ISMARA results: STAT4

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for STAT4

Z-value: 1.48

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Transcription factors associated with STAT4

Gene Symbol	Gene ID	Gene Info
STAT4 Ensembl NCBI GeneCards UniProt	ENSG00000138378.13	signal transducer and activator of transcription 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
STAT4	hg19_v2_chr2_-_192016316_192016325	0.61	4.4e-03	Click!

Activity profile of STAT4 motif

Sorted Z-values of STAT4 motif

No targets for STAT4

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	11.3	GO:0060512	prostate gland morphogenesis(GO:0060512)
0.0	8.1	GO:1900181	negative regulation of protein localization to nucleus(GO:1900181)
0.4	3.7	GO:2000660	negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.6	3.4	GO:0033591	response to L-ascorbic acid(GO:0033591)
0.1	2.7	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.2	2.6	GO:0008090	retrograde axonal transport(GO:0008090)
0.4	2.5	GO:0060574	intestinal epithelial cell maturation(GO:0060574)
0.2	2.5	GO:0018026	peptidyl-lysine monomethylation(GO:0018026)
0.1	2.4	GO:0046339	diacylglycerol metabolic process(GO:0046339)
0.7	2.1	GO:0060278	regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)

Showing 1 to 10 of 82 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	10.2	GO:0005913	cell-cell adherens junction(GO:0005913)
0.1	3.4	GO:0071682	endocytic vesicle lumen(GO:0071682)
0.0	2.9	GO:0001650	fibrillar center(GO:0001650)
0.4	2.6	GO:0031673	H zone(GO:0031673)
0.8	2.5	GO:0070557	PCNA-p21 complex(GO:0070557)
0.7	2.1	GO:0043511	inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.1	2.1	GO:0043203	axon hillock(GO:0043203)
0.2	1.9	GO:0097442	CA3 pyramidal cell dendrite(GO:0097442)
0.1	1.2	GO:0033263	CORVET complex(GO:0033263)
0.0	1.2	GO:0005758	mitochondrial intermembrane space(GO:0005758)

Showing 1 to 10 of 33 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	11.3	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.2	10.4	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1	5.9	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
1.2	3.7	GO:0005150	interleukin-1, Type I receptor binding(GO:0005150)
0.0	3.7	GO:0050840	extracellular matrix binding(GO:0050840)
0.1	2.6	GO:0051010	microtubule plus-end binding(GO:0051010)
0.8	2.5	GO:0019912	cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.0	2.5	GO:0018024	histone-lysine N-methyltransferase activity(GO:0018024)
0.1	2.4	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.0	2.3	GO:0050681	androgen receptor binding(GO:0050681)

Showing 1 to 10 of 61 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	17.2	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	4.4	PID IL1 PATHWAY	IL1-mediated signaling events
0.0	3.9	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	3.0	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	2.8	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	2.5	PID P53 REGULATION PATHWAY	p53 pathway
0.2	2.1	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.0	2.1	PID ALK1 PATHWAY	ALK1 signaling events
0.0	1.9	PID LKB1 PATHWAY	LKB1 signaling events
0.0	1.6	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III

Showing 1 to 10 of 18 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.4	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.1	2.7	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.1	2.7	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.1	2.5	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.2	2.1	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.0	2.1	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling
0.1	1.9	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism
0.1	1.9	REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	Genes involved in Mitochondrial tRNA aminoacylation
0.0	1.8	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	1.6	REACTOME PIP3 ACTIVATES AKT SIGNALING	Genes involved in PIP3 activates AKT signaling

Showing 1 to 10 of 23 entries

Results for STAT4

Z-value: 1.48

Motif logo

Transcription factors associated with STAT4

Activity-expression correlation:

Activity profile of STAT4 motif

Sorted Z-values of STAT4 motif

No targets for STAT4

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: