avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

• Motif significance table
• Sample table
• Mean activities
• All promoters sorted by FOV

• Activity table
• Activity delta table
• Regulatory interactions
• Motifs sorted by significance
• Expression table
• Download the whole report

Gene Symbol	Gene ID	Gene Info
TBX15 Links Ensembl NCBI GeneCards UniProt	ENSG00000092607.9	T-box transcription factor 15
MGA Links Ensembl NCBI GeneCards UniProt	ENSG00000174197.12	MAX dimerization protein MGA

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MGA	hg19_v2_chr15_+_41952591_41952672	0.47	3.6e-02	Click!
TBX15	hg19_v2_chr1_-_119530428_119530572	-0.26	2.7e-01	Click!

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Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	4.7	GO:1904379	protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.4	1.8	GO:1905205	positive regulation of connective tissue replacement(GO:1905205)
0.4	2.1	GO:0043553	negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.3	1.0	GO:0070563	negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.2	0.8	GO:0035627	ceramide transport(GO:0035627)
0.2	0.6	GO:0061433	cellular response to caloric restriction(GO:0061433) negative regulation of oligodendrocyte progenitor proliferation(GO:0070446)
0.2	0.7	GO:0010983	positive regulation of high-density lipoprotein particle clearance(GO:0010983)
0.2	0.7	GO:0006781	succinyl-CoA pathway(GO:0006781)
0.2	0.9	GO:0060574	intestinal epithelial cell maturation(GO:0060574)
0.1	0.7	GO:1904504	regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504)
0.1	0.9	GO:0060672	epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.1	1.3	GO:1903764	regulation of potassium ion export across plasma membrane(GO:1903764)
0.1	0.5	GO:2001160	regulation of histone H3-K79 methylation(GO:2001160) positive regulation of histone H3-K79 methylation(GO:2001162)
0.1	0.4	GO:1903570	regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.1	0.7	GO:0060800	regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.1	0.6	GO:0030807	positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123)
0.1	0.4	GO:0006597	spermine biosynthetic process(GO:0006597)
0.1	0.7	GO:0035879	plasma membrane lactate transport(GO:0035879)
0.1	0.4	GO:1903691	positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.1	1.3	GO:0046598	positive regulation of viral entry into host cell(GO:0046598)
0.1	1.0	GO:0071896	protein localization to adherens junction(GO:0071896)
0.1	0.3	GO:0018315	molybdenum incorporation into molybdenum-molybdopterin complex(GO:0018315) metal incorporation into metallo-molybdopterin complex(GO:0042040) glycine receptor clustering(GO:0072579)
0.1	0.3	GO:2000681	negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.1	0.6	GO:1902962	regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.1	0.5	GO:2000670	positive regulation of dendritic cell apoptotic process(GO:2000670)
0.1	0.8	GO:1901315	negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
0.1	0.5	GO:0039019	pronephric nephron development(GO:0039019)
0.1	0.3	GO:0046379	extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.1	0.3	GO:0046110	xanthine metabolic process(GO:0046110)
0.1	0.2	GO:0006117	acetaldehyde metabolic process(GO:0006117)
0.1	0.2	GO:0021589	hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.1	0.4	GO:1900224	positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
0.1	0.3	GO:1904501	glial cell fate determination(GO:0007403) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) regulation of chromatin-mediated maintenance of transcription(GO:1904499) positive regulation of chromatin-mediated maintenance of transcription(GO:1904501) regulation of euchromatin binding(GO:1904793)
0.1	0.5	GO:2001166	regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.1	0.5	GO:1903575	cornified envelope assembly(GO:1903575)
0.1	0.5	GO:0051697	protein delipidation(GO:0051697)
0.1	0.3	GO:0021623	optic cup structural organization(GO:0003409) oculomotor nerve morphogenesis(GO:0021622) oculomotor nerve formation(GO:0021623)
0.1	0.3	GO:0098582	innate vocalization behavior(GO:0098582)
0.1	0.2	GO:0061536	glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1	0.4	GO:0030421	defecation(GO:0030421)
0.1	0.9	GO:1904262	negative regulation of TORC1 signaling(GO:1904262)
0.1	0.5	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
0.1	0.3	GO:0010760	negative regulation of macrophage chemotaxis(GO:0010760)
0.1	0.7	GO:1990416	cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.1	0.2	GO:0048633	positive regulation of skeletal muscle tissue growth(GO:0048633)
0.1	0.5	GO:1905232	cellular response to L-glutamate(GO:1905232)
0.1	0.2	GO:0035522	monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.1	0.2	GO:0031247	actin rod assembly(GO:0031247)
0.1	0.7	GO:0002051	osteoblast fate commitment(GO:0002051)
0.1	0.3	GO:0003069	age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571)
0.1	0.3	GO:0019470	4-hydroxyproline catabolic process(GO:0019470)
0.1	0.3	GO:1903588	negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.1	0.2	GO:0002904	positive regulation of B cell apoptotic process(GO:0002904)
0.0	0.2	GO:0097010	eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.0	0.3	GO:1904217	regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0	0.2	GO:0021603	cranial nerve formation(GO:0021603)
0.0	0.3	GO:0051414	response to cortisol(GO:0051414)
0.0	0.1	GO:1901340	negative regulation of store-operated calcium channel activity(GO:1901340)
0.0	0.8	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0	0.3	GO:0038060	nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.0	0.5	GO:0035524	proline transmembrane transport(GO:0035524)
0.0	0.3	GO:2000795	negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0	0.1	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.2	GO:0007206	phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.0	0.1	GO:0060532	bronchus cartilage development(GO:0060532) lung smooth muscle development(GO:0061145)
0.0	0.3	GO:2000490	negative regulation of hepatic stellate cell activation(GO:2000490)
0.0	0.2	GO:1990564	protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0	0.4	GO:0070973	protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0	0.2	GO:0045653	negative regulation of megakaryocyte differentiation(GO:0045653)
0.0	0.2	GO:0044855	plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.0	0.6	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.2	GO:1902766	skeletal muscle satellite cell migration(GO:1902766)
0.0	0.1	GO:0021827	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836)
0.0	0.2	GO:0097475	motor neuron migration(GO:0097475)
0.0	0.1	GO:1903824	regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208) negative regulation of single strand break repair(GO:1903517) negative regulation of beta-galactosidase activity(GO:1903770) telomere single strand break repair(GO:1903823) negative regulation of telomere single strand break repair(GO:1903824)
0.0	0.1	GO:0040040	thermosensory behavior(GO:0040040)
0.0	0.3	GO:0042905	9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0	0.1	GO:0033861	negative regulation of NAD(P)H oxidase activity(GO:0033861)
0.0	0.4	GO:1904352	positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0	0.1	GO:1903045	neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
0.0	0.1	GO:0044210	'de novo' CTP biosynthetic process(GO:0044210)
0.0	0.3	GO:0016584	nucleosome positioning(GO:0016584)
0.0	0.8	GO:0030277	maintenance of gastrointestinal epithelium(GO:0030277)
0.0	0.6	GO:0090527	actin filament reorganization(GO:0090527)
0.0	0.5	GO:0032688	negative regulation of interferon-beta production(GO:0032688)
0.0	0.6	GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.0	0.1	GO:0002384	hepatic immune response(GO:0002384)
0.0	0.2	GO:0019262	N-acetylneuraminate catabolic process(GO:0019262)
0.0	0.1	GO:0048294	negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.0	0.2	GO:0017196	N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0	0.2	GO:0035290	trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) neural crest cell migration involved in autonomic nervous system development(GO:1901166)
0.0	0.1	GO:0000915	assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.0	1.2	GO:0060216	definitive hemopoiesis(GO:0060216)
0.0	0.3	GO:0032876	negative regulation of DNA endoreduplication(GO:0032876)
0.0	0.1	GO:0021834	chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834)
0.0	0.1	GO:1902595	regulation of DNA replication origin binding(GO:1902595)
0.0	0.5	GO:0031629	synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.0	0.2	GO:1903593	regulation of histamine secretion by mast cell(GO:1903593)
0.0	0.7	GO:0042776	mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0	0.4	GO:0015884	folic acid transport(GO:0015884)
0.0	0.3	GO:2001224	positive regulation of neuron migration(GO:2001224)
0.0	0.1	GO:0061086	negative regulation of histone H3-K27 methylation(GO:0061086)
0.0	0.2	GO:0099590	neurotransmitter receptor internalization(GO:0099590)
0.0	1.6	GO:0018149	peptide cross-linking(GO:0018149)
0.0	0.1	GO:1904721	negative regulation of mRNA cleavage(GO:0031438) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.0	0.1	GO:0060067	chemoattraction of serotonergic neuron axon(GO:0036517) cervix development(GO:0060067) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354) chemoattraction of axon(GO:0061642) negative regulation of cell proliferation in midbrain(GO:1904934) planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation(GO:1904955)
0.0	0.2	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.1	GO:1990737	response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.0	0.1	GO:0070940	dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.0	0.2	GO:0001915	negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0	0.2	GO:0098814	spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0	0.1	GO:0051461	positive regulation of corticotropin secretion(GO:0051461)
0.0	0.0	GO:1990641	response to iron ion starvation(GO:1990641)
0.0	0.5	GO:0010592	positive regulation of lamellipodium assembly(GO:0010592)
0.0	0.1	GO:0008204	ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
0.0	0.1	GO:2000317	negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.0	0.2	GO:1902416	positive regulation of mRNA binding(GO:1902416)
0.0	0.6	GO:0006825	copper ion transport(GO:0006825)
0.0	0.1	GO:0072752	cellular response to rapamycin(GO:0072752)
0.0	0.3	GO:0048227	plasma membrane to endosome transport(GO:0048227)
0.0	0.1	GO:0006617	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.0	0.1	GO:0032439	endosome localization(GO:0032439)
0.0	0.1	GO:0050882	voluntary musculoskeletal movement(GO:0050882)
0.0	0.4	GO:2000059	negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059)
0.0	0.4	GO:0060211	regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.0	0.1	GO:0006620	posttranslational protein targeting to membrane(GO:0006620)
0.0	0.1	GO:0051121	hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0	0.1	GO:0010645	regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
0.0	0.2	GO:0014809	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0	1.4	GO:0000186	activation of MAPKK activity(GO:0000186)
0.0	0.1	GO:0010793	regulation of mRNA export from nucleus(GO:0010793)
0.0	0.4	GO:0045717	negative regulation of fatty acid biosynthetic process(GO:0045717)
0.0	0.2	GO:0035331	negative regulation of hippo signaling(GO:0035331)
0.0	0.1	GO:1904636	response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
0.0	0.2	GO:0036066	protein O-linked fucosylation(GO:0036066)
0.0	0.1	GO:0035093	spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.0	0.3	GO:0035563	positive regulation of chromatin binding(GO:0035563)
0.0	0.1	GO:0006049	UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0	0.2	GO:1903025	regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.0	0.2	GO:0032287	peripheral nervous system myelin maintenance(GO:0032287)
0.0	0.1	GO:0003366	cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.0	0.1	GO:0097101	arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) blood vessel lumenization(GO:0072554) blood vessel endothelial cell fate specification(GO:0097101) positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0	0.1	GO:0006990	positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.0	0.2	GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0	0.0	GO:0090678	metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936)
0.0	2.1	GO:0031424	keratinization(GO:0031424)
0.0	0.1	GO:0051096	positive regulation of helicase activity(GO:0051096)
0.0	0.1	GO:0031914	negative regulation of synaptic plasticity(GO:0031914)
0.0	0.1	GO:0048341	paraxial mesoderm formation(GO:0048341)
0.0	0.1	GO:0044351	macropinocytosis(GO:0044351)
0.0	0.2	GO:0043248	proteasome assembly(GO:0043248)
0.0	0.1	GO:0090344	negative regulation of cell aging(GO:0090344)
0.0	0.1	GO:0055118	intracellular sequestering of iron ion(GO:0006880) negative regulation of cardiac muscle contraction(GO:0055118) sequestering of iron ion(GO:0097577)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.2	GO:0015812	gamma-aminobutyric acid transport(GO:0015812)
0.0	0.1	GO:2001288	positive regulation of caveolin-mediated endocytosis(GO:2001288)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	4.7	GO:0071818	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.3	0.9	GO:0070557	PCNA-p21 complex(GO:0070557)
0.2	2.0	GO:0005955	calcineurin complex(GO:0005955)
0.2	0.5	GO:0036194	muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.1	1.8	GO:0043219	lateral loop(GO:0043219)
0.1	0.3	GO:0036117	hyaluranon cable(GO:0036117)
0.1	0.6	GO:0070381	endosome to plasma membrane transport vesicle(GO:0070381)
0.1	0.3	GO:1990032	parallel fiber(GO:1990032)
0.1	0.2	GO:0035525	NF-kappaB p50/p65 complex(GO:0035525)
0.1	0.5	GO:0089701	U2AF(GO:0089701)
0.1	0.7	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.1	1.3	GO:0005916	fascia adherens(GO:0005916)
0.1	0.4	GO:0032444	activin responsive factor complex(GO:0032444)
0.1	0.5	GO:0033503	HULC complex(GO:0033503)
0.1	0.2	GO:0031213	RSF complex(GO:0031213)
0.0	0.2	GO:0000839	Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0	1.2	GO:0043205	microfibril(GO:0001527) fibril(GO:0043205)
0.0	0.5	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.0	0.3	GO:0044300	cerebellar mossy fiber(GO:0044300)
0.0	0.3	GO:0097209	epidermal lamellar body(GO:0097209)
0.0	0.2	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0	0.5	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.0	0.7	GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0	0.2	GO:0035339	SPOTS complex(GO:0035339)
0.0	0.5	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751)
0.0	0.2	GO:0031415	NatA complex(GO:0031415)
0.0	1.4	GO:0071339	MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0	0.1	GO:0043614	multi-eIF complex(GO:0043614) translation preinitiation complex(GO:0070993) glial limiting end-foot(GO:0097451)
0.0	1.6	GO:0001533	cornified envelope(GO:0001533)
0.0	0.2	GO:1990357	terminal web(GO:1990357)
0.0	1.9	GO:0045095	keratin filament(GO:0045095)
0.0	0.3	GO:0030057	desmosome(GO:0030057)
0.0	0.1	GO:0045272	plasma membrane respiratory chain complex I(GO:0045272)
0.0	0.7	GO:0005839	proteasome core complex(GO:0005839)
0.0	0.2	GO:0016013	syntrophin complex(GO:0016013)
0.0	0.1	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.6	GO:0035145	exon-exon junction complex(GO:0035145)
0.0	0.2	GO:0051286	cell tip(GO:0051286)
0.0	0.1	GO:0016222	procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0	0.4	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.0	0.2	GO:0008541	proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0	1.2	GO:0030286	dynein complex(GO:0030286)
0.0	0.4	GO:0030122	AP-2 adaptor complex(GO:0030122)
0.0	0.1	GO:0097129	cyclin D2-CDK4 complex(GO:0097129)
0.0	0.3	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	1.1	GO:0016235	aggresome(GO:0016235)
0.0	0.1	GO:0032584	growth cone membrane(GO:0032584)
0.0	0.2	GO:0033276	transcription factor TFTC complex(GO:0033276)
0.0	0.2	GO:0032039	integrator complex(GO:0032039)
0.0	0.1	GO:0034669	integrin alpha4-beta7 complex(GO:0034669)
0.0	0.1	GO:1902560	GMP reductase complex(GO:1902560)
0.0	0.2	GO:0030478	actin cap(GO:0030478)
0.0	0.2	GO:0042383	sarcolemma(GO:0042383)
0.0	0.2	GO:0045179	apical cortex(GO:0045179)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.6	1.8	GO:0036313	phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.4	2.5	GO:0019828	aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.3	0.9	GO:0019912	cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.2	0.7	GO:0004676	3-phosphoinositide-dependent protein kinase activity(GO:0004676)
0.2	0.6	GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.2	4.3	GO:0015643	toxic substance binding(GO:0015643)
0.2	0.5	GO:0005298	proline:sodium symporter activity(GO:0005298)
0.1	0.4	GO:0016768	spermine synthase activity(GO:0016768)
0.1	1.9	GO:0033192	calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1	0.7	GO:0004775	succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.1	0.3	GO:0003842	1-pyrroline-5-carboxylate dehydrogenase activity(GO:0003842)
0.1	1.3	GO:0097016	L27 domain binding(GO:0097016)
0.1	0.6	GO:0097001	ceramide binding(GO:0097001)
0.1	0.3	GO:0061599	molybdopterin adenylyltransferase activity(GO:0061598) molybdopterin molybdotransferase activity(GO:0061599)
0.1	1.0	GO:0086083	cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.1	0.6	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1	0.8	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.1	0.6	GO:0043426	MRF binding(GO:0043426)
0.1	0.5	GO:0070728	leucine binding(GO:0070728)
0.1	0.3	GO:0034040	lipid-transporting ATPase activity(GO:0034040)
0.1	0.3	GO:0047888	fatty acid peroxidase activity(GO:0047888)
0.1	0.3	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.1	1.1	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1	0.4	GO:0043183	vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1	0.5	GO:0030628	pre-mRNA 3'-splice site binding(GO:0030628)
0.1	1.3	GO:0045504	dynein heavy chain binding(GO:0045504)
0.1	0.3	GO:0043546	molybdopterin cofactor binding(GO:0043546)
0.1	0.7	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.2	GO:0034057	RNA strand-exchange activity(GO:0034057)
0.0	0.2	GO:0015375	glycine:sodium symporter activity(GO:0015375)
0.0	0.6	GO:0016724	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	1.0	GO:0001161	intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0	0.6	GO:0032050	clathrin heavy chain binding(GO:0032050)
0.0	0.5	GO:0030280	structural constituent of epidermis(GO:0030280)
0.0	4.1	GO:0005044	scavenger receptor activity(GO:0005044)
0.0	0.2	GO:0004711	ribosomal protein S6 kinase activity(GO:0004711)
0.0	0.3	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0	0.3	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
0.0	0.2	GO:0032184	SUMO polymer binding(GO:0032184)
0.0	1.6	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0	1.6	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.0	0.6	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.0	1.0	GO:0070411	I-SMAD binding(GO:0070411)
0.0	0.5	GO:0008199	ferric iron binding(GO:0008199)
0.0	0.1	GO:0070119	ciliary neurotrophic factor binding(GO:0070119)
0.0	1.1	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.0	0.4	GO:0003964	telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0	0.1	GO:0003883	CTP synthase activity(GO:0003883)
0.0	0.7	GO:0070628	proteasome binding(GO:0070628)
0.0	0.2	GO:0042030	ATPase inhibitor activity(GO:0042030)
0.0	0.3	GO:0016721	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.2	GO:0016833	oxo-acid-lyase activity(GO:0016833)
0.0	0.3	GO:0004839	ubiquitin activating enzyme activity(GO:0004839)
0.0	0.2	GO:1904929	coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.0	0.2	GO:0016454	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.3	GO:0047035	alcohol dehydrogenase (NAD) activity(GO:0004022) testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.2	GO:0071532	ankyrin repeat binding(GO:0071532)
0.0	0.1	GO:0003746	translation elongation factor activity(GO:0003746)
0.0	0.1	GO:0004310	farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.0	0.1	GO:0035033	histone deacetylase regulator activity(GO:0035033)
0.0	0.1	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.3	GO:0038132	neuregulin binding(GO:0038132)
0.0	0.1	GO:1902379	receptor tyrosine kinase-like orphan receptor binding(GO:0005115) chemoattractant activity involved in axon guidance(GO:1902379)
0.0	0.1	GO:0051120	hepoxilin A3 synthase activity(GO:0051120)
0.0	0.3	GO:0004679	AMP-activated protein kinase activity(GO:0004679)
0.0	1.0	GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0	0.5	GO:0043022	ribosome binding(GO:0043022)
0.0	0.4	GO:0005542	folic acid binding(GO:0005542)
0.0	0.1	GO:0004882	androgen receptor activity(GO:0004882)
0.0	0.1	GO:0060698	endoribonuclease inhibitor activity(GO:0060698)
0.0	0.2	GO:0046790	virion binding(GO:0046790)
0.0	0.8	GO:0046966	thyroid hormone receptor binding(GO:0046966)
0.0	0.2	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.1	GO:0031871	proteinase activated receptor binding(GO:0031871)
0.0	0.4	GO:0001222	transcription corepressor binding(GO:0001222)
0.0	0.2	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.4	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.2	GO:0045159	myosin II binding(GO:0045159)
0.0	0.4	GO:0098748	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0	0.3	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.1	GO:0033188	sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0	0.1	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.3	GO:0032036	myosin heavy chain binding(GO:0032036)
0.0	0.6	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.0	GO:0071633	dihydroceramidase activity(GO:0071633)
0.0	0.3	GO:0008494	translation activator activity(GO:0008494)
0.0	0.0	GO:0030627	pre-mRNA 5'-splice site binding(GO:0030627)
0.0	0.6	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.5	GO:0000993	RNA polymerase II core binding(GO:0000993)
0.0	0.1	GO:0003827	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0	0.4	GO:0015002	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0	0.2	GO:0005283	sodium:amino acid symporter activity(GO:0005283)
0.0	0.0	GO:0030899	calcium-dependent ATPase activity(GO:0030899)
0.0	0.7	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0	0.7	GO:0005484	SNAP receptor activity(GO:0005484)
0.0	0.7	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.0	0.2	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0	0.1	GO:0003920	GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.0	0.2	GO:0015194	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.2	GO:0017049	GTP-Rho binding(GO:0017049)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	1.3	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.0	0.9	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	1.6	PID NECTIN PATHWAY	Nectin adhesion pathway
0.0	2.8	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.0	1.1	PID MYC PATHWAY	C-MYC pathway
0.0	0.7	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0	1.5	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0	0.6	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	0.4	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	1.2	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.0	0.6	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	1.3	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.0	1.2	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.0	0.9	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	0.4	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	0.2	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.0	0.2	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.0	0.3	PID HNF3A PATHWAY	FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.3	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1	1.5	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.0	1.0	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0	0.9	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.0	2.1	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.4	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0	0.2	REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	Genes involved in Influenza Viral RNA Transcription and Replication
0.0	0.5	REACTOME ER PHAGOSOME PATHWAY	Genes involved in ER-Phagosome pathway
0.0	0.7	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.7	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	0.7	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	0.7	REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	Genes involved in Activation of NF-kappaB in B Cells
0.0	0.7	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.0	0.5	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.0	1.9	REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION	Genes involved in Cyclin E associated events during G1/S transition
0.0	0.9	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	0.4	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.3	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	0.3	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.6	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0	0.7	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.6	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.4	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.0	0.7	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.3	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism
0.0	0.4	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing