ISMARA results: TCF12

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for TCF12_ASCL2

Z-value: 1.98

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Transcription factors associated with TCF12_ASCL2

Gene Symbol	Gene ID	Gene Info
TCF12 Ensembl NCBI GeneCards UniProt	ENSG00000140262.13	transcription factor 12
ASCL2 Ensembl NCBI GeneCards UniProt	ENSG00000183734.4	achaete-scute family bHLH transcription factor 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TCF12	hg19_v2_chr15_+_57540213_57540218	-0.79	3.1e-05	Click!
ASCL2	hg19_v2_chr11_-_2292182_2292212	0.32	1.7e-01	Click!

Activity profile of TCF12_ASCL2 motif

Sorted Z-values of TCF12_ASCL2 motif

No targets for TCF12_ASCL2

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF12_ASCL2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	14.3	GO:1990573	potassium ion import across plasma membrane(GO:1990573)
0.1	9.9	GO:0010257	NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
2.1	8.6	GO:0021966	corticospinal neuron axon guidance(GO:0021966)
1.7	8.4	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
0.4	6.2	GO:0007144	female meiosis I(GO:0007144)
0.3	5.8	GO:0051599	response to hydrostatic pressure(GO:0051599)
0.6	5.7	GO:0031444	slow-twitch skeletal muscle fiber contraction(GO:0031444)
1.1	5.5	GO:0097089	methyl-branched fatty acid metabolic process(GO:0097089)
0.0	5.2	GO:0070125	mitochondrial translational elongation(GO:0070125)
0.2	5.0	GO:0070493	thrombin receptor signaling pathway(GO:0070493)

Showing 1 to 10 of 730 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	17.5	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.6	15.1	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0	9.6	GO:0072562	blood microparticle(GO:0072562)
0.4	9.1	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.1	9.0	GO:0015030	Cajal body(GO:0015030)
0.1	6.4	GO:0030964	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1	6.3	GO:0035580	specific granule lumen(GO:0035580)
0.1	5.2	GO:0031231	integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0	4.4	GO:0030672	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.4	4.1	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)

Showing 1 to 10 of 221 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	14.5	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
2.1	8.6	GO:0086062	voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
2.8	8.4	GO:0008859	exoribonuclease II activity(GO:0008859)
0.2	8.2	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1	7.7	GO:0003707	steroid hormone receptor activity(GO:0003707)
0.1	7.3	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	7.2	GO:0003735	structural constituent of ribosome(GO:0003735)
0.3	6.2	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1	5.7	GO:0004622	lysophospholipase activity(GO:0004622)
0.2	5.3	GO:0048020	CCR chemokine receptor binding(GO:0048020)

Showing 1 to 10 of 436 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	15.3	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.2	9.5	ST GA12 PATHWAY	G alpha 12 Pathway
0.3	4.8	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1	4.0	PID IL23 PATHWAY	IL23-mediated signaling events
0.1	3.8	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.1	3.6	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.1	3.5	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.0	3.5	PID FANCONI PATHWAY	Fanconi anemia pathway
0.1	2.3	PID CONE PATHWAY	Visual signal transduction: Cones
0.0	2.0	PID NOTCH PATHWAY	Notch signaling pathway

Showing 1 to 10 of 57 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	10.8	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.1	10.1	REACTOME G ALPHA S SIGNALLING EVENTS	Genes involved in G alpha (s) signalling events
0.2	9.5	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.1	8.8	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.2	8.6	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.1	8.5	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.5	7.9	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.2	7.0	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1	6.1	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.2	5.1	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement

Showing 1 to 10 of 111 entries

Results for TCF12_ASCL2

Z-value: 1.98

Motif logo

Transcription factors associated with TCF12_ASCL2

Activity-expression correlation:

Activity profile of TCF12_ASCL2 motif

Sorted Z-values of TCF12_ASCL2 motif

No targets for TCF12_ASCL2

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF12_ASCL2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: