ISMARA results: TBX5

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for TBX5

Z-value: 0.66

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Transcription factors associated with TBX5

Gene Symbol	Gene ID	Gene Info
TBX5 Ensembl NCBI GeneCards UniProt	ENSG00000089225.15	T-box transcription factor 5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TBX5	hg19_v2_chr12_-_114843889_114843921	-0.05	8.2e-01	Click!

Activity profile of TBX5 motif

Sorted Z-values of TBX5 motif

No targets for TBX5

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX5

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	3.0	GO:0001661	conditioned taste aversion(GO:0001661)
0.1	1.9	GO:0006853	carnitine shuttle(GO:0006853)
0.4	1.8	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
0.2	1.5	GO:2000857	positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.1	1.0	GO:0042997	negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.2	0.8	GO:0090076	relaxation of skeletal muscle(GO:0090076)
0.1	0.8	GO:0045345	positive regulation of MHC class I biosynthetic process(GO:0045345)
0.1	0.7	GO:0019464	glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.1	0.7	GO:2000503	positive regulation of natural killer cell chemotaxis(GO:2000503)
0.0	0.7	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949)

Showing 1 to 10 of 104 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	3.0	GO:0035976	AP1 complex(GO:0035976)
0.0	2.2	GO:0015030	Cajal body(GO:0015030)
0.0	1.6	GO:0005581	collagen trimer(GO:0005581)
0.0	0.8	GO:0005790	smooth endoplasmic reticulum(GO:0005790)
0.2	0.7	GO:0071062	rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.2	0.5	GO:0032002	interleukin-28 receptor complex(GO:0032002)
0.1	0.4	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.4	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.4	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)
0.0	0.4	GO:0098563	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)

Showing 1 to 10 of 27 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.0	GO:0070412	R-SMAD binding(GO:0070412)
0.6	1.8	GO:0008859	exoribonuclease II activity(GO:0008859)
0.2	1.8	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095)
0.0	1.0	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1	0.9	GO:0004873	asialoglycoprotein receptor activity(GO:0004873)
0.0	0.8	GO:0042169	SH2 domain binding(GO:0042169)
0.2	0.7	GO:0004047	aminomethyltransferase activity(GO:0004047)
0.0	0.7	GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.0	0.7	GO:0030247	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.6	GO:0070410	co-SMAD binding(GO:0070410)

Showing 1 to 10 of 69 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.0	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	1.6	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	0.6	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.0	0.5	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.4	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	0.2	PID RAC1 PATHWAY	RAC1 signaling pathway

Showing 1 to 6 of 6 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.0	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	1.9	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0	1.8	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	0.8	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	0.8	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	0.7	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.6	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0	0.5	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.0	0.4	REACTOME RNA POL III CHAIN ELONGATION	Genes involved in RNA Polymerase III Chain Elongation
0.0	0.3	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway

Showing 1 to 10 of 12 entries

Results for TBX5

Z-value: 0.66

Motif logo

Transcription factors associated with TBX5

Activity-expression correlation:

Activity profile of TBX5 motif

Sorted Z-values of TBX5 motif

No targets for TBX5

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX5

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: