ISMARA results: SREBF2

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SREBF2

Z-value: 1.38

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Transcription factors associated with SREBF2

Gene Symbol	Gene ID	Gene Info
SREBF2 Ensembl NCBI GeneCards UniProt	ENSG00000198911.7	sterol regulatory element binding transcription factor 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SREBF2	hg19_v2_chr22_+_42229100_42229146	-0.41	7.6e-02	Click!

Activity profile of SREBF2 motif

Sorted Z-values of SREBF2 motif

No targets for SREBF2

Network of associatons between targets according to the STRING database.

First level regulatory network of SREBF2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	8.4	GO:0051599	response to hydrostatic pressure(GO:0051599)
0.6	5.3	GO:0046618	drug export(GO:0046618)
0.1	3.8	GO:0032060	bleb assembly(GO:0032060)
0.3	3.6	GO:0014722	regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.0	3.1	GO:0030516	regulation of axon extension(GO:0030516)
0.0	2.7	GO:0035735	intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.1	2.1	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.3	2.0	GO:0019541	acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate metabolic process(GO:0019541) propionate biosynthetic process(GO:0019542)
0.0	2.0	GO:0030032	lamellipodium assembly(GO:0030032)
0.5	1.9	GO:1900154	regulation of bone trabecula formation(GO:1900154) negative regulation of bone trabecula formation(GO:1900155)

Showing 1 to 10 of 36 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	8.4	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.1	3.8	GO:0043218	compact myelin(GO:0043218)
0.1	3.6	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.0	2.7	GO:0097542	ciliary tip(GO:0097542)
0.2	1.9	GO:0035976	AP1 complex(GO:0035976)
0.4	1.3	GO:0009346	citrate lyase complex(GO:0009346)
0.2	1.0	GO:1990667	PCSK9-AnxA2 complex(GO:1990667)
0.0	1.0	GO:0000314	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1	0.9	GO:0000796	condensin complex(GO:0000796)
0.1	0.8	GO:0061689	tricellular tight junction(GO:0061689)

Showing 1 to 10 of 14 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	8.4	GO:0097110	scaffold protein binding(GO:0097110)
0.9	5.3	GO:0015307	drug:proton antiporter activity(GO:0015307)
0.8	4.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	3.0	GO:0019888	protein phosphatase regulator activity(GO:0019888)
0.0	2.4	GO:0003777	microtubule motor activity(GO:0003777)
0.1	2.1	GO:0008179	adenylate cyclase binding(GO:0008179)
0.3	2.0	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.2	1.9	GO:0016015	morphogen activity(GO:0016015)
0.0	1.9	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.0	1.6	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)

Showing 1 to 10 of 20 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	8.4	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.0	3.8	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.0	2.0	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	1.9	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0	1.9	PID BMP PATHWAY	BMP receptor signaling
0.0	1.8	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	1.6	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	1.2	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	0.9	PID AURORA B PATHWAY	Aurora B signaling
0.0	0.7	PID S1P S1P1 PATHWAY	S1P1 pathway

Showing 1 to 10 of 10 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	5.3	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.1	4.1	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.1	2.4	REACTOME KINESINS	Genes involved in Kinesins
0.1	2.0	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.0	1.6	REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	Genes involved in SHC1 events in ERBB4 signaling
0.0	0.4	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.0	0.3	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation

Showing 1 to 7 of 7 entries

Results for SREBF2

Z-value: 1.38

Motif logo

Transcription factors associated with SREBF2

Activity-expression correlation:

Activity profile of SREBF2 motif

Sorted Z-values of SREBF2 motif

No targets for SREBF2

Network of associatons between targets according to the STRING database.

First level regulatory network of SREBF2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: