ISMARA results: RFX3

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for RFX3_RFX2

Z-value: 4.61

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Transcription factors associated with RFX3_RFX2

Gene Symbol	Gene ID	Gene Info
RFX3 Ensembl NCBI GeneCards UniProt	ENSG00000080298.11	regulatory factor X3
RFX2 Ensembl NCBI GeneCards UniProt	ENSG00000087903.8	regulatory factor X2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
RFX2	hg19_v2_chr19_-_6110474_6110551	0.69	7.0e-04	Click!
RFX3	hg19_v2_chr9_-_3525968_3526016	-0.46	4.0e-02	Click!

Activity profile of RFX3_RFX2 motif

Sorted Z-values of RFX3_RFX2 motif

No targets for RFX3_RFX2

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX3_RFX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	19.2	GO:0002021	response to dietary excess(GO:0002021)
0.1	15.4	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
1.1	12.1	GO:0018103	protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.6	12.0	GO:0035641	locomotory exploration behavior(GO:0035641)
0.4	11.5	GO:1901663	ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.8	11.3	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.1	10.3	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
1.1	9.8	GO:0002318	myeloid progenitor cell differentiation(GO:0002318)
0.8	9.7	GO:0035845	photoreceptor cell outer segment organization(GO:0035845)
0.2	9.5	GO:0006298	mismatch repair(GO:0006298)

Showing 1 to 10 of 233 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	19.4	GO:0036038	MKS complex(GO:0036038)
0.1	18.7	GO:0005802	trans-Golgi network(GO:0005802)
0.0	12.8	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.7	11.8	GO:0033010	paranodal junction(GO:0033010)
0.1	11.7	GO:0005637	nuclear inner membrane(GO:0005637)
0.1	10.8	GO:0000315	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1	9.9	GO:0030665	clathrin-coated vesicle membrane(GO:0030665)
0.6	9.3	GO:0005664	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1	8.1	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	7.7	GO:0005741	mitochondrial outer membrane(GO:0005741)

Showing 1 to 10 of 112 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	17.3	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1	16.0	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.5	13.1	GO:0042609	CD4 receptor binding(GO:0042609)
0.4	12.9	GO:0000030	mannosyltransferase activity(GO:0000030)
0.0	11.4	GO:0015631	tubulin binding(GO:0015631)
0.0	11.0	GO:0017137	Rab GTPase binding(GO:0017137)
0.0	11.0	GO:0005509	calcium ion binding(GO:0005509)
0.1	10.3	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.0	9.3	GO:0046982	protein heterodimerization activity(GO:0046982)
1.5	9.1	GO:0008853	exodeoxyribonuclease III activity(GO:0008853)

Showing 1 to 10 of 162 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	15.9	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.2	11.2	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.1	11.2	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.1	8.1	PID AURORA B PATHWAY	Aurora B signaling
0.1	5.6	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.1	4.7	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	4.6	PID BARD1 PATHWAY	BARD1 signaling events
0.0	3.6	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.0	3.6	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	3.5	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining

Showing 1 to 10 of 26 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	17.3	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.3	13.5	REACTOME KINESINS	Genes involved in Kinesins
0.6	10.7	REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	Genes involved in Synthesis of substrates in N-glycan biosythesis
0.2	10.6	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1	9.8	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.0	7.8	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.1	7.3	REACTOME G1 PHASE	Genes involved in G1 Phase
0.2	7.0	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2	6.3	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	6.0	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase

Showing 1 to 10 of 64 entries

Results for RFX3_RFX2

Z-value: 4.61

Motif logo

Transcription factors associated with RFX3_RFX2

Activity-expression correlation:

Activity profile of RFX3_RFX2 motif

Sorted Z-values of RFX3_RFX2 motif

No targets for RFX3_RFX2

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX3_RFX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: