ISMARA results: REL

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for REL

Z-value: 0.99

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Transcription factors associated with REL

Gene Symbol	Gene ID	Gene Info
REL Ensembl NCBI GeneCards UniProt	ENSG00000162924.9	REL proto-oncogene, NF-kB subunit

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
REL	hg19_v2_chr2_+_61108771_61108791	0.25	3.0e-01	Click!

Activity profile of REL motif

Sorted Z-values of REL motif

No targets for REL

Network of associatons between targets according to the STRING database.

First level regulatory network of REL

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.5	GO:0031581	hemidesmosome assembly(GO:0031581)
1.7	5.0	GO:0034148	regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of CD40 signaling pathway(GO:2000349)
0.8	2.5	GO:0070563	negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.3	2.4	GO:0070164	negative regulation of adiponectin secretion(GO:0070164)
0.0	2.2	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.4	2.0	GO:0015688	iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
0.1	2.0	GO:0016540	protein autoprocessing(GO:0016540)
0.0	1.9	GO:0030262	apoptotic nuclear changes(GO:0030262)
0.4	1.8	GO:0052027	modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.1	1.8	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)

Showing 1 to 10 of 108 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	5.5	GO:0005610	laminin-5 complex(GO:0005610)
0.0	2.8	GO:0035580	specific granule lumen(GO:0035580)
0.1	2.7	GO:0005614	interstitial matrix(GO:0005614)
0.0	2.6	GO:0002102	podosome(GO:0002102)
0.1	1.7	GO:0072687	meiotic spindle(GO:0072687)
0.0	1.7	GO:0005796	Golgi lumen(GO:0005796)
0.1	1.5	GO:0098799	outer mitochondrial membrane protein complex(GO:0098799)
0.0	1.3	GO:0005865	striated muscle thin filament(GO:0005865)
0.2	1.2	GO:0035692	macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0	1.1	GO:0097342	ripoptosome(GO:0097342)

Showing 1 to 10 of 33 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	4.9	GO:0061578	Lys63-specific deubiquitinase activity(GO:0061578)
0.0	3.1	GO:0031593	polyubiquitin binding(GO:0031593)
0.0	3.0	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1	2.4	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	1.9	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1	1.8	GO:0038062	protein tyrosine kinase collagen receptor activity(GO:0038062)
0.6	1.7	GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.1	1.5	GO:0035925	mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0	1.3	GO:0005328	neurotransmitter:sodium symporter activity(GO:0005328)
0.3	1.2	GO:0004641	phosphoribosylamine-glycine ligase activity(GO:0004637) phosphoribosylformylglycinamidine cyclo-ligase activity(GO:0004641) phosphoribosylglycinamide formyltransferase activity(GO:0004644)

Showing 1 to 10 of 62 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.8	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.2	5.5	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	3.8	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.0	2.5	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.1	2.4	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.0	2.2	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.0	2.0	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0	1.5	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	1.3	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	1.2	PID IL23 PATHWAY	IL23-mediated signaling events

Showing 1 to 10 of 17 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.8	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0	5.0	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.0	2.9	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	1.7	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0	1.3	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1	1.2	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0	1.0	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.9	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0	0.9	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.1	0.7	REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon

Showing 1 to 10 of 21 entries

Results for REL

Z-value: 0.99

Motif logo

Transcription factors associated with REL

Activity-expression correlation:

Activity profile of REL motif

Sorted Z-values of REL motif

No targets for REL

Network of associatons between targets according to the STRING database.

First level regulatory network of REL

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: