avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

• Motif significance table
• Sample table
• Mean activities
• All promoters sorted by FOV

• Activity table
• Activity delta table
• Regulatory interactions
• Motifs sorted by significance
• Expression table
• Download the whole report

Gene Symbol	Gene ID	Gene Info
RXRA Links Ensembl NCBI GeneCards UniProt	ENSG00000186350.8	retinoid X receptor alpha
NR2F6 Links Ensembl NCBI GeneCards UniProt	ENSG00000160113.5	nuclear receptor subfamily 2 group F member 6
NR2C2 Links Ensembl NCBI GeneCards UniProt	ENSG00000177463.11	nuclear receptor subfamily 2 group C member 2

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NR2C2	hg19_v2_chr3_+_14989186_14989236	-0.84	3.0e-06	Click!
RXRA	hg19_v2_chr9_+_137298396_137298431	-0.76	8.8e-05	Click!
NR2F6	hg19_v2_chr19_-_17356697_17356762	0.37	1.0e-01	Click!

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Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.7	2.2	GO:0070902	mitochondrial tRNA pseudouridine synthesis(GO:0070902)
0.6	1.8	GO:0032581	ER-dependent peroxisome organization(GO:0032581)
0.4	1.4	GO:0000103	sulfate assimilation(GO:0000103)
0.4	1.8	GO:0009439	cyanate metabolic process(GO:0009439) cyanate catabolic process(GO:0009440)
0.3	2.2	GO:0010133	proline catabolic process to glutamate(GO:0010133)
0.3	0.9	GO:0002416	IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.3	0.9	GO:0019243	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.3	1.1	GO:1904106	protein localization to microvillus(GO:1904106)
0.3	0.8	GO:0046732	induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528)
0.3	0.8	GO:0002894	positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894)
0.2	0.7	GO:0009786	regulation of asymmetric cell division(GO:0009786)
0.2	0.7	GO:0080120	CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
0.2	2.4	GO:0098795	mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.2	0.8	GO:0030241	skeletal muscle myosin thick filament assembly(GO:0030241)
0.2	0.6	GO:0032917	polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.2	0.7	GO:1902445	regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
0.2	0.5	GO:0014876	response to injury involved in regulation of muscle adaptation(GO:0014876)
0.2	1.1	GO:0061143	alveolar primary septum development(GO:0061143)
0.2	3.5	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.2	0.2	GO:0050787	detoxification of mercury ion(GO:0050787)
0.2	0.8	GO:0032218	riboflavin transport(GO:0032218)
0.2	1.1	GO:1902162	mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.2	0.6	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.1	0.3	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.1	0.5	GO:0035262	gonad morphogenesis(GO:0035262)
0.1	0.7	GO:0001315	age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571)
0.1	3.1	GO:0032780	negative regulation of ATPase activity(GO:0032780)
0.1	0.4	GO:1904924	negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.1	0.5	GO:0033076	alkaloid catabolic process(GO:0009822) isoquinoline alkaloid metabolic process(GO:0033076) cellular organohalogen metabolic process(GO:0090345) cellular organofluorine metabolic process(GO:0090346)
0.1	2.5	GO:0010764	negative regulation of fibroblast migration(GO:0010764)
0.1	0.3	GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.1	0.8	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.1	0.3	GO:1904247	positive regulation of polynucleotide adenylyltransferase activity(GO:1904247)
0.1	0.5	GO:0090341	negative regulation of secretion of lysosomal enzymes(GO:0090341)
0.1	0.3	GO:2000395	regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
0.1	0.4	GO:0046882	negative regulation of B cell differentiation(GO:0045578) negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.1	1.2	GO:0006657	CDP-choline pathway(GO:0006657)
0.1	0.6	GO:0036309	protein localization to M-band(GO:0036309)
0.1	0.3	GO:0035674	tricarboxylic acid transmembrane transport(GO:0035674)
0.1	0.6	GO:2000418	positive regulation of eosinophil migration(GO:2000418)
0.1	1.7	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1	1.1	GO:1903608	protein localization to cytoplasmic stress granule(GO:1903608)
0.1	0.4	GO:0021849	neuroblast division in subventricular zone(GO:0021849)
0.1	1.3	GO:0046322	negative regulation of fatty acid oxidation(GO:0046322)
0.1	1.6	GO:0045023	G0 to G1 transition(GO:0045023)
0.1	0.3	GO:1901842	negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1	0.1	GO:2000124	regulation of endocannabinoid signaling pathway(GO:2000124)
0.1	0.5	GO:1903659	regulation of complement-dependent cytotoxicity(GO:1903659)
0.1	0.3	GO:1903939	regulation of TORC2 signaling(GO:1903939)
0.1	0.7	GO:0060754	positive regulation of mast cell chemotaxis(GO:0060754)
0.1	0.2	GO:0060730	regulation of intestinal epithelial structure maintenance(GO:0060730)
0.1	1.8	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.1	0.3	GO:1990926	short-term synaptic potentiation(GO:1990926)
0.1	0.2	GO:0006147	guanine catabolic process(GO:0006147)
0.1	0.8	GO:0017062	respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.1	1.5	GO:0033617	mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1	0.1	GO:0036324	vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
0.1	0.1	GO:2000157	regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) negative regulation of ubiquitin-specific protease activity(GO:2000157)
0.1	0.3	GO:2000314	regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314)
0.1	0.3	GO:0071348	cellular response to interleukin-11(GO:0071348)
0.1	0.3	GO:0032571	response to vitamin K(GO:0032571)
0.1	0.3	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1	0.6	GO:0006572	tyrosine catabolic process(GO:0006572)
0.1	0.3	GO:0021538	epithalamus development(GO:0021538) habenula development(GO:0021986)
0.1	0.5	GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.1	0.4	GO:0010726	positive regulation of hydrogen peroxide metabolic process(GO:0010726)
0.1	0.8	GO:0045059	positive thymic T cell selection(GO:0045059)
0.1	0.2	GO:0070574	cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.1	0.4	GO:0006680	glucosylceramide catabolic process(GO:0006680)
0.1	0.5	GO:0015793	glycerol transport(GO:0015793)
0.1	0.3	GO:0090611	ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.1	0.9	GO:0071550	death-inducing signaling complex assembly(GO:0071550)
0.1	0.8	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.1	0.1	GO:2000532	renal albumin absorption(GO:0097018) regulation of renal albumin absorption(GO:2000532)
0.1	0.6	GO:0036155	acylglycerol acyl-chain remodeling(GO:0036155)
0.1	1.1	GO:0006853	carnitine shuttle(GO:0006853)
0.0	0.3	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.0	0.4	GO:0014807	regulation of somitogenesis(GO:0014807)
0.0	0.2	GO:0006669	sphinganine-1-phosphate biosynthetic process(GO:0006669)
0.0	0.2	GO:0034255	nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250)
0.0	0.2	GO:0044550	melanin metabolic process(GO:0006582) melanin biosynthetic process(GO:0042438) secondary metabolite biosynthetic process(GO:0044550)
0.0	0.2	GO:0060024	rhythmic synaptic transmission(GO:0060024) positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.0	0.2	GO:2001178	mediator complex assembly(GO:0036034) regulation of mediator complex assembly(GO:2001176) positive regulation of mediator complex assembly(GO:2001178)
0.0	0.3	GO:0006438	valyl-tRNA aminoacylation(GO:0006438)
0.0	1.6	GO:0042776	mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0	0.7	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0	0.5	GO:1900029	positive regulation of ruffle assembly(GO:1900029)
0.0	0.4	GO:2001300	lipoxin metabolic process(GO:2001300)
0.0	0.1	GO:1904640	response to methionine(GO:1904640)
0.0	0.9	GO:0036158	outer dynein arm assembly(GO:0036158)
0.0	0.2	GO:1904100	regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
0.0	0.2	GO:1902896	terminal web assembly(GO:1902896)
0.0	0.7	GO:0072015	glomerular visceral epithelial cell development(GO:0072015)
0.0	0.2	GO:0006287	base-excision repair, gap-filling(GO:0006287)
0.0	0.4	GO:0019367	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.2	GO:2000546	positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.0	0.2	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.0	0.3	GO:0046604	positive regulation of mitotic centrosome separation(GO:0046604)
0.0	0.4	GO:0034427	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427)
0.0	0.7	GO:0060124	positive regulation of growth hormone secretion(GO:0060124)
0.0	0.4	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951) positive regulation of inclusion body assembly(GO:0090261)
0.0	0.1	GO:0031630	regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.0	0.5	GO:1904714	regulation of chaperone-mediated autophagy(GO:1904714)
0.0	0.2	GO:0031914	negative regulation of synaptic plasticity(GO:0031914)
0.0	0.4	GO:0070863	positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.0	0.3	GO:0001554	luteolysis(GO:0001554)
0.0	0.2	GO:0033132	negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0	0.3	GO:0002943	tRNA dihydrouridine synthesis(GO:0002943)
0.0	0.2	GO:0030421	defecation(GO:0030421)
0.0	0.7	GO:0050965	detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0	0.3	GO:0015911	plasma membrane long-chain fatty acid transport(GO:0015911)
0.0	0.2	GO:1902499	positive regulation of protein autoubiquitination(GO:1902499)
0.0	1.8	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0	0.3	GO:0016998	cell wall macromolecule catabolic process(GO:0016998)
0.0	0.3	GO:0051106	positive regulation of DNA ligation(GO:0051106)
0.0	0.1	GO:1903348	positive regulation of bicellular tight junction assembly(GO:1903348)
0.0	0.3	GO:0016188	synaptic vesicle maturation(GO:0016188) regulation of grooming behavior(GO:2000821)
0.0	0.1	GO:0007228	positive regulation of hh target transcription factor activity(GO:0007228)
0.0	1.1	GO:0032008	positive regulation of TOR signaling(GO:0032008)
0.0	0.9	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.1	GO:0006478	peptidyl-tyrosine sulfation(GO:0006478)
0.0	0.2	GO:0045541	negative regulation of cholesterol biosynthetic process(GO:0045541) positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716) negative regulation of cholesterol metabolic process(GO:0090206)
0.0	0.3	GO:0060736	prostate gland growth(GO:0060736)
0.0	0.4	GO:0010561	negative regulation of glycoprotein biosynthetic process(GO:0010561)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.3	GO:2000210	positive regulation of anoikis(GO:2000210)
0.0	0.2	GO:0023041	neuronal signal transduction(GO:0023041)
0.0	0.3	GO:2000427	positive regulation of apoptotic cell clearance(GO:2000427)
0.0	0.4	GO:0034356	NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.0	0.2	GO:1990928	response to amino acid starvation(GO:1990928)
0.0	0.4	GO:0006995	cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0	1.4	GO:0006636	unsaturated fatty acid biosynthetic process(GO:0006636)
0.0	0.7	GO:0036150	phosphatidylserine acyl-chain remodeling(GO:0036150)
0.0	0.1	GO:1901993	meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993)
0.0	0.1	GO:0046166	glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.0	0.3	GO:0051151	negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0	0.1	GO:0070475	rRNA base methylation(GO:0070475)
0.0	0.2	GO:0035608	protein deglutamylation(GO:0035608)
0.0	0.1	GO:0070781	arginine biosynthetic process via ornithine(GO:0042450) response to biotin(GO:0070781)
0.0	0.6	GO:0048025	negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.0	0.8	GO:0019731	antibacterial humoral response(GO:0019731)
0.0	0.2	GO:0099612	protein localization to axon(GO:0099612)
0.0	0.5	GO:0030214	hyaluronan catabolic process(GO:0030214)
0.0	0.3	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0	0.1	GO:0035565	regulation of pronephros size(GO:0035565) pronephric nephron tubule development(GO:0039020)
0.0	0.1	GO:0048205	COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0	0.0	GO:1990654	sebum secreting cell proliferation(GO:1990654)
0.0	0.4	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0	0.1	GO:0061152	trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.0	0.7	GO:0043403	skeletal muscle tissue regeneration(GO:0043403)
0.0	0.2	GO:0007625	grooming behavior(GO:0007625)
0.0	0.1	GO:0014809	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0	0.1	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.5	GO:0043968	histone H2A acetylation(GO:0043968)
0.0	0.9	GO:0033574	response to testosterone(GO:0033574)
0.0	0.0	GO:0000711	meiotic DNA repair synthesis(GO:0000711)
0.0	0.0	GO:0021938	ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938) notochord regression(GO:0060032)
0.0	0.1	GO:0021633	optic nerve structural organization(GO:0021633)
0.0	0.1	GO:0045586	regulation of gamma-delta T cell differentiation(GO:0045586)
0.0	0.0	GO:0070315	G1 to G0 transition involved in cell differentiation(GO:0070315)
0.0	0.1	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.0	0.1	GO:0015747	urate transport(GO:0015747)
0.0	0.0	GO:1903298	regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298)
0.0	1.9	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0	0.5	GO:0008334	histone mRNA metabolic process(GO:0008334)
0.0	0.3	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0	0.1	GO:0070560	protein secretion by platelet(GO:0070560)
0.0	0.3	GO:0030502	negative regulation of bone mineralization(GO:0030502)
0.0	1.3	GO:0070125	mitochondrial translational elongation(GO:0070125)
0.0	0.3	GO:0003416	endochondral bone growth(GO:0003416)
0.0	0.4	GO:0019432	triglyceride biosynthetic process(GO:0019432)
0.0	0.4	GO:0001556	oocyte maturation(GO:0001556)
0.0	0.3	GO:0045199	maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.0	0.1	GO:0006789	bilirubin conjugation(GO:0006789)
0.0	0.1	GO:0086018	regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373) SA node cell action potential(GO:0086015) SA node cell to atrial cardiac muscle cell signalling(GO:0086018)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	2.6	GO:0001405	presequence translocase-associated import motor(GO:0001405)
0.2	0.9	GO:0031251	PAN complex(GO:0031251)
0.2	0.8	GO:0036398	TCR signalosome(GO:0036398)
0.1	1.1	GO:0097165	nuclear stress granule(GO:0097165)
0.1	0.4	GO:0043512	inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.1	0.4	GO:0055087	Ski complex(GO:0055087)
0.1	0.9	GO:0005744	mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1	0.7	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.1	1.3	GO:0031931	TORC1 complex(GO:0031931)
0.1	1.5	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1	0.4	GO:0009897	external side of plasma membrane(GO:0009897)
0.1	0.6	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.1	0.9	GO:0036157	outer dynein arm(GO:0036157)
0.1	0.5	GO:0034715	pICln-Sm protein complex(GO:0034715)
0.1	0.7	GO:0061574	ASAP complex(GO:0061574)
0.1	0.7	GO:0033588	Elongator holoenzyme complex(GO:0033588)
0.1	0.8	GO:0005750	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.1	0.7	GO:0036056	filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1	0.4	GO:1990726	Lsm1-7-Pat1 complex(GO:1990726)
0.1	1.6	GO:0010369	chromocenter(GO:0010369)
0.1	0.4	GO:0005579	membrane attack complex(GO:0005579)
0.0	1.6	GO:0005763	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0	0.2	GO:0000839	Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0	0.2	GO:1990876	cytoplasmic side of nuclear pore(GO:1990876)
0.0	0.1	GO:0001534	radial spoke(GO:0001534)
0.0	2.4	GO:0031430	M band(GO:0031430)
0.0	0.1	GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0	0.3	GO:0070695	FHF complex(GO:0070695)
0.0	0.3	GO:1990111	spermatoproteasome complex(GO:1990111)
0.0	0.2	GO:0035370	UBC13-UEV1A complex(GO:0035370)
0.0	0.2	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.0	0.3	GO:0045252	oxoglutarate dehydrogenase complex(GO:0045252)
0.0	1.1	GO:0031231	integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0	0.9	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	2.4	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.0	0.3	GO:0016013	syntrophin complex(GO:0016013)
0.0	0.2	GO:1990769	proximal neuron projection(GO:1990769)
0.0	1.9	GO:0042645	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0	0.2	GO:0070435	Shc-EGFR complex(GO:0070435)
0.0	0.3	GO:0098839	postsynaptic density membrane(GO:0098839)
0.0	0.2	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	1.8	GO:0045271	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0	0.4	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	0.2	GO:0000801	central element(GO:0000801)
0.0	0.5	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	4.3	GO:0072562	blood microparticle(GO:0072562)
0.0	0.3	GO:0000815	ESCRT III complex(GO:0000815)
0.0	0.1	GO:0071595	Nem1-Spo7 phosphatase complex(GO:0071595)
0.0	0.3	GO:0042405	nuclear inclusion body(GO:0042405)
0.0	1.2	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0	0.3	GO:0000813	ESCRT I complex(GO:0000813)
0.0	0.4	GO:0035102	PRC1 complex(GO:0035102)
0.0	1.9	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.0	0.1	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.5	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.0	0.4	GO:0031528	microvillus membrane(GO:0031528)
0.0	1.4	GO:0005758	mitochondrial intermembrane space(GO:0005758)
0.0	0.1	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.0	0.2	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.9	GO:0001917	photoreceptor inner segment(GO:0001917)
0.0	2.5	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.0	0.1	GO:0071203	WASH complex(GO:0071203)
0.0	0.4	GO:0032839	dendrite cytoplasm(GO:0032839)
0.0	0.4	GO:0005640	nuclear outer membrane(GO:0005640)
0.0	0.2	GO:0032433	filopodium tip(GO:0032433)
0.0	0.3	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.5	GO:1902562	NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0	0.1	GO:0043196	varicosity(GO:0043196)
0.0	1.1	GO:0035580	specific granule lumen(GO:0035580)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.7	2.2	GO:0004730	pseudouridylate synthase activity(GO:0004730)
0.5	2.2	GO:0004657	proline dehydrogenase activity(GO:0004657)
0.4	1.2	GO:0004103	choline kinase activity(GO:0004103)
0.3	1.3	GO:0016784	3-mercaptopyruvate sulfurtransferase activity(GO:0016784)
0.3	0.9	GO:0004416	hydroxyacylglutathione hydrolase activity(GO:0004416)
0.3	0.8	GO:0047025	3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
0.2	0.5	GO:0004792	thiosulfate sulfurtransferase activity(GO:0004792)
0.2	1.3	GO:0016531	copper chaperone activity(GO:0016531)
0.2	0.6	GO:0004464	leukotriene-C4 synthase activity(GO:0004464)
0.2	1.4	GO:0050294	steroid sulfotransferase activity(GO:0050294)
0.2	0.8	GO:0005471	ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
0.2	0.6	GO:0004145	diamine N-acetyltransferase activity(GO:0004145)
0.2	0.9	GO:0019770	IgG receptor activity(GO:0019770)
0.2	0.8	GO:0032217	riboflavin transporter activity(GO:0032217)
0.2	1.2	GO:0004466	long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.1	0.6	GO:0031728	CCR3 chemokine receptor binding(GO:0031728)
0.1	1.7	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.1	0.8	GO:0051373	FATZ binding(GO:0051373)
0.1	1.0	GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.1	0.5	GO:0051431	corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.1	0.6	GO:0050252	retinol O-fatty-acyltransferase activity(GO:0050252)
0.1	0.7	GO:0043183	vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1	0.9	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095)
0.1	0.5	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.1	0.7	GO:0072345	NAADP-sensitive calcium-release channel activity(GO:0072345)
0.1	0.5	GO:0015254	glycerol channel activity(GO:0015254)
0.1	0.4	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.1	0.4	GO:0008112	nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.1	0.8	GO:0008121	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1	3.5	GO:0001848	complement binding(GO:0001848)
0.1	0.4	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.1	0.3	GO:0031812	G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1	0.4	GO:0004348	glucosylceramidase activity(GO:0004348)
0.1	0.4	GO:0016971	flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.1	0.4	GO:0023024	MHC class I protein complex binding(GO:0023024)
0.1	0.2	GO:0008892	guanine deaminase activity(GO:0008892)
0.1	0.6	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.1	0.6	GO:0004784	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1	0.5	GO:0032810	sterol response element binding(GO:0032810)
0.1	1.1	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.1	0.2	GO:0033981	D-dopachrome decarboxylase activity(GO:0033981)
0.1	1.0	GO:0003995	acyl-CoA dehydrogenase activity(GO:0003995)
0.1	0.3	GO:0070051	fibrinogen binding(GO:0070051)
0.1	0.2	GO:0000253	3-keto sterol reductase activity(GO:0000253)
0.1	0.4	GO:0034711	inhibin binding(GO:0034711)
0.1	1.5	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0	0.5	GO:0035877	death effector domain binding(GO:0035877)
0.0	0.2	GO:0008466	glycogenin glucosyltransferase activity(GO:0008466)
0.0	0.3	GO:0015142	citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0	0.1	GO:0098640	integrin binding involved in cell-matrix adhesion(GO:0098640)
0.0	0.2	GO:1902122	chenodeoxycholic acid binding(GO:1902122)
0.0	0.3	GO:0017077	oxidative phosphorylation uncoupler activity(GO:0017077)
0.0	0.7	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.3	GO:0004832	valine-tRNA ligase activity(GO:0004832)
0.0	0.3	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.8	GO:0070513	death domain binding(GO:0070513)
0.0	0.2	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.9	GO:0045504	dynein heavy chain binding(GO:0045504)
0.0	0.1	GO:0004611	phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.0	0.5	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.0	0.5	GO:0001103	RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0	0.4	GO:0009922	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0	0.2	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0	0.2	GO:0070095	fructose-6-phosphate binding(GO:0070095)
0.0	1.2	GO:0008143	poly(A) binding(GO:0008143)
0.0	0.2	GO:0004169	dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0	0.1	GO:0015227	acyl carnitine transmembrane transporter activity(GO:0015227)
0.0	0.3	GO:0009374	biotin carboxylase activity(GO:0004075) biotin binding(GO:0009374)
0.0	0.7	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0	1.8	GO:0050136	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0	0.2	GO:0097027	ubiquitin-protein transferase activator activity(GO:0097027)
0.0	0.4	GO:0030957	Tat protein binding(GO:0030957)
0.0	0.2	GO:0008481	sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.0	0.3	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.6	GO:0031432	titin binding(GO:0031432)
0.0	0.3	GO:0017150	tRNA dihydrouridine synthase activity(GO:0017150)
0.0	0.4	GO:0016500	protein-hormone receptor activity(GO:0016500)
0.0	0.1	GO:0004807	triose-phosphate isomerase activity(GO:0004807)
0.0	1.1	GO:0051183	vitamin transporter activity(GO:0051183)
0.0	1.5	GO:0030332	cyclin binding(GO:0030332)
0.0	0.7	GO:0035198	miRNA binding(GO:0035198)
0.0	0.2	GO:0016936	galactoside binding(GO:0016936)
0.0	0.3	GO:0003796	lysozyme activity(GO:0003796)
0.0	0.2	GO:0035727	lysophosphatidic acid binding(GO:0035727)
0.0	0.8	GO:0030275	LRR domain binding(GO:0030275)
0.0	0.2	GO:1990254	keratin filament binding(GO:1990254)
0.0	0.2	GO:0048408	epidermal growth factor binding(GO:0048408)
0.0	0.2	GO:0047498	calcium-dependent phospholipase A2 activity(GO:0047498)
0.0	0.7	GO:0035497	cAMP response element binding(GO:0035497)
0.0	0.1	GO:0008476	protein-tyrosine sulfotransferase activity(GO:0008476)
0.0	0.6	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.0	0.1	GO:0032393	MHC class I receptor activity(GO:0032393)
0.0	0.3	GO:0003910	DNA ligase (ATP) activity(GO:0003910)
0.0	2.0	GO:0005507	copper ion binding(GO:0005507)
0.0	0.9	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	2.2	GO:0048365	Rac GTPase binding(GO:0048365)
0.0	0.4	GO:0017070	U6 snRNA binding(GO:0017070)
0.0	0.2	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.1	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0	0.5	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.1	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0	0.1	GO:0035251	UDP-glucosyltransferase activity(GO:0035251)
0.0	0.7	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0	1.0	GO:0030507	spectrin binding(GO:0030507)
0.0	0.1	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.0	0.4	GO:0070330	aromatase activity(GO:0070330)
0.0	0.4	GO:0004535	poly(A)-specific ribonuclease activity(GO:0004535)
0.0	0.1	GO:0038052	RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0	0.1	GO:0036435	K48-linked polyubiquitin binding(GO:0036435)
0.0	0.2	GO:0005504	fatty acid binding(GO:0005504)
0.0	0.1	GO:0015501	glutamate:sodium symporter activity(GO:0015501)
0.0	0.3	GO:0098847	sequence-specific single stranded DNA binding(GO:0098847)
0.0	1.0	GO:0008173	RNA methyltransferase activity(GO:0008173)
0.0	0.4	GO:0032183	SUMO binding(GO:0032183)
0.0	0.1	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0	0.7	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0	0.2	GO:0008296	3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0	0.2	GO:0000182	rDNA binding(GO:0000182)
0.0	0.3	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.2	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.7	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	0.4	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0	0.3	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.0	0.3	GO:0043495	protein anchor(GO:0043495)
0.0	0.4	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.0	0.2	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.8	GO:0005080	protein kinase C binding(GO:0005080)
0.0	0.1	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0	0.1	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0	0.3	GO:0042288	MHC class I protein binding(GO:0042288)
0.0	0.6	GO:0003899	DNA-directed RNA polymerase activity(GO:0003899)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.1	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	0.7	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	0.8	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.0	3.0	SIG CHEMOTAXIS	Genes related to chemotaxis
0.0	2.1	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	0.5	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	1.2	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.0	2.6	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.0	0.9	PID TRAIL PATHWAY	TRAIL signaling pathway
0.0	0.2	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.0	0.7	ST GA13 PATHWAY	G alpha 13 Pathway
0.0	0.8	PID LKB1 PATHWAY	LKB1 signaling events
0.0	0.6	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	0.3	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	4.1	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.1	2.5	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1	1.1	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.1	1.5	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.1	2.2	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.0	0.9	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	1.4	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.0	2.0	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0	1.5	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.0	0.4	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.0	0.8	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	2.9	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.0	0.5	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.0	2.2	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.0	0.7	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.3	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0	0.7	REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0	0.5	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0	0.4	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
0.0	0.9	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	2.6	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	0.7	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.0	0.6	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.0	0.4	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.0	0.3	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.5	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	0.5	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	1.3	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.0	0.3	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.0	0.4	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.0	1.4	REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.0	1.0	REACTOME TRIGLYCERIDE BIOSYNTHESIS	Genes involved in Triglyceride Biosynthesis
0.0	0.3	REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA	Genes involved in Processing of Capped Intronless Pre-mRNA
0.0	0.2	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
0.0	0.3	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	1.9	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.0	1.2	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	0.2	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.0	0.3	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling