ISMARA results: RORA

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for RORA

Z-value: 1.26

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Transcription factors associated with RORA

Gene Symbol	Gene ID	Gene Info
RORA Ensembl NCBI GeneCards UniProt	ENSG00000069667.11	RAR related orphan receptor A

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
RORA	hg19_v2_chr15_-_60884706_60884743	-0.89	1.5e-07	Click!

Activity profile of RORA motif

Sorted Z-values of RORA motif

No targets for RORA

Network of associatons between targets according to the STRING database.

First level regulatory network of RORA

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	4.0	GO:0007144	female meiosis I(GO:0007144)
0.1	2.9	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
0.1	2.7	GO:0030238	male sex determination(GO:0030238)
0.1	2.4	GO:0019532	oxalate transport(GO:0019532)
0.2	2.2	GO:0060414	aorta smooth muscle tissue morphogenesis(GO:0060414)
0.2	2.2	GO:0030091	protein repair(GO:0030091)
0.1	2.0	GO:0051599	response to hydrostatic pressure(GO:0051599)
0.1	1.9	GO:0042776	mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0	1.9	GO:0043403	skeletal muscle tissue regeneration(GO:0043403)
0.2	1.8	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)

Showing 1 to 10 of 76 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.7	GO:0000922	spindle pole(GO:0000922)
0.2	2.9	GO:0042788	polysomal ribosome(GO:0042788)
0.0	2.5	GO:0032154	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0	2.0	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.2	1.9	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.4	1.8	GO:0042721	mitochondrial inner membrane protein insertion complex(GO:0042721)
0.1	1.3	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.4	1.2	GO:0002947	tumor necrosis factor receptor superfamily complex(GO:0002947)
0.0	1.2	GO:0031616	spindle pole centrosome(GO:0031616)
0.0	1.2	GO:0005665	DNA-directed RNA polymerase II, core complex(GO:0005665)

Showing 1 to 10 of 41 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.2	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)
0.4	2.9	GO:0008269	JAK pathway signal transduction adaptor activity(GO:0008269)
0.1	2.9	GO:0000217	DNA secondary structure binding(GO:0000217)
0.1	2.5	GO:0050786	RAGE receptor binding(GO:0050786)
0.0	2.5	GO:0051087	chaperone binding(GO:0051087)
0.1	2.4	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
0.3	2.2	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.2	2.2	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.7	2.1	GO:0033867	Fas-activated serine/threonine kinase activity(GO:0033867)
0.0	2.0	GO:0097110	scaffold protein binding(GO:0097110)

Showing 1 to 10 of 67 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	4.0	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1	2.9	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.0	2.4	PID IL2 1PATHWAY	IL2-mediated signaling events
0.0	2.3	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.0	2.2	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	1.7	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.0	1.5	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.0	1.4	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.0	1.3	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	1.2	PID TNF PATHWAY	TNF receptor signaling pathway

Showing 1 to 10 of 18 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.0	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0	3.1	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	2.5	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.0	2.4	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.0	2.2	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling
0.1	1.9	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.0	1.8	REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	Genes involved in p75 NTR receptor-mediated signalling
0.1	1.7	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0	1.6	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.1	1.0	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway

Showing 1 to 10 of 25 entries

Results for RORA

Z-value: 1.26

Motif logo

Transcription factors associated with RORA

Activity-expression correlation:

Activity profile of RORA motif

Sorted Z-values of RORA motif

No targets for RORA

Network of associatons between targets according to the STRING database.

First level regulatory network of RORA

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: