ISMARA results: RUNX1

Project

avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

Navigation

Downloads

Results for RUNX1_RUNX2

Z-value: 2.41

Motif logo

Transcription factors associated with RUNX1_RUNX2

Gene Symbol	Gene ID	Gene Info
RUNX1 Ensembl NCBI GeneCards UniProt	ENSG00000159216.14	RUNX family transcription factor 1
RUNX2 Ensembl NCBI GeneCards UniProt	ENSG00000124813.16	RUNX family transcription factor 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
RUNX1	hg19_v2_chr21_-_36421535_36421610	-0.96	2.2e-11	Click!
RUNX2	hg19_v2_chr6_+_45296048_45296106	-0.90	6.4e-08	Click!

Activity profile of RUNX1_RUNX2 motif

Sorted Z-values of RUNX1_RUNX2 motif

No targets for RUNX1_RUNX2

Network of associatons between targets according to the STRING database.

First level regulatory network of RUNX1_RUNX2

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.9	16.7	GO:1901750	leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.7	14.5	GO:1990573	potassium ion import across plasma membrane(GO:1990573)
0.1	12.1	GO:0002223	stimulatory C-type lectin receptor signaling pathway(GO:0002223)
3.2	9.6	GO:2000502	negative regulation of natural killer cell chemotaxis(GO:2000502)
0.1	9.6	GO:0050999	regulation of nitric-oxide synthase activity(GO:0050999)
0.4	9.2	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.9	8.3	GO:0046618	drug export(GO:0046618)
0.7	8.0	GO:0030259	lipid glycosylation(GO:0030259)
1.8	7.2	GO:2000866	positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.9	7.2	GO:0050653	chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)

Showing 1 to 10 of 577 entries

Gene overrepresentation in cellular_component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	37.4	GO:0005615	extracellular space(GO:0005615)
0.6	15.5	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.2	12.7	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.1	10.3	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.1	10.2	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.1	10.0	GO:0043202	lysosomal lumen(GO:0043202)
0.8	7.8	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.1	6.9	GO:0005844	polysome(GO:0005844)
0.4	6.5	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.1	6.3	GO:0005747	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)

Showing 1 to 10 of 191 entries

Gene overrepresentation in molecular_function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.9	16.7	GO:0036374	glutathione hydrolase activity(GO:0036374)
0.7	15.5	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
0.4	11.6	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.3	11.5	GO:0005520	insulin-like growth factor binding(GO:0005520)
1.4	8.4	GO:0015307	drug:proton antiporter activity(GO:0015307)
1.6	8.2	GO:0003947	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity(GO:0003947)
0.1	8.0	GO:0017075	syntaxin-1 binding(GO:0017075)
0.2	7.8	GO:0051787	misfolded protein binding(GO:0051787)
1.0	7.2	GO:0008955	peptidoglycan glycosyltransferase activity(GO:0008955)
0.1	6.6	GO:0005245	voltage-gated calcium channel activity(GO:0005245)

Showing 1 to 10 of 334 entries

Gene overrepresentation in C2:CP category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	15.9	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	10.5	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0	9.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	8.2	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	6.1	PID IL12 2PATHWAY	IL12-mediated signaling events
0.0	5.2	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.1	5.0	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.1	5.0	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.1	4.8	PID AURORA B PATHWAY	Aurora B signaling
0.1	4.3	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions

Showing 1 to 10 of 62 entries

Gene overrepresentation in C2:CP:REACTOME category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	14.2	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.3	11.4	REACTOME ACTIVATION OF GENES BY ATF4	Genes involved in Activation of Genes by ATF4
0.3	10.6	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.1	8.6	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.4	8.5	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.2	7.9	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.3	7.8	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.1	7.8	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.2	7.4	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.1	7.2	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions

Showing 1 to 10 of 109 entries

Results for RUNX1_RUNX2

Z-value: 2.41

Motif logo

Transcription factors associated with RUNX1_RUNX2

Activity-expression correlation:

Activity profile of RUNX1_RUNX2 motif

Sorted Z-values of RUNX1_RUNX2 motif

No targets for RUNX1_RUNX2

Network of associatons between targets according to the STRING database.

First level regulatory network of RUNX1_RUNX2

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: