ISMARA results: SOX4

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SOX4

Z-value: 1.30

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Transcription factors associated with SOX4

Gene Symbol	Gene ID	Gene Info
SOX4 Ensembl NCBI GeneCards UniProt	ENSG00000124766.4	SRY-box transcription factor 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SOX4	hg19_v2_chr6_+_21593972_21594071	0.96	2.3e-11	Click!

Activity profile of SOX4 motif

Sorted Z-values of SOX4 motif

No targets for SOX4

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	13.4	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.3	12.0	GO:0031581	hemidesmosome assembly(GO:0031581)
0.1	6.6	GO:0010507	negative regulation of autophagy(GO:0010507)
0.6	5.6	GO:1903764	regulation of potassium ion export across plasma membrane(GO:1903764)
0.2	4.8	GO:0071850	mitotic cell cycle arrest(GO:0071850)
0.1	4.6	GO:0042744	hydrogen peroxide catabolic process(GO:0042744)
0.1	4.5	GO:0006376	mRNA splice site selection(GO:0006376)
0.8	4.0	GO:0043553	negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.6	3.4	GO:0018032	protein amidation(GO:0018032)
0.1	2.1	GO:0001573	ganglioside metabolic process(GO:0001573)

Showing 1 to 10 of 87 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	12.0	GO:0030056	hemidesmosome(GO:0030056)
0.2	6.5	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.4	5.6	GO:0097025	lateral loop(GO:0043219) MPP7-DLG1-LIN7 complex(GO:0097025)
0.3	4.1	GO:0030478	actin cap(GO:0030478)
0.0	3.1	GO:0043204	perikaryon(GO:0043204)
0.3	2.4	GO:0005587	collagen type IV trimer(GO:0005587)
0.7	2.1	GO:0034686	integrin alphav-beta8 complex(GO:0034686)
0.0	1.9	GO:0005814	centriole(GO:0005814)
0.0	1.8	GO:0015030	Cajal body(GO:0015030)
0.1	1.6	GO:0061700	GATOR2 complex(GO:0061700)

Showing 1 to 10 of 44 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	14.0	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.1	6.5	GO:0003743	translation initiation factor activity(GO:0003743)
0.4	5.6	GO:0097016	L27 domain binding(GO:0097016)
0.0	4.9	GO:0047485	protein N-terminus binding(GO:0047485)
0.9	4.5	GO:0005152	interleukin-1 receptor antagonist activity(GO:0005152)
0.1	4.5	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	4.4	GO:0004222	metalloendopeptidase activity(GO:0004222)
1.3	4.0	GO:0036313	phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.6	3.4	GO:0004504	peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.1	3.3	GO:0005523	tropomyosin binding(GO:0005523)

Showing 1 to 10 of 74 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	14.1	NABA COLLAGENS	Genes encoding collagen proteins
0.1	7.1	PID AURORA A PATHWAY	Aurora A signaling
0.1	5.5	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.1	5.2	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.0	3.8	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	2.9	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	1.9	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	1.9	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.0	1.9	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.0	1.5	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression

Showing 1 to 10 of 19 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	14.1	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	6.5	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.2	5.6	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.1	3.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	2.4	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.0	2.3	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.1	1.8	REACTOME ACYL CHAIN REMODELLING OF PE	Genes involved in Acyl chain remodelling of PE
0.0	1.7	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.0	1.4	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.0	1.1	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates

Showing 1 to 10 of 23 entries

Results for SOX4

Z-value: 1.30

Motif logo

Transcription factors associated with SOX4

Activity-expression correlation:

Activity profile of SOX4 motif

Sorted Z-values of SOX4 motif

No targets for SOX4

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: