ISMARA results: TBX15

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for TBX15_MGA

Z-value: 0.67

Motif logo

Transcription factors associated with TBX15_MGA

Gene Symbol	Gene ID	Gene Info
TBX15 Ensembl NCBI GeneCards UniProt	ENSG00000092607.9	T-box transcription factor 15
MGA Ensembl NCBI GeneCards UniProt	ENSG00000174197.12	MAX dimerization protein MGA

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MGA	hg19_v2_chr15_+_41952591_41952672	0.47	3.6e-02	Click!
TBX15	hg19_v2_chr1_-_119530428_119530572	-0.26	2.7e-01	Click!

Activity profile of TBX15_MGA motif

Sorted Z-values of TBX15_MGA motif

No targets for TBX15_MGA

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX15_MGA

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	4.7	GO:1904379	protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.4	2.1	GO:0043553	negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0	2.1	GO:0031424	keratinization(GO:0031424)
0.4	1.8	GO:1905205	positive regulation of connective tissue replacement(GO:1905205)
0.0	1.6	GO:0018149	peptide cross-linking(GO:0018149)
0.0	1.4	GO:0000186	activation of MAPKK activity(GO:0000186)
0.1	1.3	GO:1903764	regulation of potassium ion export across plasma membrane(GO:1903764)
0.1	1.3	GO:0046598	positive regulation of viral entry into host cell(GO:0046598)
0.0	1.2	GO:0060216	definitive hemopoiesis(GO:0060216)
0.3	1.0	GO:0070563	negative regulation of vitamin D receptor signaling pathway(GO:0070563)

Showing 1 to 10 of 156 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	4.7	GO:0071818	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.2	2.0	GO:0005955	calcineurin complex(GO:0005955)
0.0	1.9	GO:0045095	keratin filament(GO:0045095)
0.1	1.8	GO:0043219	lateral loop(GO:0043219)
0.0	1.6	GO:0001533	cornified envelope(GO:0001533)
0.0	1.4	GO:0071339	MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1	1.3	GO:0005916	fascia adherens(GO:0005916)
0.0	1.2	GO:0043205	microfibril(GO:0001527) fibril(GO:0043205)
0.0	1.2	GO:0030286	dynein complex(GO:0030286)
0.0	1.1	GO:0016235	aggresome(GO:0016235)

Showing 1 to 10 of 54 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	4.3	GO:0015643	toxic substance binding(GO:0015643)
0.0	4.1	GO:0005044	scavenger receptor activity(GO:0005044)
0.4	2.5	GO:0019828	aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.1	1.9	GO:0033192	calmodulin-dependent protein phosphatase activity(GO:0033192)
0.6	1.8	GO:0036313	phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.0	1.6	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0	1.6	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.1	1.3	GO:0097016	L27 domain binding(GO:0097016)
0.1	1.3	GO:0045504	dynein heavy chain binding(GO:0045504)
0.1	1.1	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)

Showing 1 to 10 of 101 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.8	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.0	1.6	PID NECTIN PATHWAY	Nectin adhesion pathway
0.0	1.5	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0	1.3	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.0	1.3	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.0	1.2	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.0	1.2	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.0	1.1	PID MYC PATHWAY	C-MYC pathway
0.1	0.9	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	0.9	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway

Showing 1 to 10 of 19 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.1	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	1.9	REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION	Genes involved in Cyclin E associated events during G1/S transition
0.1	1.5	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.1	1.3	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	1.0	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0	0.9	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.0	0.9	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	0.7	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.7	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	0.7	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo

Showing 1 to 10 of 26 entries

Results for TBX15_MGA

Z-value: 0.67

Motif logo

Transcription factors associated with TBX15_MGA

Activity-expression correlation:

Activity profile of TBX15_MGA motif

Sorted Z-values of TBX15_MGA motif

No targets for TBX15_MGA

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX15_MGA

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: