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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for STAT4

Z-value: 1.48

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Transcription factors associated with STAT4

Gene Symbol Gene ID Gene Info
ENSG00000138378.13 signal transducer and activator of transcription 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
STAT4hg19_v2_chr2_-_192016316_1920163250.614.4e-03Click!

Activity profile of STAT4 motif

Sorted Z-values of STAT4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0060278 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.6 1.9 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.6 1.9 GO:0006429 leucyl-tRNA aminoacylation(GO:0006429)
0.6 3.4 GO:0033591 response to L-ascorbic acid(GO:0033591)
0.4 1.7 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.4 2.5 GO:0060574 intestinal epithelial cell maturation(GO:0060574)
0.4 3.7 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.3 2.1 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.3 1.2 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.2 1.2 GO:0006172 ADP biosynthetic process(GO:0006172)
0.2 0.9 GO:0000354 cis assembly of pre-catalytic spliceosome(GO:0000354)
0.2 0.6 GO:0016561 protein import into peroxisome matrix, translocation(GO:0016561)
0.2 1.2 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.2 0.8 GO:0032764 negative regulation of mast cell cytokine production(GO:0032764) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.2 11.3 GO:0060512 prostate gland morphogenesis(GO:0060512)
0.2 1.1 GO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947)
0.2 1.0 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.2 2.5 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.2 2.6 GO:0008090 retrograde axonal transport(GO:0008090)
0.2 0.8 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.1 0.4 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.1 1.0 GO:0007296 vitellogenesis(GO:0007296)
0.1 2.0 GO:0044351 macropinocytosis(GO:0044351)
0.1 0.5 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.1 1.0 GO:0003025 regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025) vagus nerve development(GO:0021564)
0.1 2.1 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.1 0.3 GO:1904604 regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904596) negative regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904597) regulation of advanced glycation end-product receptor activity(GO:1904603) negative regulation of advanced glycation end-product receptor activity(GO:1904604) negative regulation of connective tissue replacement(GO:1905204)
0.1 1.8 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.1 0.3 GO:0000711 meiotic DNA repair synthesis(GO:0000711)
0.1 1.2 GO:0009407 toxin catabolic process(GO:0009407) secondary metabolite catabolic process(GO:0090487)
0.1 0.4 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.1 2.0 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.1 0.5 GO:0045196 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.1 2.4 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.1 1.5 GO:0033623 regulation of integrin activation(GO:0033623)
0.1 0.7 GO:0007288 sperm axoneme assembly(GO:0007288)
0.1 0.8 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.1 0.4 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 0.9 GO:0001778 plasma membrane repair(GO:0001778)
0.1 0.7 GO:0035095 behavioral response to nicotine(GO:0035095)
0.1 0.8 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 1.4 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1 2.7 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.2 GO:0061114 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) optic placode formation involved in camera-type eye formation(GO:0046619) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.0 1.4 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 8.1 GO:1900181 negative regulation of protein localization to nucleus(GO:1900181)
0.0 0.6 GO:0099612 protein localization to axon(GO:0099612)
0.0 0.2 GO:0071469 detection of mechanical stimulus involved in sensory perception of touch(GO:0050976) cellular response to alkaline pH(GO:0071469)
0.0 0.8 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.5 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.0 0.3 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.4 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.5 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.1 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 0.3 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.3 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.3 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.0 0.1 GO:0071284 cellular response to lead ion(GO:0071284)
0.0 0.3 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.0 0.5 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 1.0 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.2 GO:0023021 termination of signal transduction(GO:0023021)
0.0 0.1 GO:0034334 adherens junction maintenance(GO:0034334)
0.0 0.5 GO:0098743 cell aggregation(GO:0098743)
0.0 0.2 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 0.3 GO:2000394 positive regulation of lamellipodium morphogenesis(GO:2000394)
0.0 0.6 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.1 GO:0061364 negative regulation of negative chemotaxis(GO:0050925) apoptotic process involved in luteolysis(GO:0061364)
0.0 1.9 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.2 GO:0044130 negative regulation of growth of symbiont in host(GO:0044130)
0.0 0.2 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.0 0.1 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.0 0.2 GO:0070777 gamma-aminobutyric acid biosynthetic process(GO:0009449) D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.1 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.3 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.1 GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049)
0.0 1.2 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 0.3 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.7 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.2 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.0 0.8 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.1 GO:0034201 response to oleic acid(GO:0034201)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0070557 PCNA-p21 complex(GO:0070557)
0.7 2.1 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.4 2.6 GO:0031673 H zone(GO:0031673)
0.2 1.9 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 0.6 GO:0032783 ELL-EAF complex(GO:0032783)
0.2 0.5 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.1 0.9 GO:0045298 tubulin complex(GO:0045298)
0.1 0.3 GO:0097441 basilar dendrite(GO:0097441)
0.1 1.2 GO:0033263 CORVET complex(GO:0033263)
0.1 0.6 GO:1990769 proximal neuron projection(GO:1990769)
0.1 3.4 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.1 0.3 GO:0034515 proteasome storage granule(GO:0034515)
0.1 2.1 GO:0043203 axon hillock(GO:0043203)
0.1 10.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.3 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.0 1.0 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.1 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.7 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.3 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.4 GO:0097470 ribbon synapse(GO:0097470)
0.0 0.1 GO:0002081 outer acrosomal membrane(GO:0002081)
0.0 0.7 GO:0042629 mast cell granule(GO:0042629)
0.0 0.5 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.2 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
0.0 0.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.4 GO:0043194 axon initial segment(GO:0043194)
0.0 1.1 GO:1990391 DNA repair complex(GO:1990391)
0.0 0.4 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 2.9 GO:0001650 fibrillar center(GO:0001650)
0.0 0.1 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.4 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.7 GO:0048786 presynaptic active zone(GO:0048786)
0.0 1.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.7 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.8 2.5 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.6 1.9 GO:0004823 leucine-tRNA ligase activity(GO:0004823)
0.4 2.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 10.4 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.2 1.2 GO:0050610 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
0.2 0.8 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.2 1.0 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.2 1.1 GO:0004522 ribonuclease A activity(GO:0004522)
0.1 0.4 GO:0032093 SAM domain binding(GO:0032093)
0.1 0.7 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 0.3 GO:1904599 advanced glycation end-product binding(GO:1904599)
0.1 1.9 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.1 0.8 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.1 2.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 5.9 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.1 0.8 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 11.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 2.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.3 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.1 0.2 GO:0098782 mechanically-gated potassium channel activity(GO:0098782)
0.1 1.2 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 1.9 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.6 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 0.5 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.1 0.5 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.1 1.5 GO:0031005 filamin binding(GO:0031005)
0.0 0.4 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.1 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 3.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.8 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.7 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848) acetylcholine binding(GO:0042166)
0.0 1.1 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 2.5 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.1 GO:1904854 proteasome core complex binding(GO:1904854)
0.0 0.2 GO:0043426 MRF binding(GO:0043426)
0.0 2.3 GO:0050681 androgen receptor binding(GO:0050681)
0.0 0.4 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 0.6 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.2 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.1 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.2 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.3 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.7 GO:0005123 death receptor binding(GO:0005123)
0.0 0.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.3 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 1.1 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.2 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 0.1 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.0 0.8 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.3 GO:0015172 L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172)
0.0 0.4 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 0.1 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 2.1 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.3 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.7 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.3 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 1.0 GO:0033558 histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558)
0.0 2.0 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 0.2 GO:0005522 profilin binding(GO:0005522)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 17.2 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 2.1 ST JAK STAT PATHWAY Jak-STAT Pathway
0.1 4.4 PID IL1 PATHWAY IL1-mediated signaling events
0.0 2.8 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 3.9 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 2.1 PID ALK1 PATHWAY ALK1 signaling events
0.0 1.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 2.5 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.2 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 1.9 PID LKB1 PATHWAY LKB1 signaling events
0.0 3.0 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.2 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.0 0.8 PID FOXO PATHWAY FoxO family signaling
0.0 0.8 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 0.2 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.4 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.0 0.9 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.9 PID PLK1 PATHWAY PLK1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.1 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 2.5 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 2.7 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.1 1.9 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.1 2.7 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 1.9 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 4.4 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 1.6 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 2.1 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.8 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.7 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 1.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.8 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 1.2 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 1.0 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 1.2 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 1.2 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.2 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.9 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.3 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.0 0.2 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.2 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.3 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation