ISMARA results: SP4

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SP4_PML

Z-value: 6.61

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Transcription factors associated with SP4_PML

Gene Symbol	Gene ID	Gene Info
SP4 Ensembl NCBI GeneCards UniProt	ENSG00000105866.9	Sp4 transcription factor
PML Ensembl NCBI GeneCards UniProt	ENSG00000140464.15	PML nuclear body scaffold

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SP4	hg19_v2_chr7_+_21467642_21467671	0.71	4.8e-04	Click!
PML	hg19_v2_chr15_+_74287118_74287144	-0.53	1.6e-02	Click!

Activity profile of SP4_PML motif

Sorted Z-values of SP4_PML motif

No targets for SP4_PML

Network of associatons between targets according to the STRING database.

First level regulatory network of SP4_PML

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	81.9	GO:0007052	mitotic spindle organization(GO:0007052)
0.7	41.1	GO:0060119	inner ear receptor cell development(GO:0060119)
0.7	34.7	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.7	34.0	GO:0030866	cortical actin cytoskeleton organization(GO:0030866)
1.4	32.7	GO:1903830	magnesium ion transmembrane transport(GO:1903830)
0.5	28.3	GO:0035329	hippo signaling(GO:0035329)
2.2	26.3	GO:0034465	response to carbon monoxide(GO:0034465)
1.1	25.6	GO:0032486	Rap protein signal transduction(GO:0032486)
0.5	25.4	GO:0051225	spindle assembly(GO:0051225)
3.5	24.3	GO:2000567	memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)

Showing 1 to 10 of 1,526 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	218.4	GO:0005829	cytosol(GO:0005829)
0.7	61.4	GO:0005876	spindle microtubule(GO:0005876)
0.4	61.0	GO:0000922	spindle pole(GO:0000922)
0.5	57.7	GO:0005901	caveola(GO:0005901)
0.1	55.9	GO:0005925	focal adhesion(GO:0005925)
0.3	52.9	GO:0005884	actin filament(GO:0005884)
0.2	44.8	GO:0000151	ubiquitin ligase complex(GO:0000151)
0.1	42.8	GO:0005759	mitochondrial matrix(GO:0005759)
1.0	38.6	GO:0097431	mitotic spindle pole(GO:0097431)
0.3	38.0	GO:0000775	chromosome, centromeric region(GO:0000775)

Showing 1 to 10 of 521 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	126.8	GO:0045296	cadherin binding(GO:0045296)
0.3	92.8	GO:0042393	histone binding(GO:0042393)
0.1	92.5	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.4	85.9	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.2	72.8	GO:0005096	GTPase activator activity(GO:0005096)
1.2	50.7	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.2	44.9	GO:0008017	microtubule binding(GO:0008017)
0.3	36.7	GO:0003777	microtubule motor activity(GO:0003777)
0.2	34.3	GO:0019208	phosphatase regulator activity(GO:0019208)
0.4	34.1	GO:0019003	GDP binding(GO:0019003)

Showing 1 to 10 of 881 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	71.4	PID PLK1 PATHWAY	PLK1 signaling events
0.9	68.9	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.9	64.0	PID NECTIN PATHWAY	Nectin adhesion pathway
0.6	57.5	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.6	53.4	PID ILK PATHWAY	Integrin-linked kinase signaling
0.4	52.1	PID E2F PATHWAY	E2F transcription factor network
0.6	47.8	PID AURORA B PATHWAY	Aurora B signaling
1.0	47.5	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.7	44.6	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.5	42.4	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2

Showing 1 to 10 of 125 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	109.3	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
1.2	62.2	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.6	52.1	REACTOME TRIGLYCERIDE BIOSYNTHESIS	Genes involved in Triglyceride Biosynthesis
1.4	46.1	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.9	45.5	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.1	42.7	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.4	42.6	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.7	35.3	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.4	35.3	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.9	34.4	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions

Showing 1 to 10 of 223 entries

Results for SP4_PML

Z-value: 6.61

Motif logo

Transcription factors associated with SP4_PML

Activity-expression correlation:

Activity profile of SP4_PML motif

Sorted Z-values of SP4_PML motif

No targets for SP4_PML

Network of associatons between targets according to the STRING database.

First level regulatory network of SP4_PML

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: