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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for RELA
Z-value: 1.74
Motif logo
Transcription factors associated with RELA
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
RELA
|
ENSG00000173039.14 | RELA proto-oncogene, NF-kB subunit |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RELA | hg19_v2_chr11_-_65430554_65430579 | 0.51 | 2.2e-02 | Click! |
Activity profile of RELA motif
Sorted Z-values of RELA motif
Network of associatons between targets according to the STRING database.
First level regulatory network of RELA
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 9.3 | GO:0072573 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of CD40 signaling pathway(GO:2000349) |
| 1.1 | 3.3 | GO:0045360 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 0.8 | 4.0 | GO:0052027 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 0.7 | 2.0 | GO:0061433 | cellular response to caloric restriction(GO:0061433) negative regulation of oligodendrocyte progenitor proliferation(GO:0070446) |
| 0.6 | 16.2 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.6 | 1.7 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 0.5 | 2.1 | GO:0002384 | hepatic immune response(GO:0002384) response to prolactin(GO:1990637) |
| 0.5 | 2.3 | GO:0070427 | nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427) |
| 0.4 | 2.6 | GO:0097368 | establishment of Sertoli cell barrier(GO:0097368) |
| 0.3 | 0.7 | GO:0035065 | regulation of histone acetylation(GO:0035065) regulation of peptidyl-lysine acetylation(GO:2000756) |
| 0.3 | 1.2 | GO:0034344 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 0.3 | 2.0 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.2 | 2.4 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 0.2 | 0.7 | GO:0003365 | establishment of cell polarity involved in ameboidal cell migration(GO:0003365) |
| 0.2 | 1.2 | GO:0097403 | cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545) |
| 0.2 | 0.9 | GO:0002268 | follicular dendritic cell differentiation(GO:0002268) |
| 0.2 | 1.2 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process(GO:0045084) |
| 0.2 | 1.4 | GO:0045359 | positive regulation of interferon-beta biosynthetic process(GO:0045359) |
| 0.2 | 1.7 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
| 0.2 | 1.0 | GO:0045659 | regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659) |
| 0.2 | 0.9 | GO:1903553 | positive regulation of extracellular exosome assembly(GO:1903553) |
| 0.2 | 0.5 | GO:0060584 | regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585) |
| 0.2 | 0.7 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 0.2 | 0.9 | GO:1902534 | single-organism membrane invagination(GO:1902534) |
| 0.2 | 1.7 | GO:0043950 | positive regulation of cAMP-mediated signaling(GO:0043950) |
| 0.2 | 0.5 | GO:0090271 | positive regulation of fibroblast growth factor production(GO:0090271) |
| 0.2 | 1.1 | GO:2000402 | negative regulation of lymphocyte migration(GO:2000402) |
| 0.1 | 0.4 | GO:0060697 | positive regulation of phospholipid catabolic process(GO:0060697) |
| 0.1 | 0.7 | GO:0033590 | response to cobalamin(GO:0033590) |
| 0.1 | 0.8 | GO:1902766 | skeletal muscle satellite cell migration(GO:1902766) |
| 0.1 | 0.4 | GO:1901842 | negative regulation of high voltage-gated calcium channel activity(GO:1901842) |
| 0.1 | 0.8 | GO:0093001 | glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001) |
| 0.1 | 1.9 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.1 | 0.4 | GO:1904899 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 0.1 | 0.8 | GO:0072674 | multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675) |
| 0.1 | 0.6 | GO:0038018 | Wnt receptor catabolic process(GO:0038018) |
| 0.1 | 2.3 | GO:0090179 | planar cell polarity pathway involved in neural tube closure(GO:0090179) |
| 0.1 | 4.4 | GO:0050716 | positive regulation of interleukin-1 secretion(GO:0050716) |
| 0.1 | 1.1 | GO:0050859 | negative regulation of B cell receptor signaling pathway(GO:0050859) |
| 0.1 | 1.9 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.1 | 0.4 | GO:0009236 | cobalamin biosynthetic process(GO:0009236) |
| 0.1 | 0.3 | GO:1990654 | sebum secreting cell proliferation(GO:1990654) |
| 0.1 | 0.5 | GO:0001827 | inner cell mass cell fate commitment(GO:0001827) inner cell mass cellular morphogenesis(GO:0001828) |
| 0.1 | 3.5 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 0.3 | GO:0072616 | interleukin-18 secretion(GO:0072616) |
| 0.1 | 0.2 | GO:0002232 | leukocyte chemotaxis involved in inflammatory response(GO:0002232) |
| 0.1 | 1.3 | GO:0048733 | sebaceous gland development(GO:0048733) |
| 0.1 | 0.3 | GO:0033364 | mast cell secretory granule organization(GO:0033364) |
| 0.1 | 0.6 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.1 | 0.5 | GO:0032185 | septin cytoskeleton organization(GO:0032185) |
| 0.1 | 0.5 | GO:1900425 | negative regulation of defense response to bacterium(GO:1900425) |
| 0.1 | 0.2 | GO:1903093 | regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) negative regulation of ubiquitin-specific protease activity(GO:2000157) |
| 0.1 | 0.4 | GO:0000255 | allantoin metabolic process(GO:0000255) |
| 0.1 | 1.3 | GO:1904259 | regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197) |
| 0.1 | 1.9 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
| 0.1 | 0.8 | GO:0052697 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
| 0.1 | 0.2 | GO:0003245 | cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) histone H3-K9 deacetylation(GO:1990619) |
| 0.1 | 1.2 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.1 | 0.9 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 0.1 | 0.4 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.1 | 0.2 | GO:0002296 | T-helper 1 cell lineage commitment(GO:0002296) |
| 0.1 | 0.4 | GO:0061086 | negative regulation of histone H3-K27 methylation(GO:0061086) |
| 0.0 | 0.2 | GO:0098582 | innate vocalization behavior(GO:0098582) |
| 0.0 | 1.8 | GO:0060644 | mammary gland epithelial cell differentiation(GO:0060644) |
| 0.0 | 0.7 | GO:0002191 | cap-dependent translational initiation(GO:0002191) |
| 0.0 | 0.2 | GO:0048205 | COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205) |
| 0.0 | 0.3 | GO:0030578 | PML body organization(GO:0030578) |
| 0.0 | 0.2 | GO:0001878 | response to yeast(GO:0001878) |
| 0.0 | 0.3 | GO:0006196 | AMP catabolic process(GO:0006196) |
| 0.0 | 0.3 | GO:2000491 | positive regulation of hepatic stellate cell activation(GO:2000491) |
| 0.0 | 0.2 | GO:0035509 | negative regulation of myosin-light-chain-phosphatase activity(GO:0035509) negative regulation of bicellular tight junction assembly(GO:1903347) |
| 0.0 | 1.4 | GO:0002076 | osteoblast development(GO:0002076) |
| 0.0 | 0.3 | GO:0034351 | regulation of glial cell apoptotic process(GO:0034350) negative regulation of glial cell apoptotic process(GO:0034351) |
| 0.0 | 0.4 | GO:1903944 | regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
| 0.0 | 0.4 | GO:0018231 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 0.0 | 0.4 | GO:0003084 | positive regulation of systemic arterial blood pressure(GO:0003084) |
| 0.0 | 0.1 | GO:0038155 | interleukin-23-mediated signaling pathway(GO:0038155) |
| 0.0 | 0.2 | GO:0044034 | negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034) |
| 0.0 | 0.2 | GO:0023035 | CD40 signaling pathway(GO:0023035) |
| 0.0 | 2.1 | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531) |
| 0.0 | 0.3 | GO:0006689 | ganglioside catabolic process(GO:0006689) |
| 0.0 | 0.3 | GO:2000544 | cell chemotaxis to fibroblast growth factor(GO:0035766) endothelial cell chemotaxis to fibroblast growth factor(GO:0035768) regulation of cell chemotaxis to fibroblast growth factor(GO:1904847) regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000544) |
| 0.0 | 0.3 | GO:0060022 | hard palate development(GO:0060022) |
| 0.0 | 0.1 | GO:0045210 | FasL biosynthetic process(GO:0045210) |
| 0.0 | 0.3 | GO:0098734 | macromolecule depalmitoylation(GO:0098734) |
| 0.0 | 0.1 | GO:0006420 | arginyl-tRNA aminoacylation(GO:0006420) |
| 0.0 | 0.1 | GO:0060282 | positive regulation of oocyte development(GO:0060282) |
| 0.0 | 0.6 | GO:0045063 | T-helper 1 cell differentiation(GO:0045063) |
| 0.0 | 0.3 | GO:0046959 | habituation(GO:0046959) |
| 0.0 | 0.8 | GO:0060334 | regulation of interferon-gamma-mediated signaling pathway(GO:0060334) |
| 0.0 | 0.2 | GO:0071802 | negative regulation of podosome assembly(GO:0071802) |
| 0.0 | 0.5 | GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) |
| 0.0 | 0.1 | GO:0045078 | positive regulation of interferon-gamma biosynthetic process(GO:0045078) |
| 0.0 | 0.2 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) |
| 0.0 | 0.5 | GO:0050858 | negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) |
| 0.0 | 1.0 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
| 0.0 | 0.1 | GO:0050976 | detection of mechanical stimulus involved in sensory perception of touch(GO:0050976) |
| 0.0 | 0.1 | GO:0061034 | olfactory bulb mitral cell layer development(GO:0061034) |
| 0.0 | 0.6 | GO:0016485 | protein processing(GO:0016485) |
| 0.0 | 0.1 | GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185) |
| 0.0 | 0.1 | GO:1904627 | response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628) |
| 0.0 | 1.7 | GO:0060333 | interferon-gamma-mediated signaling pathway(GO:0060333) |
| 0.0 | 0.6 | GO:0071425 | hematopoietic stem cell proliferation(GO:0071425) |
| 0.0 | 0.3 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.0 | 0.2 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.0 | 0.5 | GO:0030514 | negative regulation of BMP signaling pathway(GO:0030514) |
| 0.0 | 1.6 | GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418) |
| 0.0 | 0.2 | GO:0043982 | histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982) |
| 0.0 | 0.3 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.0 | 0.3 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.0 | 0.2 | GO:0010603 | regulation of cytoplasmic mRNA processing body assembly(GO:0010603) |
| 0.0 | 0.6 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
| 0.0 | 0.0 | GO:0003408 | optic cup formation involved in camera-type eye development(GO:0003408) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.5 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.3 | 2.4 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.3 | 1.3 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.2 | 2.4 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.2 | 0.9 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.2 | 2.0 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.2 | 2.0 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.1 | 4.6 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.1 | 0.8 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.1 | 0.7 | GO:0043196 | varicosity(GO:0043196) |
| 0.1 | 0.3 | GO:0005889 | hydrogen:potassium-exchanging ATPase complex(GO:0005889) |
| 0.1 | 1.8 | GO:0097342 | ripoptosome(GO:0097342) |
| 0.1 | 1.3 | GO:0045180 | basal cortex(GO:0045180) |
| 0.1 | 1.3 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 0.7 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.1 | 1.0 | GO:0030008 | TRAPP complex(GO:0030008) |
| 0.0 | 0.2 | GO:0031933 | telomeric heterochromatin(GO:0031933) |
| 0.0 | 0.2 | GO:0016938 | kinesin I complex(GO:0016938) |
| 0.0 | 2.6 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 0.5 | GO:0030478 | actin cap(GO:0030478) |
| 0.0 | 3.5 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.0 | 3.2 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 0.2 | GO:0071797 | LUBAC complex(GO:0071797) |
| 0.0 | 2.4 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 0.1 | GO:0072536 | interleukin-23 receptor complex(GO:0072536) |
| 0.0 | 1.0 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.0 | 0.2 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 0.0 | 0.7 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.0 | 0.4 | GO:0032039 | integrator complex(GO:0032039) |
| 0.0 | 1.7 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.0 | 0.4 | GO:0002178 | palmitoyltransferase complex(GO:0002178) |
| 0.0 | 0.5 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.0 | 0.5 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.0 | 0.1 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.0 | 0.3 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 0.3 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.0 | 0.2 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.0 | 0.7 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 0.5 | GO:0071011 | precatalytic spliceosome(GO:0071011) |
| 0.0 | 0.3 | GO:0031045 | dense core granule(GO:0031045) |
| 0.0 | 0.3 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.0 | 2.2 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 0.1 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.0 | 0.7 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 0.7 | GO:0055038 | recycling endosome membrane(GO:0055038) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 3.3 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
| 0.9 | 13.1 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.7 | 2.0 | GO:0046970 | NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970) |
| 0.6 | 11.0 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.3 | 2.4 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.2 | 1.7 | GO:0046979 | TAP2 binding(GO:0046979) |
| 0.2 | 1.0 | GO:0004906 | interferon-gamma receptor activity(GO:0004906) |
| 0.1 | 1.3 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.1 | 1.9 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.1 | 0.4 | GO:0003845 | 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845) |
| 0.1 | 1.0 | GO:0016314 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314) |
| 0.1 | 0.5 | GO:0052810 | 1-phosphatidylinositol-5-kinase activity(GO:0052810) |
| 0.1 | 2.0 | GO:0008199 | ferric iron binding(GO:0008199) |
| 0.1 | 0.7 | GO:0004699 | calcium-independent protein kinase C activity(GO:0004699) |
| 0.1 | 0.5 | GO:0050473 | prostaglandin-endoperoxide synthase activity(GO:0004666) arachidonate 15-lipoxygenase activity(GO:0050473) |
| 0.1 | 1.3 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.1 | 0.5 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
| 0.1 | 6.4 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.1 | 0.8 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
| 0.1 | 1.6 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.1 | 0.7 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 0.1 | 3.6 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.1 | 0.9 | GO:0070053 | thrombospondin receptor activity(GO:0070053) |
| 0.1 | 0.2 | GO:0046969 | histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969) |
| 0.1 | 0.9 | GO:0045159 | myosin II binding(GO:0045159) |
| 0.1 | 0.8 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.1 | 1.4 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.1 | 0.2 | GO:0008384 | IkappaB kinase activity(GO:0008384) |
| 0.1 | 0.5 | GO:0008440 | inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) |
| 0.1 | 2.2 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 0.3 | GO:0016308 | 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308) |
| 0.0 | 1.8 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.0 | 0.2 | GO:0031708 | endothelin B receptor binding(GO:0031708) |
| 0.0 | 1.3 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.0 | 1.9 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 0.9 | GO:0048185 | activin binding(GO:0048185) |
| 0.0 | 0.3 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
| 0.0 | 0.2 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 0.0 | 0.7 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.0 | 0.5 | GO:0016494 | C-X-C chemokine receptor activity(GO:0016494) |
| 0.0 | 0.1 | GO:0042020 | interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020) |
| 0.0 | 0.9 | GO:0032041 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.0 | 0.3 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.0 | 0.3 | GO:0098599 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.0 | 0.1 | GO:0034602 | oxoglutarate dehydrogenase (NAD+) activity(GO:0034602) |
| 0.0 | 0.4 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.0 | 0.1 | GO:0004814 | arginine-tRNA ligase activity(GO:0004814) |
| 0.0 | 0.3 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.0 | 0.7 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.0 | 0.2 | GO:0001849 | complement component C1q binding(GO:0001849) virion binding(GO:0046790) |
| 0.0 | 0.6 | GO:0046965 | retinoid X receptor binding(GO:0046965) |
| 0.0 | 0.8 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 0.1 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.0 | 0.2 | GO:0043995 | histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972) |
| 0.0 | 0.4 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.0 | 0.3 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 0.5 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.0 | 2.2 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 0.0 | 3.1 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 0.3 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.0 | 0.4 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.0 | 3.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 1.5 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.0 | 0.4 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.0 | 0.3 | GO:0005095 | diacylglycerol kinase activity(GO:0004143) GTPase inhibitor activity(GO:0005095) |
| 0.0 | 0.1 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.0 | 0.2 | GO:0001013 | RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.3 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.2 | 6.3 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 3.5 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 6.5 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.1 | 3.5 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 3.3 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 1.8 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 0.3 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 1.7 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 1.3 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 2.4 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 3.6 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 0.5 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 0.7 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 1.3 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 0.9 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.0 | 1.5 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.0 | 0.9 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 5.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.4 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 0.7 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 0.4 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 0.3 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 16.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 2.4 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.2 | 8.5 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.2 | 12.7 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 1.3 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.1 | 3.2 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.1 | 6.3 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 0.9 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 0.2 | REACTOME SEMA4D IN SEMAPHORIN SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.0 | 0.7 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 1.2 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 0.9 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.0 | 0.8 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 0.6 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 0.5 | REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX | Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| 0.0 | 3.4 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.7 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 2.1 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 2.7 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.0 | 1.1 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.0 | 0.4 | REACTOME DESTABILIZATION OF MRNA BY BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |
| 0.0 | 0.4 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 0.2 | REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
| 0.0 | 0.3 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 2.1 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.0 | 0.8 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 0.4 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 0.5 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |