ISMARA results: RUNX3

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for RUNX3_BCL11A

Z-value: 2.32

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Transcription factors associated with RUNX3_BCL11A

Gene Symbol	Gene ID	Gene Info
RUNX3 Ensembl NCBI GeneCards UniProt	ENSG00000020633.14	RUNX family transcription factor 3
BCL11A Ensembl NCBI GeneCards UniProt	ENSG00000119866.16	BAF chromatin remodeling complex subunit BCL11A

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
BCL11A	hg19_v2_chr2_-_60780546_60780566	0.96	5.3e-11	Click!
RUNX3	hg19_v2_chr1_-_25291475_25291511	-0.95	1.9e-10	Click!

Activity profile of RUNX3_BCL11A motif

Sorted Z-values of RUNX3_BCL11A motif

No targets for RUNX3_BCL11A

Network of associatons between targets according to the STRING database.

First level regulatory network of RUNX3_BCL11A

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.6	18.5	GO:0001808	negative regulation of type IV hypersensitivity(GO:0001808)
1.4	18.5	GO:0002051	osteoblast fate commitment(GO:0002051)
3.7	14.6	GO:0007499	ectoderm and mesoderm interaction(GO:0007499)
0.6	10.9	GO:0043587	tongue morphogenesis(GO:0043587)
0.4	7.7	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1	7.4	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.5	7.3	GO:0010668	ectodermal cell differentiation(GO:0010668)
0.4	6.6	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
1.0	5.9	GO:0061343	cell adhesion involved in heart morphogenesis(GO:0061343)
0.2	5.7	GO:0032463	negative regulation of protein homooligomerization(GO:0032463)

Showing 1 to 10 of 183 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	18.1	GO:0000790	nuclear chromatin(GO:0000790)
0.1	11.2	GO:0005791	rough endoplasmic reticulum(GO:0005791)
0.1	9.3	GO:0045095	keratin filament(GO:0045095)
0.1	8.9	GO:0035097	histone methyltransferase complex(GO:0035097)
0.1	7.9	GO:0002102	podosome(GO:0002102)
1.8	7.3	GO:0034676	integrin alpha6-beta4 complex(GO:0034676)
0.2	5.8	GO:0005614	interstitial matrix(GO:0005614)
0.1	4.6	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.1	3.9	GO:0043205	microfibril(GO:0001527) fibril(GO:0043205)
0.0	3.9	GO:0072562	blood microparticle(GO:0072562)

Showing 1 to 10 of 73 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	20.9	GO:0043425	bHLH transcription factor binding(GO:0043425)
3.0	18.3	GO:0042015	interleukin-20 binding(GO:0042015)
0.9	14.6	GO:0097371	MDM2/MDM4 family protein binding(GO:0097371)
0.3	8.0	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.5	7.3	GO:0038132	neuregulin binding(GO:0038132)
0.2	7.1	GO:0032041	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.6	5.5	GO:0045545	syndecan binding(GO:0045545)
0.0	5.4	GO:0005518	collagen binding(GO:0005518)
0.0	4.8	GO:0004252	serine-type endopeptidase activity(GO:0004252)
1.5	4.5	GO:0003845	11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)

Showing 1 to 10 of 125 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	22.8	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.2	18.7	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.1	8.7	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.1	7.0	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.2	6.7	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	5.3	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.1	4.9	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.0	4.5	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.1	4.0	PID EPHB FWD PATHWAY	EPHB forward signaling
0.1	3.8	PID ARF6 PATHWAY	Arf6 signaling events

Showing 1 to 10 of 44 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	19.3	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2	8.5	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.1	7.1	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2	6.0	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	4.9	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.1	4.8	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.1	4.6	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.1	4.2	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.1	4.0	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.1	3.7	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade

Showing 1 to 10 of 48 entries

Results for RUNX3_BCL11A

Z-value: 2.32

Motif logo

Transcription factors associated with RUNX3_BCL11A

Activity-expression correlation:

Activity profile of RUNX3_BCL11A motif

Sorted Z-values of RUNX3_BCL11A motif

No targets for RUNX3_BCL11A

Network of associatons between targets according to the STRING database.

First level regulatory network of RUNX3_BCL11A

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: