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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for SPDEF
Z-value: 2.24
Motif logo
Transcription factors associated with SPDEF
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
SPDEF
|
ENSG00000124664.6 | SAM pointed domain containing ETS transcription factor |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SPDEF | hg19_v2_chr6_-_34524049_34524091 | -0.73 | 2.6e-04 | Click! |
Activity profile of SPDEF motif
Sorted Z-values of SPDEF motif
Network of associatons between targets according to the STRING database.
First level regulatory network of SPDEF
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 3.9 | GO:0006043 | glucosamine catabolic process(GO:0006043) |
| 0.8 | 3.0 | GO:1990502 | dense core granule maturation(GO:1990502) |
| 0.7 | 2.8 | GO:0046833 | snRNA export from nucleus(GO:0006408) positive regulation of RNA export from nucleus(GO:0046833) |
| 0.7 | 2.0 | GO:0002188 | translation reinitiation(GO:0002188) |
| 0.7 | 3.3 | GO:0001827 | inner cell mass cell fate commitment(GO:0001827) inner cell mass cellular morphogenesis(GO:0001828) |
| 0.6 | 2.4 | GO:0016333 | morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247) |
| 0.6 | 2.3 | GO:0042144 | vacuole fusion, non-autophagic(GO:0042144) |
| 0.6 | 2.9 | GO:0039534 | negative regulation of MDA-5 signaling pathway(GO:0039534) |
| 0.5 | 1.5 | GO:0003220 | left ventricular cardiac muscle tissue morphogenesis(GO:0003220) cell proliferation involved in heart valve morphogenesis(GO:0003249) regulation of cell proliferation involved in heart valve morphogenesis(GO:0003250) |
| 0.5 | 3.7 | GO:0035977 | protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382) |
| 0.5 | 1.4 | GO:2000646 | positive regulation of receptor catabolic process(GO:2000646) |
| 0.4 | 2.6 | GO:0033031 | positive regulation of neutrophil apoptotic process(GO:0033031) |
| 0.4 | 3.4 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.4 | 2.1 | GO:1901545 | cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545) |
| 0.4 | 1.2 | GO:0019085 | early viral transcription(GO:0019085) |
| 0.4 | 2.3 | GO:2001106 | regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106) |
| 0.4 | 1.8 | GO:2000843 | testosterone secretion(GO:0035936) regulation of testosterone secretion(GO:2000843) positive regulation of testosterone secretion(GO:2000845) |
| 0.4 | 2.9 | GO:0010836 | negative regulation of protein ADP-ribosylation(GO:0010836) |
| 0.3 | 2.3 | GO:2000676 | positive regulation of type B pancreatic cell apoptotic process(GO:2000676) |
| 0.3 | 3.3 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.3 | 5.8 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 0.3 | 1.2 | GO:0000915 | assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837) |
| 0.3 | 2.1 | GO:0016344 | meiotic chromosome movement towards spindle pole(GO:0016344) |
| 0.3 | 0.9 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
| 0.3 | 2.8 | GO:1902365 | regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846) |
| 0.3 | 1.1 | GO:0010980 | regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980) apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747) |
| 0.3 | 1.0 | GO:0006421 | asparaginyl-tRNA aminoacylation(GO:0006421) |
| 0.2 | 2.0 | GO:2000812 | regulation of barbed-end actin filament capping(GO:2000812) |
| 0.2 | 2.7 | GO:1901098 | positive regulation of autophagosome maturation(GO:1901098) |
| 0.2 | 1.0 | GO:0090149 | mitochondrial membrane fission(GO:0090149) |
| 0.2 | 0.7 | GO:0044313 | protein K6-linked deubiquitination(GO:0044313) |
| 0.2 | 1.4 | GO:0033512 | L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512) |
| 0.2 | 5.8 | GO:1900364 | negative regulation of mRNA polyadenylation(GO:1900364) |
| 0.2 | 4.7 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.2 | 2.1 | GO:0071896 | protein localization to adherens junction(GO:0071896) |
| 0.2 | 1.2 | GO:0051490 | negative regulation of filopodium assembly(GO:0051490) |
| 0.2 | 2.9 | GO:2000628 | production of siRNA involved in RNA interference(GO:0030422) regulation of miRNA metabolic process(GO:2000628) |
| 0.2 | 1.4 | GO:2000048 | negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048) |
| 0.2 | 0.5 | GO:0033385 | geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386) |
| 0.2 | 0.5 | GO:0043132 | coenzyme A transport(GO:0015880) coenzyme A transmembrane transport(GO:0035349) NAD transport(GO:0043132) adenosine 3',5'-bisphosphate transmembrane transport(GO:0071106) AMP transport(GO:0080121) |
| 0.2 | 0.5 | GO:0006667 | sphinganine metabolic process(GO:0006667) |
| 0.2 | 1.1 | GO:2000568 | memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568) |
| 0.1 | 0.9 | GO:0034959 | substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959) |
| 0.1 | 3.3 | GO:0048853 | forebrain morphogenesis(GO:0048853) |
| 0.1 | 2.0 | GO:1901838 | positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838) |
| 0.1 | 3.0 | GO:0060044 | negative regulation of cardiac muscle cell proliferation(GO:0060044) |
| 0.1 | 0.7 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
| 0.1 | 1.1 | GO:1901727 | positive regulation of histone deacetylase activity(GO:1901727) |
| 0.1 | 2.3 | GO:0016576 | histone dephosphorylation(GO:0016576) |
| 0.1 | 1.7 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
| 0.1 | 0.9 | GO:0006499 | N-terminal protein myristoylation(GO:0006499) |
| 0.1 | 0.9 | GO:0002326 | B cell lineage commitment(GO:0002326) immunoglobulin V(D)J recombination(GO:0033152) |
| 0.1 | 3.2 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.1 | 1.2 | GO:0045040 | protein import into mitochondrial outer membrane(GO:0045040) |
| 0.1 | 0.7 | GO:0010025 | wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166) |
| 0.1 | 1.0 | GO:0050859 | negative regulation of B cell receptor signaling pathway(GO:0050859) |
| 0.1 | 0.6 | GO:0097211 | response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211) |
| 0.1 | 0.4 | GO:1904116 | response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117) |
| 0.1 | 1.2 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 0.1 | 1.4 | GO:0031848 | protection from non-homologous end joining at telomere(GO:0031848) |
| 0.1 | 0.3 | GO:1903423 | positive regulation of synaptic vesicle endocytosis(GO:1900244) positive regulation of synaptic vesicle recycling(GO:1903423) |
| 0.1 | 2.5 | GO:0007172 | signal complex assembly(GO:0007172) |
| 0.1 | 0.9 | GO:0033210 | leptin-mediated signaling pathway(GO:0033210) |
| 0.1 | 1.3 | GO:0031937 | positive regulation of chromatin silencing(GO:0031937) |
| 0.1 | 0.8 | GO:0035542 | regulation of SNARE complex assembly(GO:0035542) |
| 0.1 | 0.7 | GO:0033088 | negative regulation of immature T cell proliferation in thymus(GO:0033088) |
| 0.1 | 1.2 | GO:1904424 | regulation of GTP binding(GO:1904424) |
| 0.1 | 0.5 | GO:0071651 | positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651) |
| 0.1 | 0.9 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.1 | 0.2 | GO:0072720 | response to dithiothreitol(GO:0072720) |
| 0.1 | 4.3 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.1 | 0.8 | GO:0043951 | negative regulation of cAMP-mediated signaling(GO:0043951) |
| 0.1 | 1.1 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 0.1 | 0.3 | GO:0016476 | regulation of embryonic cell shape(GO:0016476) |
| 0.1 | 0.6 | GO:1904153 | negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153) |
| 0.0 | 1.2 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
| 0.0 | 0.8 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.0 | 1.3 | GO:0034315 | regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315) |
| 0.0 | 0.1 | GO:0006121 | mitochondrial electron transport, succinate to ubiquinone(GO:0006121) |
| 0.0 | 0.2 | GO:0006447 | regulation of translational initiation by iron(GO:0006447) |
| 0.0 | 0.7 | GO:0018342 | protein prenylation(GO:0018342) prenylation(GO:0097354) |
| 0.0 | 0.8 | GO:0032211 | negative regulation of telomere maintenance via telomerase(GO:0032211) |
| 0.0 | 0.3 | GO:0070945 | neutrophil mediated killing of gram-negative bacterium(GO:0070945) |
| 0.0 | 0.6 | GO:0042177 | negative regulation of protein catabolic process(GO:0042177) |
| 0.0 | 0.4 | GO:0051415 | interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418) |
| 0.0 | 1.5 | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation(GO:0010800) |
| 0.0 | 3.2 | GO:0006383 | transcription from RNA polymerase III promoter(GO:0006383) |
| 0.0 | 0.9 | GO:0043562 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.0 | 0.6 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.0 | 1.0 | GO:0016558 | protein import into peroxisome matrix(GO:0016558) |
| 0.0 | 1.3 | GO:2000114 | regulation of establishment of cell polarity(GO:2000114) |
| 0.0 | 2.2 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
| 0.0 | 0.2 | GO:0000973 | posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973) |
| 0.0 | 1.4 | GO:0007194 | negative regulation of adenylate cyclase activity(GO:0007194) |
| 0.0 | 2.0 | GO:0000281 | mitotic cytokinesis(GO:0000281) |
| 0.0 | 2.1 | GO:1901998 | toxin transport(GO:1901998) |
| 0.0 | 0.2 | GO:1902162 | regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164) |
| 0.0 | 2.9 | GO:0006306 | DNA alkylation(GO:0006305) DNA methylation(GO:0006306) |
| 0.0 | 0.2 | GO:0002084 | protein depalmitoylation(GO:0002084) |
| 0.0 | 1.1 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.0 | 1.0 | GO:0048025 | negative regulation of mRNA splicing, via spliceosome(GO:0048025) |
| 0.0 | 1.5 | GO:0043001 | Golgi to plasma membrane protein transport(GO:0043001) |
| 0.0 | 1.3 | GO:0006829 | zinc II ion transport(GO:0006829) |
| 0.0 | 1.4 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.0 | 0.6 | GO:0006054 | N-acetylneuraminate metabolic process(GO:0006054) |
| 0.0 | 0.7 | GO:0036150 | phosphatidylserine acyl-chain remodeling(GO:0036150) |
| 0.0 | 0.7 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 0.0 | 0.7 | GO:0090383 | phagosome acidification(GO:0090383) |
| 0.0 | 0.5 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.0 | 1.2 | GO:0060976 | coronary vasculature development(GO:0060976) |
| 0.0 | 2.1 | GO:0045727 | positive regulation of translation(GO:0045727) |
| 0.0 | 0.2 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
| 0.0 | 0.7 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
| 0.0 | 0.1 | GO:0097113 | AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688) |
| 0.0 | 0.8 | GO:1903146 | regulation of mitophagy(GO:1903146) |
| 0.0 | 0.6 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
| 0.0 | 1.3 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 0.0 | 1.0 | GO:0001938 | positive regulation of endothelial cell proliferation(GO:0001938) |
| 0.0 | 1.7 | GO:0042633 | molting cycle(GO:0042303) hair cycle(GO:0042633) |
| 0.0 | 2.1 | GO:0019221 | cytokine-mediated signaling pathway(GO:0019221) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 3.0 | GO:0043614 | multi-eIF complex(GO:0043614) |
| 1.0 | 2.9 | GO:1903095 | microprocessor complex(GO:0070877) ribonuclease III complex(GO:1903095) |
| 0.7 | 2.8 | GO:0005846 | nuclear cap binding complex(GO:0005846) |
| 0.7 | 2.0 | GO:0034455 | t-UTP complex(GO:0034455) |
| 0.5 | 2.4 | GO:0042643 | actomyosin, actin portion(GO:0042643) |
| 0.5 | 2.9 | GO:0010370 | perinucleolar chromocenter(GO:0010370) |
| 0.3 | 3.2 | GO:0033263 | CORVET complex(GO:0033263) |
| 0.3 | 1.2 | GO:0071001 | U4/U6 snRNP(GO:0071001) |
| 0.3 | 2.8 | GO:0055028 | cortical microtubule(GO:0055028) |
| 0.2 | 2.9 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.2 | 3.3 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.2 | 1.5 | GO:0032444 | activin responsive factor complex(GO:0032444) |
| 0.2 | 5.2 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.2 | 2.7 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 0.2 | 3.2 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.2 | 0.5 | GO:0097441 | basilar dendrite(GO:0097441) |
| 0.1 | 0.9 | GO:0031302 | intrinsic component of endosome membrane(GO:0031302) |
| 0.1 | 3.4 | GO:0031597 | cytosolic proteasome complex(GO:0031597) |
| 0.1 | 2.1 | GO:0030478 | actin cap(GO:0030478) |
| 0.1 | 1.4 | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) |
| 0.1 | 3.3 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.1 | 2.1 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.1 | 1.4 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
| 0.1 | 0.6 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.1 | 2.1 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.1 | 3.7 | GO:0070822 | Sin3-type complex(GO:0070822) |
| 0.1 | 2.6 | GO:0090545 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.1 | 1.4 | GO:0070419 | nonhomologous end joining complex(GO:0070419) |
| 0.1 | 1.2 | GO:0090543 | Flemming body(GO:0090543) |
| 0.1 | 3.9 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
| 0.1 | 0.5 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
| 0.1 | 1.2 | GO:0098799 | outer mitochondrial membrane protein complex(GO:0098799) |
| 0.1 | 2.1 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.1 | 2.5 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.1 | 2.3 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.1 | 1.0 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.0 | 1.5 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.0 | 1.0 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.0 | 0.6 | GO:0000322 | storage vacuole(GO:0000322) |
| 0.0 | 2.0 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 0.4 | GO:0000923 | equatorial microtubule organizing center(GO:0000923) |
| 0.0 | 0.4 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.0 | 0.5 | GO:0031211 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
| 0.0 | 0.2 | GO:0071817 | MMXD complex(GO:0071817) |
| 0.0 | 0.3 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.0 | 0.1 | GO:0005749 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 0.0 | 0.7 | GO:0010369 | chromocenter(GO:0010369) |
| 0.0 | 1.1 | GO:0031304 | intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305) |
| 0.0 | 3.4 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 2.6 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 0.8 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.0 | 0.8 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.0 | 5.8 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 0.6 | GO:0042588 | zymogen granule(GO:0042588) |
| 0.0 | 0.8 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 0.8 | GO:0030867 | rough endoplasmic reticulum membrane(GO:0030867) |
| 0.0 | 0.6 | GO:0030686 | 90S preribosome(GO:0030686) |
| 0.0 | 0.5 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.0 | 0.8 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.0 | 2.6 | GO:0030054 | cell junction(GO:0030054) |
| 0.0 | 0.7 | GO:0033176 | proton-transporting V-type ATPase complex(GO:0033176) |
| 0.0 | 1.0 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 2.5 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 2.2 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 1.4 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 0.4 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.0 | 2.1 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.0 | 7.7 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 0.6 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 1.4 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.0 | 1.8 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 1.3 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 2.3 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 0.1 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 0.0 | 0.2 | GO:0030914 | STAGA complex(GO:0030914) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 3.9 | GO:0004342 | glucosamine-6-phosphate deaminase activity(GO:0004342) |
| 0.5 | 2.9 | GO:0032296 | ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296) |
| 0.4 | 3.4 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.4 | 1.1 | GO:1902271 | D3 vitamins binding(GO:1902271) |
| 0.4 | 1.1 | GO:0004174 | electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649) |
| 0.3 | 1.4 | GO:0016748 | succinyltransferase activity(GO:0016748) |
| 0.3 | 2.8 | GO:0000340 | RNA 7-methylguanosine cap binding(GO:0000340) |
| 0.2 | 3.7 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.2 | 0.7 | GO:0042134 | rRNA primary transcript binding(GO:0042134) |
| 0.2 | 9.0 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.2 | 0.9 | GO:0070644 | vitamin D response element binding(GO:0070644) |
| 0.2 | 2.9 | GO:0089720 | caspase binding(GO:0089720) |
| 0.2 | 0.6 | GO:0004968 | gonadotropin-releasing hormone receptor activity(GO:0004968) |
| 0.2 | 1.2 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
| 0.2 | 1.1 | GO:0023025 | MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030) |
| 0.2 | 2.1 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 0.2 | 0.5 | GO:0071077 | coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122) |
| 0.1 | 3.2 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.1 | 3.3 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 1.5 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.1 | 2.1 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
| 0.1 | 0.7 | GO:0080019 | fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019) |
| 0.1 | 1.5 | GO:0043199 | sulfate binding(GO:0043199) |
| 0.1 | 1.4 | GO:0035312 | 5'-3' exodeoxyribonuclease activity(GO:0035312) |
| 0.1 | 3.4 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.1 | 3.6 | GO:0030275 | LRR domain binding(GO:0030275) |
| 0.1 | 0.5 | GO:0004337 | dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337) |
| 0.1 | 1.1 | GO:0030620 | U2 snRNA binding(GO:0030620) |
| 0.1 | 3.0 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.1 | 1.4 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.1 | 0.6 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.1 | 0.8 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
| 0.1 | 0.9 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.1 | 3.3 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.1 | 0.7 | GO:0008318 | protein prenyltransferase activity(GO:0008318) |
| 0.1 | 0.9 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.1 | 2.5 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.1 | 0.7 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
| 0.1 | 0.5 | GO:1990405 | protein antigen binding(GO:1990405) |
| 0.1 | 0.5 | GO:0016454 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
| 0.1 | 1.3 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.1 | 0.2 | GO:0071207 | histone pre-mRNA stem-loop binding(GO:0071207) |
| 0.1 | 0.8 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.1 | 3.0 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 1.4 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.0 | 0.2 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.0 | 0.1 | GO:0008177 | succinate dehydrogenase (ubiquinone) activity(GO:0008177) |
| 0.0 | 2.9 | GO:0042162 | telomeric DNA binding(GO:0042162) |
| 0.0 | 1.4 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.0 | 3.9 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 2.0 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.0 | 3.3 | GO:0030331 | estrogen receptor binding(GO:0030331) |
| 0.0 | 0.9 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 1.6 | GO:0019706 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.0 | 0.2 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
| 0.0 | 3.7 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 0.6 | GO:0070567 | cytidylyltransferase activity(GO:0070567) |
| 0.0 | 1.4 | GO:0051721 | protein phosphatase 2A binding(GO:0051721) |
| 0.0 | 3.3 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.0 | 0.8 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
| 0.0 | 0.3 | GO:0010385 | double-stranded methylated DNA binding(GO:0010385) |
| 0.0 | 0.9 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.0 | 0.1 | GO:0031811 | G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812) |
| 0.0 | 5.8 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 1.9 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 1.8 | GO:0043621 | protein self-association(GO:0043621) |
| 0.0 | 3.0 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 5.8 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 1.7 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 2.9 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.0 | 1.9 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 1.0 | GO:0016875 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
| 0.0 | 0.2 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.0 | 0.9 | GO:0017046 | peptide hormone binding(GO:0017046) |
| 0.0 | 2.0 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.0 | 0.3 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.0 | 1.1 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.0 | 2.3 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.0 | 0.2 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.0 | 0.9 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.0 | 0.7 | GO:0004177 | aminopeptidase activity(GO:0004177) |
| 0.0 | 1.0 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 2.3 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 0.7 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.0 | 3.1 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.0 | 0.4 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.0 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.1 | 2.7 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.1 | 1.5 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.1 | 4.9 | PID ERBB1 RECEPTOR PROXIMAL PATHWAY | EGF receptor (ErbB1) signaling pathway |
| 0.0 | 2.5 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.0 | 1.4 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 1.8 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 3.7 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 2.1 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.1 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 2.8 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.8 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 2.5 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 2.1 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 1.2 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 1.2 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 0.7 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.5 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 0.9 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 3.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 2.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 0.9 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 0.9 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 0.8 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.8 | REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT | Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat |
| 0.2 | 3.7 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.2 | 2.1 | REACTOME DESTABILIZATION OF MRNA BY BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |
| 0.2 | 4.7 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.2 | 5.8 | REACTOME DESTABILIZATION OF MRNA BY KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 0.1 | 2.1 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.1 | 3.3 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 2.8 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.1 | 3.3 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 5.7 | REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS | Genes involved in TGF-beta receptor signaling activates SMADs |
| 0.1 | 3.4 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.1 | 2.1 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.1 | 2.9 | REACTOME MICRORNA MIRNA BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 0.1 | 2.0 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.1 | 1.4 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.1 | 0.8 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.1 | 1.4 | REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY | Genes involved in Adenylate cyclase inhibitory pathway |
| 0.1 | 2.9 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 1.6 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 0.5 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.0 | 2.3 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 0.5 | REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS | Genes involved in Regulation of Water Balance by Renal Aquaporins |
| 0.0 | 1.2 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.0 | 0.9 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.0 | 0.4 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.0 | 0.5 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.0 | 0.7 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.0 | 3.9 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 0.7 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.0 | 5.3 | REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
| 0.0 | 1.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 0.5 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 0.9 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 0.6 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 0.6 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 0.9 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 1.6 | REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.0 | 5.7 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |