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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for TCF7

Z-value: 0.76

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Transcription factors associated with TCF7

Gene Symbol Gene ID Gene Info
ENSG00000081059.15 transcription factor 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TCF7hg19_v2_chr5_+_133451254_133451316-0.408.0e-02Click!

Activity profile of TCF7 motif

Sorted Z-values of TCF7 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:1902544 regulation of DNA N-glycosylase activity(GO:1902544)
0.1 0.8 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.1 0.5 GO:0043006 activation of phospholipase A2 activity by calcium-mediated signaling(GO:0043006)
0.1 0.3 GO:0072387 flavin adenine dinucleotide metabolic process(GO:0072387)
0.1 0.4 GO:0032771 regulation of monophenol monooxygenase activity(GO:0032771) positive regulation of monophenol monooxygenase activity(GO:0032773) negative regulation of catagen(GO:0051796) regulation of hair cycle by canonical Wnt signaling pathway(GO:0060901) positive regulation of melanosome transport(GO:1902910)
0.1 0.4 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.1 0.3 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.1 0.2 GO:0070668 regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
0.1 0.2 GO:0021718 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.1 0.3 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.1 1.1 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 0.6 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.1 0.8 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.1 0.2 GO:1903181 negative regulation of late endosome to lysosome transport(GO:1902823) regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181) negative regulation of protein catabolic process in the vacuole(GO:1904351) negative regulation of lysosomal protein catabolic process(GO:1905166)
0.1 0.2 GO:0018277 protein deamination(GO:0018277)
0.1 0.4 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.1 0.3 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.8 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.1 0.4 GO:0006740 NADPH regeneration(GO:0006740)
0.1 0.2 GO:1904875 regulation of DNA ligase activity(GO:1904875)
0.1 0.7 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.1 0.2 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.1 0.4 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 0.6 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.0 0.2 GO:0036292 DNA rewinding(GO:0036292)
0.0 0.2 GO:1902904 negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
0.0 0.2 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0 0.2 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.0 0.2 GO:0048698 negative regulation of collateral sprouting in absence of injury(GO:0048698)
0.0 0.2 GO:1902722 positive regulation of prolactin secretion(GO:1902722)
0.0 0.4 GO:0003350 pulmonary myocardium development(GO:0003350)
0.0 0.1 GO:0006408 snRNA export from nucleus(GO:0006408)
0.0 0.2 GO:1903232 melanosome assembly(GO:1903232)
0.0 0.2 GO:0035549 positive regulation of interferon-beta secretion(GO:0035549)
0.0 0.2 GO:0002386 immune response in mucosal-associated lymphoid tissue(GO:0002386)
0.0 0.5 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.0 0.5 GO:0090168 Golgi reassembly(GO:0090168)
0.0 1.0 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.3 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.1 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.0 0.1 GO:0046521 sphingoid catabolic process(GO:0046521)
0.0 0.1 GO:1901069 guanosine-containing compound catabolic process(GO:1901069)
0.0 0.2 GO:1903301 positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.0 0.1 GO:1904815 negative regulation of protein localization to chromosome, telomeric region(GO:1904815)
0.0 0.6 GO:0043097 pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0 0.2 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
0.0 0.5 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.3 GO:0006477 protein sulfation(GO:0006477)
0.0 0.1 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.0 0.2 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 0.1 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.1 GO:0061687 detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0 0.1 GO:0051086 chaperone mediated protein folding independent of cofactor(GO:0051086)
0.0 0.6 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.6 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 0.1 GO:0010286 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.0 0.3 GO:0030913 fusion of sperm to egg plasma membrane(GO:0007342) paranodal junction assembly(GO:0030913)
0.0 0.2 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.0 0.4 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 0.1 GO:0072086 specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268)
0.0 0.2 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.2 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.1 GO:0006172 ADP biosynthetic process(GO:0006172)
0.0 0.1 GO:0090410 malonate catabolic process(GO:0090410)
0.0 0.2 GO:0048733 sebaceous gland development(GO:0048733)
0.0 0.1 GO:0031337 cellular response to phosphate starvation(GO:0016036) positive regulation of sulfur amino acid metabolic process(GO:0031337) positive regulation of homocysteine metabolic process(GO:0050668)
0.0 0.1 GO:0007161 calcium-independent cell-matrix adhesion(GO:0007161)
0.0 0.1 GO:0072092 ureteric bud invasion(GO:0072092)
0.0 0.4 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.1 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.0 0.1 GO:0070901 mitochondrial tRNA methylation(GO:0070901)
0.0 0.1 GO:0060017 parathyroid gland development(GO:0060017)
0.0 1.0 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.2 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.1 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.1 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.2 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 0.7 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 0.0 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.0 0.1 GO:1904693 midbrain morphogenesis(GO:1904693)
0.0 1.0 GO:0006968 cellular defense response(GO:0006968)
0.0 0.0 GO:1904530 negative regulation of actin filament binding(GO:1904530) negative regulation of actin binding(GO:1904617)
0.0 0.0 GO:0060577 pulmonary vein morphogenesis(GO:0060577)
0.0 0.0 GO:0097267 omega-hydroxylase P450 pathway(GO:0097267)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0097489 multivesicular body, internal vesicle lumen(GO:0097489)
0.1 0.3 GO:0043257 laminin-8 complex(GO:0043257)
0.1 1.1 GO:0045180 basal cortex(GO:0045180)
0.1 1.0 GO:0000124 SAGA complex(GO:0000124)
0.1 0.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1 0.3 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 0.3 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.0 0.2 GO:0031905 early endosome lumen(GO:0031905)
0.0 1.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.1 GO:0008623 CHRAC(GO:0008623)
0.0 0.6 GO:0097025 lateral loop(GO:0043219) MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.2 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
0.0 0.2 GO:0031523 Myb complex(GO:0031523)
0.0 0.2 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
0.0 0.5 GO:0030478 actin cap(GO:0030478)
0.0 0.2 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.0 0.2 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
0.0 0.2 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.2 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 0.1 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.0 0.5 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.3 GO:0005610 laminin-5 complex(GO:0005610)
0.0 0.7 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 0.1 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.0 1.5 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.5 GO:0031105 septin complex(GO:0031105)
0.0 1.0 GO:0001533 cornified envelope(GO:0001533)
0.0 0.1 GO:0031515 tRNA (m1A) methyltransferase complex(GO:0031515)
0.0 0.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.2 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.2 GO:0045179 apical cortex(GO:0045179)
0.0 0.0 GO:0005584 collagen type I trimer(GO:0005584)
0.0 0.4 GO:0031527 filopodium membrane(GO:0031527)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
0.1 0.4 GO:0016652 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.1 0.5 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 0.6 GO:0004137 deoxycytidine kinase activity(GO:0004137)
0.1 0.2 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 0.2 GO:0019150 D-ribulokinase activity(GO:0019150)
0.1 0.2 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.1 0.2 GO:0072591 citrate-L-glutamate ligase activity(GO:0072591)
0.1 0.2 GO:0035651 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.1 0.3 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
0.1 0.2 GO:0045142 single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) DNA/RNA helicase activity(GO:0033677) triplex DNA binding(GO:0045142)
0.0 0.6 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.1 GO:0000224 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity(GO:0000224)
0.0 0.3 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.3 GO:0050119 N-acetylglucosamine deacetylase activity(GO:0050119)
0.0 0.2 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.0 0.2 GO:0003867 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
0.0 0.4 GO:0045545 syndecan binding(GO:0045545)
0.0 0.2 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.1 GO:1904713 beta-catenin destruction complex binding(GO:1904713)
0.0 1.0 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 0.4 GO:0001727 lipid kinase activity(GO:0001727)
0.0 1.1 GO:0005112 Notch binding(GO:0005112)
0.0 0.8 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.1 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.0 0.4 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.2 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.2 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.0 0.1 GO:0001855 complement component C4b binding(GO:0001855)
0.0 0.2 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.0 0.2 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 1.1 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.2 GO:0070404 NADH binding(GO:0070404)
0.0 0.9 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.2 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.1 GO:0038025 reelin receptor activity(GO:0038025)
0.0 0.2 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.0 0.2 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 0.2 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.0 0.1 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.0 0.1 GO:0016429 tRNA (adenine) methyltransferase activity(GO:0016426) tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
0.0 0.1 GO:0043849 Ras palmitoyltransferase activity(GO:0043849)
0.0 0.1 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.0 1.6 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.4 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 0.2 GO:0036310 annealing helicase activity(GO:0036310)
0.0 0.1 GO:0090409 malonyl-CoA synthetase activity(GO:0090409)
0.0 0.2 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 0.2 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.3 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.1 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.0 0.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 1.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.1 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.0 GO:1990175 EH domain binding(GO:1990175)
0.0 0.1 GO:0051373 FATZ binding(GO:0051373)
0.0 0.2 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.8 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.2 PID IL5 PATHWAY IL5-mediated signaling events
0.0 1.4 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.3 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.9 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.7 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.6 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.6 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.8 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.5 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
0.0 1.8 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.5 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.3 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.4 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.1 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.1 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 1.6 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.4 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation