ISMARA results: SHOX

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SHOX

Z-value: 0.68

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Transcription factors associated with SHOX

Gene Symbol	Gene ID	Gene Info
SHOX Ensembl NCBI GeneCards UniProt	ENSG00000185960.8	short stature homeobox
SHOX Ensembl NCBI GeneCards UniProt	ENSGR0000185960.8	short stature homeobox

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SHOX	hg19_v2_chrX_+_591524_591542	-0.26	2.8e-01	Click!

Activity profile of SHOX motif

Sorted Z-values of SHOX motif

No targets for SHOX

Network of associatons between targets according to the STRING database.

First level regulatory network of SHOX

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.7	GO:0048935	peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0	1.3	GO:0006337	nucleosome disassembly(GO:0006337)
0.2	1.1	GO:0060809	mesodermal to mesenchymal transition involved in gastrulation(GO:0060809)
0.0	1.1	GO:0043555	regulation of translation in response to stress(GO:0043555)
0.1	1.0	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1	1.0	GO:0001887	selenium compound metabolic process(GO:0001887)
0.1	1.0	GO:0060022	hard palate development(GO:0060022)
0.1	1.0	GO:1901078	negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0	1.0	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.3	0.9	GO:0010621	negative regulation of transcription by transcription factor localization(GO:0010621) gall bladder development(GO:0061010)

Showing 1 to 10 of 110 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.3	GO:0045095	keratin filament(GO:0045095)
0.0	1.1	GO:0016235	aggresome(GO:0016235)
0.0	0.9	GO:0030669	clathrin-coated endocytic vesicle membrane(GO:0030669)
0.2	0.8	GO:0071547	piP-body(GO:0071547)
0.0	0.8	GO:0005640	nuclear outer membrane(GO:0005640)
0.2	0.7	GO:0031523	Myb complex(GO:0031523)
0.2	0.6	GO:0043614	multi-eIF complex(GO:0043614) translation preinitiation complex(GO:0070993) glial limiting end-foot(GO:0097451)
0.0	0.6	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	0.6	GO:0031089	platelet dense granule lumen(GO:0031089)
0.0	0.6	GO:0033276	transcription factor TFTC complex(GO:0033276)

Showing 1 to 10 of 46 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.6	GO:0008327	methyl-CpG binding(GO:0008327)
0.1	1.3	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	1.3	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.3	1.0	GO:0035248	alpha-1,4-N-acetylgalactosaminyltransferase activity(GO:0035248)
0.2	1.0	GO:0098626	methylselenol reductase activity(GO:0098625) methylseleninic acid reductase activity(GO:0098626)
0.0	1.0	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.0	1.0	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	1.0	GO:0001102	RNA polymerase II activating transcription factor binding(GO:0001102)
0.0	0.9	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.9	GO:0051371	muscle alpha-actinin binding(GO:0051371)

Showing 1 to 10 of 60 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
2.9	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
1.1	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
1.1	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
1.1	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
1.0	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.7	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.6	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.5	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.4	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.3	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway

Showing 1 to 10 of 11 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.3	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS	Genes involved in CREB phosphorylation through the activation of Ras
0.1	1.0	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.0	1.0	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	1.0	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.9	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0	0.7	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.6	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.0	0.6	REACTOME PERK REGULATED GENE EXPRESSION	Genes involved in PERK regulated gene expression
0.0	0.5	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.5	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling

Showing 1 to 10 of 20 entries

Results for SHOX

Z-value: 0.68

Motif logo

Transcription factors associated with SHOX

Activity-expression correlation:

Activity profile of SHOX motif

Sorted Z-values of SHOX motif

No targets for SHOX

Network of associatons between targets according to the STRING database.

First level regulatory network of SHOX

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: