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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for TCF7L2
Z-value: 2.54
Motif logo
Transcription factors associated with TCF7L2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
TCF7L2
|
ENSG00000148737.11 | transcription factor 7 like 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TCF7L2 | hg19_v2_chr10_+_114710211_114710229 | -0.55 | 1.1e-02 | Click! |
Activity profile of TCF7L2 motif
Sorted Z-values of TCF7L2 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of TCF7L2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 12.5 | GO:0061181 | regulation of chondrocyte development(GO:0061181) |
| 2.8 | 8.5 | GO:0050787 | antibiotic metabolic process(GO:0016999) detoxification of mercury ion(GO:0050787) |
| 2.5 | 7.4 | GO:0090381 | regulation of heart induction(GO:0090381) regulation of heart induction by canonical Wnt signaling pathway(GO:0100012) |
| 2.2 | 6.7 | GO:1901202 | negative regulation of extracellular matrix assembly(GO:1901202) |
| 1.4 | 12.2 | GO:0021842 | directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) |
| 0.9 | 4.5 | GO:0002314 | germinal center B cell differentiation(GO:0002314) |
| 0.8 | 3.9 | GO:1903615 | regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615) |
| 0.7 | 2.0 | GO:1903568 | negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568) |
| 0.6 | 1.9 | GO:0036333 | hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772) |
| 0.5 | 1.5 | GO:1901069 | guanosine-containing compound catabolic process(GO:1901069) |
| 0.5 | 4.8 | GO:0086024 | adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024) |
| 0.5 | 3.3 | GO:0071486 | cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473) |
| 0.4 | 1.3 | GO:0071423 | thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) malate transmembrane transport(GO:0071423) oxaloacetate(2-) transmembrane transport(GO:1902356) |
| 0.4 | 1.6 | GO:1904059 | regulation of locomotor rhythm(GO:1904059) |
| 0.4 | 1.2 | GO:0021526 | medial motor column neuron differentiation(GO:0021526) |
| 0.4 | 2.2 | GO:0001555 | oocyte growth(GO:0001555) |
| 0.4 | 7.6 | GO:0034356 | NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356) |
| 0.4 | 1.4 | GO:1903566 | regulation of protein localization to cilium(GO:1903564) positive regulation of protein localization to cilium(GO:1903566) |
| 0.3 | 2.7 | GO:1903826 | arginine transmembrane transport(GO:1903826) |
| 0.3 | 1.2 | GO:0032915 | positive regulation of transforming growth factor beta2 production(GO:0032915) |
| 0.3 | 1.5 | GO:2000051 | Wnt receptor catabolic process(GO:0038018) negative regulation of non-canonical Wnt signaling pathway(GO:2000051) |
| 0.3 | 4.9 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.3 | 1.2 | GO:0021913 | regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913) |
| 0.3 | 1.9 | GO:0048619 | embryonic hindgut morphogenesis(GO:0048619) |
| 0.3 | 0.8 | GO:1905000 | regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000) |
| 0.2 | 6.6 | GO:0031915 | positive regulation of synaptic plasticity(GO:0031915) |
| 0.2 | 1.1 | GO:0070682 | proteasome regulatory particle assembly(GO:0070682) |
| 0.2 | 1.0 | GO:0033615 | mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) |
| 0.2 | 6.5 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.2 | 7.3 | GO:0060065 | uterus development(GO:0060065) |
| 0.2 | 0.8 | GO:0042631 | cellular response to water deprivation(GO:0042631) |
| 0.2 | 0.8 | GO:0000117 | regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117) |
| 0.1 | 1.0 | GO:0048165 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) |
| 0.1 | 4.5 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.1 | 0.4 | GO:0070632 | spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790) |
| 0.1 | 2.5 | GO:0072257 | metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307) |
| 0.1 | 0.6 | GO:0014826 | vein smooth muscle contraction(GO:0014826) |
| 0.1 | 1.2 | GO:0010265 | SCF complex assembly(GO:0010265) |
| 0.1 | 0.7 | GO:1904338 | regulation of dopaminergic neuron differentiation(GO:1904338) |
| 0.1 | 2.7 | GO:0001502 | cartilage condensation(GO:0001502) |
| 0.1 | 1.4 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
| 0.1 | 0.6 | GO:0019626 | short-chain fatty acid catabolic process(GO:0019626) |
| 0.1 | 0.5 | GO:0030573 | bile acid catabolic process(GO:0030573) |
| 0.1 | 0.9 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
| 0.1 | 0.6 | GO:0001957 | intramembranous ossification(GO:0001957) direct ossification(GO:0036072) |
| 0.1 | 0.4 | GO:1902304 | positive regulation of potassium ion export(GO:1902304) |
| 0.1 | 0.6 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
| 0.1 | 0.8 | GO:0007023 | post-chaperonin tubulin folding pathway(GO:0007023) |
| 0.1 | 0.1 | GO:0003192 | mitral valve formation(GO:0003192) |
| 0.1 | 0.3 | GO:0003219 | cardiac right ventricle formation(GO:0003219) |
| 0.1 | 0.3 | GO:0060028 | convergent extension involved in axis elongation(GO:0060028) |
| 0.1 | 5.1 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 0.5 | GO:0006041 | glucosamine metabolic process(GO:0006041) |
| 0.1 | 0.7 | GO:0045078 | positive regulation of interferon-gamma biosynthetic process(GO:0045078) |
| 0.1 | 2.8 | GO:2000171 | negative regulation of dendrite development(GO:2000171) |
| 0.0 | 2.4 | GO:1903861 | regulation of dendrite extension(GO:1903859) positive regulation of dendrite extension(GO:1903861) |
| 0.0 | 0.3 | GO:2000418 | positive regulation of eosinophil migration(GO:2000418) |
| 0.0 | 0.7 | GO:0090091 | positive regulation of extracellular matrix disassembly(GO:0090091) negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.0 | 0.7 | GO:0002517 | T cell tolerance induction(GO:0002517) |
| 0.0 | 0.5 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
| 0.0 | 0.2 | GO:1900039 | positive regulation of cellular response to hypoxia(GO:1900039) |
| 0.0 | 0.2 | GO:0000415 | negative regulation of histone H3-K36 methylation(GO:0000415) |
| 0.0 | 0.5 | GO:0035630 | bone mineralization involved in bone maturation(GO:0035630) |
| 0.0 | 1.7 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.0 | 0.3 | GO:0032511 | late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511) |
| 0.0 | 0.4 | GO:0021615 | glossopharyngeal nerve morphogenesis(GO:0021615) |
| 0.0 | 0.4 | GO:0055059 | asymmetric neuroblast division(GO:0055059) |
| 0.0 | 1.2 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.0 | 1.8 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.0 | 2.0 | GO:0035329 | hippo signaling(GO:0035329) |
| 0.0 | 0.8 | GO:0097264 | self proteolysis(GO:0097264) |
| 0.0 | 0.1 | GO:0003257 | positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation(GO:0003257) positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228) |
| 0.0 | 0.7 | GO:0035635 | entry of bacterium into host cell(GO:0035635) |
| 0.0 | 2.3 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 0.0 | 11.9 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123) |
| 0.0 | 0.4 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.0 | 1.8 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.0 | 0.4 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 0.0 | 0.1 | GO:0042761 | very long-chain fatty acid biosynthetic process(GO:0042761) |
| 0.0 | 1.9 | GO:0016574 | histone ubiquitination(GO:0016574) |
| 0.0 | 0.1 | GO:2000015 | regulation of determination of dorsal identity(GO:2000015) |
| 0.0 | 1.0 | GO:0021952 | central nervous system projection neuron axonogenesis(GO:0021952) |
| 0.0 | 3.4 | GO:0098869 | cellular oxidant detoxification(GO:0098869) |
| 0.0 | 0.3 | GO:0060539 | diaphragm development(GO:0060539) |
| 0.0 | 0.7 | GO:0045618 | positive regulation of keratinocyte differentiation(GO:0045618) |
| 0.0 | 0.7 | GO:0021535 | cell migration in hindbrain(GO:0021535) |
| 0.0 | 0.3 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
| 0.0 | 0.5 | GO:0006833 | water transport(GO:0006833) |
| 0.0 | 0.0 | GO:0032730 | positive regulation of interleukin-1 alpha production(GO:0032730) |
| 0.0 | 4.1 | GO:0015718 | monocarboxylic acid transport(GO:0015718) |
| 0.0 | 0.2 | GO:0036342 | post-anal tail morphogenesis(GO:0036342) |
| 0.0 | 0.9 | GO:1900740 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) |
| 0.0 | 0.1 | GO:0000270 | peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253) |
| 0.0 | 0.8 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.0 | 0.2 | GO:0046548 | retinal rod cell development(GO:0046548) |
| 0.0 | 0.4 | GO:0035640 | exploration behavior(GO:0035640) |
| 0.0 | 1.4 | GO:0007422 | peripheral nervous system development(GO:0007422) |
| 0.0 | 0.2 | GO:0035878 | nail development(GO:0035878) |
| 0.0 | 0.5 | GO:0050919 | negative chemotaxis(GO:0050919) |
| 0.0 | 0.4 | GO:0019433 | triglyceride catabolic process(GO:0019433) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 8.5 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.7 | 6.6 | GO:0070033 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554) |
| 0.5 | 11.8 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.4 | 1.2 | GO:0043224 | nuclear SCF ubiquitin ligase complex(GO:0043224) |
| 0.2 | 12.2 | GO:0030673 | axolemma(GO:0030673) |
| 0.2 | 0.8 | GO:0031523 | Myb complex(GO:0031523) |
| 0.1 | 2.2 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.1 | 0.4 | GO:0070762 | nuclear pore transmembrane ring(GO:0070762) |
| 0.1 | 1.2 | GO:0005638 | lamin filament(GO:0005638) |
| 0.1 | 5.6 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.1 | 0.7 | GO:0070436 | Grb2-EGFR complex(GO:0070436) |
| 0.1 | 0.4 | GO:0030936 | collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936) |
| 0.1 | 1.9 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.1 | 1.9 | GO:0045120 | pronucleus(GO:0045120) |
| 0.1 | 7.4 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.1 | 8.7 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.1 | 1.0 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.1 | 0.5 | GO:0065010 | extracellular membrane-bounded organelle(GO:0065010) |
| 0.1 | 4.8 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.1 | 1.4 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 0.6 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 0.2 | GO:0035841 | new growing cell tip(GO:0035841) |
| 0.1 | 1.7 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.1 | 1.1 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) |
| 0.0 | 0.7 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.0 | 4.5 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 1.5 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.0 | 3.5 | GO:0044291 | cell-cell contact zone(GO:0044291) |
| 0.0 | 7.1 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 0.9 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.0 | 0.9 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.0 | 0.4 | GO:0005583 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.0 | 0.2 | GO:0044305 | calyx of Held(GO:0044305) |
| 0.0 | 5.7 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 11.6 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 0.8 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 3.2 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 4.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 7.0 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 3.0 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 1.0 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.0 | 2.5 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 0.4 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.0 | 0.1 | GO:0045179 | apical cortex(GO:0045179) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 7.6 | GO:0008112 | nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760) |
| 1.5 | 4.5 | GO:0005427 | proton-dependent oligopeptide secondary active transmembrane transporter activity(GO:0005427) secondary active oligopeptide transmembrane transporter activity(GO:0015322) |
| 1.0 | 12.2 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 0.9 | 4.5 | GO:0005294 | neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294) |
| 0.4 | 12.5 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 0.4 | 8.5 | GO:0043225 | anion transmembrane-transporting ATPase activity(GO:0043225) |
| 0.4 | 1.3 | GO:0015117 | thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) |
| 0.3 | 7.6 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.3 | 2.7 | GO:0015181 | arginine transmembrane transporter activity(GO:0015181) |
| 0.2 | 0.7 | GO:0045518 | interleukin-22 receptor binding(GO:0045518) |
| 0.2 | 4.8 | GO:0031698 | beta-2 adrenergic receptor binding(GO:0031698) |
| 0.2 | 1.9 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 0.2 | 3.4 | GO:0048019 | receptor antagonist activity(GO:0048019) |
| 0.1 | 0.6 | GO:0097100 | supercoiled DNA binding(GO:0097100) |
| 0.1 | 3.9 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.1 | 0.6 | GO:0031708 | endothelin B receptor binding(GO:0031708) |
| 0.1 | 0.6 | GO:0005105 | type 1 fibroblast growth factor receptor binding(GO:0005105) |
| 0.1 | 1.2 | GO:0019788 | NEDD8 transferase activity(GO:0019788) |
| 0.1 | 6.6 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 0.8 | GO:0034988 | Fc-gamma receptor I complex binding(GO:0034988) |
| 0.1 | 0.7 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.1 | 1.0 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
| 0.1 | 4.3 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.1 | 0.5 | GO:0047787 | delta4-3-oxosteroid 5beta-reductase activity(GO:0047787) |
| 0.1 | 3.9 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.1 | 1.9 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.1 | 2.2 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.1 | 0.3 | GO:0031728 | CCR3 chemokine receptor binding(GO:0031728) |
| 0.1 | 0.3 | GO:0005502 | 11-cis retinal binding(GO:0005502) |
| 0.1 | 1.4 | GO:0043422 | protein kinase B binding(GO:0043422) |
| 0.1 | 0.5 | GO:0005237 | inhibitory extracellular ligand-gated ion channel activity(GO:0005237) |
| 0.0 | 4.1 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.0 | 6.7 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 0.5 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.0 | 1.4 | GO:0005248 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.0 | 0.2 | GO:0038052 | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
| 0.0 | 1.2 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.0 | 0.7 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.0 | 0.7 | GO:0005168 | neurotrophin TRKA receptor binding(GO:0005168) |
| 0.0 | 1.2 | GO:0005521 | lamin binding(GO:0005521) |
| 0.0 | 5.8 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.0 | 4.5 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.0 | 0.1 | GO:0004803 | transposase activity(GO:0004803) |
| 0.0 | 0.7 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.0 | 0.9 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.0 | 1.2 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.0 | 0.5 | GO:0015250 | water channel activity(GO:0015250) |
| 0.0 | 0.6 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 1.3 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.0 | 1.3 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.0 | 2.4 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 0.2 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.0 | 1.1 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 0.8 | GO:0005234 | extracellular-glutamate-gated ion channel activity(GO:0005234) |
| 0.0 | 3.1 | GO:0035326 | enhancer binding(GO:0035326) |
| 0.0 | 1.5 | GO:0016763 | transferase activity, transferring pentosyl groups(GO:0016763) |
| 0.0 | 0.1 | GO:0098821 | BMP receptor activity(GO:0098821) |
| 0.0 | 0.6 | GO:0016854 | racemase and epimerase activity(GO:0016854) |
| 0.0 | 0.9 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.0 | 0.2 | GO:0015197 | peptide transporter activity(GO:0015197) |
| 0.0 | 0.4 | GO:0005184 | neuropeptide hormone activity(GO:0005184) peptide hormone receptor binding(GO:0051428) |
| 0.0 | 0.5 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.0 | 1.2 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 0.4 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.0 | 0.8 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 0.0 | 0.1 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
| 0.0 | 0.9 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.0 | 0.2 | GO:0015271 | outward rectifier potassium channel activity(GO:0015271) |
| 0.0 | 0.3 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.0 | 0.5 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 1.0 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.0 | 0.4 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.0 | 0.0 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 12.2 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.3 | 11.3 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.2 | 6.7 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.2 | 7.1 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 7.3 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 4.0 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 1.2 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 0.7 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 1.7 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 1.8 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 0.9 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 0.8 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.0 | 0.9 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.5 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 4.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.4 | PID AP1 PATHWAY | AP-1 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 15.5 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.2 | 8.5 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.1 | 5.9 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 3.9 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 4.6 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 7.2 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 1.3 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.1 | 0.6 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.1 | 4.8 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 2.5 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 1.9 | REACTOME LIGAND GATED ION CHANNEL TRANSPORT | Genes involved in Ligand-gated ion channel transport |
| 0.0 | 6.1 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 0.0 | 0.7 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.0 | 1.2 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 1.3 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 1.9 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 0.7 | REACTOME SPRY REGULATION OF FGF SIGNALING | Genes involved in Spry regulation of FGF signaling |
| 0.0 | 0.5 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.0 | 0.5 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 0.6 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.0 | 0.5 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 1.0 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 0.6 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 0.5 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.0 | 0.7 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 0.2 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.0 | 1.1 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.0 | 0.6 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.9 | REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR | Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR) |