ISMARA results: SRF

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SRF

Z-value: 2.83

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Transcription factors associated with SRF

Gene Symbol	Gene ID	Gene Info
SRF Ensembl NCBI GeneCards UniProt	ENSG00000112658.6	serum response factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SRF	hg19_v2_chr6_+_43139037_43139094	0.37	1.1e-01	Click!

Activity profile of SRF motif

Sorted Z-values of SRF motif

No targets for SRF

Network of associatons between targets according to the STRING database.

First level regulatory network of SRF

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
16.8	50.4	GO:0050720	regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) interleukin-1 beta biosynthetic process(GO:0050720)
0.9	9.5	GO:0038044	transforming growth factor-beta secretion(GO:0038044)
0.1	8.1	GO:0060512	prostate gland morphogenesis(GO:0060512)
0.8	6.9	GO:0001661	conditioned taste aversion(GO:0001661)
0.2	6.0	GO:0071481	cellular response to X-ray(GO:0071481)
0.1	5.9	GO:0031529	ruffle organization(GO:0031529)
0.1	4.8	GO:1901998	toxin transport(GO:1901998)
0.2	4.6	GO:0051412	response to corticosterone(GO:0051412)
0.7	4.3	GO:1900041	negative regulation of interleukin-2 secretion(GO:1900041)
0.5	4.3	GO:0007296	vitellogenesis(GO:0007296)

Showing 1 to 10 of 64 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	13.1	GO:0097517	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
3.2	9.5	GO:0034685	integrin alphav-beta6 complex(GO:0034685)
0.8	6.9	GO:0035976	AP1 complex(GO:0035976)
0.3	6.2	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.1	6.1	GO:0008023	transcription elongation factor complex(GO:0008023)
0.7	6.0	GO:0097129	cyclin D2-CDK4 complex(GO:0097129)
0.1	4.8	GO:0030131	clathrin adaptor complex(GO:0030131)
0.0	4.3	GO:0042734	presynaptic membrane(GO:0042734)
0.0	3.4	GO:0005796	Golgi lumen(GO:0005796)
0.0	3.1	GO:0005667	transcription factor complex(GO:0005667)

Showing 1 to 10 of 28 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
10.1	50.4	GO:0044729	hemi-methylated DNA-binding(GO:0044729)
0.1	10.2	GO:0001102	RNA polymerase II activating transcription factor binding(GO:0001102)
0.1	9.5	GO:0001618	virus receptor activity(GO:0001618)
0.1	8.1	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.1	5.9	GO:0003785	actin monomer binding(GO:0003785)
0.0	5.3	GO:0008307	structural constituent of muscle(GO:0008307)
0.0	5.1	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1	5.0	GO:0003700	transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.2	4.8	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.1	3.6	GO:0030507	spectrin binding(GO:0030507)

Showing 1 to 10 of 48 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	50.4	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.1	11.4	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.2	9.5	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.3	6.9	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.1	6.0	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	5.0	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.1	4.3	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	3.6	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.0	3.2	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1	3.0	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events

Showing 1 to 10 of 23 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	51.4	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.3	8.7	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	7.7	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.1	6.0	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	5.4	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0	4.7	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.1	4.1	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1	4.0	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.0	3.6	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.1	3.2	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions

Showing 1 to 10 of 22 entries

Results for SRF

Z-value: 2.83

Motif logo

Transcription factors associated with SRF

Activity-expression correlation:

Activity profile of SRF motif

Sorted Z-values of SRF motif

No targets for SRF

Network of associatons between targets according to the STRING database.

First level regulatory network of SRF

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: