ISMARA results: SPDEF

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SPDEF

Z-value: 2.24

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Transcription factors associated with SPDEF

Gene Symbol	Gene ID	Gene Info
SPDEF Ensembl NCBI GeneCards UniProt	ENSG00000124664.6	SAM pointed domain containing ETS transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SPDEF	hg19_v2_chr6_-_34524049_34524091	-0.73	2.6e-04	Click!

Activity profile of SPDEF motif

Sorted Z-values of SPDEF motif

No targets for SPDEF

Network of associatons between targets according to the STRING database.

First level regulatory network of SPDEF

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	5.8	GO:0090168	Golgi reassembly(GO:0090168)
0.2	5.8	GO:1900364	negative regulation of mRNA polyadenylation(GO:1900364)
0.2	4.7	GO:0090110	cargo loading into COPII-coated vesicle(GO:0090110)
0.1	4.3	GO:0006968	cellular defense response(GO:0006968)
1.3	3.9	GO:0006043	glucosamine catabolic process(GO:0006043)
0.5	3.7	GO:0035977	protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)
0.4	3.4	GO:2000158	positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.7	3.3	GO:0001827	inner cell mass cell fate commitment(GO:0001827) inner cell mass cellular morphogenesis(GO:0001828)
0.3	3.3	GO:0097338	response to clozapine(GO:0097338)
0.1	3.3	GO:0048853	forebrain morphogenesis(GO:0048853)

Showing 1 to 10 of 120 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.7	GO:0016607	nuclear speck(GO:0016607)
0.0	5.8	GO:0072562	blood microparticle(GO:0072562)
0.2	5.2	GO:0030127	COPII vesicle coat(GO:0030127)
0.1	3.9	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
0.1	3.7	GO:0070822	Sin3-type complex(GO:0070822)
0.1	3.4	GO:0031597	cytosolic proteasome complex(GO:0031597)
0.0	3.4	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2	3.3	GO:0033018	sarcoplasmic reticulum lumen(GO:0033018)
0.1	3.3	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.3	3.2	GO:0033263	CORVET complex(GO:0033263)

Showing 1 to 10 of 75 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	9.0	GO:0008143	poly(A) binding(GO:0008143)
0.0	5.8	GO:0044325	ion channel binding(GO:0044325)
0.0	5.8	GO:0051015	actin filament binding(GO:0051015)
1.3	3.9	GO:0004342	glucosamine-6-phosphate deaminase activity(GO:0004342)
0.0	3.9	GO:0003743	translation initiation factor activity(GO:0003743)
0.2	3.7	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	3.7	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.1	3.6	GO:0030275	LRR domain binding(GO:0030275)
0.4	3.4	GO:0035800	deubiquitinase activator activity(GO:0035800)
0.1	3.4	GO:0070628	proteasome binding(GO:0070628)

Showing 1 to 10 of 86 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	9.0	PID IL3 PATHWAY	IL3-mediated signaling events
0.1	4.9	PID ERBB1 RECEPTOR PROXIMAL PATHWAY	EGF receptor (ErbB1) signaling pathway
0.0	3.7	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.0	3.0	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.0	2.8	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.1	2.7	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.0	2.5	PID IGF1 PATHWAY	IGF1 pathway
0.0	2.5	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.0	2.1	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	2.1	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly

Showing 1 to 10 of 24 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	5.8	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP
0.1	5.7	REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	Genes involved in TGF-beta receptor signaling activates SMADs
0.0	5.7	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.0	5.3	REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS	Genes involved in Class A/1 (Rhodopsin-like receptors)
0.2	4.7	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	3.9	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.2	3.7	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.1	3.4	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.1	3.3	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1	3.3	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo

Showing 1 to 10 of 38 entries

Results for SPDEF

Z-value: 2.24

Motif logo

Transcription factors associated with SPDEF

Activity-expression correlation:

Activity profile of SPDEF motif

Sorted Z-values of SPDEF motif

No targets for SPDEF

Network of associatons between targets according to the STRING database.

First level regulatory network of SPDEF

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: