ISMARA results: RFX7_RFX4

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for RFX7_RFX4_RFX1

Z-value: 3.70

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Transcription factors associated with RFX7_RFX4_RFX1

Gene Symbol	Gene ID	Gene Info
RFX7 Ensembl NCBI GeneCards UniProt	ENSG00000181827.10	regulatory factor X7
RFX4 Ensembl NCBI GeneCards UniProt	ENSG00000111783.8	regulatory factor X4
RFX1 Ensembl NCBI GeneCards UniProt	ENSG00000132005.4	regulatory factor X1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
RFX7	hg19_v2_chr15_-_56535464_56535521	-0.83	5.1e-06	Click!
RFX1	hg19_v2_chr19_-_14117074_14117141	0.74	1.7e-04	Click!
RFX4	hg19_v2_chr12_+_106994905_106994954	0.42	6.4e-02	Click!

Activity profile of RFX7_RFX4_RFX1 motif

Sorted Z-values of RFX7_RFX4_RFX1 motif

No targets for RFX7_RFX4_RFX1

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX7_RFX4_RFX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	70.6	GO:0016579	protein deubiquitination(GO:0016579)
8.6	34.4	GO:0090299	regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314)
0.1	20.3	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.1	10.6	GO:0006334	nucleosome assembly(GO:0006334)
0.0	9.1	GO:0006352	DNA-templated transcription, initiation(GO:0006352)
0.1	8.4	GO:0060612	adipose tissue development(GO:0060612)
2.7	8.0	GO:0050760	negative regulation of thymidylate synthase biosynthetic process(GO:0050760)
0.2	7.4	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.7	7.2	GO:0007288	sperm axoneme assembly(GO:0007288)
0.6	7.0	GO:0071907	determination of digestive tract left/right asymmetry(GO:0071907)

Showing 1 to 10 of 227 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	17.0	GO:0042470	melanosome(GO:0042470) pigment granule(GO:0048770)
2.4	12.0	GO:0002079	inner acrosomal membrane(GO:0002079)
0.0	8.6	GO:0000779	condensed chromosome, centromeric region(GO:0000779)
0.8	8.0	GO:1990812	growth cone filopodium(GO:1990812)
0.0	6.5	GO:0032993	protein-DNA complex(GO:0032993)
0.0	6.1	GO:0005938	cell cortex(GO:0005938)
0.3	5.9	GO:0042613	MHC class II protein complex(GO:0042613)
0.1	5.8	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
0.0	5.7	GO:0042995	cell projection(GO:0042995)
0.1	4.8	GO:0032391	photoreceptor connecting cilium(GO:0032391)

Showing 1 to 10 of 116 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	67.4	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1	14.1	GO:0008080	N-acetyltransferase activity(GO:0008080)
0.0	12.2	GO:0003713	transcription coactivator activity(GO:0003713)
0.1	11.8	GO:0043621	protein self-association(GO:0043621)
0.1	9.1	GO:0001105	RNA polymerase II transcription coactivator activity(GO:0001105)
0.4	8.3	GO:0070679	inositol 1,4,5 trisphosphate binding(GO:0070679)
0.4	8.2	GO:0048156	tau protein binding(GO:0048156)
0.8	7.5	GO:0070740	tubulin-glutamic acid ligase activity(GO:0070740)
2.1	6.4	GO:0052857	NADHX epimerase activity(GO:0052856) NADPHX epimerase activity(GO:0052857)
0.7	6.3	GO:0004396	glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)

Showing 1 to 10 of 158 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	11.2	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.2	8.0	PID ARF 3PATHWAY	Arf1 pathway
0.1	4.3	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0	2.7	PID AP1 PATHWAY	AP-1 transcription factor network
0.0	2.7	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.0	2.2	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	2.2	PID E2F PATHWAY	E2F transcription factor network
0.0	2.1	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.0	2.1	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	2.0	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions

Showing 1 to 10 of 29 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	6.6	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	4.0	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0	3.7	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0	3.5	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.0	3.2	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.1	3.0	REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.0	2.6	REACTOME NUCLEAR SIGNALING BY ERBB4	Genes involved in Nuclear signaling by ERBB4
0.1	2.5	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1	2.5	REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER	Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0	2.5	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1

Showing 1 to 10 of 50 entries

Results for RFX7_RFX4_RFX1

Z-value: 3.70

Motif logo

Transcription factors associated with RFX7_RFX4_RFX1

Activity-expression correlation:

Activity profile of RFX7_RFX4_RFX1 motif

Sorted Z-values of RFX7_RFX4_RFX1 motif

No targets for RFX7_RFX4_RFX1

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX7_RFX4_RFX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: