ISMARA results: PRRX1_ALX4

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PRRX1_ALX4_PHOX2A

Z-value: 0.59

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Transcription factors associated with PRRX1_ALX4_PHOX2A

Gene Symbol	Gene ID	Gene Info
PRRX1 Ensembl NCBI GeneCards UniProt	ENSG00000116132.7	paired related homeobox 1
ALX4 Ensembl NCBI GeneCards UniProt	ENSG00000052850.5	ALX homeobox 4
PHOX2A Ensembl NCBI GeneCards UniProt	ENSG00000165462.5	paired like homeobox 2A

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ALX4	hg19_v2_chr11_-_44331679_44331716	0.67	1.2e-03	Click!
PRRX1	hg19_v2_chr1_+_170632250_170632277	0.27	2.6e-01	Click!

Activity profile of PRRX1_ALX4_PHOX2A motif

Sorted Z-values of PRRX1_ALX4_PHOX2A motif

No targets for PRRX1_ALX4_PHOX2A

Network of associatons between targets according to the STRING database.

First level regulatory network of PRRX1_ALX4_PHOX2A

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.0	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.5	1.4	GO:2001190	positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.1	1.1	GO:1902748	positive regulation of lens fiber cell differentiation(GO:1902748)
0.0	0.9	GO:0015721	bile acid and bile salt transport(GO:0015721)
0.1	0.6	GO:0002314	germinal center B cell differentiation(GO:0002314)
0.0	0.6	GO:0030728	ovulation(GO:0030728)
0.2	0.5	GO:0045360	regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.0	0.5	GO:0043248	proteasome assembly(GO:0043248)
0.0	0.4	GO:0048280	vesicle fusion with Golgi apparatus(GO:0048280)
0.0	0.4	GO:0014029	neural crest formation(GO:0014029)

Showing 1 to 10 of 50 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.4	GO:0005577	fibrinogen complex(GO:0005577)
0.1	1.4	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.4	GO:0033179	proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1	0.3	GO:0042720	mitochondrial inner membrane peptidase complex(GO:0042720)
0.0	0.3	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.2	GO:0005965	protein farnesyltransferase complex(GO:0005965)
0.0	0.2	GO:1990357	terminal web(GO:1990357)
0.0	0.2	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.0	0.1	GO:0005968	Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0	0.1	GO:0005896	interleukin-6 receptor complex(GO:0005896)

Showing 1 to 10 of 10 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.0	GO:0051087	chaperone binding(GO:0051087)
0.0	1.4	GO:0023026	MHC class II protein complex binding(GO:0023026)
0.0	1.3	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.2	0.6	GO:0015322	proton-dependent oligopeptide secondary active transmembrane transporter activity(GO:0005427) secondary active oligopeptide transmembrane transporter activity(GO:0015322)
0.0	0.6	GO:0005540	hyaluronic acid binding(GO:0005540)
0.2	0.5	GO:0031731	CCR6 chemokine receptor binding(GO:0031731)
0.1	0.4	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.0	0.4	GO:0030881	beta-2-microglobulin binding(GO:0030881)
0.0	0.4	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.4	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)

Showing 1 to 10 of 37 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.1	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	0.4	PID ARF 3PATHWAY	Arf1 pathway

Showing 1 to 2 of 2 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.0	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	0.7	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	0.4	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.0	0.4	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.0	0.2	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS

Showing 1 to 5 of 5 entries

Results for PRRX1_ALX4_PHOX2A

Z-value: 0.59

Motif logo

Transcription factors associated with PRRX1_ALX4_PHOX2A

Activity-expression correlation:

Activity profile of PRRX1_ALX4_PHOX2A motif

Sorted Z-values of PRRX1_ALX4_PHOX2A motif

No targets for PRRX1_ALX4_PHOX2A

Network of associatons between targets according to the STRING database.

First level regulatory network of PRRX1_ALX4_PHOX2A

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: