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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for TBP
Z-value: 8.00
Motif logo
Transcription factors associated with TBP
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
TBP
|
ENSG00000112592.8 | TATA-box binding protein |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBP | hg19_v2_chr6_+_170863421_170863484 | -0.56 | 1.0e-02 | Click! |
Activity profile of TBP motif
Sorted Z-values of TBP motif
Network of associatons between targets according to the STRING database.
First level regulatory network of TBP
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.1 | 48.5 | GO:0006542 | glutamine biosynthetic process(GO:0006542) |
| 10.8 | 32.3 | GO:0035606 | peptidyl-cysteine S-trans-nitrosylation(GO:0035606) |
| 5.2 | 26.1 | GO:0015688 | iron chelate transport(GO:0015688) siderophore transport(GO:0015891) |
| 4.6 | 9.1 | GO:1900155 | regulation of bone trabecula formation(GO:1900154) negative regulation of bone trabecula formation(GO:1900155) |
| 3.9 | 15.4 | GO:0060474 | positive regulation of sperm motility involved in capacitation(GO:0060474) |
| 3.8 | 11.4 | GO:0002541 | activation of plasma proteins involved in acute inflammatory response(GO:0002541) |
| 3.3 | 20.0 | GO:1902957 | negative regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902957) |
| 3.3 | 16.5 | GO:0018262 | isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262) |
| 3.2 | 32.2 | GO:0090191 | negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191) |
| 3.2 | 9.6 | GO:2000974 | auditory receptor cell fate determination(GO:0042668) cell-cell signaling involved in cell fate commitment(GO:0045168) negative regulation of auditory receptor cell differentiation(GO:0045608) regulation of timing of neuron differentiation(GO:0060164) negative regulation of pro-B cell differentiation(GO:2000974) |
| 3.0 | 12.0 | GO:0035425 | autocrine signaling(GO:0035425) |
| 2.8 | 8.4 | GO:0001798 | positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894) |
| 2.8 | 44.5 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
| 2.2 | 6.7 | GO:0060278 | regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279) |
| 2.1 | 2.1 | GO:1904666 | regulation of ubiquitin protein ligase activity(GO:1904666) positive regulation of ubiquitin protein ligase activity(GO:1904668) |
| 2.0 | 18.1 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 2.0 | 32.0 | GO:0043587 | tongue morphogenesis(GO:0043587) |
| 1.8 | 10.5 | GO:0097368 | establishment of Sertoli cell barrier(GO:0097368) |
| 1.7 | 5.2 | GO:0060323 | body morphogenesis(GO:0010171) head morphogenesis(GO:0060323) face morphogenesis(GO:0060325) |
| 1.7 | 48.8 | GO:0051798 | positive regulation of hair follicle development(GO:0051798) |
| 1.6 | 4.9 | GO:0060734 | regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734) |
| 1.5 | 6.2 | GO:0086092 | regulation of the force of heart contraction by cardiac conduction(GO:0086092) |
| 1.5 | 4.6 | GO:0061394 | regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) |
| 1.4 | 8.4 | GO:0070295 | renal water absorption(GO:0070295) |
| 1.3 | 1.3 | GO:0002085 | inhibition of neuroepithelial cell differentiation(GO:0002085) |
| 1.2 | 40.6 | GO:0042744 | hydrogen peroxide catabolic process(GO:0042744) |
| 1.1 | 4.6 | GO:1900191 | biofilm formation(GO:0042710) single-species biofilm formation(GO:0044010) single-species biofilm formation in or on host organism(GO:0044407) regulation of single-species biofilm formation(GO:1900190) negative regulation of single-species biofilm formation(GO:1900191) regulation of single-species biofilm formation in or on host organism(GO:1900228) negative regulation of single-species biofilm formation in or on host organism(GO:1900229) |
| 1.1 | 4.6 | GO:0010430 | fatty acid omega-oxidation(GO:0010430) |
| 1.1 | 16.5 | GO:0032119 | sequestering of zinc ion(GO:0032119) |
| 1.1 | 6.5 | GO:0002501 | peptide antigen assembly with MHC protein complex(GO:0002501) |
| 1.1 | 6.4 | GO:1900042 | positive regulation of interleukin-2 secretion(GO:1900042) |
| 1.0 | 2.9 | GO:2000625 | regulation of miRNA catabolic process(GO:2000625) positive regulation of miRNA catabolic process(GO:2000627) |
| 1.0 | 2.9 | GO:1904798 | positive regulation of core promoter binding(GO:1904798) |
| 1.0 | 2.9 | GO:0010621 | negative regulation of transcription by transcription factor localization(GO:0010621) |
| 1.0 | 1.0 | GO:1903413 | cellular response to bile acid(GO:1903413) |
| 1.0 | 41.2 | GO:0050716 | positive regulation of interleukin-1 secretion(GO:0050716) |
| 0.9 | 2.8 | GO:0033693 | neurofilament bundle assembly(GO:0033693) |
| 0.9 | 6.5 | GO:0035879 | plasma membrane lactate transport(GO:0035879) |
| 0.9 | 2.7 | GO:0051037 | regulation of transcription involved in meiotic cell cycle(GO:0051037) |
| 0.9 | 5.3 | GO:1904219 | regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222) |
| 0.8 | 27.1 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 0.8 | 8.8 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.8 | 15.2 | GO:0001542 | ovulation from ovarian follicle(GO:0001542) |
| 0.8 | 2.3 | GO:0048611 | ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611) |
| 0.8 | 3.0 | GO:0044240 | multicellular organism lipid catabolic process(GO:0044240) |
| 0.7 | 2.2 | GO:0034226 | lysine import(GO:0034226) L-lysine import(GO:0061461) L-lysine import into cell(GO:1903410) |
| 0.7 | 4.2 | GO:0044800 | fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800) |
| 0.7 | 2.1 | GO:0015670 | carbon dioxide transport(GO:0015670) |
| 0.7 | 2.8 | GO:0044691 | tooth eruption(GO:0044691) |
| 0.7 | 4.1 | GO:0003278 | apoptotic process involved in heart morphogenesis(GO:0003278) |
| 0.7 | 1.4 | GO:0014016 | neuroblast differentiation(GO:0014016) |
| 0.7 | 4.1 | GO:0038031 | non-canonical Wnt signaling pathway via JNK cascade(GO:0038031) |
| 0.7 | 49.5 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.6 | 12.2 | GO:0014877 | response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 0.6 | 2.5 | GO:0006617 | SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617) |
| 0.6 | 1.9 | GO:1900390 | positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440) |
| 0.6 | 0.6 | GO:0043163 | cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229) |
| 0.5 | 5.9 | GO:1903760 | regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760) |
| 0.5 | 1.6 | GO:0035284 | rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284) |
| 0.5 | 2.6 | GO:0008050 | female courtship behavior(GO:0008050) |
| 0.5 | 2.6 | GO:0044858 | plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906) |
| 0.5 | 9.2 | GO:0006569 | tryptophan catabolic process(GO:0006569) indole-containing compound catabolic process(GO:0042436) indolalkylamine catabolic process(GO:0046218) |
| 0.5 | 14.0 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.5 | 2.4 | GO:0036414 | protein citrullination(GO:0018101) histone citrullination(GO:0036414) |
| 0.5 | 18.2 | GO:0007398 | ectoderm development(GO:0007398) |
| 0.5 | 2.3 | GO:0003430 | growth plate cartilage chondrocyte growth(GO:0003430) |
| 0.5 | 4.6 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.4 | 5.3 | GO:1902177 | positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902177) |
| 0.4 | 3.0 | GO:0016098 | monoterpenoid metabolic process(GO:0016098) |
| 0.4 | 3.2 | GO:0071494 | cellular response to UV-C(GO:0071494) |
| 0.4 | 1.5 | GO:0099640 | axo-dendritic protein transport(GO:0099640) |
| 0.4 | 8.1 | GO:0006703 | estrogen biosynthetic process(GO:0006703) |
| 0.4 | 0.7 | GO:0051040 | regulation of calcium-independent cell-cell adhesion(GO:0051040) |
| 0.4 | 3.9 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) positive regulation of glycogen (starch) synthase activity(GO:2000467) |
| 0.3 | 1.4 | GO:0035106 | operant conditioning(GO:0035106) |
| 0.3 | 1.3 | GO:0009236 | cobalamin biosynthetic process(GO:0009236) |
| 0.3 | 4.0 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
| 0.3 | 2.0 | GO:0060437 | lung growth(GO:0060437) |
| 0.3 | 1.0 | GO:0060730 | regulation of intestinal epithelial structure maintenance(GO:0060730) |
| 0.3 | 6.5 | GO:0003417 | growth plate cartilage development(GO:0003417) |
| 0.3 | 1.9 | GO:0060686 | negative regulation of prostatic bud formation(GO:0060686) |
| 0.3 | 10.5 | GO:0019731 | antibacterial humoral response(GO:0019731) |
| 0.3 | 1.5 | GO:0070837 | dehydroascorbic acid transport(GO:0070837) |
| 0.3 | 4.4 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 0.3 | 7.1 | GO:0071481 | cellular response to X-ray(GO:0071481) |
| 0.3 | 1.4 | GO:0000720 | pyrimidine dimer repair by nucleotide-excision repair(GO:0000720) |
| 0.3 | 2.5 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 0.3 | 0.6 | GO:0002725 | negative regulation of T cell cytokine production(GO:0002725) |
| 0.3 | 1.4 | GO:0010269 | response to selenium ion(GO:0010269) |
| 0.3 | 4.1 | GO:2000400 | positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400) |
| 0.3 | 3.1 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.3 | 2.3 | GO:1905232 | cellular response to L-glutamate(GO:1905232) |
| 0.3 | 6.6 | GO:0097286 | iron ion import(GO:0097286) |
| 0.3 | 3.3 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 0.2 | 0.2 | GO:0071288 | cellular response to mercury ion(GO:0071288) |
| 0.2 | 2.0 | GO:1905150 | regulation of voltage-gated sodium channel activity(GO:1905150) |
| 0.2 | 3.0 | GO:1902746 | regulation of lens fiber cell differentiation(GO:1902746) |
| 0.2 | 15.9 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.2 | 6.8 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
| 0.2 | 1.8 | GO:0019236 | response to pheromone(GO:0019236) |
| 0.2 | 2.5 | GO:0060426 | lung vasculature development(GO:0060426) |
| 0.2 | 0.7 | GO:0051097 | negative regulation of helicase activity(GO:0051097) |
| 0.2 | 1.8 | GO:0036151 | phosphatidylcholine acyl-chain remodeling(GO:0036151) |
| 0.2 | 6.1 | GO:0006706 | steroid catabolic process(GO:0006706) |
| 0.2 | 1.6 | GO:0035900 | isocitrate metabolic process(GO:0006102) response to isolation stress(GO:0035900) |
| 0.2 | 10.2 | GO:0045103 | intermediate filament-based process(GO:0045103) |
| 0.2 | 7.1 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.2 | 1.9 | GO:0000023 | maltose metabolic process(GO:0000023) |
| 0.2 | 2.1 | GO:0046689 | response to mercury ion(GO:0046689) |
| 0.2 | 1.0 | GO:0014807 | regulation of somitogenesis(GO:0014807) |
| 0.2 | 0.6 | GO:0097029 | mature conventional dendritic cell differentiation(GO:0097029) |
| 0.2 | 0.6 | GO:0061485 | memory T cell proliferation(GO:0061485) |
| 0.2 | 3.4 | GO:0006069 | ethanol oxidation(GO:0006069) |
| 0.2 | 8.7 | GO:0019433 | triglyceride catabolic process(GO:0019433) |
| 0.2 | 5.5 | GO:0048240 | sperm capacitation(GO:0048240) |
| 0.2 | 4.5 | GO:0071243 | cellular response to arsenic-containing substance(GO:0071243) |
| 0.2 | 3.7 | GO:0034587 | piRNA metabolic process(GO:0034587) |
| 0.2 | 1.5 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.2 | 2.3 | GO:0039536 | negative regulation of RIG-I signaling pathway(GO:0039536) |
| 0.2 | 14.3 | GO:0001895 | retina homeostasis(GO:0001895) |
| 0.2 | 7.2 | GO:0015813 | L-glutamate transport(GO:0015813) |
| 0.2 | 0.8 | GO:0007056 | spindle assembly involved in female meiosis(GO:0007056) |
| 0.2 | 0.6 | GO:0090131 | mesenchyme migration(GO:0090131) |
| 0.2 | 2.0 | GO:0072383 | plus-end-directed vesicle transport along microtubule(GO:0072383) |
| 0.2 | 1.5 | GO:0070307 | lens fiber cell development(GO:0070307) |
| 0.1 | 0.4 | GO:0090214 | spongiotrophoblast layer developmental growth(GO:0090214) |
| 0.1 | 1.7 | GO:1904628 | response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628) |
| 0.1 | 4.6 | GO:0036152 | phosphatidylethanolamine acyl-chain remodeling(GO:0036152) |
| 0.1 | 0.3 | GO:0021530 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) |
| 0.1 | 2.8 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.1 | 3.5 | GO:0055003 | cardiac myofibril assembly(GO:0055003) |
| 0.1 | 1.0 | GO:0010727 | negative regulation of hydrogen peroxide metabolic process(GO:0010727) |
| 0.1 | 0.7 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
| 0.1 | 0.8 | GO:1990539 | fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539) |
| 0.1 | 0.7 | GO:0042483 | negative regulation of odontogenesis(GO:0042483) |
| 0.1 | 1.8 | GO:0010818 | T cell chemotaxis(GO:0010818) |
| 0.1 | 11.2 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.1 | 0.3 | GO:0006579 | amino-acid betaine catabolic process(GO:0006579) |
| 0.1 | 0.5 | GO:0090076 | relaxation of skeletal muscle(GO:0090076) |
| 0.1 | 0.3 | GO:0051866 | general adaptation syndrome(GO:0051866) |
| 0.1 | 2.3 | GO:0035414 | negative regulation of catenin import into nucleus(GO:0035414) |
| 0.1 | 11.5 | GO:0009301 | snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795) |
| 0.1 | 1.7 | GO:0030913 | fusion of sperm to egg plasma membrane(GO:0007342) paranodal junction assembly(GO:0030913) |
| 0.1 | 0.6 | GO:0051684 | maintenance of Golgi location(GO:0051684) |
| 0.1 | 0.6 | GO:0038172 | interleukin-33-mediated signaling pathway(GO:0038172) |
| 0.1 | 1.3 | GO:0018206 | peptidyl-methionine modification(GO:0018206) |
| 0.1 | 0.8 | GO:0070162 | adiponectin secretion(GO:0070162) regulation of adiponectin secretion(GO:0070163) |
| 0.1 | 4.1 | GO:0033119 | negative regulation of RNA splicing(GO:0033119) |
| 0.1 | 3.3 | GO:0008334 | histone mRNA metabolic process(GO:0008334) |
| 0.1 | 0.7 | GO:0002074 | extraocular skeletal muscle development(GO:0002074) |
| 0.1 | 1.9 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.1 | 2.6 | GO:0032460 | negative regulation of protein oligomerization(GO:0032460) |
| 0.1 | 2.3 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.1 | 6.6 | GO:0071349 | interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349) |
| 0.1 | 0.3 | GO:0039533 | regulation of MDA-5 signaling pathway(GO:0039533) positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 0.1 | 0.9 | GO:0048260 | positive regulation of receptor-mediated endocytosis(GO:0048260) |
| 0.1 | 0.2 | GO:0007198 | adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198) |
| 0.1 | 2.8 | GO:0045671 | negative regulation of osteoclast differentiation(GO:0045671) |
| 0.1 | 13.2 | GO:0071346 | cellular response to interferon-gamma(GO:0071346) |
| 0.1 | 8.2 | GO:0022617 | extracellular matrix disassembly(GO:0022617) |
| 0.1 | 1.7 | GO:1901687 | glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687) |
| 0.1 | 2.0 | GO:0044381 | glucose import in response to insulin stimulus(GO:0044381) |
| 0.0 | 1.2 | GO:0002347 | response to tumor cell(GO:0002347) |
| 0.0 | 1.1 | GO:1900745 | positive regulation of p38MAPK cascade(GO:1900745) |
| 0.0 | 0.3 | GO:1903301 | positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301) |
| 0.0 | 0.5 | GO:0021853 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
| 0.0 | 1.0 | GO:0061436 | regulation of water loss via skin(GO:0033561) establishment of skin barrier(GO:0061436) |
| 0.0 | 0.4 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
| 0.0 | 0.9 | GO:0045665 | negative regulation of neuron differentiation(GO:0045665) |
| 0.0 | 1.9 | GO:0021591 | ventricular system development(GO:0021591) |
| 0.0 | 0.7 | GO:0015812 | gamma-aminobutyric acid transport(GO:0015812) |
| 0.0 | 0.7 | GO:0006030 | chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032) |
| 0.0 | 2.6 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.0 | 1.0 | GO:0036315 | cellular response to sterol(GO:0036315) |
| 0.0 | 0.4 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
| 0.0 | 0.2 | GO:0055014 | atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014) |
| 0.0 | 1.5 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.0 | 5.5 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.0 | 0.9 | GO:0001502 | cartilage condensation(GO:0001502) |
| 0.0 | 1.2 | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process(GO:0010667) |
| 0.0 | 3.3 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.0 | 0.2 | GO:0061365 | positive regulation of triglyceride lipase activity(GO:0061365) |
| 0.0 | 0.7 | GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process(GO:0035338) |
| 0.0 | 0.5 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 0.0 | 0.8 | GO:0010212 | response to ionizing radiation(GO:0010212) |
| 0.0 | 0.2 | GO:0016080 | synaptic vesicle targeting(GO:0016080) |
| 0.0 | 1.2 | GO:0032008 | positive regulation of TOR signaling(GO:0032008) |
| 0.0 | 0.4 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
| 0.0 | 2.7 | GO:0006903 | vesicle targeting(GO:0006903) |
| 0.0 | 1.6 | GO:0032781 | positive regulation of ATPase activity(GO:0032781) |
| 0.0 | 0.6 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.0 | 0.4 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.0 | 0.7 | GO:0097120 | receptor localization to synapse(GO:0097120) |
| 0.0 | 0.9 | GO:0000038 | very long-chain fatty acid metabolic process(GO:0000038) |
| 0.0 | 1.6 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.0 | 0.5 | GO:2000114 | regulation of establishment of cell polarity(GO:2000114) |
| 0.0 | 0.7 | GO:0045744 | negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744) |
| 0.0 | 1.3 | GO:0045669 | positive regulation of osteoblast differentiation(GO:0045669) |
| 0.0 | 4.1 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.0 | 0.8 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.0 | 0.3 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 0.0 | 0.1 | GO:0086073 | bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073) |
| 0.0 | 0.8 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
| 0.0 | 0.8 | GO:0034113 | heterotypic cell-cell adhesion(GO:0034113) |
| 0.0 | 0.1 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.0 | 0.3 | GO:0009142 | nucleoside triphosphate biosynthetic process(GO:0009142) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.9 | 15.4 | GO:1990742 | microvesicle(GO:1990742) |
| 2.2 | 6.7 | GO:0043511 | inhibin complex(GO:0043511) inhibin A complex(GO:0043512) |
| 2.0 | 18.1 | GO:0035976 | AP1 complex(GO:0035976) |
| 1.5 | 39.2 | GO:0097386 | glial cell projection(GO:0097386) |
| 1.4 | 47.8 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 1.2 | 10.0 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.9 | 2.8 | GO:0005584 | collagen type I trimer(GO:0005584) |
| 0.9 | 2.8 | GO:0036457 | keratohyalin granule(GO:0036457) |
| 0.9 | 65.6 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.9 | 7.1 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.8 | 3.3 | GO:0016222 | procollagen-proline 4-dioxygenase complex(GO:0016222) |
| 0.8 | 4.6 | GO:1990037 | Lewy body core(GO:1990037) |
| 0.6 | 7.1 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.6 | 2.3 | GO:1990745 | EARP complex(GO:1990745) |
| 0.6 | 34.3 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.5 | 92.3 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.5 | 51.3 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.5 | 2.0 | GO:0016939 | kinesin II complex(GO:0016939) |
| 0.5 | 5.9 | GO:0043219 | lateral loop(GO:0043219) |
| 0.4 | 1.3 | GO:0005674 | transcription factor TFIIF complex(GO:0005674) |
| 0.4 | 2.9 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.4 | 3.3 | GO:0034715 | pICln-Sm protein complex(GO:0034715) |
| 0.4 | 17.0 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.3 | 11.4 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.3 | 2.0 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.3 | 5.0 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.3 | 4.1 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.3 | 1.6 | GO:0016235 | aggresome(GO:0016235) |
| 0.3 | 2.3 | GO:0036128 | CatSper complex(GO:0036128) |
| 0.3 | 2.3 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.2 | 2.9 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
| 0.2 | 4.9 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.2 | 16.9 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.2 | 2.5 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) |
| 0.2 | 1.4 | GO:0000110 | nucleotide-excision repair factor 1 complex(GO:0000110) |
| 0.2 | 0.6 | GO:0070702 | inner mucus layer(GO:0070702) outer mucus layer(GO:0070703) |
| 0.2 | 2.6 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.2 | 6.2 | GO:0090533 | cation-transporting ATPase complex(GO:0090533) |
| 0.2 | 0.7 | GO:0008043 | intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288) |
| 0.2 | 2.6 | GO:0030478 | actin cap(GO:0030478) |
| 0.2 | 0.7 | GO:0044216 | host(GO:0018995) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) |
| 0.2 | 10.5 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.2 | 2.3 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.2 | 19.4 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.2 | 1.8 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.2 | 1.4 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.1 | 1.9 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.1 | 12.9 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.1 | 1.5 | GO:0001939 | female pronucleus(GO:0001939) |
| 0.1 | 3.1 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.1 | 32.4 | GO:0034774 | secretory granule lumen(GO:0034774) |
| 0.1 | 0.6 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.1 | 0.6 | GO:0045272 | plasma membrane respiratory chain complex I(GO:0045272) |
| 0.1 | 0.9 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.1 | 1.2 | GO:0071986 | Ragulator complex(GO:0071986) |
| 0.1 | 0.8 | GO:0097208 | alveolar lamellar body(GO:0097208) |
| 0.1 | 9.0 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.1 | 8.0 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 19.5 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.1 | 2.6 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.1 | 2.1 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.1 | 8.5 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 1.1 | GO:0097225 | sperm midpiece(GO:0097225) |
| 0.1 | 3.5 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.1 | 1.3 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 3.6 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 1.7 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 4.3 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 0.8 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.0 | 1.8 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 3.2 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 0.5 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.0 | 4.1 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 6.8 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 2.0 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.0 | 5.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 0.6 | GO:0005686 | U2 snRNP(GO:0005686) |
| 0.0 | 0.2 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.0 | 4.3 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 0.9 | GO:0005774 | vacuolar membrane(GO:0005774) |
| 0.0 | 4.8 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 0.7 | GO:0031011 | Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202) |
| 0.0 | 12.8 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 16.6 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.0 | 0.6 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.0 | 5.5 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 2.7 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 0.3 | GO:0071437 | invadopodium(GO:0071437) |
| 0.0 | 1.5 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 3.4 | GO:0009986 | cell surface(GO:0009986) |
| 0.0 | 0.1 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.0 | 0.4 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 0.6 | GO:0014704 | intercalated disc(GO:0014704) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.1 | 48.5 | GO:0016211 | glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880) |
| 6.9 | 48.4 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 6.5 | 51.9 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 5.1 | 15.4 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
| 4.2 | 41.8 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 2.1 | 10.4 | GO:0050253 | retinyl-palmitate esterase activity(GO:0050253) |
| 2.1 | 6.2 | GO:0086040 | sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086040) |
| 2.0 | 49.4 | GO:0019841 | retinol binding(GO:0019841) |
| 1.7 | 8.4 | GO:0015254 | glycerol channel activity(GO:0015254) |
| 1.5 | 12.1 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
| 1.4 | 8.7 | GO:0047006 | 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006) |
| 1.1 | 6.7 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 1.1 | 58.2 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 1.0 | 14.0 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.7 | 2.9 | GO:0031728 | CCR3 chemokine receptor binding(GO:0031728) |
| 0.7 | 4.2 | GO:0045569 | TRAIL binding(GO:0045569) |
| 0.7 | 4.1 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.7 | 6.1 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.6 | 1.8 | GO:0017130 | poly(C) RNA binding(GO:0017130) |
| 0.6 | 1.8 | GO:0016503 | pheromone receptor activity(GO:0016503) |
| 0.6 | 4.2 | GO:0046790 | virion binding(GO:0046790) |
| 0.6 | 6.6 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.5 | 1.6 | GO:0051538 | 3 iron, 4 sulfur cluster binding(GO:0051538) |
| 0.5 | 6.5 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.5 | 4.9 | GO:0072542 | protein phosphatase activator activity(GO:0072542) |
| 0.5 | 2.4 | GO:0004668 | protein-arginine deiminase activity(GO:0004668) |
| 0.5 | 5.9 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.4 | 4.4 | GO:0019864 | IgG binding(GO:0019864) |
| 0.4 | 1.3 | GO:0070697 | activin receptor binding(GO:0070697) |
| 0.4 | 1.5 | GO:0008426 | protein kinase C inhibitor activity(GO:0008426) |
| 0.4 | 2.3 | GO:0004906 | interferon-gamma receptor activity(GO:0004906) |
| 0.4 | 3.3 | GO:0019798 | procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798) |
| 0.3 | 1.4 | GO:0004995 | tachykinin receptor activity(GO:0004995) |
| 0.3 | 2.7 | GO:0004771 | sterol esterase activity(GO:0004771) |
| 0.3 | 1.4 | GO:0033265 | acetylcholinesterase activity(GO:0003990) choline binding(GO:0033265) |
| 0.3 | 2.6 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.3 | 2.1 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 0.3 | 1.5 | GO:0033300 | dehydroascorbic acid transporter activity(GO:0033300) |
| 0.3 | 1.5 | GO:0034875 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875) |
| 0.3 | 5.3 | GO:0015194 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.3 | 69.5 | GO:0002020 | protease binding(GO:0002020) |
| 0.3 | 0.8 | GO:0098640 | integrin binding involved in cell-matrix adhesion(GO:0098640) |
| 0.3 | 18.1 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.2 | 2.7 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.2 | 1.7 | GO:0035473 | lipase binding(GO:0035473) |
| 0.2 | 1.9 | GO:0032450 | alpha-1,4-glucosidase activity(GO:0004558) maltose alpha-glucosidase activity(GO:0032450) |
| 0.2 | 2.3 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.2 | 1.9 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.2 | 2.5 | GO:0008312 | 7S RNA binding(GO:0008312) |
| 0.2 | 4.5 | GO:0010857 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) calcium-dependent protein kinase activity(GO:0010857) |
| 0.2 | 1.8 | GO:0004983 | neuropeptide Y receptor activity(GO:0004983) |
| 0.2 | 2.4 | GO:0015250 | water channel activity(GO:0015250) |
| 0.2 | 1.4 | GO:1990599 | 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599) |
| 0.2 | 27.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.2 | 2.6 | GO:0045159 | myosin II binding(GO:0045159) |
| 0.2 | 1.5 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.2 | 4.1 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.2 | 4.7 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.2 | 2.9 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.1 | 3.1 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.1 | 2.2 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.1 | 6.8 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.1 | 3.0 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.1 | 4.5 | GO:0005527 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 4.0 | GO:0017081 | chloride channel regulator activity(GO:0017081) |
| 0.1 | 0.5 | GO:0043891 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891) |
| 0.1 | 1.2 | GO:0003956 | NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956) |
| 0.1 | 5.9 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.1 | 2.2 | GO:0031701 | angiotensin receptor binding(GO:0031701) type 1 angiotensin receptor binding(GO:0031702) |
| 0.1 | 0.9 | GO:0004957 | prostaglandin E receptor activity(GO:0004957) |
| 0.1 | 0.8 | GO:0005353 | fructose transmembrane transporter activity(GO:0005353) |
| 0.1 | 1.0 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.1 | 2.0 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
| 0.1 | 2.9 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
| 0.1 | 0.8 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
| 0.1 | 0.3 | GO:0047150 | betaine-homocysteine S-methyltransferase activity(GO:0047150) |
| 0.1 | 2.2 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
| 0.1 | 2.8 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 0.1 | 5.2 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.1 | 5.0 | GO:0004623 | phospholipase A2 activity(GO:0004623) |
| 0.1 | 12.9 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.1 | 0.6 | GO:0002114 | interleukin-33 receptor activity(GO:0002114) |
| 0.1 | 0.7 | GO:0005332 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) |
| 0.1 | 3.2 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.1 | 1.9 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 17.9 | GO:0004866 | endopeptidase inhibitor activity(GO:0004866) |
| 0.1 | 0.6 | GO:0016413 | O-acetyltransferase activity(GO:0016413) |
| 0.1 | 2.9 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.1 | 25.8 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.1 | 8.0 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.1 | 0.8 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.1 | 1.5 | GO:0008392 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
| 0.1 | 6.6 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.1 | 0.3 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.1 | 2.0 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
| 0.1 | 3.7 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 1.9 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.1 | 0.8 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.0 | 2.0 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.0 | 20.2 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 1.1 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.0 | 6.9 | GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811) |
| 0.0 | 1.5 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 0.9 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.9 | GO:0015245 | fatty acid transporter activity(GO:0015245) |
| 0.0 | 2.6 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.3 | GO:0004331 | 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331) |
| 0.0 | 0.7 | GO:0004568 | chitinase activity(GO:0004568) |
| 0.0 | 2.1 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.0 | 36.3 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.0 | 1.7 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.0 | 0.9 | GO:0005313 | L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172) |
| 0.0 | 4.9 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.0 | 0.5 | GO:0086008 | voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008) |
| 0.0 | 0.7 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.0 | 0.4 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.0 | 0.6 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.0 | 0.2 | GO:0043176 | amine binding(GO:0043176) serotonin binding(GO:0051378) |
| 0.0 | 0.3 | GO:0035251 | UDP-glucosyltransferase activity(GO:0035251) |
| 0.0 | 2.1 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 0.7 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.0 | 1.5 | GO:0004177 | aminopeptidase activity(GO:0004177) |
| 0.0 | 0.1 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 0.0 | 4.1 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.7 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.0 | 0.5 | GO:0001608 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.0 | 0.4 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.0 | 0.1 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.0 | 0.3 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
| 0.0 | 0.3 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.0 | 1.5 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 1.0 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.0 | 0.1 | GO:0030627 | pre-mRNA 5'-splice site binding(GO:0030627) |
| 0.0 | 3.1 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
| 0.0 | 0.6 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.0 | 1.0 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 0.3 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 0.1 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.0 | 0.3 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.0 | 0.1 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
| 0.0 | 0.1 | GO:0017018 | myosin phosphatase activity(GO:0017018) |
| 0.0 | 1.4 | GO:0016782 | transferase activity, transferring sulfur-containing groups(GO:0016782) |
| 0.0 | 1.1 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 88.2 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.6 | 18.1 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.4 | 73.4 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.4 | 7.1 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.3 | 21.9 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.3 | 2.3 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.2 | 7.1 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.2 | 9.6 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.2 | 66.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 9.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 4.9 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.2 | 4.1 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.2 | 5.9 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.1 | 12.2 | PID FOXO PATHWAY | FoxO family signaling |
| 0.1 | 5.4 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 9.8 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 12.5 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 0.6 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.1 | 7.7 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 4.6 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 4.9 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 4.2 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.1 | 5.9 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 7.2 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 1.1 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 4.6 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.1 | 2.0 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.1 | 4.9 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 2.6 | PID ERBB1 RECEPTOR PROXIMAL PATHWAY | EGF receptor (ErbB1) signaling pathway |
| 0.1 | 2.1 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.1 | 3.7 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 0.3 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 3.1 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.1 | 1.7 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 1.6 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 4.6 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 1.7 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.0 | 1.4 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.0 | 2.0 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 2.0 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 1.5 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 2.6 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.0 | 0.6 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 0.7 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 0.3 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.6 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.0 | 3.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 41.8 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 1.2 | 39.8 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 1.0 | 15.4 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.8 | 4.2 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |
| 0.8 | 18.1 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.7 | 11.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.7 | 10.7 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.7 | 22.2 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.7 | 6.7 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.5 | 15.8 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.4 | 9.2 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.4 | 7.9 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.3 | 6.5 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.3 | 6.2 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.3 | 12.3 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.3 | 16.8 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.3 | 31.1 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.2 | 12.4 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.2 | 5.9 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.2 | 3.3 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 0.2 | 2.8 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.2 | 3.9 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.2 | 3.0 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.1 | 4.3 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.1 | 2.9 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.1 | 1.4 | REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX | Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex |
| 0.1 | 0.6 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.1 | 0.8 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.1 | 6.9 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.1 | 4.9 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.1 | 1.8 | REACTOME ACTIVATED POINT MUTANTS OF FGFR2 | Genes involved in Activated point mutants of FGFR2 |
| 0.1 | 0.9 | REACTOME PROSTANOID LIGAND RECEPTORS | Genes involved in Prostanoid ligand receptors |
| 0.1 | 3.3 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 3.8 | REACTOME ELONGATION ARREST AND RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.1 | 3.9 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 2.9 | REACTOME RNA POL II PRE TRANSCRIPTION EVENTS | Genes involved in RNA Polymerase II Pre-transcription Events |
| 0.1 | 1.9 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 12.1 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.1 | 3.5 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 1.6 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 1.4 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |
| 0.0 | 2.6 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 1.2 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 0.0 | 1.2 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 0.0 | 7.0 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.0 | 0.4 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.0 | 2.4 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 1.7 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 2.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 1.5 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 0.6 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 15.5 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.0 | 2.5 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 3.6 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.7 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 2.7 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 1.1 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.5 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 0.3 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 0.0 | 2.0 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.0 | 0.2 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.0 | 0.7 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |