ISMARA results: TEAD3

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for TEAD3_TEAD1

Z-value: 4.35

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Transcription factors associated with TEAD3_TEAD1

Gene Symbol	Gene ID	Gene Info
TEAD3 Ensembl NCBI GeneCards UniProt	ENSG00000007866.14	TEA domain transcription factor 3
TEAD1 Ensembl NCBI GeneCards UniProt	ENSG00000187079.10	TEA domain transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TEAD3	hg19_v2_chr6_-_35464817_35464894	0.77	7.2e-05	Click!
TEAD1	hg19_v2_chr11_+_12696102_12696164	0.32	1.8e-01	Click!

Activity profile of TEAD3_TEAD1 motif

Sorted Z-values of TEAD3_TEAD1 motif

No targets for TEAD3_TEAD1

Network of associatons between targets according to the STRING database.

First level regulatory network of TEAD3_TEAD1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	34.6	GO:0031581	hemidesmosome assembly(GO:0031581)
0.2	32.2	GO:0070268	cornification(GO:0070268)
1.4	28.8	GO:0016540	protein autoprocessing(GO:0016540)
0.3	18.1	GO:2000249	regulation of actin cytoskeleton reorganization(GO:2000249)
1.0	17.7	GO:0048739	cardiac muscle fiber development(GO:0048739)
0.9	17.5	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
4.6	13.8	GO:0002605	negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) negative regulation of dendritic cell antigen processing and presentation(GO:0002605) negative regulation of endothelial cell chemotaxis(GO:2001027)
0.5	13.6	GO:0032331	negative regulation of chondrocyte differentiation(GO:0032331)
0.5	13.1	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
1.2	12.4	GO:0090191	negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191)

Showing 1 to 10 of 230 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	35.0	GO:0005615	extracellular space(GO:0005615)
0.1	31.2	GO:0030027	lamellipodium(GO:0030027)
0.1	24.2	GO:0005882	intermediate filament(GO:0005882)
4.3	17.4	GO:0005607	laminin-2 complex(GO:0005607)
0.0	16.7	GO:0005769	early endosome(GO:0005769)
0.3	14.6	GO:0009925	basal plasma membrane(GO:0009925)
0.9	13.8	GO:0030478	actin cap(GO:0030478)
0.1	13.8	GO:0034707	chloride channel complex(GO:0034707)
0.4	12.8	GO:0030056	hemidesmosome(GO:0030056)
0.1	11.2	GO:0030018	Z disc(GO:0030018)

Showing 1 to 10 of 102 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	22.4	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.2	21.2	GO:0008307	structural constituent of muscle(GO:0008307)
1.2	17.5	GO:0038062	protein tyrosine kinase collagen receptor activity(GO:0038062)
1.0	14.4	GO:0038132	neuregulin binding(GO:0038132)
0.2	14.3	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.4	13.9	GO:0051428	peptide hormone receptor binding(GO:0051428)
3.4	13.8	GO:0070052	collagen V binding(GO:0070052)
0.1	13.7	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.1	13.2	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
1.1	13.1	GO:0090599	alpha-glucosidase activity(GO:0090599)

Showing 1 to 10 of 166 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	34.6	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.4	28.5	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.4	25.0	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.1	10.1	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.1	9.5	PID NOTCH PATHWAY	Notch signaling pathway
0.1	9.3	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.2	8.9	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.1	8.2	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.1	8.1	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1	6.6	PID TGFBR PATHWAY	TGF-beta receptor signaling

Showing 1 to 10 of 39 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	19.9	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.1	18.2	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.2	11.6	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1	11.4	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.4	9.6	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.1	9.6	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.2	8.5	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.2	6.8	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.2	6.6	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.2	6.1	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)

Showing 1 to 10 of 55 entries

Results for TEAD3_TEAD1

Z-value: 4.35

Motif logo

Transcription factors associated with TEAD3_TEAD1

Activity-expression correlation:

Activity profile of TEAD3_TEAD1 motif

Sorted Z-values of TEAD3_TEAD1 motif

No targets for TEAD3_TEAD1

Network of associatons between targets according to the STRING database.

First level regulatory network of TEAD3_TEAD1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: