.1 0.6 GO:0045399 response to molecule of fungal origin(GO:0002238) positive regulation of interleukin-3 production(GO:0032752) interleukin-3 biosynthetic process(GO:0042223) regulation of interleukin-3 biosynthetic process(GO:0045399) positive regulation of interleukin-3 biosynthetic process(GO:0045401) cellular response to molecule of fungal origin(GO:0071226)
0.1 1.5 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
0.1 0.4 GO:1900155 regulation of bone trabecula formation(GO:1900154) negative regulation of bone trabecula formation(GO:1900155)
0.1 0.4 GO:0072255 metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936)
0.1 0.3 GO:0048213 Golgi vesicle prefusion complex stabilization(GO:0048213)
0.1 1.1 GO:0044598 polyketide metabolic process(GO:0030638) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598)
0.1 0.3 GO:0009405 pathogenesis(GO:0009405)
0.1 0.8 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.1 0.6 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.1 0.3 GO:1901143 insulin catabolic process(GO:1901143)
0.1 0.2 GO:0034164 negative regulation of toll-like receptor 9 signaling pathway(GO:0034164)
0.1 0.3 GO:1904693 midbrain morphogenesis(GO:1904693)
0.1 0.7 GO:0006657 CDP-choline pathway(GO:0006657)
0.1 0.5 GO:0006526 arginine biosynthetic process(GO:0006526)
0.1 0.3 GO:0034093 positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
0.0 0.9 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.4 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.0 0.7 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.5 GO:0032237 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.3 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.0 0.2 GO:0035964 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0 0.2 GO:0036369 transcription factor catabolic process(GO:0036369)
0.0 0.2 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0 0.5 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0 0.4 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.0 0.3 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.1 GO:1990167 protein K27-linked deubiquitination(GO:1990167) protein K33-linked deubiquitination(GO:1990168)
0.0 0.1 GO:0016094 polyprenol biosynthetic process(GO:0016094)
0.0 0.3 GO:2001300 lipoxin metabolic process(GO:2001300)
0.0 0.1 GO:0060406 positive regulation of penile erection(GO:0060406)
0.0 0.2 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.0 0.2 GO:0043686 co-translational protein modification(GO:0043686)
0.0 0.4 GO:0044126 regulation of growth of symbiont in host(GO:0044126)
0.0 0.2 GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis(GO:0051563)
0.0 0.7 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.3 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.7 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.5 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.1 GO:2000053 negative regulation of B cell differentiation(GO:0045578) regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053)
0.0 0.1 GO:0042998 positive regulation of Golgi to plasma membrane protein transport(GO:0042998)
0.0 0.3 GO:0070294 renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294)
0.0 0.2 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.2 GO:0070269 pyroptosis(GO:0070269)
0.0 0.3 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.0 0.1 GO:2000435 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.0 0.0 GO:0002856 negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838) negative regulation of natural killer cell mediated immune response to tumor cell(GO:0002856) negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002859)
0.0 0.1 GO:0015692 lead ion transport(GO:0015692)
0.0 0.1 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.0 0.1 GO:0010793 regulation of mRNA export from nucleus(GO:0010793)
0.0 0.2 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.3 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.1 GO:0019046 release from viral latency(GO:0019046)
0.0 0.1 GO:0034344 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.0 0.3 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.0 0.9 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 0.1 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.0 0.3 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.1 GO:0018352 protein-pyridoxal-5-phosphate linkage(GO:0018352)
0.0 0.3 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 0.5 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 0.2 GO:2000344 positive regulation of acrosome reaction(GO:2000344)
0.0 0.1 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.0 0.2 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.5 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.2 GO:0006449 regulation of translational termination(GO:0006449)
0.0 0.1 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.3 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.0 1.1 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.0 0.2 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 0.2 GO:0086016 AV node cell action potential(GO:0086016) AV node cell to bundle of His cell signaling(GO:0086027)
0.0 0.8 GO:0035666 TRIF-dependent toll-like receptor signaling pathway(GO:0035666)
0.0 0.0 GO:0030451 regulation of complement activation, alternative pathway(GO:0030451) negative regulation of complement activation, alternative pathway(GO:0045957)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.4 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0097513 myosin II filament(GO:0097513)
0.1 1.4 GO:0097025 lateral loop(GO:0043219) MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 0.6 GO:0019815 B cell receptor complex(GO:0019815)
0.1 0.2 GO:1990716 axonemal central apparatus(GO:1990716)
0.0 0.7 GO:0042587 glycogen granule(GO:0042587)
0.0 0.2 GO:0031592 centrosomal corona(GO:0031592)
0.0 0.8 GO:0070938 contractile ring(GO:0070938)
0.0 0.3 GO:0035061 interchromatin granule(GO:0035061)
0.0 0.8 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 1.5 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.7 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.2 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.2 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.0 0.2 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.0 0.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.3 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.1 GO:0070826 paraferritin complex(GO:0070826)
0.0 0.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.5 GO:0034706 sodium channel complex(GO:0034706)
0.0 0.3 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.4 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.3 GO:0017119 Golgi transport complex(GO:0017119)
0.0 1.4 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.2 GO:0035253 ciliary rootlet(GO:0035253) gamma-secretase complex(GO:0070765)
0.0 0.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.6 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.3 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.0 0.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0003955 NAD(P)H dehydrogenase (quinone) activity(GO:0003955) 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
0.2 1.4 GO:0042015 interleukin-20 binding(GO:0042015)
0.2 1.5 GO:0004396 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 0.7 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 0.6 GO:0004850 uridine phosphorylase activity(GO:0004850)
0.1 1.4 GO:0097016 L27 domain binding(GO:0097016)
0.1 0.5 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1 0.3 GO:0031626 beta-endorphin binding(GO:0031626)
0.1 1.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 0.6 GO:0016936 galactoside binding(GO:0016936)
0.1 0.3 GO:0034736 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.1 0.3 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 0.5 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.1 0.2 GO:0030626 U12 snRNA binding(GO:0030626)
0.0 0.2 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.0 0.3 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
0.0 0.2 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 0.8 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 0.2 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.4 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.5 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.7 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 0.8 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.1 GO:1904455 ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455)
0.0 0.4 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.1 GO:0033149 FFAT motif binding(GO:0033149)
0.0 0.2 GO:0004906 interferon-gamma receptor activity(GO:0004906)
0.0 0.6 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.2 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.5 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.2 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.0 0.2 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 0.9 GO:0017166 vinculin binding(GO:0017166)
0.0 0.1 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 0.1 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.4 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 1.4 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.2 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.1 GO:0015087 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 0.2 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.1 GO:0042954 lipoprotein transporter activity(GO:0042954)
0.0 1.6 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.4 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.3 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.3 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.1 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.0 0.1 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.0 0.1 GO:0031208 POZ domain binding(GO:0031208)
0.0 0.3 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.6 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.6 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.1 GO:0030151 molybdenum ion binding(GO:0030151)
0.0 0.2 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 0.6 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 0.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.3 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.0 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.0 0.2 GO:0031014 troponin T binding(GO:0031014)
0.0 0.2 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.6 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.4 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.0 GO:0004877 complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.2 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 0.3 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 1.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.2 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.6 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.8 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 1.4 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.7 PID ATR PATHWAY ATR signaling pathway
0.0 1.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.4 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 0.6 PID ATM PATHWAY ATM pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.7 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.6 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.5 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 1.3 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.8 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.5 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.0 1.7 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.7 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.7 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.8 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.8 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.3 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.4 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.6 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.2 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport