ISMARA results: SIX5_SMARCC2

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SIX5_SMARCC2_HCFC1

Z-value: 1.91

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Transcription factors associated with SIX5_SMARCC2_HCFC1

Gene Symbol	Gene ID	Gene Info
SIX5 Ensembl NCBI GeneCards UniProt	ENSG00000177045.6	SIX homeobox 5
SMARCC2 Ensembl NCBI GeneCards UniProt	ENSG00000139613.7	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
HCFC1 Ensembl NCBI GeneCards UniProt	ENSG00000172534.9	host cell factor C1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SIX5	hg19_v2_chr19_-_46272462_46272562	0.78	4.4e-05	Click!
HCFC1	hg19_v2_chrX_-_153236819_153236978	0.77	6.9e-05	Click!
SMARCC2	hg19_v2_chr12_-_56583332_56583369	0.12	6.0e-01	Click!

Activity profile of SIX5_SMARCC2_HCFC1 motif

Sorted Z-values of SIX5_SMARCC2_HCFC1 motif

No targets for SIX5_SMARCC2_HCFC1

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX5_SMARCC2_HCFC1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	8.0	GO:0016579	protein deubiquitination(GO:0016579)
0.3	6.2	GO:1990001	inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
1.2	4.6	GO:0033499	galactose catabolic process via UDP-galactose(GO:0033499)
0.0	4.0	GO:0070125	mitochondrial translational elongation(GO:0070125)
0.2	3.0	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.2	3.0	GO:0006108	malate metabolic process(GO:0006108)
0.1	2.9	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	2.9	GO:0030433	ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.7	2.8	GO:0043137	DNA replication, removal of RNA primer(GO:0043137)
0.1	2.6	GO:0007220	Notch receptor processing(GO:0007220)

Showing 1 to 10 of 252 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.5	GO:0000922	spindle pole(GO:0000922)
0.2	3.4	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)
0.0	3.3	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.0	2.9	GO:0005762	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.3	2.6	GO:0032133	chromosome passenger complex(GO:0032133)
0.2	2.6	GO:0070765	gamma-secretase complex(GO:0070765)
0.0	2.5	GO:0070469	respiratory chain(GO:0070469)
0.1	2.4	GO:0031080	nuclear pore outer ring(GO:0031080)
0.7	2.2	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	2.2	GO:0042645	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)

Showing 1 to 10 of 122 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.8	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0	5.3	GO:0002039	p53 binding(GO:0002039)
0.2	4.6	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.7	3.0	GO:0047860	diiodophenylpyruvate reductase activity(GO:0047860)
0.2	2.6	GO:0097322	7SK snRNA binding(GO:0097322)
0.8	2.5	GO:0051908	double-stranded DNA 5'-3' exodeoxyribonuclease activity(GO:0051908)
0.2	2.3	GO:0019237	centromeric DNA binding(GO:0019237)
0.2	2.2	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	2.2	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.7	2.1	GO:0008309	double-stranded DNA exodeoxyribonuclease activity(GO:0008309)

Showing 1 to 10 of 161 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.1	PID AURORA B PATHWAY	Aurora B signaling
0.1	3.6	PID AURORA A PATHWAY	Aurora A signaling
0.0	3.0	ST GAQ PATHWAY	G alpha q Pathway
0.1	2.6	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.0	2.5	PID BARD1 PATHWAY	BARD1 signaling events
0.0	2.2	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.0	2.1	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	1.8	PID PLK1 PATHWAY	PLK1 signaling events
0.0	1.4	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	1.2	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks

Showing 1 to 10 of 21 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	12.1	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.1	4.5	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	3.5	REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6	Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.1	3.4	REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	Genes involved in NRIF signals cell death from the nucleus
0.1	3.3	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.0	3.2	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.1	2.2	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.1	2.2	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.1	2.1	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
0.1	2.0	REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	Genes involved in Synthesis of substrates in N-glycan biosythesis

Showing 1 to 10 of 56 entries

Results for SIX5_SMARCC2_HCFC1

Z-value: 1.91

Motif logo

Transcription factors associated with SIX5_SMARCC2_HCFC1

Activity-expression correlation:

Activity profile of SIX5_SMARCC2_HCFC1 motif

Sorted Z-values of SIX5_SMARCC2_HCFC1 motif

No targets for SIX5_SMARCC2_HCFC1

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX5_SMARCC2_HCFC1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: