ISMARA results: RCOR1

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for RCOR1_MTA3

Z-value: 2.17

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Transcription factors associated with RCOR1_MTA3

Gene Symbol	Gene ID	Gene Info
RCOR1 Ensembl NCBI GeneCards UniProt	ENSG00000089902.8	REST corepressor 1
MTA3 Ensembl NCBI GeneCards UniProt	ENSG00000057935.9	metastasis associated 1 family member 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
RCOR1	hg19_v2_chr14_+_103058948_103059005	0.79	3.1e-05	Click!
MTA3	hg19_v2_chr2_+_42795839_42795887	0.73	2.5e-04	Click!

Activity profile of RCOR1_MTA3 motif

Sorted Z-values of RCOR1_MTA3 motif

No targets for RCOR1_MTA3

Network of associatons between targets according to the STRING database.

First level regulatory network of RCOR1_MTA3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	36.9	GO:0007062	sister chromatid cohesion(GO:0007062)
0.2	18.7	GO:0006334	nucleosome assembly(GO:0006334)
0.2	17.9	GO:0006368	transcription elongation from RNA polymerase II promoter(GO:0006368)
0.8	17.0	GO:0051988	regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.4	14.9	GO:0061641	CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.3	13.9	GO:0000281	mitotic cytokinesis(GO:0000281)
0.4	13.1	GO:0032201	telomere maintenance via semi-conservative replication(GO:0032201)
0.4	12.1	GO:1902857	positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.6	10.3	GO:0090168	Golgi reassembly(GO:0090168)
0.4	10.1	GO:1904776	regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)

Showing 1 to 10 of 1,644 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	79.5	GO:0005829	cytosol(GO:0005829)
0.3	44.2	GO:0000922	spindle pole(GO:0000922)
0.1	41.6	GO:0030027	lamellipodium(GO:0030027)
0.3	35.0	GO:0000776	kinetochore(GO:0000776)
0.0	29.9	GO:0005730	nucleolus(GO:0005730)
0.3	20.7	GO:0005876	spindle microtubule(GO:0005876)
0.5	19.4	GO:0032156	septin cytoskeleton(GO:0032156)
0.4	17.9	GO:0035371	microtubule plus-end(GO:0035371)
0.4	17.1	GO:0097431	mitotic spindle pole(GO:0097431)
0.2	17.1	GO:0017053	transcriptional repressor complex(GO:0017053)

Showing 1 to 10 of 534 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	94.7	GO:0045296	cadherin binding(GO:0045296)
0.2	49.2	GO:0042393	histone binding(GO:0042393)
0.1	31.2	GO:0061659	ubiquitin-like protein ligase activity(GO:0061659)
0.1	28.4	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.1	24.4	GO:0005525	GTP binding(GO:0005525)
0.2	23.5	GO:0019783	ubiquitin-like protein-specific protease activity(GO:0019783)
0.1	19.8	GO:0017048	Rho GTPase binding(GO:0017048)
0.2	15.0	GO:0019003	GDP binding(GO:0019003)
0.2	14.8	GO:0003777	microtubule motor activity(GO:0003777)
0.4	14.3	GO:0017056	structural constituent of nuclear pore(GO:0017056)

Showing 1 to 10 of 918 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	52.0	PID PLK1 PATHWAY	PLK1 signaling events
0.3	41.4	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.5	37.0	PID AURORA B PATHWAY	Aurora B signaling
0.5	31.4	PID ATR PATHWAY	ATR signaling pathway
0.3	24.9	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.4	22.0	PID BARD1 PATHWAY	BARD1 signaling events
0.3	17.8	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.1	14.8	PID E2F PATHWAY	E2F transcription factor network
0.1	14.0	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.3	13.3	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network

Showing 1 to 10 of 119 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	62.7	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.1	28.3	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.5	25.5	REACTOME KINESINS	Genes involved in Kinesins
0.3	25.5	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.4	23.8	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.5	22.5	REACTOME DOUBLE STRAND BREAK REPAIR	Genes involved in Double-Strand Break Repair
0.4	20.5	REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT	Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.2	20.1	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.4	19.8	REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	Genes involved in TGF-beta receptor signaling activates SMADs
0.2	17.6	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis

Showing 1 to 10 of 205 entries

Results for RCOR1_MTA3

Z-value: 2.17

Motif logo

Transcription factors associated with RCOR1_MTA3

Activity-expression correlation:

Activity profile of RCOR1_MTA3 motif

Sorted Z-values of RCOR1_MTA3 motif

No targets for RCOR1_MTA3

Network of associatons between targets according to the STRING database.

First level regulatory network of RCOR1_MTA3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: