ISMARA results: SOX10

Project

avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

Navigation

Downloads

Results for SOX10_SOX15

Z-value: 2.66

Motif logo

Transcription factors associated with SOX10_SOX15

Gene Symbol	Gene ID	Gene Info
SOX10 Ensembl NCBI GeneCards UniProt	ENSG00000100146.12	SRY-box transcription factor 10
SOX15 Ensembl NCBI GeneCards UniProt	ENSG00000129194.3	SRY-box transcription factor 15

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SOX15	hg19_v2_chr17_-_7493390_7493488	-0.81	1.3e-05	Click!
SOX10	hg19_v2_chr22_-_38380543_38380569	0.23	3.3e-01	Click!

Activity profile of SOX10_SOX15 motif

Sorted Z-values of SOX10_SOX15 motif

No targets for SOX10_SOX15

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX10_SOX15

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	18.3	GO:0010506	regulation of autophagy(GO:0010506)
2.4	9.5	GO:0048687	modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.0	9.1	GO:0007411	axon guidance(GO:0007411)
0.5	8.0	GO:1901898	negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.3	6.2	GO:0071786	endoplasmic reticulum tubular network organization(GO:0071786)
0.6	4.7	GO:1903026	negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.5	4.4	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.2	4.1	GO:0000920	cell separation after cytokinesis(GO:0000920)
0.2	4.1	GO:0070933	histone H4 deacetylation(GO:0070933)
0.1	3.8	GO:0060065	uterus development(GO:0060065)

Showing 1 to 10 of 198 entries

Gene overrepresentation in cellular_component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	8.8	GO:0005871	kinesin complex(GO:0005871)
0.0	7.5	GO:0036464	cytoplasmic ribonucleoprotein granule(GO:0036464)
0.2	6.2	GO:0071782	endoplasmic reticulum tubular network(GO:0071782)
0.1	6.2	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.2	5.8	GO:0000930	gamma-tubulin complex(GO:0000930)
0.0	4.6	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.1	4.1	GO:0035861	site of double-strand break(GO:0035861)
0.4	4.0	GO:0042382	paraspeckles(GO:0042382)
0.2	3.7	GO:0000815	ESCRT III complex(GO:0000815)
0.0	3.6	GO:0000777	condensed chromosome kinetochore(GO:0000777)

Showing 1 to 10 of 89 entries

Gene overrepresentation in molecular_function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	13.2	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810)
0.6	9.5	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.2	8.9	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1	8.6	GO:0003777	microtubule motor activity(GO:0003777)
0.0	7.4	GO:0004386	helicase activity(GO:0004386)
1.2	5.8	GO:0031849	olfactory receptor binding(GO:0031849)
0.2	5.5	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.1	5.3	GO:0003785	actin monomer binding(GO:0003785)
0.2	4.4	GO:0008432	JUN kinase binding(GO:0008432)
0.2	4.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)

Showing 1 to 10 of 129 entries

Gene overrepresentation in C2:CP category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.0	PID SHP2 PATHWAY	SHP2 signaling
0.2	6.7	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.3	6.6	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.2	5.5	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	5.4	PID AURORA B PATHWAY	Aurora B signaling
0.1	3.8	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.1	3.8	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	3.4	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.0	2.9	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.1	2.7	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development

Showing 1 to 10 of 33 entries

Gene overrepresentation in C2:CP:REACTOME category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	14.5	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.1	8.0	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.1	6.0	REACTOME KINESINS	Genes involved in Kinesins
0.0	4.6	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.1	4.4	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	3.7	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.1	3.3	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0	3.3	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.0	2.9	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.0	2.5	REACTOME TRAFFICKING OF AMPA RECEPTORS	Genes involved in Trafficking of AMPA receptors

Showing 1 to 10 of 47 entries

Results for SOX10_SOX15

Z-value: 2.66

Motif logo

Transcription factors associated with SOX10_SOX15

Activity-expression correlation:

Activity profile of SOX10_SOX15 motif

Sorted Z-values of SOX10_SOX15 motif

No targets for SOX10_SOX15

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX10_SOX15

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: